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( Hana Park ),( Jae Hyung Jung ),( Min Kyung Jung ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Simon Weonsang Ro ),( Jeon Han Park ),( Eui-cheol Shin ),( Kwang-hyub Han ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Regulatory T cell (Treg) play an essential role in regulation of antitumor immunity. Although several studies regarding Treg in hepatocellular carcinoma (HCC) have been reported, knowledge of Treg after transarterial chemoembolization (TACE) is still unrevealed. The aim of this study was to investigate clinical impact of Treg in HCC patients who treated with TACE. Methods: We measured the frequency of peripheral blood Tregs in 23 healthy controls and 27 HCC patients undergoing TACE between 2010 and 2012 at Severance Hospital. The patients were divided into two groups according to tumor response; complete response group and incomplete response group. Results: The frequency of Treg in HCC patients was significantly higher than in healthy controls (7.52±2.62% vs. 4.99±1.4%, P<0.001). In a Treg subpopulation, the frequency of Treg (II) was significantly higher in HCC patients than in healthy controls (2.51±1.08% in HCC vs. 0.60±0.28% in healthy controls, P<0.001). In comparison of Tregs numbers at baseline and post-TACE by tumor response, the change of Treg (III) in complete response group from before to after TACE was statistically significant (63.8±42.2/mm3→53.2±31.9/mm3, P=0.050). The complete response group contained more patients with low post-TACE Treg (III) numbers, and the incomplete response group more patients with high post-TACE Treg (III) numbers, with statistical significance (70.9% vs. 29.4% in complete response group; 30.0% vs. 70.0% in incomplete response group, P=0.040). Patients with high post-TACE Treg (III) exhibited a significantly shorter time to progression than those with high post-TACE Treg (III) (3.8 months vs. 11.6 months, P=0.038). On multivariate analysis, hypoalbuminemia (HR 3.324; 95% CI (1.098-10.063), P=0.034) and high post-TACE Treg (III) (HR 3.080; 95% CI (1.091-8.696), P=0.034) were independent sig-nificant prognostic factors in terms of progression. Conclusions: High peripheral blood Treg (III) levels at 1 month after TACE were independently prognostic of poor progression-free survival.
( Hana Park ),( Seung Up Kim ),( Jun Jeong Choi ),( Jun Yong Park ),( Sang Hoon Ahn ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Young Nyun Park ),( Do Young Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.4
A 63-year-old man with a history of hepatitis-B-related hepatocellular carcinoma (HCC) in the left lateral portion of the liver received repeated transcatheter arterial chemoembolization (TACE) and salvage radiotherapy. Two months after completing radiotherapy, he presented with dysphagia, epigastric pain, and a protruding abdominal mass. Computed tomography showed that the bulging mass was directly invading the adjacent stomach. Endoscopy revealed a fistula from the HCC invading the stomach. Although the size of the mass had decreased with the drainage through the fistula, and his symptoms had gradually improved, he died of cancer-related bleeding and hepatic failure. This represents a case in which an HCC invaded the stomach and caused a hepatogastric fistula after repeated TACE and salvage radiotherapy. (Korean J Hepatol 2010;16:401-404)
Park, Hana,Yoon, Jin Young,Park, Kyeong Hye,Kim, Do Young,Ahn, Sang Hoon,Han, Kwang-Hyub,Chon, Chae Yoon,Park, Jun Yong WJG Press 2012 WORLD JOURNAL OF GASTROENTEROLOGY Vol.18 No.16
<P>To evaluate long-term clinical course of Budd-Chiari syndrome (BCS) and predictive factors associated with the development of hepatocellular carcinoma (HCC) and survival.</P>
( Soo-kyung Park ),( Chang Hwan Choi ),( Jaeyoung Chun ),( Heeyoung Lee ),( Eun Sun Kim ),( Jae Jun Park ),( Chan Hyuk Park ),( Bo-in Lee ),( Yunho Jung ),( Dong-il Park ),( Do Young Kim ),( Hana Park 대한장연구학회 2020 Intestinal Research Vol.18 No.1
The treatment of inflammatory bowel disease (IBD) has been revolutionized for the last 10 years by the increasing use of immunomodulators and biologics. With immunosuppression of this kind, opportunistic infection is an important safety concern for patients with IBD. In particular, viral hepatitis is determined by the interaction between the virus and the host’s immunity, and the risk of reactivation increases if immunity is compromised by immunosuppression therapy. Parts of Asia, including Korea, still show intermediate endemicity for the hepatitis A virus and hepatitis B virus compared with the United States and Western Europe. Thus, members of IBD research group of the Korean Association for the Study of Intestinal Diseases have produced a guideline on the prevention and management of viral hepatitis in IBD. (Intest Res 2020;18:18-33)
Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer
Park Hana,신승각,주이진,Song Do Seon,Jang Jeong Won,Park Joong-Won 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.6
Background/Aims: Multiple meta-analyses and observational studies have reported that alcohol is a risk factor for liver cancer. However, whether there is a safe level of alcohol consumption remains unclear. We performed a systematic review and meta-analysis of the correlation between low-level alcohol consumption and the risk of liver cancer. Methods: Nested case-control studies and cohort studies involving the general population published prior to July 2019 were searched. In total, 28 publications (31 cohorts) with 4,899 incident cases and 10,859 liver cancer-related deaths were included. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: Compared with those with low levels of alcohol consumption, moderate and heavy drinkers (≥1 drink/day for females and ≥2 drinks/day for males) had pooled ORs of 1.418 (95% CI, 1.192 to 1.687; p<0.001) for liver cancer incidence and 1.167 (95% CI, 1.056 to 1.290; p=0.003) for liver cancer mortality. The pooled OR for liver disease-related mortality for those with more than low levels of alcohol consumption was 3.220 (95% CI, 2.116 to 4.898; p<0.001) and that for all-cause mortality was 1.166 (95% CI, 1.065 to 1.278; p=0.001). The sensitivity analysis showed that none of the studies had a strong effect on the pooled OR. The Egger test, Begg rank correlation test, and the funnel plot showed no overt indication of publication bias. Conclusions: Continuous consumption of more than a low-level of alcohol (≥1 drink/day for females and ≥2 drinks/ day for males) is related to a higher risk of liver cancer.
( Hana Park ),( Ji-ye Song ),( Hee Jung An ),( Yun Bin Lee ),( Joo Ho Lee ),( Mi Na Kim ),( Young Eun Chon ),( Yeon Jung Ha ),( Seong Gyu Hwang ),( Kyu Sung Rim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Transarterial chemoembolization (TACE) is widely used as a treatment modality for intermediate stage of hepatocellular carcinoma (HCC). Although several studies showed enhanced natural killer (NK) cell response after local treatment for HCC have been reported, knowledge of impact on NK cell after TACE is still unrevealed. The aim of this research was to investigate immunologic changes after TACE in HCC patients. Methods: Total 23 patients undergoing TACE for hepatocellular carcinoma were enrolled. Absolute counts of peripheral blood lymphocytes followed by phenotypic and functional characterization of NK cell population were carried out the day before, 1 and 4 weeks after TACE. Results: Peripheral blood lymphocytes kinetics revealed decrease of NK cell population at 1 week after TACE from the baseline (4.18% at 1 week vs. 9.54% at baseline, P=0.047), and restoration of NK cell population at 4 week after TACE from 1 week after TACE (12.24% at 4 week vs. 4.18% at baseline, P=0.040). This was along with significantly increased level of inhibitory NK receptor, NKG2A, at both time points of 1 week and 4 week after TACE from the baseline (20.24% at 1 week from 4.26% at baseline, P<0.001; 23.92% at 4 week from 4.26% at baseline, P<0.001), while there were no significant changes in activating NK receptors. Anti-K562 cell cytotoxicity appeared consistently decreased in terms of absolute activity at 1 week after TACE as compared to baseline, and showed a tendency to restore at 4 weeks after TACE. Conclusions: Unlike previously reported immunologic changes in patients with local treatment for HCC, immunologic function seems to be compromised shortly after TACE. This result suggests that various therapeutic strategies can have different effects on body immune function, and better understanding of the changes in the immune system in HCC patients will promise better tumor control.
Park, Hana,Park, Jun Yong,Kim, Seung Up,Kim, Do Young,Han, Kwang-Hyub,Chon, Chae Yoon,Ahn, Sang Hoon WJG Press 2013 World journal of gastroenterology Vol.19 No.43
<P>To examine the efficacy of telbivudine (LdT) + adefovir (ADV) vs continuation of lamivudine (LAM) + ADV in patients with LAM-resistant chronic hepatitis B (CHB) who show a suboptimal response to LAM + ADV.</P>
Total synthesis of 2′,4′,6′‐trimethoxy‐3′,5′‐dimethylchalcone derivatives
Park Rae Yeon,Lee Hana,Park Kwangyong 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.5
2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC), which is isolated from plants, has recently attracted much attention due to its beneficial pharmacological effects. The preparation of twelve 2′,4′,6′-trimethoxy-3′,5′- dimethylchalcone (DMDMC) derivatives, which are dimethylated-derivatives of DMC, is reported herein for the first time. Our synthetic method allowed the efficient construction of the DMDMC derivatives from phloroglucinol in 37.8%– 46.5% overall yields. This promising approach would be advantageous for the production of many different DMDMC derivatives in a short period of time.