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      • Suppressive effects of three diketopiperzines from marine-derived bacteria on TGFBIp-mediated septic responese in human endothelial cells and mice

        ( Byeongjin Jung ),( Sae Kwang Ku ),( Ming Gao ),( Kyung Min Kim ),( Min Su Han ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

        Diketopiperazine is a naturally occurring cyclic dipeptide found from diverse living organisma. The com-pounds in this structure class have been known with a broad spectrum of bioactivities including anti-inflamma-tory activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGB- β. TGFBIp is released by human umbilical vein endothelica cells and functions as a mediator of experi-mental sepsis. Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and we hypothesized that 1-3 could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of 1-3 effectively inhibited lipopolysac-charide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, 1-3 sup-pressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, 1-3 sup-pressed TGFBIp-mediated and CLP-induced septic response. Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflamma-tory diseases inhibition of the TGFBIp signaling pathway.

      • 인터넷을 통해서 본 미국 고등학교의 생물교육 내용 분석

        윤한선,김종균,김현섭 공주대학교 사범대학 과학교육연구소 1999 과학교육연구 Vol.30 No.1

        컴퓨터 통신과 인터넷에 힘입어 앞으로의 교육은 온라인 교육이 보편화될 것이다. 생물 교육에도 온라인 교육이 교육의 한 형태로 자리매김할 것으로 예상되므로 인터넷상의 학습 정보가 어느 정도인가를 파악하는 것은 매우 의미있는 일이라 생각된다. 따라서, 본 연구는 우리 나라보다 인터넷이 먼저 도입되고 또 많은 정보가 실려 있는 미국 고등학교 홈페이지의 생물 교과 내용을 조사 및 분석하여 우리 나라 고등학교의 생물 교과 온라인 교육 자료 제작에 참고할 수 있도록 함으로써 생물 교과의 수업에 조금이나마 도움을 주는 데 목적을 두고 수행되었다. 생물 교과 내용이 우수한 고등학교를 선정하기 위해서 미국에서 일반적으로 많이 적용하고 있는 4개의 홈페이지에 실린 19개 Topic을 기준으로 삼았다. 미국의 고등학교 홈페이지에 실린 내용이 그 기준에 어느 정도 접근하였는지를 조사하여, 접근률이 가장 큰 것에서부터 10개의 홈페이지를 선정, 그 내용을 분석하였다. 그 결과는 다음과 같다. 1. 미국 고등학교 훔페이지에는 학생들이 스스로 공부할 수 있는 생물 교과 내용이 충분히 있었고, 각 Topic에는 관련 사이트들이 많이 연결되어 있어서 각자의 능력에 맞는 내용을 선택하여 이용할 수 있게 되어 있었다. 2. 또한 전자우편을 통하여 질문과 답변뿐만 아니라 시험문항에 대한 답을 교환할 수도 있었다. 3. 표준으로 삼은 4개의 홈페이지와 상위 10개 홈페이지에 주로 소개되는 Topic은 Classical Genetics, The Cell, Biological Evolution, Chemistry of Life, Plants, Molecular Basis of Heredity, Energy, Diversity of Organisms, Behavior of Organisms, Cellular Respiration의 순서로 나타났는데, 이들 내용은 우리 나라 고등학교의 생물 교과 온라인 수업에 이용될 내용을 선정하는 데 참고로 삼을 만하였다. The continuous development of internet makes us not only use many types of information such as letters, pictures, sounds, animations and video-visions synthetically, but ?? communicate with each other. In a short time, we will make use of the computer with multimedia instead of the blackboard in education. And the on-line education will be world-wide by the help of telecommunication and internet. Naturally, it also will be applied to biology education. The purpose of this study is to analyze the homepages of the United States high school in order to help building up the data-base for high school biology curriculum of our country. For this study, we first investigated the references. Next, we classified and standardized the curriculums of the United States high school. After that, we searched for the high school home pages in the registered engine. Finally, we selected and analyzed the home pages close to the standard biology curriculum of them. The analyzed results were as follows. 1. The homepages of the United States high school were contained much biology related contents, and linked to various related topic sites including many animations to stimulate interest of students. It means that United States high school make good use of internet for the biology learning. 2. The homepags of the United States high school were also contained the teaching plan, the informations and questions for examination so that students may catch the way of learning. 3. It may be possible that students self-study using them. because the homepages were composed of the simple and systematic structure.

      • KCI등재
      • 스포츠 活動을 通한 老人의 意識構造 變化 調査 硏究 : Gate Ball을 중심으로

        金韓燮 관동대학교 1989 關大論文集 Vol.17 No.1

        Through introducing Gate Ball to the Aged people as their activity the following were gained. 1. Those who play G.B. showed good response to their recreational actirity. The male group who does'nt play G.B. show their interest on sports to certain degree while female group showed much correlation in their interest on sports between those who play G.B. and those who does not. 2. In the inquiry into their attitude toward sports, The male group responded that survey if they exercise, they can have patience and they feel so good, While the female group replied that when they are going to exercise, they feel uneasy, they break their friendship etc. 3. As to the result of G.B, both male and female group provide time for playing G.B and they feel fun competing with others, and they need to use their brain by some opeeration. 4. As to the number of practising and the time of playing G.B age does not seem to affect the number and time, thereby showing that G.B must be a very useful sports through the amount of activity be small. 5. As to the increase of friends, 13.3 percent of them answerd So. 6. Both the male and fmale group consider that the atmosphere between their family members became brighter after they had play G.B. 7. The relation betwen the number of pulsebeet and age during the game showed no correlation. It has been stabilized. Only the female group showed a little correlation between the number of their pulse-beet and their age.

      • KCI등재
      • 1999-2002년 시기의 한국영화 붐에 대한 연구

        강한섭 한국영화교육학회 2003 영화교육연구 Vol.5 No.-

        The years between 1999-2002 are thought boom periods by many researchers. There were several significant accomplishments in the number of screens and volume of ticket sales and export. With the box-office success of 'Shiri' in 1999, the Korean film industry had entered unexpected boom years. But the over all market size had shrinked by 5-10% annually during same years. What happened? The purpose of this study is an critical overview of the recent korean f h boom with the theory of the Austrian school of economics. According to neoclassical theory, consumer demand is determined by the utility of each commodity to the consumer. But consumers often are persuaded by false and misleading advertising, and their actions are guided not by a pursuit for utility but by impulse, fear or simple caprice. What is unique to the Austrian economic theory is their stress on problem of information in economics. From this developed the Austrians' concern with both capital and business cycle theory which believes that economic boom and bust is a series of cyclical events caused by bouts of bank credit at a market rate of interest below the rate of return on capital. The boom years cannot be prolonged indefinitely without real productivity gains. With several big box office flops, the new capital formation must be prematurely terminated. The korean film boom come to an abrupt stop in 2002. And korean film industry is in the middle of passing bubble-bust times.

      • KCI등재
      • 人文系 高等學校 (男,女)學生의 體育成積, 身體 充實指數, 體力章과의 相關關係 調査

        金漢燮 관동대학교 1984 關大論文集 Vol.12 No.2

        It is a matter of course that our wish to be more healthy has been, and is enshrined in heart. Physical power has been improved owing to the highly-developed science and technology, moreover, middle and high school student's physical fitness has made a remarkable progress. This can be attributed the systematic training and normalized school education in gymanastics. The purpose of this paper is to prove the correlationship between Physical Fitness Test, physique index and physical achievement. 1. The correlation rate between Physical Fitness Test and Physique Index is 0.20∼0.40, being little significant. 2. The correlation rate between student's physical Achievement records and Physical Fitness Test 0.40∼0.60 (both male and female), proving to be clearly significant. 3. It has turned out that there is a noticeable relationship between physical achievement records and physique Index. This research shouss that middle and high school student's physical grouth can be achieved by performing student's physical check-up two times rather than just once a year. A more accurate measurement of student's physical conditions will be helpful their growth.

      • 2¼Cr-1Mo강 압력용기 용접이음부의 재열균열에 관한 역학적 연구

        권영섭,노찬승,방한서 朝鮮大學校 機械技術硏究所 1999 機械技術硏究 Vol.2 No.2

        구조물에 사용되는 각종 압력용기들의 재질은 고온 및 고압에 견딜 수 있도록 요구되고 있다. 따라서, 내열, 내압 및 내부식성이 뛰어난 2¼Cr-1Mo강의 수요가 향후 증대될 전망이다 용접잔류응력은 일반적으로 응접구조물에 각종 악영향을 미치는 것으로 알려져 있다. 이 때문에 용접잔류응력. 확산성 수소제거 및 용접 열영향부의 연화등을 목적으로 용접후열처리(PWHT)를 수행하나, PWHT를 행하면 사용 강재의 종류에 따라 재열균열이 발생하고 있다. 본 연구에서는 2¼Cr-1Mo강에 대하여 실험과 수치해석 기법을 통하여 용접이음부의 재열균열 감수성평가 및 상당크리프 변형율의 재열균열 발생에 판정에 대한 역학적 지표로서의 적용성을 검토하였다. 2¼Cr-1Mo steels are widely used to fabricate pressure vessels. Residual stresses, in general, are known to be harmful to the soundness of the welded structures. PWHT is release residual stresses, which may cause cracks. But, in those PWHT process, 2¼Cr-1Mo steels are apt to occur reheat crack frequently. In this reason, it is strongly needed to analysis and examine the mechanical behavior of welded joints through welding to PWHT process. So, in this study, welded nozzle parts of pressure vessel where reheat cracks are frequently occur are selected for examine the crack-occurrence mechanism.

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