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- 저자 : Hamid, AlaviMajd (검색결과 1,264 건)
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Hamid Aboutaleb Kadkhodaeian,Taki Tiraihi,Hamid Ahmadieh,Hossein Ziaei,Narsis Daftarian,Taher Taheri 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.3
BACKGROUND: Retinal degeneration causes blindness, and cell replacement is a potential therapy. The purpose of this study is to formation of pigmented neurospheres in a simple medium, low-cost, high-performance manner over a short period of time while expressing markers of RPE cells and the activation of specific genes of the pigment cells. Also, these neurospheres have the ability to produce a monolayer of retinal pigment epithelium-like cells (RPELC) with the ability of photoreceptor outer segment phagocytosis. METHODS: BMSC were isolated from pigmented hooded male rats and were immunoreactive to BMSC markers, then converted into neurospheres, differentiated into pigmented spheres (PS), and characterized using Retinal pigment epithelium-specific 65 kDa protein (RPE65), Retinaldehyde-binding protein 1 (CRALBP) and orthodenticle homeobox 2 (OTX2) markers by immunocytochemistry, RT-PCR and RT-qPCR. The PS were harvested into RPELC. The functionality of RPELC was evaluated by phagocytosis of fluorescein-labeled photoreceptor outer segment. RESULTS: The BMSC immunophenotype was confirmed by immunostained for fibronectin, CD90, CD166 and CD44. These cells differentiated into osteogenic and lipogenic cells. The generated neurospheres were immunoreactive to nestin and stemness genes. The PS after 7–14 days were positive for RPE65 (92.76–100%), CRALBP (95.21–100%) and OTX2 (94.88–100%), and after 30 days RT-PCR, qPCR revealed increasing in gene expression. The PS formed a single layer of RPELC after cultivation and phagocyte photoreceptor outer segments. CONCLUSION: Bone marrow stromal stem cells can differentiate into functional retinal pigmented epithelium cells in a simple, low-cost, high-performancemanner over a short period of time. These cells due to expressing theRPELCgenes andmarkers can be used in cell replacement therapy for degenerative diseases including age-relatedmacular degeneration as well as retinitis pigmentosa.
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Hamid Khademhosseini Beheshti,Hamid Lankarani 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.5
This paper obtains a Mathematical Dynamic Model (MADYMO) for occupant lumbar load evaluation under CFR Part 23 and 25 at extreme ranges of temperature. The validation of results is performed by full scale sled test results. Aircraft industries are using viscoelastic polyurethane foams as seat cushion. Visco-elastic foams bring not only more comfort to the passengers in long term sitting but it also maintains more safety during unpredicted crashes and hard landings. Aircraft seat cushions are exposed to varying temperature ranges during their life time. This fact has motivated aircraft industries to evaluate the seat cushion dynamic behavior at extreme ranges of temperatures in addition to what is mentioned in Federal Aviation Administration (FAA) Regulations at room temperature. This research provides a methodology based on simulation and modeling to eliminate, or at least, minimize the number of full scale dynamic sled tests defined by regulations for aircraft seats at extreme ranges of temperature.
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The Impact of Supply Chain Management on Organizational Performance and Customer Satisfaction
Hamid Babaei Meybodi,Seyed Hamid Emadi,Tina Roostapisheh,Haniyeh Ghiyasvand Mohammadkha 대한산업공학회 2018 Industrial Engineeering & Management Systems Vol.17 No.3
The present study has been conducted with the purpose of investigating the impact of supply chain management (SCM) on organizational performance and customer satisfaction in two factories in Shiraz Industrial Estate. Therefore, according to the research subject, the variables of supply chain management, organizational performance and also customer satisfaction have been defined. In terms of objective, this is an applied study and in terms of nature and method, this is a descriptive-correlational study. The statistical population consists of 100 people and the sample consists of 80 people. The reliability and validity of research have firstly been examined and then the results were analyzed using SPSS and LISREL. The obtained results indicate the impact of supply chain management on organizational performance and customer satisfaction.
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RNAi and miRNA in Viral Infections and Cancers
Mollaie, Hamid Reza,Monavari, Seyed Hamid Reza,Arabzadeh, Seyed Ali Mohammad,Shamsi-Shahrabadi, Mahmoud,Fazlalipour, Mehdi,Afshar, Reza Malekpour Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Since the first report of RNA interference (RNAi) less than a decade ago, this type of molecular intervention has been introduced to repress gene expression in vitro and also for in vivo studies in mammals. Understanding the mechanisms of action of synthetic small interfering RNAs (siRNAs) underlies use as therapeutic agents in the areas of cancer and viral infection. Recent studies have also promoted different theories about cell-specific targeting of siRNAs. Design and delivery strategies for successful treatment of human diseases are becomingmore established and relationships between miRNA and RNAi pathways have been revealed as virus-host cell interactions. Although both are well conserved in plants, invertebrates and mammals, there is also variabilityand a more complete understanding of differences will be needed for optimal application. RNA interference (RNAi) is rapid, cheap and selective in complex biological systems and has created new insight sin fields of cancer research, genetic disorders, virology and drug design. Our knowledge about the role of miRNAs and siRNAs pathways in virus-host cell interactions in virus infected cells is incomplete. There are different viral diseases but few antiviral drugs are available. For example, acyclovir for herpes viruses, alpha-interferon for hepatitis C and B viruses and anti-retroviral for HIV are accessible. Also cancer is obviously an important target for siRNA-based therapies, but the main problem in cancer therapy is targeting metastatic cells which spread from the original tumor. There are also other possible reservations and problems that might delay or even hinder siRNA-based therapies for the treatment of certain conditions; however, this remains the most promising approach for a wide range of diseases. Clearly, more studies must be done to allow efficient delivery and better understanding of unwanted side effects of siRNA-based therapies. In this review miRNA and RNAi biology, experimental design, anti-viral and anti-cancer effects are discussed.
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Improvement of surface conditions of 36 Cr Ni Mo 6 steel by ball burnishing process
Hamid Hamadache,Zahia Zemouri,Lakhdar Laouar,Serge Dominiak 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.4
Ball burnishing, a mechanical surface treatment, is becoming more popular as a finishing process. As results ball burnishing is noticedas a very simple way of surface mirror finishing and surface work-hardening. Applying the optimal input parameters, a pre-machinedsurface roughness Ra about of 3.01 μm can be finished to approximately 0.30 μm, whereas an initial hardness HRA about 66.35 can beincreased to 71.33. A metallographic observation and some measurement of micro-hardness show that the depth of penetration strengthenedby plastic surface deformation (PSD) reaches 100 μm. Results analysis show that burnishing force, burnishing ball radius and numberof ball burnishing tool passes have the most significant effects on both surface responses (Ra and HRA). For the generating of highsurface qualities and strengthening superficial layers, an alternative to chip-forming process and heat treatments can be given by ball PSDprocess.
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Effect of brittleness on the micromechanical damage and failure pattern of rock specimens
Hamid Reza Nejati,Mehrdad Imani,Kamran Goshtasbi,Amin Nazerigivi 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.29 No.4
Failure patterns of rock specimens represent valuable information about the mechanical properties and crack evolution mechanism of rock. Several kinds of research have been conducted regarding the failure mechanism of brittle material, however; the influence of brittleness on the failure mechanism of rock specimens has not been precisely considered. In the present study, experimental and numerical examinations have been made to evaluate the physical and mechanical phenomena associated with rock failure mechanisms through the uniaxial compression test. In the experimental part, Unconfined Compressive Strength (UCS) tests equipped with Acoustic Emission (AE) have been conducted on rock samples with three different brittleness. Then, the numerical models have been calibrated based on experimental test results for further investigation and comparing the micro-cracking process in experimental and numerical models. It can be perceived that the failure mode of specimens with high brittleness is tensile axial splitting, based on the experimental evidence of rock specimens with different brittleness. Also, the crack growth mechanism of the rock specimens with various brittleness using discrete element modeling in the numerical part suggested that the specimens with more brittleness contain more tensile fracture during the loading sequences.
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Hamid Madani,Hadi Hosseini,Maryam Shokravi 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.22 No.4
Vibration analysis of embedded functionally graded (FG)-carbon nanotubes (CNT)-reinforced piezoelectric cylindrical shell subjected to uniform and non-uniform temperature distributions are presented. The structure is subjected to an applied voltage in thickness direction which operates in control of vibration behavior of system. The CNT reinforcement is either uniformly distributed or functionally graded (FG) along the thickness direction indicated with FGV, FGO and FGX. Effective properties of nano-composite structure are estimated through Mixture low. The surrounding elastic foundation is simulated with spring and shear constants. The material properties of shell and elastic medium constants are assumed temperature-dependent. The motion equations are derived using Hamilton's principle applying first order shear deformation theory (FSDT). Based on differential cubature (DC) method, the frequency of nano-composite structure is obtained for different boundary conditions. A detailed parametric study is conducted to elucidate the influences of external applied voltage, elastic medium type, temperature distribution type, boundary conditions, volume percent and distribution type of CNT are shown on the frequency of system. In addition, the mode shapes of shell for the first and second modes are presented for different boundary conditions. Numerical results indicate that applying negative voltage yields to higher frequency. In addition, FGX distribution of CNT is better than other considered cases.
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Hamid Radmanesh,S.H.Fathi,G.B. Gharehpetian 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.5
Recently, various types of Solid State Fault Current Limiters (SSFCLs) have been proposed. These SSFCLs can improve the voltage quality, decrease the transmission losses, and also can enhance the distribution network stability but there are some practical problems with these FCLs. This paper proposes a modified FCL with focusing on the components optimization, efficiency improvement and reducing the cost. The suggested FCL uses a series AC reactor with controllable power electronic switches named Thyristor-Controlled AC Reactor (TCAR) which is connected in series with the feeder to limit the fault current and avoid fault current problems, which impairs overall distribution network reliability. The influence of TCAR on the fault current is analyzed using analytical, simulation and laboratory tests. The performance of the proposed TCAR in the simple distribution network is examined. The simulation and experimental results are in a good agreement with together and show the proper operation of the proposed TCAR during the normal and fault operation modes.
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