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CDK2 is Required for the DNA Damage Response during Porcine Early Embryonic Development
HaiYang Wang,Yu-Jin Jo,Tian-Yi Sun,Suk Namgoong,Xiang-Shun Cui,Jeong Su Oh,Nam-Hyung Kim 한국수정란이식학회 2016 한국수정란이식학회 학술대회 Vol.2016 No.10
CDK2 inhibition plays a central role in DNA damage–induced cell cycle arrest and DNA repair. However, whether CDK2 also influences early porcine embryo development is unknown. In this study, we examined whether CDK2 is involved in the regulation of oocyte meiosis and early embryonic development of porcine. We found that disrupting CDK2 activity with RNAi or an inhibitor did not affect meiotic resumption or MII arrest. However, CDK2 inhibitor-treated embryos showed delayed cleavage and ceased development before the blastocyst stage. Disrupting CDK2 activity is able to induce sustained DNA damage as demonstrated by the formation of distinct γH2AX foci in nuclei of day 3- and day 5-embryos. Inhibiting CDK2 triggers a DNA damage checkpoint by activating of the ATM-P53-P21 pathway. However, the mRNA expression of genes involved in non-homologous end-joining (NHEJ) or homologous recombination (HR) pathways for double strand break (DSB) repair reduced after administering CDK2 inhibitor to 5-day-old embryos. Furthermore, CDK2 inhibition caused apoptosis in day 7 blastocysts. Thus, our results indicate that an ATM-P53-P21 DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.
Study on Preparation and Properties of PAI Materials Containing Trifluoromethyl in Side Chain
Haiyang Yang,Duxin Li,Jun Yang,Jin Wang,Shunchang Gan,Kaikai Cao,Yufeng Liu 한국고분자학회 2021 Macromolecular Research Vol.29 No.10
Polyamide-imide (PAI) materials with good heat resistance, excellent friction, wear properties, and low water absorption were prepared by acyl chloride process with diamine monomer containing trifluoromethyl in the side chain. The results showed that PAI prepared from 2,2'-bis(trifluoromethyl)-[1,1'-biphenyl]- 4,4'-diamine without flexible hinge group had the best heat resistance, with T g as high as 302.6℃ and T d5% as 490.1℃. With the increase of the proportion of flexible hinge groups in diamine monomer, the thermal properties of PAI materials would decrease. The wear mechanism of PAI prepared from 2,2'-bis(trifluoromethyl)- [1,1'-biphenyl]-4,4'-diamine was mainly adhesive wear. With the increase of the proportion of flexible hinge groups in diamine monomer, the wear mechanism would change from abrasive wear, slight adhesive wear to severe adhesive wear. The friction coefficient and wear loss of PAI prepared by 1,4-bis(4-amino-2-trifluoromethylphenoxy) benzene were the smallest, which were 0.4706 and 3.5, respectively. PAI synthesized by diamine monomer containing trifluoromethyl had low water absorption and high water contact angle. With the increasing flexibility of monomer containing trifluoromethyl diamine, the elongation at break and tensile strength of the material increased gradually.
Bimetallic Au–Sn/AC catalysts for acetylene hydrochlorination
Yanzhao Dong,Haiyang Zhang,Wei Li,Mengxia Sun,Cuili Guo,Jinli Zhang 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.35 No.-
A series of Au–Sn/AC catalysts for acetylene hydrochlorination were prepared by an incipient wetnessimpregnation method and characterized by BET, XPS, TEM, TPR, XRD, ICP-AES and TPD techniques. It isindicated that Au1Sn1/AC catalyst shows the highest activity and stability with the 95% acetyleneconversion after 48 h reaction under the conditions of 170 8C and an acetylene gas hourly space velocityof 720 h 1. The Sn additive can make the Au species dispersed well and weaken the occurrence of cokedeposition, as well as inhibit the reduction of Au3+ to Au0, thereby improving the catalytic activity andstability.
Yuling Qiu,Yali Chen,Haiyang Yu,Qianxiang Zhou,Ran Wang,Meihua Jin,Dexin Kong 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.2
Bee venom has been used for treating various diseases for a long time. However, the bioactive constituents of bee venom and its mechanisms remain poorly understood. In the present study, phospholipase A2 (Bt-PLA2) cDNA was cloned, and a mature form of Bt-PLA2 was purified from bumblebee venom (Bombus terrestris). The differentiation induction and apoptosis induction activities of Bt-PLA2 on chronic myelogenous leukemia (CML) K562 cells were also evaluated. Bt-PLA2 cDNA has 540 nucleotides that encode a 180-amino-acid protein. The purified, mature form of Bt-PLA2 was an 18-kDa protein, and it inhibited K562 cell growth, determined by an IC50 value of 29.5 ng/μl. Moreover, Bt-PLA2 induced erythroid differentiation of K562 cells in a dose-dependent manner, and this was supplemented with the upregulation of glycophorin A (GPA) mRNA expression. Bt-PLA2- induced apoptosis, analyzed by DAPI staining, was correlated with the result analyzed by AnnexinV-FITC/PI binding. Furthermore, activation of caspase 3 and poly ADP-ribose polymerase (PARP) and inhibition of p-Akt, determined by western blot, further demonstrated that Bt-PLA2 induced apoptosis mainly through the Akt pathway. The parallel induction of erythroblasts differentiation of K562 cells and apoptosis due to Bt-PLA2 treatment demonstrated the potential use of Bt-PLA2 as an anti-leukemia drug lead.
Xuechen Rao,Lanxiang Liu,Haiyang Wang,Ying Yu,Wenxia Li,Tingjia Chai,Wei Zhou,Ping Ji,Jin-Lin Song,Hong Wei,Peng Xie 한국뇌신경과학회 2021 Experimental Neurobiology Vol.30 No.1
An increasing number of studies have recently indicated the important effects of gut microbes on various functions of the central nervous system. However, the underlying mechanisms by which gut microbiota regulate brain functions and behavioral phenotypes remain largely unknown. We therefore used isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic analysis to obtain proteomic profiles of the hippocampus in germ-free (GF), colonized GF, and specific pathogen-free (SPF) mice. We then integrated the resulting proteomic data with previously reported mRNA microarray data, to further explore the effects of gut microbes on host brain functions. We identified that 61 proteins were upregulated and 242 proteins were downregulated in GF mice compared with SPF mice. Of these, 124 proteins were significantly restored following gut microbiota colonization. Bioinformatic analysis of these significant proteins indicated that the glucocorticoid receptor signaling pathway and inflammation-related pathways were the most enriched disrupted pathways. This study provides new insights into the pathological mechanisms of gut microbiota-regulated diseases.
맹해양,김언군,방영,배기형,Meng. Haiyang,Jin. Yanjun,Pang Ying,Bae. Gihyeong 한국물류학회 2015 물류학회지 Vol.25 No.2
본 논문의 목적은 고대부터 운하의 교통, 운반수단으로 이용된 중국 대운하의 역사와 현황 그리고 이에 대한 경제적 파급효과에 대하여 분석함으로써 대운하의 중요성을 재확인하여 향후 중국의 물류정책에 일조하는데 있다. 중국의 대운하는 항만과 연해항만의 통합운영으로 물류단지 및 내륙도시 해안화의 효과로 지역균형 발전에 대한 파급효과는 크며 남수복조공정으로 인하여 중국의 물 자원 전략은 비교적 안정적으로 확보되어 있고 수해방지 및 생태의 완화효과도 있다. 그리고 교통혼잡의 완화로 연해 운송활성화를 통한 해외 화물수송의 효율성을 높일 수 있을 뿐만 아니라 연안 운송 활성화를 촉진시켜 국내 물류비용을 절감할 수 있다. 특히 해양⋅도로⋅수로의 통합되는 운송수단 및 물류정보화 그리고 관련 플랫폼의 개발로 물류의 혁신은 지속화 되고 있다. 또한 운하는 농산물의 발전, 소로와 접목한 반도체 및 미디어단지의 형성, 레저⋅관광산업이 개발에 대하여 크게 이바지 한다. 중국의‘신 실크로드 글로벌 전략’에 따른 세계지역의 운하건설 참여이다. 따라서 이러한 신 실크전략의 일환 으로 여타 교통수단과 통합된 운하는 철도실크로드전략. 에너지실크로드전략(말레이반도 크라 운하건설)전략으로 국제 지역 간 경제통합을 촉진시켰다. 나아가 중국의 글로벌 경제성장에 큰 파급효과를 줄 것이고 국가경쟁력을 제고시킬 것이다. The purpose of this study is to review historical background of China’s grand canal, that has been used for goods transport as well as traffic mean since old days, and to analyze its economic influence, and to reconfirm its importance, so that to support future logistic policy of China. The China’s grand canal allows unified operation of ocean ports and coastal harbors as well as makes inland city to coastal harbor, so that gives big influence to the balanced regional development. The construction of grand canal has improved water resource availability as well as flood prevention. and the traffic congestion can be relieved by revitalization of coastal transport, so the efficiency of export freight traffic can be improved. also the mass transport can give cut-down effect on logistic cost. China can participate in world-wide canal construction projects, as of the part of Global New Silkroad Strategy. Furthermore it can give big influence to global economic growth of China as well as improve national competitiveness.