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Laifa Ding,Binhao Qin,Keke Ge,Zhibin Zeng,Khaskin Vladyslav,Feng Li,Yupeng Zhang,Haiyan Wang 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.8
The butt joint of 30 mm-thick Ti–6Al–3Nb–2Zr–1Mo titanium alloys were achieved by the magnetron-controlled narrow gapTIG welding. Microstructure and mechanical properties of joint were comprehensively explored. Ti6321 base metal (BM)was composed of primary α (accounting for 55%) and structure of β transformation (secondary α + β phase). Fine grainedheat affected zone was composed of primary α, acicular α and β phase. Coarse grained heat affected zone was composed ofacicular α and clusters of α phase with different orientations. The fusion zone (FZ) was composed of acicular α phase, lathα phase and a few β phase. The ratio of high-angle grain boundaries in the HAZ reached the maximum of 94.5% while thoseof the FZ and BM were 78.1% and 59.4%, respectively. Due to the differences in microstructures and grain orientation, thehardness of FZ (286 HV) was lower than those of BM (304 HV) and HAZ (306 HV). The tensile strength of the weldingjoint (838 MPa) reached 95% of the BM (883 MPa), and the joint showed excellent impact performance with great impactenergies of FZ (72 J) and HAZ (75 J), higher than that of BM (51 J). It was owing to the greater ratio of high-angle grainboundaries in FZ and HAZ that could store more grain boundary energies. Thicker phases hinder the growth of cracks, and,therefore, improve the impact performance of the joint.
Wei Tian,Chenyu Wang,Ran Chu,Haiyan Ge,Xiao Sun,Mingjiang Li 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Endometriosis is a common gynecological disease in women of childbearing age. Commonly used treatment methods, such as endocrine and surgical therapies, display poor therapeutic effects with a high relapse probability. Thus, novel treatments for endometriosis are required. Methods In our study, polydopamine (PDA), letrozole (LTZ), and agarose (AG) hydrogels were combined to construct an injectable hydrogel with near-infrared controlled drug delivery named LTZ-PDA@AG hydrogel for endometriosis treatment. The release of letrozole can be accurately controlled by the near-infrared light intensity, exposure duration, polydopamine concentration, and hydrogel composition. Meanwhile, we isolated endometrial stromal cells from endometrium in patients with endometriosis, and constructed the rats’ model of endometriosis to verify the biological effects of LTZ-PDA@AG hydrogel. Results Owing to the sufficiently deep penetration of near-infrared light, the LTZ-PDA@AG hydrogel displayed a high temperature increase for efficient photothermal therapy. In addition, high local temperatures can further enhance the diffusion and penetration of letrozole, thereby achieving excellent therapeutic effect in vivo. Importantly, the in vivo and vitro test demonstrated the capacity of the nanocomposite hydrogel for endocrine-photothermal synergistic therapy and the biocompatibility. Conclusion Our work proposes a novel concept for precision endometriosis therapy by photothermal-enhanced endocrine therapy for endometriosis, which is proposed for the first time for the treatment of endometriosis and demonstrates excellent potential for further clinical translation.
Linyue Pan,Yuting Tan,Bin Wang,Wenjia Qiu,Yulei Yin,Haiyan Ge,Huili Zhu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose Caspase recruitment domain containing protein 9 (CARD9) has been demonstrated to be a pro-tumor factor in various cancers. However, our previous study found a significant decrease of CARD9 in malignant pleural effusion compared with benign pleural effusion. So we investigated the role of CARD9 in non-small cell lung cancer (NSCLC) and its working mechanism. Materials and Methods Immunohistochemistry, western blot, and quantitative real-time polymerase chain reaction were used to detect the expression of CARD9 in specimens of NSCLC patients. The Cancer Genome Atlas (TCGA) database was also used to analyze the expression of CARD9 in NSCLC and its predicting value for prognosis. Immunofluorescence was used for CARD9 cellular location. Cell growth assay, clonal formation assay, wound healing assay, matrigel invasion assay, and flow cytometry were used to test cell proliferation, migration, invasion, apoptosis, and cycle progression of NSCLC cells with CARD9 knockdown or CARD9 overexpression. Co-immunoprecipitation was used to identify the interaction between CARD9 and B-cell lymphoma 10 (BCL10). SB203580 was used to inhibit p38 activation. Results CARD9 was decreased in NSCLC tissues compared with normal tissues; low CARD9 expression was associated with poor survival. CARD9 was expressed both in tumor cells and macrophages. Downregulation of CARD9 in NSCLC cells enhanced the abilities of proliferation, invasion, and migration via activated mitogen-activated protein kinases (MAPK)/p38 signaling, while overexpression of CARD9 presented antitumor effects. BCL10 was identified to interact with CARD9. Conclusion We demonstrate that CARD9 is an independent prognostic factor in NSCLC patients and inhibits proliferation, migration, and invasion by suppressing MAPK/p38 pathway in NSCLC cells.