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Yoshiki Ikeda,Masato Yoshihara,Satoshi Tamauchi,Akira Yokoi,Nobuhisa Yoshikawa,Hiroaki Kajiyama 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.4
Objective: The survival benefits of retroperitoneal lymphadenectomy (RLNA) for epithelial ovarian cancer (EOC) remain controversial because clinical behaviors differ among subtypes. The purpose of the present study was to clarify whether RLNA increases the survival rate of advanced high-grade serous carcinoma (HGSC). Methods: This was a retrospective cohort analysis of 3,227 patients with EOC treated between 1986 and 2017 at 14 institutions. Among them, 335 patients with stage IIB-IV HGSC who underwent optimal cytoreduction (residual tumor of <1 cm) were included. Patients were divided into the RLNA group (n=170) and non-RLNA group (n=165). All pathological slides were assessed based on a central pathological review. Oncologic outcomes were compared between the two groups in the original and weighted cohorts adjusted with the inverse probability of treatment weighting. Results: The median observation period was 49.8 (0.5–241.5) months. Overall, 219 (65%) out of 335 patients had recurrence or progression, while 146 (44%) died of the disease. In the original cohort, RLNA was a significant prognostic factor for longer progression-free survival (PFS) (hazard ratio [HR]=0.741; 95% confidence interval [CI]=0.558–0.985) and overall survival (OS) (HR=0.652; 95% CI=0.459–0.927). In the weighted cohort in which all variables were well balanced as standardized differences decreased, RLNA was also a significant prognostic factor for more favorable oncologic outcomes (PFS, adjusted HR=0.742; 95% CI=0.613–0.899) and OS, adjusted HR=0.620; 95% CI=0.488–0.787). Conclusion: The present study demonstrated that RLNA for stage III-IV HGSC with no residual tumor after primary debulking surgery contributed to better oncologic outcomes.
Fuka Ikeda,Yuki Okamoto,Kei Nishikawa,Hiroaki Yamada,Masayuki Okamoto,Toshihiko Tanaka 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper proposes a sinusoidal chargingdischarging method of the lithium-ion batteries (LiBs) to reduce the capacitances of the dc-capacitors in the previously proposed smart charger (SC) for electric vehicles (EVs) in single-phase three-wire distribution feeders with power quality compensator. The dc-capacitor current in the three-leg pulse-width-modulated (PWM) rectifier is detected, and then added to the reference value for the output current of the bidirectional dc-dc converter that is used to charge or discharge the LiBs. The addition of the detected dc-capacitor current to the reference value of the bidirectional dc-dc converter achieves the sinusoidal chargingand discharging-operations of the LiBs in EVs. The sinusoidal charging- and discharging-operations sink the voltage ripples in the dc-capacitors of both the PWM rectifier and bidirectional dc-dc converter in the SC. This achieves the substantial reduced dc-capacitors in the SC. The simulation results demonstrate that balanced and sinusoidal source currents with a unity power factor can be achieved reducing the capacitances of dc-capacitors in the SC.