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Guoning Wang,Xiong Du,Ying Shi,Heng-Ming Tai,Yongliang Ji 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.3
Frequency coupling in the phase domain is a recently reported phenomenon for phase locked loop (PLL) based three-phase grid-inverter systems. This paper investigates the mechanism and stabilization method for the frequency coupling to the stability of grid-inverter systems. Self and accompanying admittance models are employed to represent the frequency coupling characteristics of the inverter, and a small signal equivalent circuit of a grid-inverter system is set up to reveal the mechanism of the frequency coupling to the system stability. The analysis reveals that the equivalent inverter admittance is changed due to the frequency coupling of the inverter, and the system stability is affected. In the end, retuning the bandwidth of the phase locked loop is presented to stabilize the three-phase grid-inverter system. Experimental results are given to verify the analysis and the stabilization scheme.
[10]-Gingerol Induces Intrinsic Apoptosis in A2058 Human Melanoma Cells
Guon, Tae Eun,Chung, Ha Sook The Korean Society of Food and Nutrition 2022 韓國食品營養學會誌 Vol.35 No.3
The objective of the present study was to investigate the molecular mechanisms involved in the activity of [10]-gingerol using A2058 human melanoma cells. [10]-Gingerol inhibited the proliferation of A2058 cells by 50% at a concentration of 52 μM. Such inhibition was dose-dependent accompanied by morphological change indicative of apoptosis. Furthermore, flow cytometric analysis by Annexin V and PI double staining showed that [10]-gingerol increased the extent of apoptosis. Analysis of the mechanism of these events indicated that [10]-gingerol increased the ratio of Bax to Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner.
Comparative Study of Zhu Xi and Wang Fu-zhi on the theories of Mind, Nature, Feeling, and Ability
Guon, Ji-yong 성균관대학교 동아시아학술원 2001 Sungkyun Journal of East Asian Studies Vol.1 No.1
Comparative Study of Zhu Xi and Wang Fu-zhi on the theories of Mind, Nature, Feeling, and Ability
Wang, Guoning,Du, Xiong,Shi, Ying,Tai, Heng-Ming,Ji, Yongliang The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.3
Frequency coupling in the phase domain is a recently reported phenomenon for phase locked loop (PLL) based three-phase grid-inverter systems. This paper investigates the mechanism and stabilization method for the frequency coupling to the stability of grid-inverter systems. Self and accompanying admittance models are employed to represent the frequency coupling characteristics of the inverter, and a small signal equivalent circuit of a grid-inverter system is set up to reveal the mechanism of the frequency coupling to the system stability. The analysis reveals that the equivalent inverter admittance is changed due to the frequency coupling of the inverter, and the system stability is affected. In the end, retuning the bandwidth of the phase locked loop is presented to stabilize the three-phase grid-inverter system. Experimental results are given to verify the analysis and the stabilization scheme.
Tae Eun Guon,정하숙(Ha Sook Chung) 한국차학회 2022 한국차학회지 Vol.28 No.2
생강(ginger, Zingiber officinale Roscoe)은 생강과(Zingiberaceae)에 속하는 다년생 초본(草本)으로 열대 아시아가 원산지이며, 아시아, 아프리카, 아메리카 지역에서 재배되고 있다. 지하에서 성장하는 덩이줄기인 생강은 색이 진한 노란색부터 황색 또는 붉은색을 띄는 다육질이며 향신료 및 기능성 소재로 꾸준히 활용되고 있다. 생강에는 폴리페놀 등 400여 종류의 화합물이 밝혀진 바 있으며, [6]-shogaol, [6]-gingerol, [8]-gingerol 및 [10]-gingerol 등의 향신 화합물이 주요한 성분으로, 항암, 항산화, 혈소판응고억제, 항균, 혈당저하, 관절염 개선, 탈모 억제, 항염증, 체중 감소, 해열 및 멜라닌 생성 억제 효과 등이 보고되었다. 본 연구는 생강의 주요성분이 함유된 대용차 소재개발을 목적으로, 국내산 생강으로부터 [10]-gingerol을 분리하여 동정한 후, 인체 피부세포(human keratinocytes)에서 생성되는 산화적 스트레스에 의한 [10]-gingerol의 효능을 분자수준에서 관찰하였다. 실험 결과, [10]-gingerol은 1, 3, 5 μM 농도에서 인체 피부세포의 heme oxygenase-1 (HO-1) mRNA levels을 농도 의존적으로 증가시켰으며, nuclear factor erythroid 2-related factor 2 (Nrf2)의 증가 및 kelch-like ECH-associated protein 1에 의해 세포질 안정성이 저하되는 것을 확인하였다. 결론적으로, mild oxidative stress 조건에서 [10]-gingerol이 ERK/Nrf2/HO-1 signaling pathway을 통해 antioxidant enzyme의 작용을 증가시키는 것을 확인하였다. The present study was designed to investigate the molecular mechanisms of bioactive components against mild oxidative stress in human keratinocytes (HaCaTs). Solvent extraction and fractionation of the rhizomes of Zingiber officinale resulted in the isolation of [10]-gingerol. At concentrations of 1, 3, and 5 µM [10]-gingerol dose-dependently increased HO-1 (heme oxygenase-1) mRNA and protein levels, with a significant effect at 5 µM. This augmentation of HO-1 by [10]-gingerol was attributed to the upregulation of Nrf2 (nuclear factor erythroid 2-related factor 2), which markedly reduced the cytoplasmic stability of Keap1 (kelch-like ECH-associated protein 1). Furthermore, our findings indicate that the upregulation of HO-1 by [10]-gingerol increased resistance to mild oxidative stress, suggesting that [10]-gingerol might enhance the activities of antioxidant enzymes by stimulating Nrf2. Our experimental findings indicate that the mild attenuating effect of [10]-gingerol against oxidative stress involves the ERK/Nrf2/HO-1 signaling pathway.
Tae Eun Guon,정하숙 한국식품영양학회 2022 韓國食品營養學會誌 Vol.35 No.6
The present study was designed to investigate the antiproliferative activity and molecular mechanisms of Bibimbap in HT-29 human colorectal adenocarcinoma cells. Bibimbap extract inhibited the proliferation of HT-29 cells by 50% at a concentration of 10.1±0.17 mg/mL for 48 h. The population of live cells decreased slightly, and the morphology changed with a reduction in cell volume (pyknosis) with Bibimbap. Treatment with 5 mg/mL of Bibimbap resulted in slight cell shrinkage. Furthermore, as the Bibimbap dose increased to 10 mg/mL, these characteristics were more evident, and HT-29 cells exhibited partial detachment by staining with the DNA-binding dye Hoechst 33342. Flow cytometric analysis by Annexin V and PI double staining showed that Bibimbap increased the levels of apoptosis. Analysis of the mechanism of these events showed that Bibimbap-treated cells exhibited a mitochondria-dependent apoptotic pathway through the modulation of caspase-3, caspase-8, caspase-9, and poly-ADP ribose polymerase, as well as Bax and Bcl-2 expression in dose- and time-dependent manners. Consequently, Bibimbap exerts a significant antiproliferative effect on HT-29 human colorectal adenocarcinoma cells. Key words: Bibimbap, antiproliferation, HT-29, human colorectal adenocarcinoma cells, mitochondrial apoptosis, Korean dish