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The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder
Iria Grande,Gabriel Rodrigo Fries,Mauricio Kunz,Flavio Kapczinski 대한신경정신의학회 2010 PSYCHIATRY INVESTIGATION Vol.7 No.4
The cognitive impairment and neuroanatomical changes that takes place among patients with bipolar disorder (BD) patients has been well described. Recent data suggest that changes in neuroplasticity, cell resilience and connectivity are the main neuropathological findings in BD. Data from differential lines of research converges to the brain-derived neurotrophic factor (BDNF) as an important contributor to the neuroplasticity changes described among BD patients. BDNF serum levels have been shown to be decreased in depressive and manic episodes,returning to normal levels in euthymia. BDNF has also been shown to decrease as the disorder progresses. Moreover, factors that negatively influence the course of BD, such as life stress and trauma have been shown to be associated with a decrease in BDNF serum levels. These findings suggest that BDNF plays a central role in the progression of BD. The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the potential use of serum BDNF as a biomarker in BD.
On Observability of Fuzzy Dynamical Matrix Lyapunov Systems
Murty, Madhunapantula Suryanarayana,Kumar, Grande Suresh Department of Mathematics 2008 Kyungpook mathematical journal Vol.48 No.3
In this paper we generate a fuzzy dynamical matrix Lyapunov system and obtain a sufficient condition for the observability of this system.
The role of basic energy-loss processes in layer-resolved surface investigations with ions
G.Schiwietz,P.L.Grande 한국물리학회 2003 Current Applied Physics Vol.3 No.1
Ab initio quantum mechanical calculations have been performed for the energy loss of protons backscattered from an Al surface.Results from rst-order perturbation theory are compared to full numerical atomic-orbital coupled-channel calculations. It is shownthat both inner shells and non-perturbative eects are important for the understanding of ion energy-loss spectra.. 2002 Elsevier Science B.V. All rights reserved.
Bocchinfuso, Gianfranco,Palleschi, Antonio,Orioni, Barbara,Grande, Giacinto,Formaggio, Fernando,Toniolo, Claudio,Park, Yoonkyung,Hahm, Kyung-Soo,Stella, Lorenzo John Wiley Sons, Ltd. 2009 Journal of peptide science Vol.15 No.9
<P>Most antimicrobial peptides exert their activity by interacting with bacterial membranes, thus perturbing their permeability. They are investigated as a possible solution to the insurgence of bacteria resistant to the presently available antibiotic drugs. However, several different models have been proposed for their mechanism of membrane perturbation, and the molecular details of this process are still debated. Here, we compare fluorescence spectroscopy experiments and molecular dynamics (MD) simulations regarding the association with lipid bilayers and lipid perturbation for two different amphiphilic helical antimicrobial peptides, PMAP-23 and trichogin GA IV. PMAP-23, a cationic peptide member of the cathelicidin family, is considered to induce membrane permeability according to the Shai-Matsuzaki-Huang “carpet” model, while trichogin GA IV is a neutral peptide, member of the peptaibol family. Although several lines of evidence suggest a “barrel-stave” mechanism of pore formation for the latter peptide, its length is only half the normal thickness of a lipid bilayer. Both fluorescence spectroscopy experiments and MD simulations indicated that PMAP-23 associates with membranes close to their surface and parallel to it, and in this arrangement it causes a severe perturbation to the bilayer, both regarding its surface tension and lipid order. By contrast, trichogin GA IV can undergo a transition from a surface-bound state to a transmembrane orientation. In the first arrangement, it does not cause any strong membrane perturbation, while in the second orientation it might be able to span the bilayer from one side to the other, despite its relatively short length, by causing a significant thinning of the membrane. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.</P>
Paulo A. Augusto,Teresa Castelo-Grande,Pedro Augusto,Domingos Barbosa,A.M. Est?vez 한국물리학회 2007 Current Applied Physics Vol.7 No.3
A new device, MAGCLATMoped by the authors. In a previous article the equations of movement for non-magnetic particles in this new device were analyzed and inthis paper the limiting conditions set by the dierent variables and equations of movement are presented for the case of the non-magneticparticles. The knowledge of these limiting conditions is important as they set the boundaries within which we may manipulate theMAGCLATM’s operating and design variables.
Sintered Duplex Stainless Steels Corrosion Properties
Dobrzanski L.A.,Brytan Z.,Grande M. Actis,Rossob M.,Park Woo-Young,Kim Cheol-Su 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
This work presents mechanical properties and corrosion resistance of duplex stainless steels obtained through powder metallurgy starting from austenitic, martensitic powders by controlled addition of alloying elements in the right quantity to obtain the chemical composition of the structure similar to biphasic one. In the mixes preparations the Schaffler's diagram was taken into consideration. Prepared mixes of powders have been sintered in a vacuum furnace with argon backfilling. After sintering rapid cooling was applied using nitrogen. Corrosion properties have been studied through electrochemical methods in 1M NaCl.
Paulo A. Augusto,Teresa Castelo-Grande,Pedro Augusto,A.M. Est?vez,Domingos Barbosa 한국물리학회 2007 Current Applied Physics Vol.7 No.3
The theoretical principles of MAGCLATMsusceptibility, are presented for the magnetic particles. An empirical coecient (TCG2) is introduced in the equations of movement toaccount for deviations between experimental and theoretical values.