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Kazuhiko Goto,Takenao Sugi,Yoshitaka Matsuda,Satoru Goto,Hiroki Fukuda,Yoshinobu Goto,Takao Yamasaki,Shozo Tobimatsu 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
Visual evoked potentials (VEPs) are the electrical responses from the brain concerned with visual information processing. Amplitude of VEPs is smaller than that of background EEG activity, and the stimulus-locked averaging method is usually used for obtained the waveform. VEP response to each stimulus is not completely the same however it is varying with its amplitude and duration. Therefore, amplitude of averaged VEP waveform deteriorates due to their variability in raw data. Feature extraction of background EEG activity during visual stimulation is also a one of significant items in VEP analysis. In that case, separation of VEP component and background EEG component (mainly posterior dominant rhythm) is crucial. In the past, we proposed the method of estimating both amplitude of VEP and dominant rhythm by use of EEG model. This present study, the proposed method was applied to actual recorded VEP data and its effectiveness was evaluated. EEGs with visual stimulus were recorded from nine healthy young adults. Usefulness of the proposed method was investigated by comparing the conventional power spectrum averaging method. The proposed method will be applicable to show an accurate VEP analysis and characteristic analysis of background activity under visual stimulus.
The leading ideal of a complete intersection of height two, Part II
Goto, Shiro,Heinzer, William,Kim, Mee-Kyoung Elsevier 2007 Journal of algebra Vol.312 No.2
<P><B>Abstract</B></P><P>Let (S,n) be a regular local ring and let I=(f,g) be an ideal in <I>S</I> generated by a regular sequence f,g of length two. Let R=S/I and m=n/I. As in [S. Goto, W. Heinzer, M.-K. Kim, The leading ideal of a complete intersection of height two, J. Algebra 298 (2006) 238–247], we examine the leading form ideal <SUP>I∗</SUP> of <I>I</I> in the associated graded ring G=<SUB>grn</SUB>(S). If <SUB>grm</SUB>(R) is Cohen–Macaulay, we describe precisely the Hilbert series H(<SUB>grm</SUB>(R),λ) in terms of the degrees of homogeneous generators of <SUP>I∗</SUP> and of their successive GCD's. If D=GCD(<SUP>f∗</SUP>,<SUP>g∗</SUP>) is a prime element of <SUB>grn</SUB>(S) that is regular on <SUB>grn</SUB>(S)/(<SUP>f∗</SUP>D,<SUP>g∗</SUP>D), we prove that <SUP>I∗</SUP> is 3-generated and a perfect ideal. If <SUB>ht<SUB>grn</SUB>(S)</SUB>(<SUP>f∗</SUP>,<SUP>g∗</SUP>,<SUP>h∗</SUP>)=2, where h∈I is such that <SUP>h∗</SUP> is of minimal degree in <SUP>I∗</SUP>∖(<SUP>f∗</SUP>,<SUP>g∗</SUP>)<SUB>grn</SUB>(S), we prove <SUP>I∗</SUP> is 3-generated and a perfect ideal of <SUB>grn</SUB>(S), so <SUB>grm</SUB>(R)=<SUB>grn</SUB>(S)/<SUP>I∗</SUP> is a Cohen–Macaulay ring. We give several examples to illustrate our theorems.</P>
No Association between the CDX2 G543C Polymorphism and Risk of Gastric Atrophy and Cancer
Goto, Yasuyuki,Kato, Tsuyoshi,Ando, Takafumi,Goto, Hidemi,Hamajima, Nobuyuki Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Ectopic expression of CDX2 in the stomach is closely associated with chronic Helicobacter pylori (H. pylori) infection and intestinal metaplasia. Whether CDX2 has tumor suppression or tumorigenesis potential remains to be elucidated. In this study, we investigated the association between the CDX2 G543C polymorphism (silent mutation) and the risk for H. pylori-induced gastric atrophy and cancer as well as H. pylori infection, using 454 Japanese subjects undergoing a health checkup and 202 gastric cancer patients. The frequency of the minor allele was the same as previously reported in China, but different from that reported in England. CDX2 G543C was not associated with risk of H. pylori infection, gastric atrophy, or gastric cancer, although the point estimate for non-cardiac differentiated gastric cancer as compared to controls with gastric atrophy was 2.22 (95%CI=0.17-29.4). In conclusion, our results indicate that the CDX2 G543C polymorphism is unlikely to affect the H. pylori infection-gastric atrophy-gastric cancer sequence.
Quantitative analysis between visual mismatch negativity and psychopathology scale for schizophrenia
Kazuhiko Goto,Takenao Sugi,Toshihiko Maekawa,Katuya Ogata,Yoshinobu Goto,Shozo Tobimatsu,Masatoshi Nakamura 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Visual mismatch negativity (v-MMN) in electroencephalographic (EEG) record provides an index of preattentive information processing of the brain v-MMN is considered to reflect schizophrenia. The positive and negative syndrome scale (PANSS) is usually used in clinical diagnosis on patients with schizophyenia for estimating the degree of disorder. In this study, the relationship between v-MMN and PANSS was analyzed. Characteristic parameters of peals including N1, N2, P300, and MMN were established respectively. Estimated function was constructed by selected parameters. P300 was most significant characteristic related to all items of FANSS.
A New Latent Class Model for Analysis of Purchasing and Browsing Histories on EC Sites
Goto, Masayuki,Mikawa, Kenta,Hirasawa, Shigeichi,Kobayashi, Manabu,Suko, Tota,Horii, Shunsuke Korean Institute of Industrial Engineers 2015 Industrial Engineeering & Management Systems Vol.14 No.4
The electronic commerce site (EC site) has become an important marketing channel where consumers can purchase many kinds of products; their access logs, including purchase records and browsing histories, are saved in the EC sites' databases. These log data can be utilized for the purpose of web marketing. The customers who purchase many product items are good customers, whereas the other customers, who do not purchase many items, must not be good customers even if they browse many items. If the attributes of good customers and those of other customers are clarified, such information is valuable as input for making a new marketing strategy. Regarding the product items, the characteristics of good items that are bought by many users are valuable information. It is necessary to construct a method to efficiently analyze such characteristics. This paper proposes a new latent class model to analyze both purchasing and browsing histories to make latent item and user clusters. By applying the proposal, an example of data analysis on an EC site is demonstrated. Through the clusters obtained by the proposed latent class model and the classification rule by the decision tree model, new findings are extracted from the data of purchasing and browsing histories.
Goto, Tsuyoshi,Hirata, Mariko,Aoki, Yumeko,Iwase, Mari,Takahashi, Haruya,Kim, Minji,Li, Yongjia,Jheng, Huei-Fen,Nomura, Wataru,Takahashi, Nobuyuki,Kim, Chu-Sook,Yu, Rina,Seno, Shigeto,Matsuda, Hideo,A American Society for Biochemistry and Molecular Bi 2017 The Journal of biological chemistry Vol.292 No.22
<P>Obesity causes excess fat accumulation in white adipose tissues (WAT) and also in other insulin-responsive organs such as the skeletal muscle, increasing the risk for insulin resistance, which can lead to obesity-related metabolic disorders. Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is a master regulator of fatty acid oxidation whose activator is known to improve hyperlipidemia. However, the molecular mechanisms underlying PPAR alpha activator-mediated reduction in adiposity and improvement of metabolic disorders are largely unknown. In this study we investigated the effects of PPAR alpha agonist (fenofibrate) on glucose metabolism dysfunction in obese mice. Fenofibrate treatment reduced adiposity and attenuated obesity-induced dysfunctions of glucose metabolism in obese mice fed a high-fat diet. However, fenofibrate treatment did not improve glucose metabolism in lipodystrophic A-Zip/F1 mice, suggesting that adipose tissue is important for the fenofibrate-mediated amelioration of glucose metabolism, although skeletal muscle actions could not be completely excluded. Moreover, we investigated the role of the hepatokine fibroblast growth factor 21 (FGF21), which regulates energy metabolism in adipose tissue. In WAT of WT mice, but not of FGF21-deficient mice, fenofibrate enhanced the expression of genes related to brown adipocyte functions, such as Ucp1, Pgc1a, and Cpt1b. Fenofibrate increased energy expenditure and attenuated obesity, whole body insulin resistance, and adipocyte dysfunctions in WAT in high-fat-diet-fed WT mice but not in FGF21-defi-the fenofibrate-mediated improvement of whole body glucose metabolism in obese mice via the amelioration of WAT dysfunctions.</P>
Historical Perspective on Fluid Machinery Flow Optimization in an Industry
Goto, Akira Korean Society for Fluid machinery 2016 International journal of fluid machinery and syste Vol.9 No.1
Fluid-dynamic design of fluid machinery had heavily relied on empiricism and experimental observations for many years. Since 1980s, thanks to the advancements in Computational Fluid Dynamics (CFD), a variety of flow physics have been revealed. The contribution by CFD is indispensable; however, the challenge is required not only on the advancements in CFD technologies but also innovation of "design (optimization) technologies" because of the complex interactions between 3-D flow fields and the complex 3-D flow passage configurations, etc. This paper presents historical perspective on fluid machinery flow optimization in an industry with some messages for the future.
Goto, M.,Ando, Y.,Han, S.Z.,Kim, S.S.,Kawagoishi, N.,Euh, K. Pergamon Press ; Elsevier Science Ltd 2010 Engineering fracture mechanics Vol.77 No.11
The growth behavior of cracks is monitored on specimens of ultrafine grained copper produced by equal channel angular pressing. Temporary retardation of crack growth under low stress amplitudes occurs when the crack length reaches about 0.1mm, but there is no similar retardation at high stress amplitudes. Dependent on stress amplitude, different crack growth path morphologies develop. Analysis of the fracture surfaces is conducted by scanning electron microscopy, showing planer, granular and striated surfaces. The physical background of growth path and fracture surface formation is discussed by considering crack growth mechanism and microstructural inhomogeneity.
Goto, M.,Iwamura, T.,Han, S.Z.,Kim, S.,Yamamoto, T.,Lim, S.H.,Ahn, J-H.,Kitamura, J.,Lee, J. Elsevier 2019 International journal of fatigue Vol.123 No.-
<P><B>Abstract</B></P> <P>Fatigue tests were conducted on round bar specimens of a solution-treated and air-cooled Cu-Ni-Si alloy with high solute concentrations of 6% Ni and 1.5% Si. This alloy was strengthened by disc-shaped Ni<SUB>2</SUB>Si precipitates, a few tens of nanometers in diameter, formed during air cooling. The results were compared with those of a conventional solution-treated Cu-Ni-Si alloy cooled by water quenching. The correlation between the tensile and fatigue strengths of the two alloys differed completely from the general tendency that enhanced tensile strength brings an increase in fatigue strength. Indeed, the fatigue strength of the air-cooled Cu-Ni-Si alloy was 1.1 times higher than that of the water-quenched alloy, while the tensile strength was only 75% that of the water-quenched alloy. Moreover, the electrical conductivity of the air-cooled specimens in International Annealed Copper Standard (IACS) percentage points was 1.7 times higher than that of the water-quenched specimens. The physical background for the superior fatigue strength of the air-cooled Cu-Ni-Si alloy, including the role of microstructure, is discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Air cooling (AC) instead of water quenching (WQ) was applied after SHT. </LI> <LI> Fatigue strength of AC specimen was 1.1 times greater than WQ one. </LI> <LI> Electrical conductivity of AC specimen was 1.7 times greater than WQ one. </LI> <LI> Superior characteristics of AC specimen was discussed based on microstructure. </LI> </UL> </P>