Most facile synthesis of Zn-Al:LDHs nanosheets at room temperature via environmentally friendly process and their high power generation by flexoelectricity

Choi, Min-Ju,Eom, Ji-Ho,Shin, Sung-Ho,Nah, Junghyo,Choi, Jin-Seok,Song, Hyun-A.,An, Hyesung,Kim, Hyun You,Pammi, S.V.N.,Choi, Goeun,Choy, Jin-Ho,Swathi, Ippili,Jella, Venkatraju,Park, Byeong-Ju,Choi, ELSEVIER SCIENCE B.V. AMSTERDAM 2018 Materials today energy Vol.2018 No.10

Calculation method for the solar and lunar motions in the Chongxiu Daming calendar

Choi Goeun,Mihn Byeong-Hee,Lee Ki-Won 한국천문학회 2016 天文學會報 Vol.41 No.1

The Change of the Timekeeping system(時刻制度) before and after the solar calendar in Korea

GoEun Choi,Young Sook Ahn 한국천문학회 2014 天文學會報 Vol.39 No.2

Enabling Nanohybrid Drug Discovery through the Soft Chemistry Telescope

Choi, Goeun,Piao, Huiyan,Kim, Myung Hun,Choy, Jin-Ho American Chemical Society 2016 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.55 No.43

<P>An attempt is made to describe an emerging convergence science: 'nanomedicine'. In particular, inorganic compounds such as anionic clays, layered double hydroxides (LDHs), at nanoscale, are underlined, with regard to how they could interact with bioactive and/or drug molecules to form novel intercalative hybrid drug systems with biocompatibility, imaging and targeting functions eventually for gene and/or drug delivery. In this regard, LDHs are focused as an important inorganic biomaterial for drug and gene delivery carriers with very high additive value in the near future, especially in biomedical industries including pharmaceutical, cosmeceutical, and nutraceutical ones, compared to any other industrial applications. In this review, the drug delivery systems based on clay nanoparticles are described in terms of nanotoxicity, intercellular uptake mechanism, and intracellular trafficking pathways in vitro, and finally passive and active targeting functions in vivo. In addition, several studies highlighting recent advances in chemotherapy and gene therapy with nano LDHs are also discussed, from the viewpoint of state-of-the-art convergence technology based on nanomedicine.</P>

Anionic clay as the drug delivery vehicle: tumor targeting function of layered double hydroxide-methotrexate nanohybrid in C33A orthotopic cervical cancer model

Choi, Goeun,Piao, Huiyan,Alothman, Zeid A,Vinu, Ajayan,Yun, Chae-Ok,Choy, Jin-Ho DOVE MEDICAL PRESS 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-

<P>Methotrexate (MTX), an anticancer agent, was successfully intercalated into the anionic clay, layered double hydroxides to form a new nanohybrid drug. The coprecipitation and subsequent hydrothermal method were used to prepare chemically, structurally, and morphologically well-defined two-dimensional drug-clay nanohybrid. The resulting two-dimensional drug-clay nanohybrid showed excellent colloidal stability not only in deionized water but also in an electrolyte solution of Dulbecco’s Modified Eagle’s Medium with 10% fetal bovine serum, in which the average particle size in colloid and the polydispersity index were determined to be around 100 and 0.250 nm, respectively. The targeting property of the nanohybrid drug was confirmed by evaluating the tumor-to-blood and tumor-to-liver ratios of the MTX with anionic clay carrier, and these ratios were compared to those of free MTX in the C33A orthotopic cervical cancer model. The biodistribution studies indicated that the mice treated with the former showed 3.5-fold higher tumor-to-liver ratio and fivefold higher tumor-to-blood ratio of MTX than those treated with the latter at 30 minutes postinjection.</P>

Emerging nanomaterials with advanced drug delivery functions; focused on methotrexate delivery

Choi, Goeun,Kim, Tae-Hyun,Oh, Jae-Min,Choy, Jin-Ho Elsevier 2018 Coordination Chemistry Reviews Vol.359 No.-

<P><B>Abstract</B></P> <P>This review focuses on therapeutic applications of various drug delivery nanovehicles encapsulated with the anti-cancer drug, methotrexate (MTX). Currently, a number of studies have been conducted to explore advanced chemotherapeutic systems with nonviral nanovehicles such as liposomes, polymeric micelles, polymersomes, solid lipids, dendrimers, porous metal and metal oxide particles, carbons with various nanostructures, and layered double hydroxides (LDHs). Out of various anticancer drugs, MTX was hybridized with those drug delivery nanovehicles not only to overcome its adverse effects, but also to induce advanced functions into those hybrid systems, such as enhanced solubility, controlled release, passive and active targeting, aimed to eventually enhance bioavailability of MTX. In particular, two dimensional LDHs are introduced rather in detail as one family of inorganic nanovehicles, since the therapeutic efficacies for MTX-LDHs have been systematically studied with <I>in vivo</I> orthotopic models, those which are clinically better correlated and therefore, more efficient to predict drug efficacy and toxicity than the standard one like xenograft model. Attempts are also made here to provide therapeutic results on chemically well defined MTX-LDH advanced drug delivery systems, such as their <I>in vitro</I> and <I>in vivo</I> targeting functions, biocompatibility and nanotoxicities and ability to overcome drug resistance. In addition, recent advances and challenges in advanced hybrid DDSs are discussed from the viewpoint of state-of-the-art nanomedicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Organic and inorganic drug delivery vehicles. </LI> <LI> Enhanced therapeutic efficacy of anti-cancer drug, Methotrexate. </LI> <LI> Two dimensional drug delivery systems based on layered double hydroxides. </LI> <LI> Nano-toxicity of drug delivery vehicles and their nanohybrids with drug. </LI> <LI> Targeting functions of drug delivery systems evidenced by orthotopic and xenograft mice models. </LI> </UL> </P>

Correlation Between MDR1, Drug Sensitivity, and Treatment Outcomes in Canine Lymphoma Patients

Goeun CHOI,Minyoung OH,Nahee KO,Gyurim KIM,Sujin NAMGOONG,Inha YOO,Jamin KOO 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.10

ADHD성향 아동과 지지체계를 대상으로 한 통합적 지원 프로그램에 대한 평가 연구

최고은(Choi, Goeun),권지성(Kwon, Ji-Sung) 한국사회복지학회 2013 한국사회복지학 Vol.65 No.3

이 연구의 목적은 ADHD성향 아동과 지지체계를 대상으로 한 통합적 지원 프로그램의 영향을 평가하려는 것이다. ADHD성향 아동과 지지체계의 변화를 목표로 ADHD성향 아동과 그를 둘러싼 가족 중심의 환경체계에 대한 개입을 중심으로 한 프로그램을 설계하고 수행하였다. 구체적으로는 ADHD성향 아동에 대한 개별 미술심리치료, 집단생활적응력향상프로그램, 문화체험을 진행하였으며, 부모에게 개별상담 제공과 학교 및 교사와의 정기적인 네트워크 회의를 실시하였다. 세부프로그램별로 표준화된 척도와 기록물, 면접 등을 통해 자료를 수집하고 분석한 결과, ADHD성향 아동의 심리․정서적 안정과 문제행동의 감소라는 변화가 나타났으며, 지지체계의 구성원들에게는 ADHD성향 아동의 변화가능성을 확인하고 긍정적으로 인식하는 계기를 제공해주는 효과가 나타났다. 이러한 결과를 통해 ADHD 성향 아동에 대한 지원시 주변환경에 대한 개입과 지지체계 구축을 통해 통합적으로 지원할 필요성이 있음을 확인하였으며, 이와 관련된 실천 지침들을 제언하였다. The purpose of this study was to evaluate the integrated support program for children with ADHD tendencies and their social support system. The program, including individual art therapy, group life skills programs, culture experiences, individual counseling programs and regular network meetings between parents and teachers were carried out to children with ADHD tendencies in order to build environmental support systems. As results, the psychological and emotional behaviors of children with ADHD tendencies have changed. This study, also, was able to verify the possibility of positive changes for the children with ADHD. Based on these results, the practical guidelines for building the support systems of children with ADHD tendencies were suggested.

애니메이션의 재미 요소 분석 -유아용 애니메이션 <냉장고 나라 코코몽>을 중심으로-

최고은 ( Goeun Choi ),이종한 ( Jonghan Lee ) 한국영상미디어협회 2013 예술과 미디어 Vol.12 No.2

유아에게 유아용 애니메이션 시청은 놀이의 한 부분이고 이러한 놀이의 본질을 결정짓는 것이 곧 재미 요소이다. 유아기는 사고체계가 형성되는 시기 이며 놀이와 재미를 최초로 인지하고 추구하는 시 기이다. 따라서 인간이 느끼는 재미의 기초단계이고 발생지라고 할 수 있다. 또한 애니메이션을 즐기는 최초의 시기 역시 유아기로 보고 이들이 느끼는 재 미에 대해 연구하고자 하는 것이 본 논문의 목적이 다. 본고에서 말하는 재미란, 기존에 자신이 알고 있던 정보와 새로운 정보와의 불일치에서 발생하는 것을 전제로 한다. 이는 심리학에서 말하는 인지적 재미에 해당한다. 이를 기초로 유아용 애니메이션에 서 발견할 수 있는 재미 요소를 크게 캐릭터 행동 에서 나타나는 유머와 이야기 맥락에서의 후속정보 가 제시된 추론과정으로 나누었다. 그리하여 본고에 서 선정한 유아용 애니메이션 <냉장고 나라 코코몽>을 분석한 결과 캐릭터 행동의 유머에서는 첫째, 의인화된 캐릭터의 과장과 둘째, 신체에 대한 왜곡 과 변형 셋째, 예상치 못 한 엉뚱함(반전,의외성)을 찾을 수 있었다. 다음, 이야기 맥락에서 후속정보가 제시된 추론과정에서는 내러티브 안에서 궁금증의 유발과 추론과정으로의 유도를 위해 중요 정보를 뒤로 미룬 뒤 결말 부분에서 중요 정보를 제시하는 것을 통해 궁금증을 해결하는 구조가 나타났다. 이 와 같은 분석은 유아용 애니메이션을 대상으로 삼 고 진행하였지만, 재미를 느끼는 요소는 본문과 같이 원초적이며 유아기에 인지능력 대부분이 형성되기 때문에 직관적으로 재미를 느끼는 요소에 대한 분석은 유아기 애니메이션을 분석함으로써 이미 그 대강을 파악할 수 있다고 생각한다. 따라서 이 연구를 바탕으로 애니메이션에서 발견할 수 있는 재미 란 무엇이며, 그 실마리가 무엇인지를 찾는 과정중의 하나로 여겨지기를 바란다. Young children`s watch of animations for them is a part of play, and an essential determinant of a play is a fun element. Early childhood is a period to from the way of thinking and recognize/pursue play and fun for the first time in their life. In this vein, early childhood seems to be a basic stage and birthplace of fun, felt by human beings. In addition, the first period of enjoying animations is early childhood as well. On this account, the purpose of this study was to examine the fun elements of animation for young children. Fun in this study is based upon premise that it is generated form the inconsistency between already known information and new information. This is the cognitive fun of psychology. Based on this definition, the fun that could be found out in animation for young children was classified into the humor presented by character`s behavior and the reasoning process to which follow-up information in the context of story was presented. This study selected and analyzed such two animation for young children as <Fresh World Cocomong>. Study findings are as follows: As for the humor of character`s behavior, such three elements as (1) the exaggeration of personified characters; (2) the distortion and transformation of body; and (3) unexpected goofiness (reversal, exception) were found out. As for the reasoning process to which follow-up information in the context of story was presented, found out was such a structure of gratifying curiosity as leaving important information behind and presenting it in finale, in order to arouse curiosity within narrative and induce to the process of reasoning. This study was carried out only with animations for young children as study subjects. However, since fun elements are instinctive, as above, and most of cognitive ability is formed in early childhood, the outline of elements of intuitive fun seems to be grasped by examining animations for early childhood alone. The investigator hopes this study will be regarded as a process of seeking the answer to the questions: ``what fun could be found out in animations?`` and ``what is the clue to find out it?``

유아교육에서 기록 다시 읽기: 아카이브 담론을 중심으로

최고은(Choi, Goeun),정혜영(Jung, Hyeyoung) 한국열린유아교육학회 2024 열린유아교육연구 Vol.29 No.4

With the recent shift to a learner-centered curriculum, documentation as an educational practice in early childhood education(ECE) has garnered increased attention in comprehending children’s play and learning. Exploration of archives as well as documentation is crucial as they are not mere methods or learning outcomes. Drawing on the discourse of archival studies, which encompass history, society, politics, and culture, this study reviews the meanings of archives and explores new dimensions in ECE. The findings reveal that archives signify ‘evidence and representation,’ ‘memory and deconstruction,’ ‘creation and possibility,’ and have evolved alongside shifts in social paradigms, historical events, and physical environments. Moreover, the findings suggests that archives in ECE can progress from ‘production’ to ‘creation’, from ‘what and how much’ to ‘why and within what context,’ and from ‘responsibility’ to ‘response-ability.’ This study proposes crucial implications to inspire educators with a new perspective on pedagogical archives, particularly through performative movements and educational experimentation.