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RISS 인기검색어
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- 저자 : Goeun Choi (검색결과 81 건)
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Enabling Nanohybrid Drug Discovery through the Soft Chemistry Telescope
Choi, Goeun,Piao, Huiyan,Kim, Myung Hun,Choy, Jin-Ho American Chemical Society 2016 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.55 No.43
<P>An attempt is made to describe an emerging convergence science: 'nanomedicine'. In particular, inorganic compounds such as anionic clays, layered double hydroxides (LDHs), at nanoscale, are underlined, with regard to how they could interact with bioactive and/or drug molecules to form novel intercalative hybrid drug systems with biocompatibility, imaging and targeting functions eventually for gene and/or drug delivery. In this regard, LDHs are focused as an important inorganic biomaterial for drug and gene delivery carriers with very high additive value in the near future, especially in biomedical industries including pharmaceutical, cosmeceutical, and nutraceutical ones, compared to any other industrial applications. In this review, the drug delivery systems based on clay nanoparticles are described in terms of nanotoxicity, intercellular uptake mechanism, and intracellular trafficking pathways in vitro, and finally passive and active targeting functions in vivo. In addition, several studies highlighting recent advances in chemotherapy and gene therapy with nano LDHs are also discussed, from the viewpoint of state-of-the-art convergence technology based on nanomedicine.</P>
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A study on the relationship between MDR1 mutation and ex vivo drug sensitivities of canine lymphomas
Choi Goeun,Yap Qi Jing,Ko Nahee,Namgoong Sujin,Lee Haeryung,Oh Minyoung,Choi Gyucheol,Lim Sungwon,구자민 한국생물공학회 2025 Biotechnology and Bioprocess Engineering Vol.30 No.2
The MDR1 gene encodes P-glycoprotein, a key adenosine triphosphate-dependent efflux pump involved in drug metabolism. Mutations in MDR1 can lead to altered drug transport, contributing to multi-drug resistance in canine lymphoma, which complicates treatment and affects patient survival. The objective of this study was to investigate the relationship between MDR1 mutations and ex vivo drug sensitivities in canine lymphoma patients. Using patient-derived cells from 76 dogs, we assessed cell size, granularity, antigen expression, and drug sensitivity to 12 anti-cancer agents, while also examining clinical outcomes. Our results showed that MDR1-mutated cells exhibited significantly higher ex vivo sensitivity to mitoxantrone, melphalan, and dexamethasone. Additionally, T-cell lymphomas displayed lower drug sensitivity and worse clinical outcomes compared to B-cell lymphomas. Importantly, MDR1-mutated patients demonstrated inferior survival, with a median overall survival of 74 days compared to 204 days for wild-type patients. In this manner, MDR1 mutation is a critical factor influencing drug sensitivity and clinical outcomes in canine lymphomas. Incorporating MDR1 genotyping and ex vivo drug sensitivity testing could enable more personalized and effective treatment strategies, improving both safety and efficacy for affected dogs.
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Choi, Goeun,Piao, Huiyan,Alothman, Zeid A,Vinu, Ajayan,Yun, Chae-Ok,Choy, Jin-Ho DOVE MEDICAL PRESS 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P>Methotrexate (MTX), an anticancer agent, was successfully intercalated into the anionic clay, layered double hydroxides to form a new nanohybrid drug. The coprecipitation and subsequent hydrothermal method were used to prepare chemically, structurally, and morphologically well-defined two-dimensional drug-clay nanohybrid. The resulting two-dimensional drug-clay nanohybrid showed excellent colloidal stability not only in deionized water but also in an electrolyte solution of Dulbecco’s Modified Eagle’s Medium with 10% fetal bovine serum, in which the average particle size in colloid and the polydispersity index were determined to be around 100 and 0.250 nm, respectively. The targeting property of the nanohybrid drug was confirmed by evaluating the tumor-to-blood and tumor-to-liver ratios of the MTX with anionic clay carrier, and these ratios were compared to those of free MTX in the C33A orthotopic cervical cancer model. The biodistribution studies indicated that the mice treated with the former showed 3.5-fold higher tumor-to-liver ratio and fivefold higher tumor-to-blood ratio of MTX than those treated with the latter at 30 minutes postinjection.</P>
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Emerging nanomaterials with advanced drug delivery functions; focused on methotrexate delivery
Choi, Goeun,Kim, Tae-Hyun,Oh, Jae-Min,Choy, Jin-Ho Elsevier 2018 Coordination Chemistry Reviews Vol.359 No.-
<P><B>Abstract</B></P> <P>This review focuses on therapeutic applications of various drug delivery nanovehicles encapsulated with the anti-cancer drug, methotrexate (MTX). Currently, a number of studies have been conducted to explore advanced chemotherapeutic systems with nonviral nanovehicles such as liposomes, polymeric micelles, polymersomes, solid lipids, dendrimers, porous metal and metal oxide particles, carbons with various nanostructures, and layered double hydroxides (LDHs). Out of various anticancer drugs, MTX was hybridized with those drug delivery nanovehicles not only to overcome its adverse effects, but also to induce advanced functions into those hybrid systems, such as enhanced solubility, controlled release, passive and active targeting, aimed to eventually enhance bioavailability of MTX. In particular, two dimensional LDHs are introduced rather in detail as one family of inorganic nanovehicles, since the therapeutic efficacies for MTX-LDHs have been systematically studied with <I>in vivo</I> orthotopic models, those which are clinically better correlated and therefore, more efficient to predict drug efficacy and toxicity than the standard one like xenograft model. Attempts are also made here to provide therapeutic results on chemically well defined MTX-LDH advanced drug delivery systems, such as their <I>in vitro</I> and <I>in vivo</I> targeting functions, biocompatibility and nanotoxicities and ability to overcome drug resistance. In addition, recent advances and challenges in advanced hybrid DDSs are discussed from the viewpoint of state-of-the-art nanomedicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Organic and inorganic drug delivery vehicles. </LI> <LI> Enhanced therapeutic efficacy of anti-cancer drug, Methotrexate. </LI> <LI> Two dimensional drug delivery systems based on layered double hydroxides. </LI> <LI> Nano-toxicity of drug delivery vehicles and their nanohybrids with drug. </LI> <LI> Targeting functions of drug delivery systems evidenced by orthotopic and xenograft mice models. </LI> </UL> </P>
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