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      • KCI등재

        The Walls of Utopia and the Fall of the Wall in Berlin: The German Art Dispute and its Implications for the Cultural Reunification of Korea in Berlin as the Theatre of the Cold War

        에크하르트J.길렌 ( Eckhart J. Gillen ),박순홍(중역) 한국미학예술학회 2016 美學·藝術學硏究 Vol.47 No.-

        본 논문은 분단국가 안에서 분단도시 베를린이 양분되었던 미술 현장의 문제 상황을 통해 한국의 역사와 대조되는 독일의 특수성을 설명한다. 서방 연합이 통치했던 동독(GDR)의 수도 베를린의 서쪽 지역은 독일이 통일되어 가는 과정속에서 핵심적인 역할을 맡았다. 서베를린은 극동의 교두보였다. 동독과 서독 사이의 정치적.경제적.이념적.문화적 차이에서 비롯된 깊은 분열에 대해 알기 위해서는 서베를린의 냉전기 이문화 집단 거주지(enclave)가 이상적인 장소였다. 베를린은 서방 연합과 동구권 국가에서 예술이 발전해가는 과정을 살펴볼 수 있는 최적의 장소였다. 서베를린은 미술에서의 플럭서스와 해프닝, 독일 팝아트 같은 새로운 실험이 배양될 수 있었다. 동베를린은 국제 미술계의 주요 미술사적 사건들로부터 단절되어 있었다. 그곳의 많은 예술가들은 시대착오적인 지위에 만족한 채 그들만의 예술을 발전시켜 왔다. 동독의 예술가들에게 기준은 진실성과 도덕성이었다. 서방에서 예술가들은 자신의 예술작품에 책임을 느끼지, 자신이 살고 있는 체제 또는 국가 이념과 그 사회의 도덕성은 아니다. 서베를린은 독일의 두 개념 사이에 놓인 이상적인 기준점이었다. 본 논문은 1945년부터 1990년까지 서베를린과 동베를린의 미술 현장에서 발생한 차이와 공통된 양상이 갖는 함의를 다룬다.

      • KCI등재

        Effects of Eccentric Exercise Associated with Patellofemoral Tendinopathy: A Systematic Review

        Joshua Mark Prall,Madison Gillen,Elizabeth Talbot,Samantha Flater,Ryan Bibeau,John Ricciuti,Stan Dacko 물리치료재활과학회 2023 Physical therapy rehabilitation science Vol.12 No.4

        Background: Patellofemoral tendinopathy is a common condition that is associated with anteromedial knee pain due to chronicrepetitive tendon overloading. Physical therapy in combination with an eccentric exercise program has been thought to be the goldstandard of treatment for patellofemoral tendinopathy. The aim of this study was to examine the literature regarding theeffectiveness of treating patellofemoral tendinopathy with eccentric exercise and other interventions. Methods: A literature search of Medline Complete, PubMed, CINAHL Complete, and Journal of Science and Medicine in Sports was conducted using PEDro guidelines. Results: Eight articles met our selection criteria. The 8 articles investigated individuals who all had pain at the inferior pole of thepatella or were diagnosed via ultrasound for patellar tendinopathy. The articles investigated the effects of eccentric exercise versus other treatments such as, progressive tendon-loading exercise therapy (PTLE), extracorporeal shock wave therapy (ESWT),percutaneous electrolysis (PNE), dry needling (DN), and concentric hip muscle strengthening. Ultimately, each treatment resultedin decreased pain and patellar stiffness, along with improvement in outcome measures, but it was found that no intervention was more effective than eccentric exercise alone, besides progressive tendon-loading exercise therapy. Conclusions: Moderate to strong mixed evidence exists to show the effect of eccentric exercise in combination with otherinterventions decreases patellofemoral pain and increased functional mobility in individuals with patellofemoral tendinopathy. Progressive tendon-loading exercise therapy was the one treatment that showed more significant improvements in outcome

      • SCOPUSKCI등재

        Review of Qualitative Approaches for the Construction Industry: Designing a Risk Management Toolbox

        Zalk, David M.,Spee, Ton,Gillen, Matt,Lentz, Thomas J.,Garrod, Andrew,Evans, Paul,Swuste, Paul Occupational Safety and Health Research Institute 2011 Safety and health at work Vol.2 No.2

        Objectives: This paper presents the framework and protocol design for a construction industry risk management toolbox. The construction industry needs a comprehensive, systematic approach to assess and control occupational risks. These risks span several professional health and safety disciplines, emphasized by multiple international occupational research agenda projects including: falls, electrocution, noise, silica, welding fumes, and musculoskeletal disorders. Yet, the International Social Security Association says, "whereas progress has been made in safety and health, the construction industry is still a high risk sector." Methods: Small- and medium-sized enterprises (SMEs) employ about 80% of the world's construction workers. In recent years a strategy for qualitative occupational risk management, known as Control Banding (CB) has gained international attention as a simplified approach for reducing work-related risks. CB groups hazards into stratified risk 'bands', identifying commensurate controls to reduce the level of risk and promote worker health and safety. We review these qualitative solutions-based approaches and identify strengths and weaknesses toward designing a simplified CB 'toolbox' approach for use by SMEs in construction trades. Results: This toolbox design proposal includes international input on multidisciplinary approaches for performing a qualitative risk assessment determining a risk 'band' for a given project. Risk bands are used to identify the appropriate level of training to oversee construction work, leading to commensurate and appropriate control methods to perform the work safely. Conclusion: The Construction Toolbox presents a review-generated format to harness multiple solutions-based national programs and publications for controlling construction-related risks with simplified approaches across the occupational safety, health and hygiene professions.

      • KCI등재
      • SCISCIESCOPUS

        Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits

        Marquardt, J.U.,Seo, D.,Andersen, J.B.,Gillen, M.C.,Kim, M.S.,Conner, E.A.,Galle, P.R.,Factor, V.M.,Park, Y.N.,Thorgeirsson, S.S. Elsevier Science Publishers 2014 Journal of hepatology Vol.60 No.2

        Background & Aims: Human hepatocarcinogenesis is as a multi-step process starting from dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC). However, the sequential molecular alterations driving malignant transformation of the pre-neoplastic lesions are not clearly defined. This lack of information represents a major challenge in the clinical management of patients at risk. Methods: We applied next-generation transcriptome sequencing to tumor-free surrounding liver (n=7), low- (n=4) and high-grade (n=9) dysplastic lesions, eHCC (n=5) and pHCC (n=3) from 8 HCC patients with hepatitis B infection. Integrative analyses of genetic and transcriptomic changes were performed to characterize the genomic alterations during hepatocarcinogenesis. Results: We report that changes in transcriptomes of early lesions including eHCC were modest and surprisingly homogenous. Extensive genetic alterations and subsequent activation of prognostic adverse signaling pathways occurred only late during hepatocarcinogenesis and were centered on TGFβ, WNT, NOTCH, and EMT-related genes highlighting the molecular diversity of pHCC. We further identify IGFALS as a key genetic determinant preferentially down-regulated in pHCC. Conclusions: Our results define new hallmarks in molecular stratification and therapy options for patients at risk for HCC, and merit larger prospective investigations to develop a modified clinical-decision making algorithm based on the individualized next-generation sequencing analyses.

      • KCI등재

        High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women

        Nicole G. Barra,Isabella Y. Fan,Jenna B. Gillen,Marianne Chew,Katarina Marcinko,Gregory R. Steinberg,Martin J. Gibala,Ali A. Ashkar 대한암예방학회 2017 Journal of cancer prevention Vol.22 No.4

        High intensity interval training (HIIT) boosts natural killer (NK) cell number and activity in normal weight breast cancer patients; however, whether this occurs in obese individuals is not well established. The goal of this study was to determine whether HIIT effectively boosts NK cells as a therapeutic strategy against breast cancer in an obese mouse model and in overweight/obese women. Diet induced female C57Bl/6 obese mice were assigned to undergo HIIT for four weeks or remain sedentary. Female participants were subjected to a six weeks HIIT protocol. HIIT mice acclimatized to treadmill running were subsequently injected with 5 × 105 polyoma middle T (MT) breast cancer cells intravenously. NK cell number and activation were monitored using flow cytometry, and tumor burden or lipid content evaluated from histological lung and liver tissues, respectively. In both mice and humans, circulating NK cell number and activation (CD3‒NK1.1+CD27+ and CD3‒CD56+, respectively) markedly increased immediately after HIIT. HIIT obese mice had reduced lung tumor burden compared to controls following MT challenge, and had diminished hepatic lipid deposition despite minimal body weight loss. Our findings demonstrate that HIIT can benefit obese individuals by enhancing NK cell number and activity, reducing tumor burden, and enhancing metabolic health.

      • SCISCIESCOPUS

        Quantitative surface analysis of Fe&n.bond;Ni alloy films by XPS, AES and SIMS

        Kim, K. J.,Moon, D. W.,Park, C. J.,Simons, D.,Gillen, G.,Jin, H.,Kang, H. J. Heyden & Son 2007 Surface and interface analysis Vol.39 No.8

        <P>A comparison of quantitative surface analyses of Fe&n.bond;Ni alloy thin films by various methods has been proposed as a pilot study by the Surface Analysis Working Group of the Consultative Committee for Amount of Substance (CCQM). To test the suitability of Fe&n.bond;Ni for this purpose, alloy films with different compositions were grown on Si(100) wafers by ion-beam sputter deposition and the compositions were certified by an isotope dilution method using inductively coupled plasma-mass spectrometry. The alloy compositions measured with X-ray photoelectron spectroscopy (XPS) and Auger electron spectroscopy (AES) using sensitivity factors determined from pure Fe and Ni metal films agreed with the certified mean values to better than 2%. The alloy compositions quantified by secondary ion mass spectrometry (SIMS) with a C<SUB>60</SUB> ion source agreed to better than 4% with the certified compositions if one of the alloys was used to establish the relative sensitivity factors (RSFs). These results indicate that the quantification of the Fe&n.bond;Ni alloy is a good method for a CCQM pilot study because matrix effects and ion-sputtering effects are small for these analytical methods. Copyright © 2007 John Wiley & Sons, Ltd.</P>

      • KCI등재

        Impact of nonphysician, technology-guided alert level selection on rates of appropriate trauma triage in the United States: a before and after study

        Harrigan Megan E.,Boremski Pamela A.,Collier Bryan R.,Tegge Allison N.,Gillen Jacob R. 대한외상학회 2023 大韓外傷學會誌 Vol.36 No.3

        Purpose: The rates of overtriage and undertriage are critical metrics in trauma care, influenced by the criteria for trauma team activation (TTA) and compliance with these criteria. An analysis of undertriaged patients at a level I trauma center revealed suboptimal compliance with existing criteria. This study was conducted to assess triage patterns after the implementation of compliance-focused process interventions.Methods: Several workflow changes were made to transform a physician-driven, free-text alert system into a nonphysician, hospital dispatcher–guided system. The latter system employs dropdown menus to maximize compliance with existing TTA criteria. The preintervention period included patients who presented to the level I trauma center between May 12, 2020, and December 31, 2020. The postintervention period incorporated patients who presented from May 12, 2021, through December 31, 2021. We evaluated the rates of appropriate triage, overtriage, and undertriage using the Standardized Trauma Assessment Tool and patient characteristics from the trauma registry. All statistical analyses were conducted with an α level of 0.05.Results: The patient characteristics were largely comparable between the preintervention and postintervention groups. The new system was associated with improved overall compliance with the existing TTA criteria (from 70.3% to 79.3%, P=0.023) and a decreased rate of undertriage (from 6.0% to 3.2%, P=0.002) at the expense of increasing overtriage (from 46.6% to 57.4%, P<0.001), ultimately decreasing the appropriate triage rate (from 78.4% to 74.6%, P=0.007).Conclusions: This study assessed an easily implementable workflow change designed to improve compliance with TTA criteria. Improved compliance decreased undertriage rates to below the target threshold of 5%, albeit at the expense of increased overtriage. The observed decrease in appropriate triage despite compliance improvements suggests that the current TTA criteria at this institution are not adequately tailored to optimally balance the minimization of both undertriage and overtriage. This finding underscores the importance of improved compliance in evaluating the efficacy of TTA criteria.

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