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Scalable Production of Sensor Arrays Based on High-Mobility Hybrid Graphene Field Effect Transistors
Gao, Zhaoli,Kang, Hojin,Naylor, Carl H.,Streller, Frank,Ducos, Pedro,Serrano, Madeline D.,Ping, Jinglei,Zauberman, Jonathan,Rajesh,Carpick, Robert W.,Wang, Ying-Jun,Park, Yung Woo,Luo, Zhengtang,Ren, American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.41
<P>We have developed a scalable fabrication process for the production of DNA biosensors based on gold nanoparticle-decorated graphene field effect transistors (AuNP-Gr-FETs), where monodisperse AuNPs are created through physical vapor deposition followed by thermal annealing. The FETs are created in a four-probe configuration, using an optimized bilayer photolithography process that yields chemically clean devices, as confirmed by XPS and AFM, with high carrier mobility (3590 +/- 710 cm2/V.s) and low unintended doping (Dirac voltages of 9.4 +/- 2.7 V). The AuNP-Gr-FETs were readily functionalized with thiolated probe DNA to yield DNA biosensors with a detection limit of 1 nM and high specificity against noncomplementary DNA. Our work provides a pathway toward the scalable fabrication of high-performance AuNP-Gr-FET devices for label-free nucleic acid testing in a realistic clinical setting.</P>
Luo, J.,Gao, F.,Kim, D.H.,Peden, C.H.F. Elsevier Science Publishers 2014 CATALYSIS TODAY - Vol.231 No.-
The effects of K loading and thermal aging on the structural properties and high temperature performance of Pt/K/Al<SUB>2</SUB>O<SUB>3</SUB> lean NO<SUB>x</SUB> trap (LNT) catalysts were investigated using in situ X-ray diffraction (XRD), temperature-programmed decomposition/desorption of NO<SUB>x</SUB> (NO<SUB>x</SUB>-TPD), transmission electron microscopy (TEM), NO oxidation, and NO<SUB>x</SUB> storage tests. In situ XRD results demonstrate that KNO<SUB>3</SUB> becomes extremely mobile on the Al<SUB>2</SUB>O<SUB>3</SUB> surface, and experiences complex transformations between orthorhombic and rhombohedral structures, accompanied by sintering, melting and thermal decomposition upon heating. NO<SUB>x</SUB> storage results show an optimum K loading around 10% for the best performance at high temperatures. At lower K loadings where the majority of KNO<SUB>3</SUB> stays as a surface layer, the strong interaction between KNO<SUB>3</SUB> and Al<SUB>2</SUB>O<SUB>3</SUB> promotes KNO<SUB>3</SUB> decomposition and deteriorates high-temperature performance. At K loadings higher than 10%, the performance drop is not caused by NO<SUB>x</SUB> diffusion limitations as for the case of barium-based LNTs, but rather from the blocking of Pt sites by K species, which adversely affects NO oxidation. Thermal aging at 800<SUP>o</SUP>C severely deactivates the Pt/K/Al<SUB>2</SUB>O<SUB>3</SUB> catalysts due to Pt sintering. However, in the presence of potassium, some Pt remains in a dispersed and oxidized form. These Pt species interact strongly with K and, therefore, do not sinter. After a reduction treatment, these Pt species remain finely dispersed, contributing to a partial recovery of NO<SUB>x</SUB> storage performance.
Gao, Xia,Fu, Xuping,Li, Tao,Zi, Jian,Luo, Yao,Wei, Qing,Zeng, Erliang,Xie, Yi,Li, Yao,Mao, Yumin 생화학분자생물학회 2003 Journal of biochemistry and molecular biology Vol.36 No.6
In microarray data mining, one of the key problems is how to handle weak signals. Based on a bent piecewise linear accumulated distribution generally found in the microarray data, a new detectable threshold finding method is proposed to filter genes with unreliable information in this paper. More reliable and reproducible data is produced for the subsequent data mining.
Exploratory Study: A Modification Training Method of Attentional Bias Toward Safety
Gao, Jingqi,Wu, Xiang,Luo, Xiaowei,Zhang, Ao Occupational Safety and Health Research Institute 2021 Safety and health at work Vol.12 No.3
Background: The high sensitivity of individuals toward safety information in production activities, that is, attentional bias toward safety (ABS), can positively predict safe behaviors. It has become a hot topic in current organizational safety behavior research. However, there is no literature on its modification method. Methods: Based on the modified dot-probe task, we designed a modification training method of ABS. The training method required subjects to respond to the location of detection points that presented after safety stimulus and neutral stimulus pictures. Subjects' attentional bias values of safety and neutral pictures were measured during the experiment. Twenty-one students were selected and divided into a control group and training group to gain comparable results. Results: A novel training method was developed in this study to promote the efficacy of safety stimulus by activating ABS of the subjects. Moreover, repeated trainings and preacquired relative knowledge can enhance this effect. Conclusion: This study develops an experimental approach to evaluate the effectiveness of safety education and safety training, and also provides a new research idea for accident prevention.
Buckling and vibrational information of an annular nanosystem covered with piezoelectric layer
Gao, Jie,Nie, Rong,Feng, Yongyi,Luo, Jiawei,Li, Siyu Techno-Press 2022 Advances in nano research Vol.13 No.3
Resently, the use of smart structures has been heightened up rapidly. For this issue, vibration analysis related to a graphene nanoplatelet composite (GPLRC) nanodisk which is attached to a piezoelectric layer and is subjected to thermal loads is explored in the current paper. The formulation of this study is obtained through the energy method and nonlocal strain gradient theory, and then it is solved employing generalized differential quadrature method (GDQM). Halpin-Tsai model in addition to the mixture's rule are utilized to capture the material properties related to the reinforced composite layer. The compatibility conditions are presented for exhibiting the perfect bounding between two layers. The results of this study are validated by employing the other published articles. The impact of such parameters as external voltage, the radius ratio, temperature difference, and nonlocality on the vibrational frequency of the system is investigated in detail.
ACCURACY OF LAMOST DR1 STELLAR PARAMETERS
GAO, HUA,ZHANG, HUA-WEI,XIANG, MAO-SHENG,HUANG, YANG,LIU, XIAO-WEI,LUO, A-LI,ZHANG, HAO-TONG,WU, YUE,ZHANG, YONG,LI, GUANG-WEI,DU, BING The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
We adopt the PASTEL catalog combined with SIMBAD radial velocities as a testing standard to validate the stellar parameters (effective temperature $T_{eff}$, surface gravity log g, metallicity [Fe/H] and radial velocity $V_r$) from the first data release (DR1) of The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) survey. After applying data reduction and temperature constraints to the sample obtained by cross-identification, we compare the stellar parameters from DR1 and PASTEL. The results show that the DR1 results are reliable under certain conditions. We derive a dispersion of 110 K, 0.19 dex, 0.11 dex and $4.91kms^{-1}$ in specified effective temperature ranges, for $T_{eff}$, log g, [Fe/H] and $V_r$ respectively. Systematic errors are negligible except for those of $V_r$. In addition, for stars with PASTEL [Fe/H] < -1:5, the metallicities in DR1 are systematically higher than those in PASTEL.
Crystalline Bilayer Graphene with Preferential Stacking from Ni-Cu Gradient Alloy
Gao, Zhaoli,Zhang, Qicheng,Naylor, Carl H.,Kim, Youngkuk,Abidi, Irfan Haider,Ping, Jinglei,Ducos, Pedro,Zauberman, Jonathan,Zhao, Meng-Qiang,Rappe, Andrew M.,Luo, Zhengtang,Ren, Li,Johnson, Alan T. Ch American Chemical Society 2018 ACS NANO Vol.12 No.3
<P>We developed a high-yield synthesis of highly crystalline bilayer graphene (BLG) with two preferential stacking modes using a Ni-Cu gradient alloy growth substrate. Previously reported approaches for BLG growth include flat growth substrates of Cu or Ni-Cu <I>uniform</I> alloys and “copper pocket” structures. Use of flat substrates has the advantage of being scalable, but the growth mechanism is either “surface limited” (for Cu) or carbon precipitation (for uniform Ni-Cu), which results in multicrystalline BLG grains. For copper pockets, growth proceeds through a carbon back-diffusion mechanism, which leads to the formation of highly crystalline BLG, but scaling of the copper pocket structure is expected to be difficult. Here we demonstrate a Ni-Cu gradient alloy that combines the advantages of these earlier methods: the substrate is flat, so easy to scale, while growth proceeds by a carbon back-diffusion mechanism leading to high-yield growth of BLG with high crystallinity. The BLG layer stacking was almost exclusively Bernal or twisted with an angle of 30°, consistent with first-principles calculations we conducted. Furthermore, we demonstrated scalable production of transistor arrays based crystalline Bernal-stacked BLG with a band gap that was tunable at room temperature.</P> [FIG OMISSION]</BR>
Design of Direct-Current Fuzzy Controller for Mitigating Commutation Failure in HVDC System
Gao, Benfeng,Yuan, Kewei,Dong, Peiyi,Luo, Chao,Zhao, Shuqiang The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.4
Commutation failures can deteriorate the availability of high-voltage direct current (HVDC) links and may lead to outage of the HVDC system. Most commutation failures are caused by voltage reduction due to ac system faults on inverter side. The commutation failure process can be divided into two stages. The first stage, from the occurrence to the clearing of faults, is called 'Deterioration Stage'. The second stage, from the faults clearing to restoring the power system stability, is called 'Recovery Stage'. Based on the analysis of the commutation failure process, this paper proposes a direct-current fuzzy controller including prevention and recovery controller. The prevention controller reduces the direct current to prevent Commutation failures in the 'Deterioration Stage' according to the variation of ac voltage. The recovery controller magnifies the direct current to speed up the recovery of power system in the 'Recovery Stage', based on the recovery of direct voltage. The validity of this proposed fuzzy controller is further proved by simulation with CIGRE HVDC benchmark model in PSCAD/EMTDC. The results show the commutation failures can be mitigated by the proposed direct-current fuzzy controller.
Gao Shan,Guo Tingting,Luo Shuyu,Zhang Yan,Ren Zehao,Lang Xiaona,Hu Gaoyong,Zuo Duo,Jia Wenqing,Kong Dexin,Yu Haiyang,Qiu Yuling 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.6
Chronic myeloid leukemia (CML) is a slowly progressing hematopoietic cell disorder. Sphingosine kinase 1 (SPHK1) plays established roles in tumor initiation, progression, and chemotherapy resistance in a wide range of cancers, including leukemia. However, small-molecule inhibitors targeting SPHK1 in CML still need to be developed. This study revealed the role of SPHK1 in CML and investigated the potential anti-leukemic activity of hirsuteine (HST), an indole alkaloid obtained from the oriental plant Uncaria rhynchophylla, in CML cells. These results suggest that SPHK1 is highly expressed in CML cells and that overexpression of SPHK1 represents poor clinical outcomes in CML patients. HST exposure led to G2/M phase arrest, cellular apoptosis, and downregulation of Cyclin B1 and CDC2 and cleavage of Caspase 3 and PARP in CML cells. HST shifted sphingolipid rheostat from sphingosine 1-phosphate (S1P) towards the ceramide coupled with a marked inhibition of SPHK1. Mechanistically, HST significantly blocked SPHK1/S1P/S1PR1 and BCR-ABL/PI3K/Akt pathways. In addition, HST can be docked with residues of SPHK1 and shifts the SPHK1 melting curve, indicating the potential protein-ligand interactions between SPHK1 and HST in both CML cells. SPHK1 overexpression impaired apoptosis and proliferation of CML cells induced by HST alone. These results suggest that HST, which may serve as a novel and specific SPHK1 inhibitor, exerts anti-leukemic activity by inhibiting the SPHK1/S1P/ S1PR1 and BCR-ABL/PI3K/Akt pathways in CML cells, thus conferring HST as a promising anti-leukemic drug for CML therapy in the future.