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- 저자 : Ganesan, Palanivel (검색결과 291 건)
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Ganesan Venkatasubramanian 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.1
From neurophenomenological perspectives, schizophrenia has been conceptualized as “a disorder with heterogeneous manifestations that can be integrally understood to involve fundamental perturbations in consciousness”. While these theoretical constructs based on consciousness facilitate understanding the ‘gestalt’ of schizophrenia, systematic research to unravel translational implications of these models is warranted. To address this, one needs to begin with exploration of plausible biological underpinnings of “perturbed consciousness” in schizophrenia. In this context, an attractive proposition to understand the biology of consciousness is “the orchestrated object reduction (Orch-OR) theory” which invokes quantum processes in the microtubules of neurons. The Orch-OR model is particularly important for understanding schizophrenia especially due to the shared ‘scaffold’ of microtubules. The initial sections of this review focus on the compelling evidence to support the view that “schizophrenia is a disorder of consciousness” through critical summary of the studies that have demonstrated self-abnormalities, aberrant time perception as well as dysfunctional intentional binding in this disorder. Subsequently, these findings are linked with ‘Orch-OR theory’ through the research evidence for aberrant neural oscillations as well as microtubule abnormalities observed in schizophrenia. Further sections emphasize the applicability and translational implications of Orch-OR theory in the context of schizophrenia and elucidate the relevance of quantum biology to understand the origins of this puzzling disorder as “fundamental disturbances in consciousness”.
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SFRHPC interior beam-column-slab joints under reverse cyclic loading
Ganesan, N.,Nidhi, M.,Indira, P.V. Techno-Press 2015 Advances in concrete construction Vol.3 No.3
Beam-column joints are highly vulnerable locations which are to be designed for high ductility in order to take care of unexpected lateral forces such as wind and earthquake. Previous investigations reveal that the addition of steel fibres to concrete improves its ductility significantly. Also, due to presence of slab the strength and ductility of the beam increases considerably and ignoring the effect of slab can lead to underestimation of beam capacity and defiance of strong column weak beam concept. The influence of addition of steel fibres on the strength and behaviour of steel fibre reinforced high performance concrete (SFRHPC) interior beam-column-slab joints was investigated experimentally. The specimens were subjected to reverse cyclic loading. The variable considered was the volume fraction of crimped steel fibres i.e., 0%, 0.5% and 1.0%. The results show that the addition of steel fibres improves the first crack load, strength, ductility, energy absorption capacity and initial stiffness of the beam.
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Interpreting Recent Developments in Myanmar as an Attempt to Establish Political Legitimacy
Ganesan, N. 서울대학교 통일평화연구원 2013 Asian Journal of Peacebuilding Vol.1 No.2
Myanmar is currently undergoing widespread changes that are transforming the country's political and socio-economic landscape. These changes include the newly promulgated Constitution that was ratified in 2008 and a national election held in November 2010. Additionally, by-elections in April 2012 saw the return to Parliament of the National League for Democracy and its leader Aung San Suu Kyi. The reforms under the new Thein Sein-led government include a congenial working relationship with the political opposition, freeing political prisoners and the granting of amnesty to political exiles to encourage their return, the negotiation of ceasefire agreements with almost all of the ethnic insurgent armies, and the inauguration of the Myanmar Peace Centre as a vehicle for the resolution of domestic conflict. These and related reforms are designed to secure the government's internal and external political legitimacy which it has lacked since the fall of the previous socialist government in 1988.
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Ganesan, Vinoth,Ramasamy, Parthiban,Kim, Jinkwon Elsevier 2017 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY - Vol.42 No.9
<P><B>Abstract</B></P> <P>Developing highly efficient and cost-effective electrocatalysts for oxygen evolution reaction (OER) is crucial for renewable energy storage technologies. Here, we synthesized hierarchical Co-based bimetallic sulfide nanostructures as an efficient electrocatalyst for OER. Ni<SUB>3.5</SUB>Co<SUB>5.5</SUB>S<SUB>8</SUB> nanostructures were synthesized by solvothermal sulfurization and thermal annealing of pre-synthesized homogenous bimetallic metal–organic frameworks (MOFs). Electron microscopy studies revealed that the Ni<SUB>3.5</SUB>Co<SUB>5.5</SUB>S<SUB>8</SUB> has hollow nanocage like morphology with thin nanosheets grown on the surface. In addition, Co<SUB>9</SUB>S<SUB>8</SUB> hollow nanocages were also synthesized for comparative electrocatalytic evaluation with the Ni<SUB>3.5</SUB>Co<SUB>5.5</SUB>S<SUB>8</SUB> nanosheet-assembled hollow nanocages (NAHNs). The Ni<SUB>3.5</SUB>Co<SUB>5.5</SUB>S<SUB>8</SUB> NAHNs has exhibited a low overpotential of 333 mV at the current density of 10 mA cm<SUP>−2</SUP> (1.563 V <I>vs</I> RHE) and Tafel slope of 48.5 mV dec<SUP>−1</SUP> for the oxygen evolution reaction in 1 M KOH. Benefitting from their structural merits, Ni<SUB>3.5</SUB>Co<SUB>5.5</SUB>S<SUB>8</SUB> NAHNs manifest excellent OER electrocatalytic activity compared to most of the recently reported non-precious catalyst for OER.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hierarchical Ni<SUB>3.5</SUB>Co<SUB>5.5</SUB>S<SUB>8</SUB> nanosheet assembled hollow nanocages (NAHNs) were successfully synthesized. </LI> <LI> Ni<SUB>3.5</SUB>Co<SUB>5.5</SUB>S<SUB>8</SUB> NAHNs provide high porous nature and large surface area. </LI> <LI> Explored as efficient, low potential electrocatalyst to drive the oxygen evolution reaction. </LI> <LI> Ni<SUB>3.5</SUB>Co<SUB>5.5</SUB>S<SUB>8</SUB> NAHNs catalyst exhibited better OER stability. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Ganesan, P.,Sivanantham, A.,Shanmugam, S. Royal Society of Chemistry 2016 Journal of materials chemistry. A, Materials for e Vol.4 No.42
<P>Efficient and durable electrocatalysts for water splitting (both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER)) are required for the replacement of expensive noble metal-based catalysts used in water electrolysis devices. Herein, we describe the inexpensive synthesis of electrochemically deposited nickel iron sulphides on nickel foam (NiFeS/NF) and their use as highly efficient bi-functional water splitting catalysts that can meet the current energy demands. The NiFeS/NF electrocatalysts exhibited low overpotentials of approximately 231 mV for the OER and 180 mV for the HER in 1 M KOH. Moreover, the NiFeS/NF electrocatalysts exhibited a turnover frequency of one order of magnitude higher than those of state-of-the-art noble metal catalysts (RuO2 and Pt/C) for the OER and HER. In addition to this excellent activity, the bi-functional catalyst also exhibited an outstanding OER and HER electrode stability for over 200 h with minimal loss in activity. Further, it can be directly used in the practical application of alkaline electrolyte membrane water electrolysis. The high performance, prolonged electrode stability, and facile synthesis as an adherent coating on nickel foam suggest that NiFeS/NF electrocatalysts might be suitable for use as alternative commercially viable catalysts.</P>
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Ganesan Rethinam,Anand Duraiswamy,G. Dayanand Reddy,P. Elankani,Sampath Kundrapakkam Srinivasan 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.2
Acute kidney injury (AKI) is described as a disorder with a sudden loss of kidney function. AKI is also attributed to several aetiologies such as diabetes, cardiac problems, etc. Developing a therapy for AKI is challenging due to its complex pathophysiology. The present study investigated the effect of Sphaeranthus amaranthoides Burm f. aqueous extract, a Siddha Kalpha drug, against gentamicin-induced AKI. Animals were initially pre-administered with different concentrations of S. amaranthoides and later induced with gentamicin on the 8th day. Biochemical, anti-inflammatory and antioxidant markers were analysed. Further, HRLCMS analysis was carried out to identify the bioactive components. Components including myo-inositol, traumatic acid, rosmarinic acid, etc. were identified. In the animals induced with gentamicin, KIM1, LDH, GGT, creatinine, BUN and electrolytes were elevated in both serum and urine, while noted within normal range in S. amaranthoides pre-administered groups. Histopathology analysis revealed prevention of necrosis, tubular epithelial cell degeneration and glomerular congestion in S. amaranthoides administered animals. Lipid peroxidation, KIM1, Cystatin C, TNFα, IL6 and NFκB were within normal range in tissues. Thus, it is evident that S. amaranthoides is effective in protecting kidney damage and treating AKI. Further studies will be conducted to analyse the pathways resurrecting kidney damage.
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Strength and behaviour of bamboo reinforced concrete wall panels under two way in-plane action
Ganesan, N.,Indira, P.V.,Himasree, P.R. Techno-Press 2018 Advances in concrete construction Vol.6 No.1
An experimental investigation has been carried out on the use of an environmentally sustainable material, bamboo, in the construction of precast concrete structural wall panels. The strength and behaviour of three prototype bamboo reinforced concrete wall panel specimens under two-way in-plane action was studied. The specimens with varying aspect ratio and thinness ratio were tested to fail under a uniformly distributed in-plane load applied at an eccentricity of t/6. The aspect ratio of the specimens considered includes 1.667, 1.818 and 2 and the thinness ratio includes 12.5, 13.75 and 15. The influence of aspect ratio and thinness ratio of bamboo reinforced concrete wall panels, on its strength and behaviour was discussed. Varnished and sand blasted bamboo splints of 20 mm width and thickness varying from 8 to 15 mm were used as reinforcement in concrete. Based on the study, an empirical equation was developed considering the geometrical parameters of bamboo reinforced concrete wall panels for predicting its ultimate strength under two way in-plane action.
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Ganesan, Vinothkumar,Sivanesan, Dharmalingam,Yoon, Sungho American Chemical Society 2017 Inorganic Chemistry Vol.56 No.3
<P>A series of water-soluble half-sandwich [Cp*Rh-III(N<^>N)Cl](+) (Cp* = pentamethylcyclopentadiene, N<^>N-substituted 2,2'-bipyridine) complexes containing electron-donating substituents around the 2,2'-bipyridyl ligand were synthesized and fully characterized for the regioselective reduction of nicotinamide coenzyme (NAD(+)). The influence of the positional effect of the substituents on the structural, electrochemical, and catalytic properties of the catalyst was systematically studied in detail. The catalytic efficiency of the substituted bipyridine Cp*RhIII complexes are inversely correlated with their redox potentials. The 5,5'-substituted bipyridine Cp*RhIII complex, which had the lowest reduction potential, most effectively regenerated NADH with a turnover frequency of 1100 h(-1). Detailed kinetic studies on the generation of intermediate(s) provide valuable mechanistic insight into this catalytic cycle and help to direct the future design strategy of corresponding catalysts.</P>
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