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Wegner, Dietrich H.G. INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1982 YONSEI REPORTS ON TROPICAL MEDICINE Vol.13 No.1
東南亞 諸地域에 分布하고 있는 住血吸蟲類는 Schistosoma japonicum이며 이들의 驅除는 近年에 이르기까지 매우 어려운 狀態에 있었고, 韓國에 있어서도 例外아니게 肝吸蟲 및 肺吸蟲等 여러 吸蟲類에 依해 큰 損失을 입고 있다. 여기에 새로히 開發된 Biltricide(praziquantel)가 上記 寄生蟲들에 對해 著效하며 매우 安定性이 높아 希望的인 將來를 期約하고 있어 實驗成績을 通하여 이를 紹介하는 바다. 特히 亞細亞 諸國, Africa 및 南美等地의 여러나라에서 本製劑에 對한 臨床試驗으로 卓越한 效能이 確認되었으며 安定性이 保障되었다. 副作用도 胃腸症勢, 中樞神經障碍 및 allergy反應等 其他症勢等으로 나타나나 極少하며 輕하고 一過性이어서 別다른 加療가 必要없고, 投與後 呼訴하는 症勢들의 大部分은 投藥以前에 이미 가지고 있었던 것으로 나타났다.
Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obese mice
Benn, T.,Kim, B.,Park, Y.K.,Wegner, C.J.,Harness, E.,Nam, T.G.,Kim, D.O.,Lee, J.S.,Lee, J.Y. Butterworths ; Elsevier Science Ltd 2014 The Journal of nutritional biochemistry Vol.25 No.10
Obesity is closely associated with chronic, low-grade inflammation. We investigated if polyphenol-rich blackcurrant extract (BCE) can prevent inflammation in vivo. Male C57BL/6J mice were fed a modified AIN-93M control diet containing high fat/high cholesterol (16% fat, 0.25% cholesterol by weight) or the control diet supplemented with 0.1% BCE (wt/wt) for 12 weeks. In BCE-fed mice, the percentage of body weight and adipocyte size of the epididymal fat were significantly lower than those of control mice. There were fewer crown-like structures (CLS) with concomitant decreases in F4/80, cluster of differentiation 68 and inhibitor of nuclear factor κB kinase ε (IKKε) mRNA in the epididymal adipose of BCE-fed mice. F4/80 and IKKε mRNA levels were positively correlated with CLS number. In the skeletal muscle of mice fed with BCE, mRNA expression of genes involved in energy expenditure and mitochondrial biogenesis, including PPARα, PPARδ, UCP-2, UCP-3 and mitochondrial transcription factor A, were significantly increased. When splenocytes from BCE-fed mice were stimulated by lipopolysaccharides, tumor necrosis factor α and interleukin-1β mRNA were significantly lower than control splenocytes. Together, the results suggest that BCE supplementation decreases obesity-induced inflammation in adipose tissue and splenocytes, at least in part, by modulating energy metabolism in skeletal muscle.
Moon, Jisook,Schwarz, Sigrid C.,Lee, Hyun‐,Seob,Kang, Jun Mo,Lee, Young‐,Eun,Kim, Bona,Sung, Mi‐,Young,Hö,glinger, Gü,nter,Wegner, Florian,Kim, Jin Su,Chung, Hyung‐,Min unknown 2017 Stem cells translational medicine Vol.6 No.2
<P><B>Abstract</B></P><P>We have developed a good manufacturing practice for long‐term cultivation of fetal human midbrain‐derived neural progenitor cells. The generation of human dopaminergic neurons may serve as a tool of either restorative cell therapies or cellular models, particularly as a reference for phenotyping region‐specific human neural stem cell lines such as human embryonic stem cells and human inducible pluripotent stem cells. We cultivated 3 different midbrain neural progenitor lines at 10, 12, and 14 weeks of gestation for more than a year and characterized them in great detail, as well as in comparison with Lund mesencephalic cells. The whole cultivation process of tissue preparation, cultivation, and cryopreservation was developed using strict serum‐free conditions and standardized operating protocols under clean‐room conditions. Long‐term‐cultivated midbrain‐derived neural progenitor cells retained stemness, midbrain fate specificity, and floorplate markers. The potential to differentiate into authentic A9‐specific dopaminergic neurons was markedly elevated after prolonged expansion, resulting in large quantities of functional dopaminergic neurons without genetic modification. In restorative cell therapeutic approaches, midbrain‐derived neural progenitor cells reversed impaired motor function in rodents, survived well, and did not exhibit tumor formation in immunodeficient nude mice in the short or long term (8 and 30 weeks, respectively). We conclude that midbrain‐derived neural progenitor cells are a promising source for human dopaminergic neurons and suitable for long‐term expansion under good manufacturing practice, thus opening the avenue for restorative clinical applications or robust cellular models such as high‐content or high‐throughput screening. S<SMALL>TEM</SMALL> C<SMALL>ELLS</SMALL> T<SMALL>RANSLATIONAL</SMALL> M<SMALL>EDICINE</SMALL><I>2017;6:576–588</I></P>