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Belen Lopez-Millan,Rafael Diaz de la Guardia,Heleia Roca-Ho,Carmen M García-Herrero,Jessie R Lavoie,Michael Rosu-Myles,Elena Gonzalez-Rey,Francisco O’Valle,Gabriel Criado,Mario Delgado,Pablo Menendez 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide analogs, including lenalidomide and pomalidomide. These are new generation IMiDs that exhibit direct antitumor activity as well as anti-inflammatory/immunomodulatory properties, and are FDA-approved for the treatment of several hematological malignances. Here we investigated the potential therapeutic effects of lenalidomide and pomalidomide in several experimental murine models of autoimmune/inflammatory diseases: 2,4,6-trinitrobenzene sulfonic acid- and dextran sulfate sodium-induced inflammatory bowel disease and type II collagen-induced arthritis. Lenalidomide displayed a strong therapeutic effect in all these models of autoimmune/inflammatory diseases, while the effect of pomalidomide was less pronounced. In vitro experiments confirmed the immunosuppressive effect of both IMiDs on the proliferative response of stimulated human lymphocytes and on the balance of secreted cytokines toward an anti-inflammatory profile. We conclude that lenalidomide may offer a therapeutic opportunity against autoimmune/inflammatory diseases.
Dynamic behavior of pergola bridge decks of high-speed railways
Jokin Ugarte,Antonio Carnerero,Francisco Millanes 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.61 No.1
This paper analyzes the dynamic behavior of the deck of pergola bridges affected by moving loads, specifically high-speed trains. Due to their characteristic advantages, pergola bridges have become a widely used structural typology on high-speed railways. In spite of such wide-spread use, there are few technical bibliographies published in this field. The first part of this paper develops a simple analytical methodology to study the complex dynamic behavior of these double dimensional structures. The second part compares the results obtained by the proposed formulae and the dynamic response obtained with different and gradually more complex FE models. The results obtained by the analytical model are in close agreement with those obtained by the FE models, demonstrating its potential application in the early design stages of this kind of structure.
Julio Gir?-Calle,Javier Vioque,Maria del Mar Yust,Justo Pedroche,Manuel Alaiz,Francisco Millan 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.2
Pulses should be part of a healthy diet, and it is also becoming clear that they have health-promoting effects. Nevertheless, most studies on the bioactive or health-promoting properties of pulses have been carried out using soybeans. We have studied cell growth-regulating properties, which may be responsible for anti-cancer properties, in chickpea seeds. Chickpea seeds are a staple in the traditional diet of many Mediterranean, Asian, and South and Central American countries. In addition, chickpea seeds have industrial applications since they can be used for the preparation of protein concentrates and isolates. The cell lines Caco-2 (epithelial intestinal) and J774 (macrophages) have been exposed to chickpea seed extracts and protein preparations in order to screen the different chickpea fractions for effects on cell growth. Both cell growth-promoting and cell growth-inhibiting effects were found. Most interestingly, a fraction soluble in ethanol and acetone specifically and almost completely inhibited the growth of Caco-2 cells exhibiting a cancerous phenotype. It is concluded that chickpea seeds are a source of bioactive components and deserve further study for their possible anti-cancer effect.