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Palmar and plantar fibromatosis: a review
Brian D. Stewart,Alessandra F. Nascimento 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.4
Palmar fibromatosis (Dupuytren disease/contracture) is the most common type of fibromatosis, defined as a benign proliferation of fibroblasts and myofibroblasts. The disease process is most common in white, middle-aged and older men occurring at the distal palmar crease leading to nodules and contracture, which in many cases recur after surgical treatment. In a similar process, plantar fibromatosis (Ledderhose disease) is a proliferation of fibroblasts and myofibroblasts on the plantar aponeurosis of mostly middle-aged patients that may lead to painful nodules but usually does not lead to contracture. Both processes are histologically similar, composed of a bland cellular proliferation of spindle cells with a bluish appearance and with a variable amount of background collagen, depending on the age of the lesion. The etiology of both lesions is still uncertain, while treatment ranges from observation to surgery, with some pharmacologic agents being investigated with mixed success. In this paper we provide an overview of both processes with regards to clinical and radiologic findings, pathophysiology, diagnosis, treatment, and prognosis.
Chemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract
José A.A. Santos,Andrea Calheiros,Diogo D. Nascimento,Ana Luiza R. Bérenger,Fábio C. Amendoeira,Hugo C. Castro-Faria-Neto,Maria Raquel Figueiredo,Luiz A. Alves,Valber da Silva Frutuoso 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Different species of the family Clusiaceae, including Rheedia longifolia, are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studies. In previous studies, we found that the aqueous extract from R. longifolia leaves presented important anti-inflammatory and analgesic activity. We investigated the chemical profile of R. longifolia and characterized the pharmacological effect of different chemically identified fractions in pharmacological models of neurogenic and inflammatory nociception. The pharmacological tests showed that oral treatment with aqueous crude extract and fractions of methanol extract of R. longifolia leaf induced a significant antinociceptive effect using von Frey filaments. In addition, the most polar fractions presented antinociceptive activity in a neurogenic model of nociception (capsaicin model). The chromatographic analysis indicated the presence of bisflavonoids in the fractions obtained from the methanol extract. These results suggest that bisflavonoids found in methanol-extracted fractions are involved in the inhibition of inflammatory and neurogenic nociception. It is important that the R. longifolia aqueous extract treatment inhibited ulcer formation induced by indomethacin, suggesting an anti-ulcerogenic activity closely associated with its analgesic effect.
Identification of Secreted Virulence Factors of Chromobacterium violaceum
Thiago Castro-Gomes,Santuza M. R. Teixeira,Mariana S. Cardoso,Wanderson D. DaRocha,Letícia A. Laibida,Andréa M. A. Nascimento,Luciana W. Zuccherato,Maria Fátima Horta,Marcelo P. Bemquerer 한국미생물학회 2014 The journal of microbiology Vol.52 No.4
Chromobacterium violaceum, a component of tropical soilmicrobiota, is an opportunistic pathogenic bacterium thatcan infect humans and other animals. In addition to identifyinga large number of genes that demonstrate the vast biotechnologicalpotential of this bacterium, genome sequencingrevealed several virulence factors, including different cytolysins,which can be related to its pathogenicity. Here weconfirmed these predictions from genomic analyses by identifying,through mass spectrometry, proteins present in theculture supernatant of C. violaceum that may constitute secretedvirulence factors. Among them, we identified a secretedcollagenase and the product of a gene with sequence similarityto previously characterized bacterial porins.
Methodology for corrosion evaluation in HAZ of 11%-Cr ferritic stainless steel
Carmem C. F. Nascimento,Samuel F. Rodrigues,Vinicius M. de Morais,Louriel O. Vilarinho 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.8
A novel methodology is proposed for corrosion-wear measurement in the Heat affected zone (HAZ) of 11%-Cr ferritic stainless steel. Weld beads with different stress-concentration were manufactured by using MIG/MAG process. After, the welded sample is extracted from the plate, the beads were bended and external stress was applied. Finally, they were inserted in ferric-chloride solution. Corrosive wear were assessed by means of optical microscopy in the HAZ by using polymeric resin mask and comparing profiles before and after inserting the sample into the solution. The results demonstrate the feasibility of the proposed methodology for assessing corrosive wear in the HAZ.
Antimutagenic Effect of Aqueous Extract from Agaricus brasiliensis on Culture of Human Lymphocytes
Paula H. Gameiro,Jose´ S. Nascimento,Beatriz H.G. Rocha,Clause F.B. Piana,Raquel A. Santos,Catarina S. Takahashi 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.2
The mushroom Agaricus brasiliensis (sun mushroom), native from the southeast of Brazil, is well known by its medicinal properties that include effects on diabetes, cholesterol levels, and osteoporosis. The antimutagenic effects of A. brasiliensis has been investigated recently and revealed some controversial results depending on the temperature by which the A. brasiliensis tea is obtained. In the present study, we evaluated the effect of the A. brasiliensis extract prepared in two different temperatures, 4°C and 25°C, on the doxorubicin-induced DNA strand breaks and chromosomal aberrations (CAs) in human lymphocytes. The results demonstrated that A. brasiliensis was able to reduce the DXR-induced DNA damage in both temperatures; however, the CA test was more sensitive to demonstrate a better reduction when the cells were treated with an extract obtained at 25°C. A. brasiliensis extract obtained in different temperatures exhibited antigenotoxic and anticlastogenic effects in human lymphocytes.
Luciana S. Aragão-França,Viviane C. J. Rocha,Andre Cronemberger-Andrade,F. H. B. Costa,José Fernandes Vasconcelos,Daniel Abensur Athanazio,Daniela Nascimento Silva,E. S. Santos,Cássio Santana Meira,C. 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.4
Purpose: The use of tolerogenic dendritic cells (TolDCs) to control exacerbated immune responses may be a prophylactic and therapeutic option for application in autoimmune and allergic conditions. The objective of this work was to evaluate the effects of TolDC administration in a mouse model of allergic airway inflammation caused by mite extract. Methods: Mouse bone marrow-derived TolDCs were induced by incubation with granulocyte- macrophage colony-stimulating factor (GM-CSF) and dexamethasone, and then characterized by flow cytometry and cytokine production by enzyme- linked immunosorbent assay (ELISA). For the in vivo model of Blomia tropicalis-induced allergy, mice transplanted with antigen-pulsed TolDCs were sensitized intraperitoneally with B. tropicalis mite extract (BtE) adsorbed to aluminium hydroxide. After challenge by nasal administration of BtE, bronchoalveolar lavage fluid (BALF), lungs, spleen and serum were collected for analysis. Results: Induction of TolDCs was efficiently achieved as shown by low expression of major histocompatibility complex (MHC) II, programmed death-ligand (PD-L) 2 and pro-inflammatory cytokine production, and up-regulation of interleukin (IL)-10, upon LPS stimulation in vitro. Transplantation of 1 or 2 doses of BtE-pulsed TolDCs reduced the number of inflammatory cells in BALF and lungs as well as mucus deposition. Moreover, compared to saline-injected controls, TolDC-treated mice showed lower serum levels of anti-BtE immunoglobulin E (IgE) antibodies as well as reduced Gata3 and IL-4 gene expression in the lungs and decreased IFN-γ levels in the supernatant of splenocyte cultures Transplantation of TolDCs increased the percentage of the regulatory T cells in the spleen and the lungs. Conclusions: Preventive treatment with TolDCs protects against dust mite-induced allergy in a mouse model, reinforcing the use of tolerogenic dendritic cells for the management of allergic conditions.
Green synthesis of carbon nanodots from agro-industrial residues
Allan Jr. Gonçalves Afonso,Felipe Thomaz Aquino,Gisele M. L. Dalmônico,Matheus V. Nascimento,Ernesto Wrasse,Kelen M. F. Rossi de Aguiar 한국탄소학회 2022 Carbon Letters Vol.32 No.1
Fluorescent nanostructures based on carbon, or carbon dots, are attracting much attention and interest because of their diverse properties which can be applied in several fields of knowledge, such as optics, biomedicine, environmental research, among others. Such properties are in part, derived from its intrinsic luminescence from tunable functional groups. In this work, we produced carbon nanodots (CND) using agro-industrial residues, such as Lolium perenne and malt bagasse. The methods used were conventional hydrothermal syntheses and microwave-assisted hydrothermal synthesis. To the best of our knowledge, this is the first time that carbon dots synthesized from this ryegrass type are reported. The synthesis methods were one step (no catalyst, base, or acid were added for passivation), and the functional groups responsible for the luminescence and high solubility in water were identified by infrared spectroscopy, being mainly C=O, C–OH, C–N, and N–H. According to our theoretical studies, the C=O group introduced a new energy level for electronic transitions that can affect the emission properties. Fluorescence images of osteoblasts using CNDs were acquired and their chelating property towards Pb2+ and Cr6+ detection was tested.