http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이온교환 수지에 대한 벤젠폴리칼 복시산들의 흡착성에 관한 연구
이대운,김영환,유의경 연세대학교 대학원 1980 延世論叢 Vol.16 No.2
Absorption behavior of benzene polycarbofylic acids such as benzoic, phthalic, trimesic, hemimellitic, trimellitic, pyromellitic, and mellitic acid, on Amberlite CG-400 and on XAD-2 was studied. In order to investigate sorption mechanism of these acids, effect of pH, concentration of MeOH, and other inorganic ion on long D value were studied. Several acids were separated by Amberlite CG-400, Cl- resin With ZnCl2-, NiCl2- and CdCl2- MeOH solutions
Amberlite XAD 수지에 대한 Oxime 화합물의 흡착성에 관한 연구
유의경 세종대학교 1985 세종대학 논문집 Vol.12 No.이공
The adsorption behaviors of some oxime compounds on the Amberlite XAD resins were studied by measuring their distribution coefficients (olg Kd) in various media. The oxime compounds investigated were α-benzoinoxime, dimethylglyoxime, α-furildioxime, nioxime and salicylaldoxime which are well known as chelating agents for some metal ions. The Amberlite XAD resins were XAD-2, XAD-4, XAD-7 and XAD-8. To investigate the experimental factors in measuring log Kd of these oxime compounds, offect of shaking time, concentration of sample, amount of resin, concentration of methanol added and pH in the medium were studied. The decreasing order of log Kd values of the oxime compounds at the given experinental condition was as follows;α-benzoinoxime>salicylaldoxime>α-furildioxime nioxime>dimethylglyoxime (on XAD-2 and XAD-4 resins), while α-benzoinoxime>salicylaldoxime>α-furildioxime>dimethylglyoxime>nioxime (on XAD-7 and XAD-8 resins). The decreasing order of log Kd values of the oxime compounds on the Amberlite XAD resins was as follows: XAD-4>XAD-2>XAD-7>XAD-8
Pteridine-$C_7$ Side Chain에서 2-탈아미노화와 2-Methyl기 치환에 따른 Aminopterin 중간체 합성에 관한 연구
유의경,류성렬,Yu Euy Kyung,Ryu Seoung Ryuall 대한화학회 1993 대한화학회지 Vol.37 No.1
2-Amino-3-cyano-6-chloromethylpyrazine으로부터 합성한 methotrexate(MTX) 중간 유도체의 모핵인 pteridine ring의 $C_2$-amino 대신 $HCH_3$기, 또는 $nH_2$기로 치환된 화합물 (7a),(7b)와 (7c)를 두 단계에 걸쳐 합성하였다. 출발물질인 dibenzyl 4,4'-dithiobisbenzoate(12)와 2-amino-3-cyano-6-chloromethylpyrazine으로부터 합성한 2-amino-3-cyano-6-[(S-p-carbenzyloxyphenyl)thiomethyl]-pyrazine(14)화합물을 formamidine HCl, acetamidine HCl과 guanidine HCl 등과 각각 반응시켜 cyclization시키고, 이 화합물을 ethanol 용매하에서 0.2N NaOH를 사용한 알칼리 가수분해로 pteroic acid유도체를 합성하였다. A new series of 2-desamino, 2-desamino-2-methyl, and 2-amino analogues of aminopterin intermediates (7a), (7b), and (7c) were synthesized from 2-amino-3-cyano-6-chloromethylpyrazine. These derivatives were synthesized via two step sequence. Thus, cyclization of 2-amino-3-cyano-6-[(S-p-carbenzyloxyphenyl)thiomethyl]-pyrazine(14) with formamidine HCl, acetamidine HCl or guanidine HCl provided condensed compounds (15a), (15b) which upon base hydrolysis yielded the desired products (7a), (7b) and (7c).
Curie - point pyrolyzer - GC / MSD 를 이용한 4- hydroxy -3- methoxybenzaldehyde 의 열분해물 분석
유의경,김옥찬 ( Euy Kyung Yu,Ok Chan Kim ) 한국공업화학회 1997 공업화학 Vol.8 No.1
바니린을 Curie-point pyrolyzer-GC/MSD 장치를 사용하여 920, 740, 500, 333℃에서 각각 열분해하고, 열분해 생성물을 분리 및 확인하였다. 확인된 성분중에서 920℃에서는 95개 성분, 740℃에서는 40개 성분, 500℃에서는 17개 성분, 333℃에서는 11개 성분을 확인할 수 있었으며 이 열분해 반응생성물 중 주요 생성물인 벤젠, 페놀, 2-히드록시 벤즈알데히드, 2-메록시페놀, 4-메록시벤즈알데히드, 벤즈알데히드, 메록시벤젠, 1,3-시크로펜타디엔 등은 바니린의 작용기가 해리되었거나, 분해된 생성물로 생각되며, 1,3-benzodioxole-5-carbox-aldehyde, 메틸벤젠, 스틸렌, 메틸페놀 등은 500℃ 이하에서도 바니린의 메록시 작용기가 해리되어 생성되는 것으로 생각된다. This study was carried out to present a analysis of pyrolytic degradation of 4-hydroxy-3-methoxybenzaldehyde(vanillin) pyrolyzed at 330℃∼920℃ by Curie-point pyrolyzer connected with GC/MSD by on-line system. Identified by GC/MSD were 100 pyrolytic products of vanillin. The pyrolysis of the compound gave benzene, phenol, 1,3-cyclopentadiene, methyl benzene, benzaldehyde, benzofuran, and cresol as major products, which were produced by pyrolytic degradation and synthesis of vanillin radicals.
Anticancer Agent인 Methotrexate에 대한 새로운 합성 연구
유의경,류성렬,Yu Euy Kyung,Ryu Seoung Ryuall 대한화학회 1993 대한화학회지 Vol.37 No.1
새로운 methotrexate 중간체인 diethyl N-[4-{[(2,4-diamino-6-yl)methyl]-amino}benzoyl]-L-glutamate(10)를 합성하기 위하여 p-nitrobenzoic acid를 chlorination한 다음 L-glutamic acid와 coupling하고 이를 esterification한 후, 환원과 methylation시켜 diethyl N-(4-methylaminobenzoyl)-L-glutamate(7)를 합성하였다. 이 화합물(7)을 DMF 존재하에서 NaH와 allyl chloride를 가하여 allylation한 다음 여기에 $IN_3$ addition 반응으로 diethyl-p-[N-(2-azido-3-iodopropyl)-N-methyl]aminobenzoyl-L-glutamate(9)를 합성하였다. 이 화합물(9)을 2,4,5,6-tetraaminopyrimidine hydrochloride와 cyclization시켜 methotrexate diethylester를 얻었다. New synthetic method for diethyl N-[4-{[(2,4-diamino-6-yl)methyl]-amino}benzoyl]-L-glutamate(10) which is an intermediate of methotrexate is described. p-Nitrobenzoyl-L-glutamate was obtained via a two-step sequence which involves condensation of p-nitrobenzoyl chloride with diethyl-L-glutamate and Fischer esterification reaction with ethanol. Reductive methylation of diethyl-p-nitrobenzoyl-L-glutamate were carried out by reaction with formic acid and paraformaldehyde in the presence of $PtO_2$ catalyst and yielded diethyl N-(4-methylaminobenzoyl)-L-glutamate(7). It was followed by allylation and iodoazidozation to give the diethyl-p-[N-(2-azido-3-iodopropyl)-N-methyl]aminobenzoyl-L-glutamate(9). The cyclization reaction of compound(9) with 2,4,5,6-tetraaminopyrimidine was carried out by intermolecular nucleophilic substitution to give the desired methotrexate diethylester.
새로운 Azole 항진균제의 합성과 항균활성에 관한 연구
유의경,류성렬,변윤섭 ( Euy Kyung Yu,Seoung Ryuall Ryu,Youn Seop Byoun ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2
Reaction of cis-and-trans-2-(Bromomethyl)-2-(2,4-dichlophenyl)-1,3-dioxolane-4-methanol(11) with 1-Ethyl-6-fluoro-1,4-dihyddro-4-oxo-7-(1-thiomorpholinyl)quinoline-3-carboxylic acid(8), afforded Azole Ester compounds(12). These Compounds were tested for antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa.
Polyacryloylcephalexine과 Polymethacryloylcephalexine의 합성 및 그 항균작용
유의경,권규혁,차월석,나재운,Euy Kyung Yu,Gwon, Gyu Hyeok,Wol Suk Cha,Jae-Woon Na 대한화학회 1993 대한화학회지 Vol.37 No.7
방출조절성 약제를 개발하기 위한 방법으로 polyacrylic acid와 polymethacrylic acid에 thionylchloride로 chlorination하여 cephalexine을 반응시켜 Polyacryloylcephalexine 과 polymethacryloylcephalexine을 합성하였다. Polyacryloylcephalexine 중합체약에 대한 최소 발육 저지 농도로서 항균력은 Micrococcus luteus ATCC 9341과 Escherichia coli ESS이 우수하고, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Klebsiella pueumouiae KCTC 1560, Escherichia coli KCTC 1039, Salmonella typhimurium KCTC 1925 균주들에 대해서도 항균성이 대체적으로 우수하였다. polymethacryloylcephalexine 중합체약에 대한 최소 발육 저지 농도는 Micrococcus luteus ATCC 9341과 Klebsiella pueumouiae KCTC 1560이 우수하고, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Escherichia coli KCTC 1039, Escherichia coli ESS, Salmonella typhimurium KCTC 1925 균주들에 대해서는 항균력이 양호하였다. Polyacryloylcephalexine and polymethacryloylcephalexine were prepared by the reaction of polyacryloylchloride or polymethacryloyl chloride with cephalexine. The antimicrobial activities of these polymeric drugs were investigated by the common twofold dilution technique and the minimum inhibitory concentration (MIC) of polymeric durgs was also examined. Polyacryloylcephalexine revealed an excellent antibacterial activity against Micrococcus luteus ATCC 9341, Escherichia coli ESS, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Klebsiella pueumouiae KCTC 1560, Escherichia coli KCTC 1039, Salmonella typhimurium KCTC 1925. Polymethacryloylcephalexine revealed an excellent antibacterial activity against Micrococcus luteus ATCC 9341, Klebsiella pueumouiae KCTC 1560, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Escherichia coli KCTC 1039, Escherichia coli ESS, Salmonella typhimurium KCTC 1925.