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Patient-Derived Xenograft Models of Epithelial Ovarian Cancer for Preclinical Studies
Heo, Eun Jin,Cho, Young Jae,Cho, William Chi,Hong, Ji Eun,Jeon, Hye-Kyung,Oh, Doo-Yi,Choi, Yoon-La,Song, Sang Yong,Choi, Jung-Joo,Bae, Duk-Soo,Lee, Yoo-Young,Choi, Chel Hun,Kim, Tae-Joong,Park, Woong- 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4
<P><B>Purpose</B></P><P>Patient-derived tumor xenografts (PDXs) can provide more reliable information about tumor biology than cell line models. We developed PDXs for epithelial ovarian cancer (EOC) that have histopathologic and genetic similarities to the primary patient tissues and evaluated their potential for use as a platform for translational EOC research.</P><P><B>Materials and Methods</B></P><P>We successfully established PDXs by subrenal capsule implantation of primary EOC tissues into female BALB/C-nude mice. The rate of successful PDX engraftment was 48.8% (22/45 cases). Hematoxylin and eosin staining and short tandem repeat analysis showed histopathological and genetic similarity between the PDX and primary patient tissues.</P><P><B>Results</B></P><P>Patients whose tumors were successfully engrafted in mice had significantly inferior overall survival when compared with those whose tumors failed to engraft (p=0.040). In preclinical tests of this model, we found that paclitaxel-carboplatin combination chemotherapy significantly deceased tumor weight in PDXs compared with the control treatment (p=0.013). Moreover, erlotinib treatment significantly decreased tumor weight in epidermal growth factor receptor–overexpressing PDX with clear cell histology (p=0.023).</P><P><B>Conclusion</B></P><P>PDXs for EOC with histopathological and genetic stability can be efficiently developed by subrenal capsule implantation and have the potential to provide a promising platform for future translational research and precision medicine for EOC.</P>
조은철(Eun-Chel Cho),조영현(Young Hyun Cho),이준신(Junsin Yi) 한국태양광발전학회 2018 Current Photovoltaic Research Vol.6 No.2
The traditional silicon heterojunction solar cells consist of intrinsic amorphous silicon to prevent recombination of the silicon surface and doped amorphous silicon to transport the photo-generated electrons and holes to the electrode. Back contact solar cells with silicon heterojunction exhibit very high open-circuit voltages, but the complexity of the process due to form the emitter and base at the backside must be addressed. In order to solve this problem, the structure, manufacturing method, and new materials enabling the carrier selective contact (CSC) solar cell capable of achieving high efficiency without using a complicated structure have recently been actively developed. CSC solar cells minimize carrier recombination on metal contacts and effectively transfer charge. The CSC structure allows very low levels of recombination current (eg, Jo < 9fA/cm2), thereby achieves high open-circuit voltage and high efficiency. This paper summarizes the core technology of CSC solar cell, which has been spotlighted as the next generation technology, and is aiming to speed up the research and development in this field.
Optimizing of a-IGZO TFT according to Pulse Duty ratio of Pulse-RF and Pulse-DC
Jaewoong Cho,Jaemin Kim,Eun-Chel Cho,Junsin Cho 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
During the sputtering process, in the atmosphere of Ar: O2 – 19L 1, it was possible to confirm the change in the characteristics of the Bottom Gate TFT structure according to the plasma duty ratio change, and to find the optimal conditions in each condition of Pulsed-DC and Pulsed-RF. Afterwards, a-IGZO thin film according to each optimized condition was deposited to a thickness of 50 nm on a glass substrate to see the deposition characteristics of the thin film, and the stoichiometric investigation through XPS, surface roughness and optical bandgap through AFM were measured.
조은철(Eun-Chel Cho),김동섭(Dong-Seop Kim),민요셉(Yo-Sep Min),조영현(Young-Hyun Cho),A.U.Ebong,이수홍(Soo-Hong Lee) 한국태양에너지학회 1997 한국태양에너지학회 논문집 Vol.17 No.1
개방전압과 단락전류와 같은 태양전지 출력변수들은 접합깊이, 도핑농도, 금속접합 및 태양전지 구조에 의한 변수들이다. 태양전지 설계의 중요한 요소로서 인이 도핑된 에미터와 금속사이의 금속접합은 일함수 차이가 작아 낮은 직렬저항을 가져야 한다. PESC 태양전지는 금속 접합장벽 전극으로 티타늄을 사용한다. 새로운 접합장벽 전극물질로 티타늄과 일함수가 비슷하지만 전기전도도가 우수한 크롬은 금속 접합장벽 전극으로 유망한 금속이다. 티타늄은 일함수 차가 작지만, 접합장벽으로 크롬은 태양전지 제조시 티타늄보다 우수한 전기적 특성들을 갖는다. 본 논문에서는 실리콘 태양전지의 접합장벽 금속전극의 특성을 비교 분석하였다. The solar cell electrical output parameters such as the open circuit voltage (Voc) and short circuit current density (J_sc) are intrinsic characteristics depending on junction depth, doping concentration, metal contacts barriers and cell structure. As a rule of thumb for solar cell design, the metal contact barriers for phosphorus doped emitter should have lower work function in order to provide lower series resistance. The fabrication of PESC (passivated emitter solar cell) structure usually involves the use of titanium as a metal contact barrier. Chromium, which work function is similar to titanium but conductance is higher than titanium is being investigated as the new metal contact barrier. Although titanium has lower work function difference than chromium, the electric performances of chromium as contact barrier are higher than titanium. This better performance is attributed to the lower resistivity from chromium. This paper, therefore, compares the attributes of metal barrier contacts using titanium and chromium.
Song, Kwon-Ho,Choi, Chel Hun,Lee, Hyo-Jung,Oh, Se Jin,Woo, Seon Rang,Hong, Soon-Oh,Noh, Kyung Hee,Cho, Hanbyoul,Chung, Eun Joo,Kim, Jae-Hoon,Chung, Joon-Yong,Hewitt, Stephen M.,Baek, Seungki,Lee, Kyun American Association for Cancer Research 2017 Cancer Research Vol.77 No.18
<P>These findings link a regulator of cancer stem-like cells to epigenetic silencing events that may improve immunotherapy outcomes.</P><P>Cancer immunoediting drives the adaptation of tumor cells to host immune surveillance. Immunoediting driven by antigen (Ag)-specific T cells enriches NANOG expression in tumor cells, resulting in a stem-like phenotype and immune resistance. Here, we identify HDAC1 as a key mediator of the NANOG-associated phenotype. NANOG upregulated HDAC1 through promoter occupancy, thereby decreasing histone H3 acetylation on K14 and K27. NANOG-dependent, HDAC1-driven epigenetic silencing of cell-cycle inhibitors CDKN2D and CDKN1B induced stem-like features. Silencing of TRIM17 and NOXA induced immune and drug resistance in tumor cells by increasing antiapoptotic MCL1. Importantly, HDAC inhibition synergized with Ag-specific adoptive T-cell therapy to control immune refractory cancers. Our results reveal that NANOG influences the epigenetic state of tumor cells via HDAC1, and they encourage a rational application of epigenetic modulators and immunotherapy in treatment of NANOG<SUP>+</SUP> refractory cancer types. <I>Cancer Res; 77(18); 5039–53. ©2017 AACR</I>.</P>
Analysis of a-IGZO channel layer deposited via Pulsed-DC sputtering
Jiwon Choi,Jaemin Kim,Eun-Chel Cho,Junsin Yi 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
The characteristics of a-IGZO thin films deposited by Pulsed-DC magnetron sputtering and RF magnetron sputtering were analyzed. The effect of the characteristics of thin films on the electrical characteristics of TFT devices according to the sputtering method was investigated. It has been confirmed that the characteristics of the transistor fabricated using Pulsed-DC are better. This result will be helpful in the research on the fabrication of oxide semiconductors.