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Plenary Lecture 1 : PL1-1 ; LEAN Processes in Emergency Medicine
( William T Durkin ) 대한응급의학회 2014 대한응급의학회 학술대회초록집 Vol.2014 No.2
As providers are asked to see more patients with fewer resources, both time and capital, it is essential that they become more efficient. Eliminating waste while optimizing the use of personnel and equipment allows us to do a better job for the patient and the healthcare system in general. LEAN helps us to achieve this goal. Applying techniques used in industry, we can streamline our processes and best utilize increasingly limited resources. This talk will demonstrate how using some of these techniques have improved emergency departments. One must remember LEAN is a journey, and not a “quick fix” to poorly functioning departments.
Unexpected Observations on the Receptors for Angiotensin Ⅱ
Sadashiva Karnik,Yasser Saad,Takanobu Takezako,Shannon Durkin,Shin-ichiro Miura,Jing-Li Zhang,John Boros,Ramaswamy Ramchandran 이화여자대학교 세포신호전달연구센터 2002 고사리 세포신호전달 심포지움 Vol. No.4
The renin-angiotensin system(RAS) is a master control switch in the regulation of blood pressure. Transgenic and gene knockout mouse model studies as well as the effectiveness of RAS inhibitors in controlling essential hypertension and heart failure establish the importance RAS in the pathogenesis of cardiovascular disease. The octapeptide hormone angiotensin Ⅱ(Ang Ⅱ) is the mediator of RAS functions. The cell surface receptors for Ang Ⅱ belong to seven transmembrane(7TM) helical receptor superfamily. 7TM receptors are conformational switches that couple a wide variety of external stimuli to intracellular signal transduction pathways via heterotrimeric G-proteins to modulate cellular functions. To understand the mechanism of activation of function in the Ang Ⅱ type-1(AT1) and type-2 receptors, we have systematically studied structural analogs of Ang Ⅱ in combination with site-directed mutants of the receptors. Our studies suggest that conformation of the unliganded Ang Ⅱ type 1(AT1) and type 2(AT2) receptors are distinctly different. The AT1 receptor is prototypical: in that the unliganded receptor is in an inactive state(R), and the transition to a functionally active state(R*) requires the binding of the hormone to the transmembrane domain of the receptor. The bound hormone, generates an unconstrained intermediate state(R') which partially conforms to the R* state. In contrast, the unliganded AT2 receptors are in the R' state. Despite the importance of Ang Ⅱ receptors in human disease process, familial mutations of RAS have not been found implying that either such mutations are embryonic lethal or unknown mechanisms may exist in vivo for masking defective RAS phenotypes. In some studies, molecular variants of RAS have been implicated in the inherited predisposition towards cardiovascular disease. Our objectives are to study the association of genetic variability of Ang Ⅱ receptors with cardiovascular disease. We will discuss the results obtained from these two projects. 1. Noda, K. et al.(1996) Biochemistry 35, 16435-16442. 2. Feng YH, et al. Biochemistry 37:15791-15798(1998) 3. Miura, S., et al.(1999) J. Biol. Chem. 274, 7103-7110. 4. Karnik, S. S.(2000) in Drugs, Enzymes and Receptors of Renin-Angiotensin System: Celebrating a century of discovery: A. Husain & R. M Graham Eds. Harwood Academic Publishers. This work was supported by grants HL57470 from the NIH and an Established Investigator A ward from the American Heart Association.
Generation of Induced Pluripotent Stem Cells from Mouse Hepatocytic Lineage Cells
Dongho Choi,Kye-Yoon Park,Jeonghoon Heo,Cheul Hyung Cho,Marian Durkin,Agnes Holczbauer,Jens U. Marquardt,Valentina M. Factor,Karim Si-Tayeb,Stephen A. Duncan,Snorri S. Thorgeirsson 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.3
Comparison of Hepatic Differentiation Potential between Human ES and iPS Cells
Dongho Choi,Kye-Yoon Park,Jeonghoon Heo,Cheul Hyung Cho,Marian Durkin,Agnes Holczbauer,Jens U. Marquardt,Valentina M. Factor,Karim Si-Tayeb,Stephen A. Duncan,Snorri S. Thorgeirsson 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.3
총회구연 : 그랜드볼룸 ; 인간배아줄기세포와 인간역분화만능줄기세포의 간세포 분화능에 대한 비교연구 (초)
( Dong Ho Choi ),( Kye Yoon Park ),( Jeon Hoon Heo ),( Cheul Hyung Cho ),( Marian Durkin ),( Agnes Holczbauer ),( Jens U. Marquardt ),( Valentina M. Factor ),( Karim Si Tayeb ),( Stephen A. Duncan ),( 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.3(S)