Comprehensive review on physical properties of supercritical carbon dioxide calculated by molecular simulation

Gaoliang Liao,Yuntao Du,Feng Zhang,Jiaqiang E 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.1

The applications of molecular simulation in supercritical carbon dioxide (S-CO2) and its mixtures are reviewed. First, an overview of physical properties of S-CO2 and CO2 models is given. Secondly, the accuracy of S-CO2 thermodynamic and transport properties calculated by different models is compared. It shows that Zhang’s model has relatively better global accuracy in calculating thermodynamic properties. EPM2, Zhang and Cygan models have similar accuracy when calculating transport properties based on equilibrium molecular simulation (EMD) method, but generally have higher deviations when calculating thermal conductivity. Therefore, EMD and non-equilibrium molecular simulation (NEMD) methods have been compared in calculating thermal conductivity. The results show that NEMD is better than EMD but the process is complicated. The structural properties are also discussed in this part. Thirdly, the applications of molecular simulation in S-CO2 binary organic, binary inorganic and multiple mixtures are reviewed. Finally, the summary and the prospect of future works are given.

Risk Factors for Cervical Cancer in Rural Areas of Wuhan China: a Matched Case-control Study

Zhang, Bin,Zhou, Ai-Fen,Zhu, Chang-Cai,Zhang, Ling,Xiang, Bing,Chen, Zhong,Hu, Rong-Hua,Zhang, Ya-Qi,Qiu, Lin,Zhang, Yi-Ming,Xiong, Chao-Du,Du, Yu-Kai,Shi, Yu-Qin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Cervical cancer is a serious public health problem in developing countries. We investigated possible risk factors for cervical cancer in rural areas of Wuhan China using a matched case-control study with 33 women diagnosed with cervical cancer and 132 healthy women selected from the same area as matched controls. A questionnaire, which included questions about general demography conditions, environmental and genetic factors, the first sexual intercourse, first marriage age, age at first pregnancy, pregnancy first child's age, female personal health history, social psychological factors, dietary habits, smoking and alcohol status and other living habits was presented to all participants. At the same time, HPV infection of every participant was examined in laboratory testing. Results showed HPV infection (P<0.000, OR=23.4) and pregnancy first child's age (P<0.000, OR=13.1) to be risk factors for cervical cancer. Menopause (P=0.003, OR=0.073) was a protective factor against cervical cancer. However, there was no indication of associations of environmental (drinking water, insecticide, disinfectant) genetic (cancer family history), or life-style factors (smoking status, alcohol status, physical training, sleep quality), including dietary habits (intake of fruit and vegetable, meat, fried food, bean products and pickled food) or social psychological factors with cervical cancer. The results suggest that the risk of cervical cancer in Chinese rural women may be associated with HPV infection, menopause and the pregnancy first child's age.

Enhancement of transglutaminase production in Streptomyces mobaraensis DSM 40587 by non-nutritional stress conditions: Effects of heat shock, alcohols, and salt treatments

Lili Zhang,Lanwei Zhang,Huaxi Yi,Ming Du,Yingchun Zhang,Xue Han,Zhen Feng,Jingyan Li,Yuehua Jiao,Yanhe Zhang,Chunfeng Guo 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.7

Stress-mediated bioprocess is a strategy designed to enhance biological target productivity. In this study,an attempt was made to enhance transglutaminase (TGase) production by Streptomyces mobaraensis by using different stress conditions including heat shock, alcohols and salt stress. Results showed that the effects of stress on TGase production depended on the type applied. For heat shock, TGase production (1.32 U/ml) was recorded maximum in the culture treated at 48 h post inoculation in water bath at 60 oC for 1 min. For alcohols treatment, the maximum activity of TGase (1.77 and 1.75 U/ml) was obtained when 3% methanol was added into the medium at 0 or 24 h of fermentation. However, a 3.5-fold increased production of TGase (3.8 U/ml) was observed in the medium supplemented with 0.2mol/l MgCl2 compared with the basic medium at the beginning of fermentation. In conclusion, TGase production from S. mobaraensis was improved by heat shock, methanol and salt stress treatments, MgCl2 stress was the most effective.

Trans-arterial Chemo-Embolization in Treating Elderly Patients with Hepatocellular Carcinoma

Zhang, Jian-Feng,Liu, Jun-Mao,Zhang, Nin,Du, Chao,Zheng, Qin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

Background: This analysis was conducted to evaluate the efficacy and safety of Trans-arterial Chemo-Embolization (TACE) in treating Elderly patients with Hepatocellular Carcinoma (EHPC). Methods: Clinical studies evaluating the efficacy and safety of TACE on response and safety for patients with EHPC were identified by using a predefined search strategy. Pooled response rate of treatment were calculated. Results: In TACE based regimen, clinical studies which including patients with EHPC were considered eligible for the evaluation of response. And, in these TACE based treatments, pooled analysis suggested that, in all 288 patients whose response could be assessed, the pooled reponse rate was 29.5%(85/288) in TACE based treatment. The most commonly encountered TACE-related morbidity was liver function impairment. No grade III or IV renal or liver toxicity were observed. No treatment related death occurred in EHPC patients with TACE based treatments. Conclusion: This evidence based analysis suggests that TACE based treatments are associated with mild response rate and accepted toxicities for treating patients with EHPC.

Tracking the movement trajectory of newly emerged adult Chinese citrus flies with insect harmonic radar

Zhang-Zhang He,Jie Luo,Lian-You Gui,Deng-Ke Hua,Tian-Hua Du,Fu-Lian Wang,Peng Liang,Yong-Fang Shi,Xuan Yang 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.3

Previous work reveals that the adult Chinese citrus fly, Bactrocera minax (Enderlein), emerges from the ground in citrus orchards and presumably disperses to alternate food sources in neighboring shrubs and trees, where it stays and becomes reproductively mature, and then later returns to the orchard to lay eggs. We investigated the trajectories of early emerged adult Chinese citrus flies, which were tracked with portable harmonic radar in 2013, 2014, 2015, and 2016 in four different habitats in Hubei province of China that presumably provided food sources for adults. This study we investigated whether early emerged adult Chinese citrus flies migrate into forests. A total of 47 adults were tracked following release in a citrus orchard. Our results showed that a total of 33 adults released in a citrus orchard flew into the forest, and 14 adults that disappeared during the tracking process in the citrus orchard. A total of 10 adults (in 2014) that were tracked and released in the forest flew to the forest. Of the adult flies investigated, 54.5% flew directly into the forest, while the remaining 45.5% finally arrived in the forest after repeatedly adjusting their trajectories. When there were Castanea mollissima Blume (Fagaceae) in the surrounding forest, the proportion of frequency of adult landing on the plant represented 58.3% and 88.5% of landing on all species in 2014 and in 2015, respectively. We conclude that early emerged adult Chinese citrus flies in the mosaic-type citrus orchard of the hilly terrain landform dispersed into adjacent forest.

Engineering Bifunctional Antibodies with Constant Region Fusion Architectures

Du, Juanjuan,Cao, Yu,Liu, Yan,Wang, Ying,Zhang, Yong,Fu, Guangsen,Zhang, Yuhan,Lu, Lucy,Luo, Xiaozhou,Kim, Chan Hyuk,Schultz, Peter G.,Wang, Feng American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.51

<P>We report a method to generate bifunctional antibodies by grafting full-length proteins into constant region loops of a full-length antibody or an antigen-binding fragment (Fab). The fusion proteins retain the antigen binding activity of the parent antibody but have an additional activity associated with the protein insert. The engineered antibodies have excellent <I>in vitro</I> activity, physiochemical properties, and stability. Among these, a Her2 × CD3 bispecific antibody (BsAb) was constructed by inserting an anti-Her2 single-chain variable fragment (ScFv) into an anti-CD3 Fab. This bispecific antibody efficiently induces targeted cell lysis in the presence of effector cells at as low as sub-picomolar concentrations <I>in vitro</I>. Moreover, the Her2 × CD3 BsAb shows potent <I>in vivo</I> antitumor activity in mouse Her2<SUP>2+</SUP> and Her2<SUP>1+</SUP> xenograft models. These results demonstrate that insertion of a full-length protein into non-CDR loops of antibodies provides a feasible approach to generate multifunctional antibodies for therapeutic applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2017/jacsat.2017.139.issue-51/jacs.7b09641/production/images/medium/ja-2017-09641x_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja7b09641'>ACS Electronic Supporting Info</A></P>

Inhibitory Effects of Phenolic Alkaloids of Menispermum Dauricum on Gastric Cancer in Vivo

Zhang, Hong-Feng,Wu, Di,Du, Jian-Kuo,Zhang, Yan,Su, Yun-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

The present study was conducted to investigate effects and mechanisms of action of phenolic alkaloids of Menispermum dauricum (PAMD) on gastric cancer in vivo. In vitro, cell apoptosis of human gastric cancer cell line SGC-7901 was observed using fluorescence staining. In vivo, a mice model was constructed to observe tumor growth with different doses. Cell apoptosis was examined using flow cytometry and K-RAS protein expression using Western blotting. The mRNA expression of P53, BCL-2, BAX, CASPASE-3, K-RAS was examined by real-time PCR. PAMD significantly suppressed tumor growth in the xenograft model of gastric cancer in a dose-dependent manner (p<0.01). Functionally, PAMD promoted cell apoptosis of the SGC-7901 cells and significantly increased the rate of cell apoptosis of gastric tumor cells (p<0.05). Mechanically, PAMD inhibited the expression of oncogenic K-RAS both at the mRNA and protein levels. In addition, PAMD affected the mRNA expression of the cell apoptosis-related genes (P53, BCL-2, BAX, CASPASE-3). PAMD could suppress gastric tumor growth in vivo, possibly through inhibiting oncogenic K-RAS, and induce cell apoptosis possibly by targeting the cell apoptosis-related genes of P53, BCL-2, BAX, CASPASE-3.

Compatibility of lithium salts with solvent of the non-aqueous electrolyte in Li–O₂ batteries

Du, Peng,Lu, Jun,Lau, Kah Chun,Luo, Xiangyi,Bareñ,o, Javier,Zhang, Xiaoyi,Ren, Yang,Zhang, Zhengcheng,Curtiss, Larry A.,Sun, Yang-Kook,Amine, Khalil The Royal Society of Chemistry 2013 Physical chemistry chemical physics Vol.15 No.15

<P>The stability of lithium salts, especially in the presence of reduced oxygen species, O<SUB>2</SUB> and H<SUB>2</SUB>O (even in a small amount), plays an important role in the cyclability and capacity of Li–O<SUB>2</SUB> cells. This combined experimental and computational study provides evidence that the stability of the electrolyte used in Li–O<SUB>2</SUB> cells strongly depends on the compatibility of lithium salts with solvent. In the case of the LiPF<SUB>6</SUB>–1NM3 electrolyte, the decomposition of LiPF<SUB>6</SUB> occurs in the cell as evidenced by <I>in situ</I> XRD, FT-IR and XPS analysis, which triggers the decomposition of 1NM3 solvent due to formation of HF from the decomposition of LiPF<SUB>6</SUB>. These reactions lead to degradation of the electrolyte and cause poor cyclability of the cell. The same reactions are not observed when LiTFSI and LiCF<SUB>3</SUB>SO<SUB>3</SUB> are used as the lithium salts in 1NM3 solvent, or LiPF<SUB>6</SUB> is used in TEGDME solvent.</P> <P>Graphic Abstract</P><P>We provided evidence that the stability of the electrolyte used in Li–O<SUB>2</SUB> cells strongly depends on the compatibility of lithium salts with solvent. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cp50500f'> </P>

Effect of aggregates of elements induced by rare earth doping on toughening of tailing-derived glass-ceramics

Du Yongsheng,Ma Jie,Zhang Xuefeng,Zhang Hongxia,Chen Hua,Ouyang Shunli,Baowei Li 한양대학교 세라믹연구소 2019 Journal of Ceramic Processing Research Vol.20 No.4

Tailings glass-ceramics doped with different proportion of CeO2 were prepared by conventional melts and controllable crystallization. The effect of CeO2 on the microstructure, element distribution characteristics and fracture toughness of glassceramics was studied in this paper. Significant change in microstructure was not observed with the addition of rare earth oxide, but the phenomenon of element aggregates begins to appear in glass-ceramics and the element enrichment of Si, Al, Na and Ce can be observed in the element aggregates. As a result, the integrity of the glass network structure can be improved and the strength of glass phase contributed to the enhancement of fracture toughness. The doping of 3.0% CeO2 achieved a remarkable improvement on fracture toughness that reached 2.86 MPa*m1/2 with a Vickers hardness of 8.49 GPa.

On minimum submodular cover with submodular cost

Du, Hongjie,Wu, Weili,Lee, Wonjun,Liu, Qinghai,Zhang, Zhao,Du, Ding-Zhu Springer-Verlag 2011 Journal of global optimization Vol.50 No.2