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RISS 인기검색어
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- 저자 : Dou Chen (검색결과 46 건)
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Chen, ShiJun,Zhang, Qi,He, Biao,Huang, SuRong,Hui, Dou-Dou The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.1
In order to meet the thermal performance analysis accuracy requirements of high density permanent magnet synchronous motor (PMSM), a method of multi physical domain coupling thermal analysis based on control circuit, electromagnetic and thermal is presented. The circuit, electromagnetic, fluid, temperature and other physical domain are integrated and the temperature rise calculation method that considers the harmonic loss on the frequency conversion control as well as the loss non-uniformly distributed and directly mapped to the temperature field is closer to the actual situation. The key is to obtain the motor parameters, the realization of the vector control circuit and the accurate calculation and mapping of the loss. Taking a 48 slots 8 poles high density PMSM as an example, the temperature rise distribution of the key components is simulated, and the experimental platform is built. The temperature of the key components of the prototype machine is tested, which is in agreement with the simulation results. The validity and accuracy of the multi physical domain coupling thermal analysis method are verified.
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ShiJun Chen,Qi Zhang,Biao He,SuRong Huang,Dou-Dou Hui 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.1
In order to meet the thermal performance analysis accuracy requirements of high density permanent magnet synchronous motor (PMSM), a method of multi physical domain coupling thermal analysis based on control circuit, electromagnetic and thermal is presented. The circuit, electromagnetic, fluid, temperature and other physical domain are integrated and the temperature rise calculation method that considers the harmonic loss on the frequency conversion control as well as the loss non-uniformly distributed and directly mapped to the temperature field is closer to the actual situation. The key is to obtain the motor parameters, the realization of the vector control circuit and the accurate calculation and mapping of the loss. Taking a 48 slots 8 poles high density PMSM as an example, the temperature rise distribution of the key components is simulated, and the experimental platform is built. The temperature of the key components of the prototype machine is tested, which is in agreement with the simulation results. The validity and accuracy of the multi physical domain coupling thermal analysis method are verified.
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Cordycepsmilitaris polysaccharide triggers apoptosis and G0/G1 cell arrest in cancer cells
Cheng Chen,Mei-LinWang,Chao Jin,Huijuan Chen,Shao-Hui Li,Shu-Ying Li,Xing-Fan Dou,Jun-Qiang Jia,Zhong-Zheng Gui 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.3
Although many studies have shown the antitumor properties of Cordyceps militaris (artificial cultivated from Bombyx mori pupa) polysaccharides, little is known regarding the mechanism of its effects. This study was conducted to determine the mechanism of antitumor effects of C. militaris polysaccharide extract by evaluating apoptosis rate and cell cycle progression status in human liver cancer cell SMMC-7721, stomach cancer cell BGC-823 and breast cancer cell MCF-7. Results showed that C. militaris polysaccharides inhibited proliferation of SMMC-7721, BGC-823 and MCF-7 cells with an IC50 of 192 ± 23.2 μg/mL, 237 ± 12.7 μg/mL and 165 ± 16.3 μg/mL, respectively. We also found that C. militaris polysaccharides at increasing concentrations induced apoptosis dose dependently in those cancer cells: apoptosis rates were 48.3%, 59.4% and 70.9% for SMMC-7721, 41.3% and 57.0%, 72.2% for BGC-823 and 61.3%, 66.9% and 80.6% for MCF-7 at 110, 156 and 323 mg/mL of C. militaris polysaccharides, respectively. C. militaris polysaccharides arrested SMMC-7721, BGC-823 and MCF-7 cells at G0/G1 and G2/M phases with corresponding decrease in S-phase. This study suggests that C. militaris polysaccharides may exert its antitumor effects in those cancer cells by suppressing its growth, arresting the G0/G1-phase, reducing DNA synthesis and inducing apoptosis.
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( Jia-yi Dou ),( Yu-chen Jiang ),( Zhong-he Hu ),( Kun-chen Yao ),( Ming-hui Yuan ),( Xiao-xue Bao ),( Mei-jie Zhou ),( Yue Liu ),( Zhao-xu Li ),( Li-hua Lian ),( Ji-xing Nan ),( Yan-ling Wu ) 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.3
The present study focused on the potential mechanism of betulin (BT), a pentacyclic triterpenoid isolated from the bark of white birch (Betula pubescens), against chronic alcohol-induced lipid accumulation and metaflammation. AML-12 and RAW 264.7 cells were administered ethanol (EtOH), lipopolysaccharide (LPS) or BT. Male C57BL/6 mice were fed Lieber-DeCarli liquid diets containing 5% EtOH for 4 weeks, followed by single EtOH gavage on the last day and simultaneous treatment with BT (20 or 50 mg/kg) by oral gavage once per day. In vitro, MTT showed that 0-25 mM EtOH and 0-25 μM BT had no toxic effect on AML-12 cells. BT could regulate sterolregulatory-element-binding protein 1 (SREBP1), lipin1/2, P2X7 receptor (P2X7r) and NOD-like receptor family, pyrin domains-containing protein 3 (NLRP3) expressions again EtOH-stimulation. Oil Red O staining also indicated that BT significantly reduced lipid accumulation in EtOH-stimulated AML-12 cells. Lipin1/2 deficiency indicated that BT might mediate lipin1/2 to regulate SREBP1 and P2X7r expression and further alleviate lipid accumulation and inflammation. In vivo, BT significantly alleviated histopathological changes, reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and triglyceride (TG) levels, and regulated lipin1/2, SREBP1, peroxisome proliferator activated receptor α/γ (PPARα/γ) and PGC-1α expression compared with the EtOH group. BT reduced the secretion of inflammatory factors and blocked the P2X7r-NLRP3 signaling pathway. Collectively, BT attenuated lipid accumulation and metaflammation by regulating the lipin1/2-mediated P2X7r signaling pathway.
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Computed Tomography Manifestations of Histologic Subtypes of Retroperitoneal Liposarcoma
Lu, Jing,Qin, Qin,Zhan, Liang-Liang,Yang, Xi,Xu, Qing,Yu, Jing,Dou, Li-Na,Zhang, Hao,Yang, Yan,Chen, Xiao-Chen,Yang, Yue-Hua,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Objective: Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20% of all mesenchymal malignancies, often occurring in deep soft tissue of retroperitoneal space. Accurate preoperative diagnosis is therefore necessary. We explored whether computed tomography (CT) could be used to differentiate between the various types of retroperitoneal liposarcoma (RPLS). Method: Forty-seven cases of RPLS, diagnosed surgically and histologically, were analyzed retrospectively. CT features were correlated with postoperative pathological appearance. Results: The study radiologist identified 29, 11, 2, 2 and 3 RPLS as atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL), dedifferentiated liposarcoma (DDL), myxoid/round cell liposarcoma (ML/RCL), pleomorphic liposarcoma (PL) and mixed-type liposarcoma. Analysis of CT scans revealed the following typical findings of the different subtypes of RPLS: ALT/WDL was mainly visible as a well-delineated fatty hypodense tumor with uniform density and integrity margin; DDL was marked by the combination of focal nodular density and hypervascularity. ML/RCL, PL and mixed liposarcoma showed malignant biological behaviour and CT findings need further studies. Conclusions: CT scanning can reveal important details including internal components, margins and surrounding tissues. Based on CT findings, tumor type can be roughly evaluated and biopsy location and therapeutic scheme guided.
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Dou, Xue,Wang, Ren-Ben,Meng, Xiang-Jiao,Yan, Hong-Jiang,Jiang, Shu-Mei,Zhu, Kun-Li,Xu, Xiao-Qing,Chen, Dong,Song, Xian-Rang,Mu, Dian-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Objective: The purpose of this study was to examine the role of programmed cell death 4 (PDCD4) expression in predicting tumor response to neoadjuvant chemoradiotherapy and outcomes for patients with locally advanced rectal cancer. Methods: Clinicopathological factors and expression of PDCD4 were evaluated in 92 patients with LARC treated with nCRT. After the completion of therapy, 4 cases achieved clinical complete response (cCR), and thus the remaining 88 patients underwent a standardized total mesorectal excision procedure. There were 38 patients (41.3%) with a good response (TRG 3-4) and 54 (58.7%) with a poor one (TRG 0-2). Results: Immunohistochemical staining analyses showed that patients with high expression of PDCD4 were more sensitive to nCRT than those with low PDCD4 expression (P=0.02). High PDCD4 expression before nCRT and good response (TRG3-4) were significantly associated with improved 5-year disease-free survival and 5-year overall survival (P<0.05). Multivariate analysis demonstrated that the pretreatment PDCD4 expression was an independent prognostic factor. Conclusion: Our study demonstrated that high expression of PDCD4 protein is a useful predictive factor for good tumor response to nCRT and good outcomes in patients with LARC.
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Optimal control strategy for excitation parameters of SRGs
Dou, Yuyu,Chen, Dong The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.6
To solve the inherent contradiction between convergence speed and optimization accuracy in the traditional optimal control strategy for the excitation parameters of SRGs, a novel optimal control strategy for the excitation parameters is proposed. In this strategy, the turn-off angle is fixed at its optimal value and kept constant, and the turn-on angle is optimized through two steps. In the first step, the optimal searching region of the turn-on angle is calculated by a fitting formula. Then in the second step, the golden section algorithm is used to optimize the turn-on angle. Meanwhile, the phase current amplitude is used as the degree of freedom necessary to regulate the generation power. Experimental results indicate that the novel optimal control strategy for excitation parameters can effectively improve convergence speed and efficiency of SRGs.
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Removal of tar component over cracking catalysts from high temperature fuel gas
Dou, B.,Pan, W.,Ren, J.,Chen, B.,Hwang, J.,Yu, T.U. Pergamon ; Elsevier Science Ltd 2008 Energy conversion and management Vol.49 No.8
Five catalysts were evaluated for removal of tar components in high temperature fuel gas cleaning. 1-Methylnaphthalene was chosen as a model of the tar components. The NiMo catalyst having the highest surface area exhibited the highest activity of tar removal among the five catalysts. The effects of reaction temperature and space velocity on tar removal were studied in the range of 250-650<SUP>o</SUP>C and 3000-9000h<SUP>-1</SUP>, respectively. A lumped kinetic model was developed to describe the removal process. A sequential method to estimate the rate constants in the lumped kinetic model was adopted, which greatly simplifies the data treatments. Kinetic constants and activation energies were determined by a nonlinear regression program. The results showed that the predicted yields were very close to the experimental ones.
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The stability and removal of water-dispersed CdSe/CdS core-shell quantum dots from water
Chen, Xu,Ok, Yong Sik,Mohan, Dinesh,Pittman Jr., Charles U.,Dou Jr., Xiaomin Elsevier 2017 CHEMOSPHERE - Vol.185 No.-
<P><B>Abstract</B></P> <P>The increasingly wide use of semiconductor nanocrystals inevitably leads to their release into aquatic environment. The aggregation behaviors of 3-mercaptopropionic acid-capped CdSe/CdS core-shell quantum dots (MPA-QDs) under various water chemistry conditions were examined and their removal using Fe<SUP>3+</SUP> and Al<SUP>3+</SUP> coagulants was evaluated. Cationic species rather than concentrations affected the stability of MPA-QDs. Adding 2 mM Ca<SUP>2+</SUP> led to a much larger ζ-potential decrease and particle size increase than adding 150 mM K<SUP>+</SUP> at each tested solution pH. This indicated that complexation and depletion of surface-bound carboxyl groups by divalent Ca<SUP>2+</SUP> has a more pronounced effect than compression of the electrical double layer by high concentrations of monovalent K<SUP>+</SUP>. The presence of humic acid increased the stability of MPA-QDs, which might increase negative surface charging <I>via</I> overcoating or bind to the surface of MPA-QDs. The nanoparticles exhibited similar aggregation kinetics patterns in tap water and seawater, but varying patterns in the lake water because of the co-existence of 2.3 mM total of Ca<SUP>2+</SUP> and Mg<SUP>2+</SUP>. MPA-QDs (5 mg L<SUP>−1</SUP>) were readily coagulated by 2.4 mM Al<SUP>3+</SUP> or 1.2 mM Fe<SUP>3+</SUP> in tap water. Al<SUP>3+</SUP> and Fe<SUP>3+</SUP> can bind with carboxyl groups of the surface capping ligands, neutralize the negative charges on the surface of MPA-QDs and decrease the electrostatic repulsion forces to induce MPA-QDs aggregation. In addition, MPA-QDs could be bound with and wrapped into the flocs of hydrolysis products of coagulants. The results reported here could help broaden our understanding of the impacts and remediation of water-dispersed core-shell QD nanoparticles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The stability, aggregation and remediation of core/shell QDs were evaluated. </LI> <LI> Ca<SUP>2+</SUP> led to severe aggregation of soluble QDs than K<SUP>+</SUP> at much lower concentrations. </LI> <LI> Depletion of surface bound ligand has a more pronounced effect than compression EDL. </LI> <LI> QDs exhibited different aggregation patterns in tap water, seawater and lake water. </LI> <LI> Both Fe<SUP>3+</SUP> and Al<SUP>3+</SUP> were able to remediate QDs from water but the former was better. </LI> </UL> </P>
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