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Yun, Dong-Jin,Kim, Seyun,Jung, Changhoon,Lee, Chang-Seok,Sohn, Hiesang,Won, Jung Yeon,Kim, Yong Su,Chung, JaeGwan,Heo, Sung,Kim, Seong Heon,Seol, Minsu,Shin, Weon Ho The Royal Society of Chemistry 2018 Physical chemistry chemical physics Vol.20 No.4
<P>Correction for ‘Direct characterization of graphene doping state by <I>in situ</I> photoemission spectroscopy with Ar gas cluster ion beam sputtering’ by Dong-Jin Yun <I>et al.</I>, <I>Phys. Chem. Chem. Phys.</I>, 2018, 20, 615-622.</P>
Seol, Dong-Won,Hur, Jun-Wook,Kim, Dong-Soo,Nam, Yoon-Kwon,Bang, In-Chul,Park, In-Seok The Korean Society of Fisheries and Aquatic Scienc 2009 Fisheries and Aquatic Sciences Vol.12 No.1
We conducted a histological analysis to investigate the influence of nutritional changes on melano-macrophages (MMs) accumulation in the kidney of sub-adult rock bream (Oplegnathus fasciatus). Four experimental groups were established (initial control, control, fed and starved), and fed commercial feed amounting to 1-3% of their body weight for 2 weeks prior to initiation of experiments. Kidney MMs with dark brown pigment were randomly observed in the kidneys of starved fish, increasing rapidly after 4 weeks, while deposition levels remained low throughout the experiment in the control and fed groups. These results suggest that catabolic tissue breakdown is a major factor contributing to the formation of pigments within MMs. Results also suggest that the degree of MMs deposition in the kidney can be used as alternative indicators in identifying starvation in wild and cultured rock bream.
Fibrin-Reinforced Collagen Matrix Enhances Tissue Regeneration and Angiogenesis
Seol, Dong Lim,Jang, Won Hee,Lee, Sung Jae,Yang, Young Il Trans Tech Publications, Ltd. 2005 Key Engineering Materials Vol.288 No.-
<P>The goal of this study was to investigate effects of fibrin reinforcement of collagen sponges on fibroblasts-mediated contraction and in vivo tissue regeneration, especially angiogenesis. Human dermal fibroblasts (HDFs)-populated collagen sponges reinforced with or without fibrin were cultivated via the free-floating method in vitro. They were then evaluated using xenogeneic implantation into nude mice. The HDFs-populated collagen sponges reinforced with fibrin exhibited significantly decreased HDFs-mediated contraction in vitro (p<0.05). Microvascular and cellular densities of the collagen sponges were significantly higher with fibrin than without (p<0.01). Cell ingrowths, neovascularization, and deposition of ECM matrix were more evenly distributed in the fibrin-reinforced collagen matrices. The results demonstrated that fibrin reinforcement of porous collagen sponges can reduce cell-mediated contraction in vitro while enhancing functional integration with surrounding tissue in vivo.</P>
Seol, Dong Lim,Kim, Hyeong In,Lee, Woo Jung,Jang, Won Hee,Kim, Jeong Koo,Lee, Sung Jae,Yang, Young Il Trans Tech Publications, Ltd. 2005 Key Engineering Materials Vol.288 No.-
<P>A culture system that is capable of providing even and uniform distribution and deposition of cells and extracellular matrix (ECM) is desired to enhance biological functions of the tissue-engineered artificial dermis (TEADs). For this purpose, we have developed a perfusion culture system that offers uniform exchange of nutrients and gases along the scaffold. Viability and effectiveness of the system were investigated by comparing biological and mechanical properties of TEADs. Results showed that the TEADs constructed by the perfusion culture system revealed significantly increased cell growth, ECM synthesis, and elastic modulus compared to those by the conventional static culture system. In addition, histological findings indicated that cells were more evenly distributed and ECM deposition increased in TEADs with the perfusion culture system. Therefore, it can be suggested that the perfusion culture system can constitute a more promising approach for constructing the TEADs.</P>
( Dong Ju Kim ),( Yoon Mi Jeoun ),( Dong-won Lee ),( Ja Seol Koo ),( Sang Woo Lee ) 대한장연구학회 2018 Intestinal Research Vol.16 No.4
Background/Aims: Ulcerative colitis undergoes periods of exacerbation and remission. Fecal calprotectin levels increase with gut inflammation and correlate with endoscopic disease activity in ulcerative colitis. Intestinal blood loss and fecal immunochemical test levels also correlate with endoscopic disease activity. This study statistically evaluated the usefulness of fecal calprotectin, fecal immunochemical test, and C-reactive protein (CRP) as markers of disease activity. Methods: A total 106 ulcerative colitis patients who underwent endoscopy and fecal calprotectin, fecal immunochemical test, and CRP testing, from March 2015 to August 2016, were retrospectively reviewed. Disease activity was assessed using a partial Mayo score and Mayo endoscopic score. The ability of fecal and serologic tests to reflect endoscopic disease severity was statistically evaluated. Results: Among 106 patients, 68 underwent endoscopy and stool study within 2 weeks. In patients with mild to severe activity, fecal immunochemical test and fecal calprotectin were superior to CRP at Mayo endoscopic score detection rate. The area under the curves of fecal immunochemical test and fecal calprotectin for the detection of Mayo endoscopic score ≥1 were 0.956 and 0.942, respectively, and were superior to that of CRP (0.756). At Mayo endoscopic score, the effects of combination of fecal immunochemical test and CRP or fecal calprotectin and CRP were found to be higher than those of the independent fecal immunochemical test or fecal calprotectin. Conclusions: Fecal immunochemical test and fecal calprotectin can effectively detect active ulcerative colitis better than remission. As these markers reflect the status of mucosal inflammation, they may reduce the requirement for invasive endoscopic examination. (Intest Res 2018;16:563-570)
Predicting pre-and post-resectional histologic discrepancies in gastric low-grade dysplasia
( Dong Woo Lee ),( Ji Hyun Kim ),( Yeong Min Lee ),( Tae Seon Oh ),( Si Hyeong Lee ),( Min Ji Kim ),( Jin Won Hwang ),( Sang Heon Lee ),( Sang Young Seol ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background and Aims: The aim of this study was to evaluate the validity of the parameters of conventional white-light endoscopy and magnifying endoscopy with narrow-band imaging (MENBI) for the prediction of discrepancies between pre- and post-resectional histology in cases of gastric adenoma with low-grade dysplasia (LGD) that was diagnosed based on endoscopically biopsied specimens. Patients and Methods: The medical records of 266 lesions with gastric LGD that were diagnosed by endoscopic forceps biopsies were retrospectively reviewed. These patients all underwent MENBI examinations followed by analyses of the incidence of histologic discrepancies and histologic heterogeneity. The relationship between white-light endoscopic/MENBI parameters and the presence of histologic discrepancies was also analyzed. Results: Discrepancies between the preand post-resectional histologies were found in 74 cases (27.9%). Among those cases, the histology was upgraded in 71 cases, whereas the histology was downgraded in three cases. The presence of erythema, positive MENBI and the existence of discontinuous lesions on the histologic analysis were independent factors for the prediction of upgraded histologic discrepancies (p value=0.001, <0.001 and 0.011, respectively). Positive MENBI demonstrated the highest predictive value, with a multivariate adjusted odds ratio of 46.92. Histologic heterogeneity in post-resectional specimens was found in 38.0% of cases with upgraded histologic discrepancies. Conclusions: MENBI can provide more accurate information than white-light endoscopy for the prediction of pre- and post-resectional histologic discrepancies in biopsy-proven gastric LGD. Endoscopic resection is strongly recommended in cases indicates surface erythema on conventional white-light endoscopy or positive MENBI, irrespective of the lesion size.
Dong Won Seol,Soo Yeon Im,Woo June Hur,Min Ouk Park,Dong Soo Kim,Jae Yoon Jo,In Seok Park 한국유전학회 2008 Genes & Genomics Vol.30 No.3
Haematological features pertaining to aerobic capability were compared between diploid and triploid specimens of the Far Eastern catfish, Silurus asotus. No significant differences between diploids and triploids were found for the haematocrit value, total haemoglobin, and mean corpuscular haemoglobin concentration, while the mean corpuscular volume, mean corpuscular haemoglobin, and plasma glucose concentration were significantly higher in triploids than in diploids, and the number of red blood cells was significantly lower in triploids than in diploids. The oxygen consumption rate did not differ significantly between diploid and triploid fish ( P>0.05). Nevertheless, the respiratory frequency was higher in triploids than in diploids ( P< 0.05). Triploids were characterized by a lower concentration of circulating blood cells, and aquaculture practice should consider the need for a lower surface to volume ratio.