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Sheng-Min Wang,Sung-Soo Park,See Hyun Park,Nak-Young Kim,Dong Woo Kang,Hae-Ran Na,Young-Yi Bae,Jong Wook Lee,Seunghoon Han,Hyun Kook Lim 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.2
Objective: No previous study examined impact of dementia in the outcome of allogeneic hematopoietic stem cell trans-plantation (HSCT). We aimed to investigate overall survival (OS) of patients with dementia after receiving HSCT. Methods: Among 8,230 patients who underwent HSCT between 2002 and 2018, 5,533 patients younger than 50 years were first excluded. Remaining patients were divided into those who were and were not diagnosed with dementia before HSCT (dementia group: n = 31; no dementia: n = 2,666). Thereafter, among 2,666 participants without dementia, 93 patients were selected via propensity-matched score as non-dementia group. Patients were followed from the day they received HSCT to the occurrence of death or the last follow-up day (December 31, 2018), whichever came first. Results: With median follow-up of 621 days for dementia group and 654 days for non-dementia group, 2 year-OS of dementia group was lower than that of non-dementia group (53.3% [95% confidence interval, 95% CI, 59.0−80.2%] vs. 68.8% [95% CI, 38.0−68.2%], p = 0.076). In multivariate analysis, dementia had significant impacts on OS (hazard risk = 2.539, 95% CI, 1.166−4.771, p = 0.017). Conclusion: Our results indicated that patients diagnosed with dementia before HSCT have 2.539 times higher risk of mortality after transplantation than those not having dementia. With number of elderly needing HSCT is increasing, further work to establish treatment guidelines for the management of HSCT in people with dementia is needed.
Sheng-Min Wang,Kyung-Do Han,Nak-Young Kim,Yoo Hyun Um,Dong Woo Kang,Hae-Ran Na,Chang Uk Lee,Hyun Kook Lim 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.10
Objective Previous studies investigating association of alcohol intake and fracture risk in elderly yielded conflicting results. We first examined the association between alcohol intake and total fracture risk in elderly subjects and further analyzed whether the association varied by fracture locations.Methods This is a nationwide population-based cohort study which included all people aged 66 (n=1,431,539) receiving the National Screening Program during 2009-2014. Time-to-event were defined as duration from study recruitment, the day they received health screening, to the occurrence of fracture.Results Total fracture was significantly lower in mild drinkers [adjusted hazard ratio (aHR)=0.952; 95% confidence interval (95% CI) =0.931-0.973] and higher in heavy drinkers (aHR=1.246; 95% CI=1.201-1.294) than non-drinkers. Risk pattern of alcohol consumption and fracture differed according to affected bones. Similar J-shaped trends were observed for vertebra fractures, but risk of limb fracture showed a linear relationship with alcohol intake. For hip fracture, risk decrement was more pronounced in mild and moderate drinkers, and significant increment was noted only in very severe drinkers [≥60 g/day; (aHR)=1.446; 1.162-1.801].Conclusion Light to moderate drinking generally lowered risk of fractures, but association between alcohol and fracture risk varied depending on the affected bone lesions.
Sheng-Min Wang,See Hyun Park,Nak-Young Kim,Dong Woo Kang,Hae-Ran Na,Yoo Hyun Um,Seunghoon Han,Sung-Soo Park,Hyun Kook Lim 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.6
Objective Despite a high prevalence of dementia in older adults hospitalized with severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2), or so called COVID-19, research investigating association between preexisting diagnoses of dementia and prognosis of COVID-19 is scarce. We aimed to investigate treatment outcome of patients with dementia after COVID-19. Methods We explored a nationwide cohort with a total of 2,800 subjects older than 50 years who were diagnosed with COVID-19 between January and April 2020. Among them, 223 patients had underlying dementia (dementia group). We matched 1:1 for each dementia- non-dementia group pair yielding 223 patients without dementia (no dementia group) using propensity score matching. Results Mortality rate after COVID-19 was higher in dementia group than in no dementia group (33.6% vs. 20.2%, p=0.002). Dementia group had higher proportion of patients requiring invasive ventilatory support than no dementia group (34.1% vs. 22.0%, p=0.006). Multivariable analysis showed that dementia group had a higher risk of mortality than no dementia group (odds ratio=3.05, p<0.001). We also found that patients in dementia group had a higher risk of needing invasive ventilatory support than those in no dementia group. Conclusion Our results suggest that system including strengthen quarantines are required for patients with dementia during the COVID- 19 pandemic.
Han, Jing,Wang, Dong-sheng,Liu, Shui-bing,Zhao, Ming-gao The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.3
Cytisine (CYT), a partial agonist of ${\alpha}4{\beta}2-nicotinic$ receptors, has been used for antidepressant efficacy in several tests. Nicotinic receptors have been shown to be closely associated with depression. However, little is known about the effects of CYT on the depression. In the present study, a mouse model of depression, the unpredictable chronic mild stress (UCMS), was used to evaluate the activities of CYT. UCMS caused significant depression-like behaviors, as shown by the decrease of total distances in open field test, and the prolonged duration of immobility in tail suspension test and forced swimming test. Treatment with CYT for two weeks notably relieved the depression-like behaviors in the UCMS mice. Next, proteins related to depressive disorder in the brain region of hippocampus and amygdala were analyzed to elucidate the underlying mechanisms of CYT. CYT significantly reversed the decreases of 5-HT1A, BDNF, and mTOR levels in the hippocampus and amygdala. These results imply that CYT may act as a potential anti-depressant in the animals under chronic stress.
Han Xinyu,Dong Sheng 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1
Medium-long period waves significantly affect the construction of coastal engineering structures. This study investigated the interaction between regular waves and a vertical breakwater through laboratory experiments and smoothed particle hydrodynamics (SPH) simulations. Four SPH models, established using different diffusion terms and turbulence models, were compared. The numerical results were consistent with the test results. The experimental results and the improved Goda's results were consistent. The medium-long period wave force was 1.5e2 times greater than the short-period wave force. Consequently, a new formula was proposed to describe the relationship between the wave force and wave period. Furthermore, the energy evolution of wave propagation with and without a vertical breakwater was studied. It was found that the longer the period, the slower the attenuation of the wave kinetic and potential energies. The dynamic potential energy per unit length in front of the breakwater increased with an increase in the period.
XML 데이타 제공자를 사용하는 OLE / COM 기반 OpenGIS 서버의 개발
홍동숙(Dong-Suk Hong),윤재관(Jae-Kwan Yun),장염승(Yan-Sheng Zhang),이강준(Kang-Jun Lee),한기준(Ki-Joon Han) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.1B
최근 지리 정보 시스템(GIS)이 전 국가적으로 대중화되면서 서로 다른 분야에서 구축되어 서로 다른 환경에 분산되어 있는 이질적인 공간 데이타의 상호운용성에 대한 필요성이 증가하고 있다. 이러한 상호운용성을 위해 OGC에 의해 표준 사양인 OpenGIS 이 개발되었고, 이 사양을 바탕으로 개방형 지리 정보 시스템을 개발하여 다양한 데이타 소스간의 상호운용성을 얻고자 하는 연구가 활발히 이루어지고 있다. 그러나, OpenGIS 사양을 따르는 상호운용성 지원 방법에서는 다양한 형태의 데이타 소스별로 데이타 제공자의 개발이 필요하다. 따라서 이러한 부담을 줄이고 효율적인 데이타 저장 및 관리를 위한 단일처리 모델의 제시가 필요하다. 이에 본 논문에서는 표준 데이타 언어인 XML과 기타 다른 관련기술을 OpenGIS 서버의 데이타 제공자 컴포넌트에 도입하여, OpenGIS 사양을 따르는 기존의 이질적인 데이타 소스와의 연등을 지원할 뿐 아니라 표준화 된 저장 구조의 데이타 소스에 대한 하나의 효율적인 데이타 제공자를 갖는 OpenGIS 서버를 설계 및 구현한다. 본 시스템은 OpenGIS의 지리 데이타 구조와 저리에 대한 인터페이스의 표준화를 통해 상호운용성을 보장하고, OLE/COM 사양을 이용하여 각 컴포넌트들의 재사용성을 지원하여, 또한 문서 저장 및 전달을 위한 데이타 형식의 표준인 XML을 사용하여 문서구조의 검증 기능과 문서접근 방식의 단일화를 지원한다.
( Jing Han ),( Dong Sheng Wang ),( Shui Bing Liu ),( Ming Gao Zhao ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.3
Cytisine (CYT), a partial agonist of α4β2-nicotinic receptors, has been used for antidepressant efficacy in several tests. Nicotinic receptors have been shown to be closely associated with depression. However, little is known about the effects of CYT on the depression. In the present study, a mouse model of depression, the unpredictable chronic mild stress (UCMS), was used to evaluate the activities of CYT. UCMS caused significant depression-like behaviors, as shown by the decrease of total distances in open field test, and the prolonged duration of immobility in tail suspension test and forced swimming test. Treatment with CYT for two weeks notably relieved the depression-like behaviors in the UCMS mice. Next, proteins related to depressive disorder in the brain region of hippocampus and amygdala were analyzed to elucidate the underlying mechanisms of CYT. CYT significantly reversed the decreases of 5-HT1A, BDNF, and mTOR levels in the hippocampus and amygdala. These results imply that CYT may act as a potential anti-depressant in the animals under chronic stress.
웹 기반 공간 OODBMS를 위한 형상 버전 관리자의 개발
김동오(Dong-O Kim),장염승(Yan-Sheng Zhang),한기준(Ki-Joon Han) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1B
최근 웹이 활성화되고 인터넷이 대중화되면서 지리 정보 시스템 분야에서도 웹 상에서 공간 데이타의 검색 및 관리의 필요성이 대두되었다. 또한, 지리 정보 시스템에서 다루는 공간 데이타는 가변적이고 대용량이기 때문에 이러한 데이타를 효율적으로 처리하기 위해서는 웹 기반 공간 OODBMS의 사용이 적합하다. 이러한 웹 기반 공간 OODBMS를 사용하는 실제 응용프로그램에서 다중 사용자 환경에서의 협동 작업이 효율적으로 수행되기 위해서는 객체들의 버전 뿐만 아니라 일정 영역내의 연관된 객체들의 집합인 형상을 효율적으로 관리하는 것이 절실히 필요하다. 이에 본 논문에서는 기존의 형상 관리 시스템, 버전 관리 시스템, 협동 작업 기법을 분석하여 웹 기반 공간 OODBMS를 위한 형상 버전 관리 모델을 제시하였다. 형상 버전 관리 모델은 형상을 효과적으로 관리하기 위하여 형상 그래프와 형상 버전 클래스, 형상 Generic 클래스, 형상 노드 클래스와 같은 세 개의 형상 버전 관리 클래스를 내부적으로 사용한다. 또한, 본 논문에서는 이러한 형상 버전 관리 모델에 따라 형상 버전 처리 모듈, 형상 Generic 처리 모듈, 형상 모드 처리 모듈, 형상 그래프 처리 모듈, 협동 작업 처리 모듈로 구성되는 웹 기반 공간 OODBMS를 위한 형상 버전 관리자를 개발하였다.