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다중 RNA의 동시 전달을 위한 지질 나노 전달 시스템
이드보라(Deborah Lee),이지예(Ji Ye Lee),이효정(Hyojeong Lee),조현지(Hyeonji Cho),송서윤(Seoyoon Song),이시은(Sieun Lee),전태준(Tae-Joon Jeon),김선민(Sun Min Kim) 대한기계학회 2024 大韓機械學會論文集B Vol.48 No.7
약물 전달 시스템의 발전에서 리포솜(liposome)은 임상적으로 승인된 제형과 더불어 광범위하게 수용되고 있다. 이와 동시에 핵산 기반 치료법, 특히 메신저 리보 핵산(mRNA)과 짧은 간섭 리보 핵산(siRNA)은 표적화된 개인 맞춤형 의료 치료법을 위한 새로운 길을 열고 있다. 그러나 이를 이용한 효과적인 치료를 위해서는 여러 리보 핵산(RNA)을 동시에 전달할 수 있는 효율적인 전달 시스템을 개발해야 한다. 이에 따라 이 연구에서는 지질 나노입자(LNP)의 장점과 기존 리포솜 전달 시스템을 결합한 다중구조의 전달 시스템을 개발하였다. 다중 LNP는 리포솜의 내부에 캡슐화되어 여러 RNA를 동시에 전달한다. 이 연구는 다중 RNA 전달을 위한 유망한 플랫폼이며 핵산 기반 병용 요법 분야의 발전을 가져올 것으로 예상된다. In the field of drug delivery systems, liposomes have gained widespread acceptance through clinically approved formulations. Concurrently, the domain of nucleic acid-based therapeutics, particularly messenger RNA (mRNA) and small interfering RNA (siRNA), has opened new avenues for targeted and personalized medical interventions. However, realizing their full therapeutic potential depends on the development of efficient delivery systems capable of multi-delivering RNAs. Therefore, this paper presents an innovative approach that merges the advantages of lipid nanoparticles (LNPs) with established liposomal delivery systems. This study underscores a promising platform for multiple RNA delivery and controlled releases, offering the potential for advancements in the field of nucleic acid-based combination therapy.
Detection of a Novel Missense Mutations in Atrichia with Papular Lesions
( Deborah Lee ),( Sang Hyun Kim ),( Ji Sung Chun ),( Myeong Hoon Joo ),( Ji Yeon Kim ),( Seon Wook Hwang ),( Hyo Joon Kang ),( Sung Wook Park ),( Ho Suk Sung ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2
Background: Atrichia with papular lesions (APL) is a rare inherited disease characterized by early onset of total hair loss, followed by papular lesions over the extensor areas of the body. Recently, mutations in the human hairless (HR) gene have been implicated in its pathogenesis. The identification of mutations in the HR gene is important for differentiating between APL and alopecia universalis (AU). Objective: We compared the HR genes of patients with presumed AU who showed minimal or no response to treatment with the HR genes of healthy controls. Methods: The subjects were 11 patients with presumed AU who had not responded to treatments. Fifty healthy people were included as controls for molecular analysis. To screen for mutations, polymerase chain reaction was performed. Results: DNA analysis identified a novel heterozygous G-to-A transition at nucleotide position 191 in exon 5. The mutation was not found in the controls, other AU patients, or any unaffected family members except for the patients` mother and maternal grandfather, who were heterozygous HR gene carriers. Conclusion: Our study identifies a novel missense mutation in exon 5 of the HR gene in a Korean APL patient previously diagnosed as AU. (Ann Dermatol 23(2) 132∼137, 2011)
Case Reports : Steatocystoma Multiplex Confined to the Scalp with Concurrent Alopecia
( Deborah Lee ),( Ji Sung Chun ),( Soon Kwon Hong ),( Jong Keun Seo ),( Joon Hee Choi ),( Jae Kyoung Koh ),( Ho Suk Sung ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2s
Steatocystoma multiplex (SM) is an uncommon disorder of the pilosebaceous unit characterized by the development of numerous sebum-containing dermal cysts which rarely involves the scalp. Here, we report a case of a 50-year-old man with multiple cystic nodules and alopecic patches on his scalp. On histopathological examination, the folded cyst was found to be lined by stratified squamous epithelium, while flattened sebaceous gland cells were identified in the cystic wall. Pigment casts were present in the hair papillae and perifollicular regions, suggesting trichotillomania as a possible cause of the observed alopecia. This case appears to represent an unusual clinical manifestation of SM. (Ann Dermatol 23(S2) S258~S260, 2011)
Deborah Lee 한국피부장벽학회 2009 한국피부장벽학회지 Vol.11 No.1
Aged epidermis displays altered drug permeability, increased susceptibility to irritant contact dermatitis, and severe xerosis suggesting compromise of aged epidermal barrier. However, cutaneous barrier function is normal or even supernormal under basal conditions in aged skin. Functional pathology of the epidermis is revealed only after an active insult. The aged barrier is perturbed more readily and recovered more slowly in aged than in young skin. Global reduction of all key stratum corneum (SC) lipids, most profoundly cholesterol, with reduced activity of key enzymes and decreased extracellular lamellar bilayers could explain the impaired barrier recovery in aged epidermis. That is, main cause of impaired barrier function of advanced age(>75 years) is reduction of synthesis of key species of epidermal lipid. On the other hand, epidermal lipid synthesis is normal and the defective permeability barrier is associated with defective SC acidity in moderately aged (50-80 years) skin. Decreased Na+/H+ antiporter (NHE1) accounts for the pH abnormality in moderately aged epidermis and lead to increased SC pH. The increased pH results in abnormal lipid-processing and delayed maturation of SC lamellar membrane. Moreover, increased pHdependent activation of serine protease accelerates corneodesmosome degradation leading to abnormal SC integrity. Delayed barrier recovery and abnormal lipid-processing in moderately aged mice were normalized by reacidification. Dry environment induces epidermal proliferation and scaling in both aged and young skin and no remarkable difference is found in skin barrier recovery of aged skin in a dry environment. Superimposition of photoaging on chronologically aged (CA) skin neither alter basal barrier function, nor cause a further abnormality in barrier integrity but, cause a further abnormality in permeability barrier homeostasis in aged skin. Functional disturbance of SC in UV irradiated skin is not due to direct effect of UV radiation on SC, but just reflect secondary changes possibly caused by UV damage on underlying viable skin tissue that induce an epidermal proliferative response.
( Deborah Lee ),( Doo Jin Oh ),( Jung Wook Kim ),( Sung Wook Park ),( Min Kyung Oh ),( Ho Suk Sung ),( Seon Wook Hwang ) 대한피부과학회 2008 Annals of Dermatology Vol.20 No.4
Background: Combination therapy using cyclosporine A (CsA) together with low-dose corticosteroids has adequate efficacy with little toxicity for the treatment of severe alopecia areata (AA). Objective: We wanted to evaluate the clinical efficacy of combination therapy using CsA with low-dose corticosteroid for the treatment of severe AA and we also wanted to determine the safe therapeutic concentration of CsA in the peripheral blood. Methods: We treated 34 cases of severe AA with combination therapy for 24 weeks and we evaluated the efficacy at 12 and 24 weeks. We monitored the peripheral blood concentration of CsA to determine the therapeutic range of CsA that has the fewest side effects. Results: Of the patients, 77.4% (n=24) and 22.6% (n=10) were classified in the responder and poor-responder groups, respectively. The mean trough concentration of CsA was 95.1 and 101.2 ng/ml in the responder and poor-responder groups, respectively. For the patients with side effects associated with CsA, the mean CsA concentration was 195.8 ng/ml. Conclusion: We found that combination therapy with systemic CsA and low-dose corticosteroids effectively treats severe AA and this therapy results in a safe, therapeutic concentration of CsA in the peripheral blood. (Ann Dermatol (Seoul) 20(4) 172∼178, 2008)