Trust and Capitalism: The Need to Bring Back Regulation

Donatienne Delorme,Prashant Pereira 고려대학교 응용문화연구소 2015 에피스테메 Vol.0 No.14

The entire world has been affected in some way or other by the 2008 financial crisis. While economic recovery has been seen in high-income countries, risks for emerging and developing economies are affecting global growth. Many developing countries, which were considered the centre of growth during or since the 2008 Financial crisis seem to be currently affected in some way or other. We thus notice that risky, uncontrolled behavior in terms of lending practices by unregulated banks in the USA led to the Subprime and subsequent global financial crisis. The whole world and regulatory bodies spanning the globe seem to be determined to prevent such further crises by bringing about rule books and regulations to prevent repeats of conditions that could reproduce such situations. Financial regulation is a constant issue that is discussed in terms of regulatory needs. Everybody wants it to be done but most Stakeholders do not have a clear idea of why it should be put in place; nor how it should be done.

Rent Seeking , The Bracero Program And Current Mexican Farm Labor Policy

(Lisa Basurto),(Charles D . Delorme),(David R . Kamerschen) 한국국제경제학회 2001 International Economic Journal Vol.15 No.1

Money and Output in Central America

Jr.,Kamerschen, David R.,DeLorme, Charles D.,Lopez, Salvador THE INSTITUTE OF EAST AND WEST STUDIES YONSEI UNIV 1993 Global economic review Vol.22 No.2

Oxadiazolone derivatives, new promising multi-target inhibitors against <i>M. tuberculosis</i>

Nguyen, Phuong Chi,Delorme, Vincent,Bé,narouche, Anaï,s,Guy, Alexandre,Landry, Valé,rie,Audebert, Sté,phane,Pophillat, Matthieu,Camoin, Luc,Crauste, Cé,line,Galano, Jean-Ma Elsevier 2018 Bioorganic chemistry Vol.81 No.-

<P><B>Abstract</B></P> <P>A set of 19 oxadiazolone (<B>OX</B>) derivatives have been investigated for their antimycobacterial activity against two pathogenic slow-growing mycobacteria, <I>Mycobacterium marinum</I> and <I>Mycobacterium bovis</I> BCG, and the avirulent <I>Mycobacterium tuberculosis</I> (<I>M. tb</I>) mc<SUP>2</SUP>6230. The encouraging minimal inhibitory concentrations (MIC) values obtained prompted us to test them against virulent <I>M. tb</I> H37Rv growth either in broth medium or inside macrophages. The <B>OX</B> compounds displayed a diversity of action and were found to act either on extracellular <I>M. tb</I> growth only with moderated MIC<SUB>50</SUB>, or both intracellularly on infected macrophages as well as extracellularly on bacterial growth. Of interest, all <B>OX</B> derivatives exhibited very low toxicity towards host macrophages. Among the six potential <B>OXs</B> identified, <B>HPOX</B>, a selective inhibitor of extracellular <I>M. tb</I> growth, was selected and further used in a competitive labelling/enrichment assay against the activity-based probe Desthiobiotin-FP, in order to identify its putative target(s). This approach, combined with mass spectrometry, identified 18 potential candidates, all being serine or cysteine enzymes involved in <I>M. tb</I> lipid metabolism and/or in cell wall biosynthesis. Among them, Ag85A, CaeA, TesA, KasA and MetA have been reported as essential for <I>in vitro</I> growth of <I>M. tb</I> and/or its survival and persistence inside macrophages. Overall, our findings support the assumption that <B>OX</B> derivatives may represent a novel class of multi-target inhibitors leading to the arrest of <I>M. tb</I> growth through a cumulative inhibition of a large number of Ser- and Cys-containing enzymes involved in various important physiological processes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The OX analogs represent a novel class of multi-target inhibitors against <I>M. tb.</I> </LI> <LI> Some OX inhibit either extracellular, or both intra- and extracellular <I>M. tb</I> growth. </LI> <LI> These OXs are not toxic towards host macrophages. </LI> <LI> OX probes are attractive chemical tools to identify (Ser/Cys)-enzymes in living mycobacteria. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Relationship Between Economic Aid-and Economic Development

David R. KAMERSCHEN,John G. DONANDSON,Jr,Charles D. DELORME,Jr. THE INSTITUTE OF EAST AND WEST STUDIES YONSEI UNIV 1989 Global economic review Vol.18 No.1

The major purpose of this paper is to examine the relationship between economic aid and economic development measured both in physical output(GDP) and physieal welfare (PQL) terms. A fundamental rationale is to deter-mine whether the negative relationship between aid and development first observed by Criffin and Enos (1970) was robust to newer data and alternative modelling. A sample of six countries has been chosen from different regions of the world. For each country, data have been collected on total official development assistance, real Gross Domestic Product, and the physical quality of life index based on three equally weighted components (life expectancy, infant mortality rate, and literacy rate) Using this data, four different regression equations have been estimated for each country. From the preliminary results discussed in this paper, it appears that a negative economic relationship between economic aid and economic development is not only possible, but actually occurs in certain countries. Of the six countries examined in this paper, only one, the Sudan exhibited positive effects on both welfare (PQL) and output (GDP). In the other countries, official development assistance (ODA) is either completely neutral or ineffective in terms of welfare and output, or the results were mixed between positive and negative coefficients . But one must be very cautious in reaching any strong conclusions on ODA effectiveness because of the fundamental identification problem resulting from the fact that the ODA going to any one nation is very, very small and because there is little variation in ODA across various nations. Thus, it is difficult to infer anything definitive about the potential impact of a substantial infusion of ODA-if it were to be made available. Additional work in this area is essential to a general understanding oft these relationships in question. Different formulations of the same kind of model should be helpful in eliciting additional results. For example, it might be advantageous to reformulate this study using only countries from one region of the world. Applying the model to African countries might be fruitful in that the two African countries in this study demonstrate more impact from development assistance. Another alternative might be the use of cross-sectional or pooled cross-sectional data on a much larger sample of countries. However, the present paucity of data makes this alternative difficult, if not impossible, at the present.

1995년 일본 고베지진 전·후 항공사진을 이용한 이미지 상관분석에 대한 예비 결과

배한경(Hankyung Bae),최진혁(Jin-Hyuck Choi),김동은(Dong-Eun Kim),Arthur Delorme,Yann Klinger,이희권(Hee-Kwon Lee) 대한지질학회 2022 대한지질학회 학술대회 Vol.2022 No.10

Efflux Attenuates the Antibacterial Activity of Q203 in <i>Mycobacterium tuberculosis</i>

Jang, Jichan,Kim, Ryangyeo,Woo, Minjeong,Jeong, Jinsun,Park, Da Eun,Kim, Guehye,Delorme, Vincent American Society for Microbiology 2017 Antimicrobial Agents and Chemotherapy Vol.61 No.7

<P>New and improved treatments for tuberculosis (TB) are urgently needed. Recently, it has been demonstrated that verapamil, an efflux inhibitor, can reduce bacterial drug tolerance caused by efflux pump activity when administered in combination with available antituberculosis agents. The aim of this study was to evaluate the effectiveness of verapamil in combination with the antituberculosis drug candidate Q203, which has recently been developed and is currently under clinical trials as a potential antituberculosis agent. We evaluated changes in Q203 activity in the presence and absence of verapamil in vitro using the resazurin microplate assay and ex vivo using a microscopy-based phenotypic assay for the quantification of intracellular replicating mycobacteria. Verapamil increased the potency of Q203 against Mycobacterium tuberculosis both in vitro and ex vivo, indicating that efflux pumps are associated with the activity of Q203. Other efflux pump inhibitors also displayed an increase in Q203 potency, strengthening this hypothesis. Therefore, the combination of verapamil and Q203 may be a promising combinatorial strategy for anti-TB treatment to accelerate the elimination of M. tuberculosis.</P>