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- 저자 : Dayeon Lee (검색결과 99 건)
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Grazing Behavior and Forage Selection of Goats (Capra hircus)
Lee, Sang-Hoon,Lee, Jinwook,Chowdhury, M.M.R.,Jeon, Dayeon,Lee, Sung-Soo,Kim, Seungchang,Kim, Do Hyung,Kim, Kwan-Woo The Korean Society of Grassland and Forage Science 2019 한국초지조사료학회지 Vol.39 No.3
The normal feeding approach of goats might be due to their precise anatomical and physiological characteristics of entity, which permit them to be highly selective, to eat legume silages and wild green grass. This review has been designed to consider the grazing behavior, fodder selection, and feed composition of goats. Various herbs and corns consumed by goats have numerous nutritive resources. Based on the general herbaceous intake activities and behavior of goats, they prefer wild grass such as grass grown in the steep hills than soft grass. Because the digestion capacity of cellulose feed has higher digestion level compared to other non-ruminants within rumen and it is advantageous to use wild forest or mountain grass which comprises high proportion of cellulose feed for goat. In South Korea, there are abundant feed resources for goats because of occupying large areas of mountains. Thus, goat production and feeding costs could be reduced if plants are used from the wild forest as a feed for goats relative to grassland grazing. Also, it is expected to contribute in improvement of goat farming with harmonious relationship between the grassland and wild forest while satisfying animal welfare and physiological desires of livestock.
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The Xingxing Blood Metaphor and its Color in Chinese Classical Poetry
Dayeon Lee 중국어문학연구회 2019 중국어문학논집 Vol.0 No.119
‘Xingxing blood’ was acknowledged in ancient China as a kind of metaphor which represented red color. But it looks too violent to convey beautiful red color. How could think of a monkey shedding blood when seeing flowers or fruits? This paper contends that there existed a reason for using the metaphor. According to some writings, the xingxing is regarded as an mysterious and unfamiliar animal for ancient people, which resulted in the birth of this attractive metaphor. To develop this question, I will use a complete enumeration method of analyzing all the poems which contain “猩” meaning red. Therefore, I divide the objects comparing to the color of xingxing blood into the four types with arranged in chronological order. The result is predicted that xingxing blood represented exotic scarlet-red, which was differentiated from traditional Chinese red colors. Being vivid and bright, it would be paired with the fancy objects. More importantly, this result could suggest a significant finding that ancient Chinese people cared much about outstanding and intuitive expressions in order to write poems more clearly.
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Barriers and Facilitators of Older Adults’ Usage of Mobility Devices: A Scoping Review
Dayeon Lee,Sunghee H Tak 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim(s): The study aimed to explore the barriers and facilitators related to the usage of mobility devices among older adults. Method(s): A total of 815 literatures were retrieved from Scopus by organizing queries with the words “Assistive technology”, “Older adults”, and “Disability” between the period of 2000-2020. Among them, eight primary research studies met the eligibility criteria and were selected in the scoping review. Systematic processes of study identification, data extraction and data synthesis were used. Result(s): The barriers and facilitators were identified in terms of three aspects – environment, user and device. Environmental barriers included limited indoor and outdoor accessibility, transportation option and weather. Curb ramps for helping accessibility, amenities for anti-fatigue and crime surveillance were identified as the environmental facilitators. Negative perceptions of older adults prevented them from using mobility devices, in particular, when they considered it as a sign of disability and dependence. However, users’ adoption of mobility devices was facilitated if devices were perceived as an aid for balancing and preventing older adults from falling or recommended by medical staff. In addition, the design of the devices influenced the positive or negative acceptance of the older adults. Fashionable design is often desired. Conclusion(s): The findings suggest that a policy improvement is important to lower barriers of mobility device usage and improve the environment for older adults with mobility impairment. In addition, the design and functions of the mobility devices need to meet the needs and preferences of older adults, while preserving their self-image and dignity.
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Lee Dayeon,Yoon Cheol-Hee,Choi Sin Young,Kim Jung-Eun,조영걸,Choi Byeong-Sun,Park Jihwan 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3
Background: The latent reservoir of Human Immunodificiency Virus-1 (HIV-1) has been a major barrier to the complete eradication of HIV-1 and the development of HIV therapy. Longterm non-progressors (LTNPs) are a rare group of patients with HIV-1 who can spontaneously control HIV-1 replication without antiretroviral therapy. Transcriptome analysis is necessary to predict the pathways involved in the natural control of HIV-1, elucidate the mechanisms involved in LTNPs, and find biomarkers for HIV-1 reservoir therapy. Materials and Methods: In this study, we obtained peripheral blood mononuclear cells from two LTNP subjects at multiple time points and performed RNA-sequencing analyses. Results: We found that LTNPs and normal subjects had different transcriptome profiles. Functional annotation analysis identified that differentially expressed genes in LTNPs were enriched in several biological pathways such as cell cycle-related pathways and the transforming growth factor-beta signaling pathway. However, genes that were downregulated in LTNPs were associated with immune responses such as the interferon response and IL2- STAT5 signaling. Protein-protein interaction network analysis showed that CD8A, KLRD1, ASGR1, and MLKL, whose gene expression was upregulated in LTNPs, directly interacted with HIV-1 proteins. The network analysis also found that viral proteins potentially regulated host genes that were associated with immune system processes, metabolic processes, and gene expression regulation. Conclusion: Our longitudinal transcriptome analysis of the LTNPs identified multiple previously undescribed pathways and genes that may be useful in the discovery of novel therapeutic targets and biomarkers.
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Lee, So D.,Yu, Dayeon,Lee, Do Y.,Shin, Hyun‐,Soo,Jo, Jeong‐,Hyeon,Lee, Yong C. John Wiley and Sons Inc. 2019 Cancer Science Vol.110 No.2
<P>Cisplatin is a well‐known anticancer drug used to treat various cancers. However, development of cisplatin resistance has hindered the efficiency of this drug in cancer treatment. Development of chemoresistance is known to involve many signaling pathways. Recent attention has focused on microRNAs (miRNAs) as potentially important upstream regulators in the development of chemoresistance. CD44 is one of the gastric cancer stem cell markers and plays a role in regulating self‐renewal, tumor initiation, metastasis and chemoresistance. The purpose of the present study was to examine the mechanism of miRNA‐mediated chemoresistance to cisplatin in CD44‐positive gastric cancer stem cells. We sorted gastric cancer cells according to level of CD44 expression by FACS and analyzed their miRNA expression profiles by microarray analysis. We found that miR‐193a‐3p was significantly upregulated in CD44(+) cells compared with CD44(−) cells. Moreover, SRSF2 of miR‐193a‐3p target gene was downregulated in CD44(+) cells. We studied the modulation of Bcl‐X and caspase 9 mRNA splicing by SRSF2 and found that more pro‐apoptotic variants of these genes were generated. We also found that downstream anti‐apoptotic genes such as Bcl‐2 were upregulated, whereas pro‐apoptotic genes such as Bax and cytochrome C were downregulated in CD44(+) cells compared to CD44(−) cells. In addition, we found that an elevated level of miR‐193a‐3p triggered the development of cisplatin resistance in CD44(+) cells. Inhibition of miR‐193a‐3p in CD44(+) cells increased SRSF2 expression and also altered the levels of multiple apoptotic genes. Furthermore, inhibition of miR‐193a‐3p reduced cell viability and increased the number of apoptotic cells. Therefore, miR‐193a‐3p may be implicated in the development of cisplatin resistance through regulation of the mitochondrial apoptosis pathway. miR‐193a‐3p could be a promising target for cancer therapy in cisplatin‐resistant gastric cancer.</P>
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Yu, Dayeon,Shin, Hyun-Soo,Lee, Yeo Song,Lee, Yong Chan United States and Canadian Academy of Pathology [e 2014 Laboratory investigation Vol.94 No.12
<P>Cancer stem cells have the capacity to form new tumors and are thus considered to be a cause of metastasis and tumor recurrence. However, many of the mechanisms determining cancer stem cell characteristics are still unknown. MicroRNAs (miRNAs) are possible modulators of cancer stem cell generation and may be involved in the retention of cancer stem cell characteristics. The aim of this study was to examine the miRNA expression profiles regulating the cancer stem-like cell characteristics in gastric cancer. We sorted gastric cancer stem-like cells using the stem cell marker CD44 by fluorescence-activated cell sorting. CD44(+) cells formed more and larger spheres compared with CD44(-) cells. Cancer stem cell markers were overexpressed in CD44(+) cells. CD44(+) cells showed increased expression of mesenchymal cell markers, whereas epithelial markers were downregulated. In miRNA microarray, the miR-106b family comprising miR-106b, miR-93, and miR-25 was significantly upregulated in CD44(+) cells than in CD44(-) cells. Smad7, which inhibits transforming growth factor-β (TGF-β)/Smad signaling as a target of the miR-106b family, was downregulated in CD44(+) cells. Furthermore, expression of TGF-β/Smad signal molecules was activated in CD44(+) cells, in accordance with the action of the miR-106b family. Inhibition of miR-106b showed suppression of the TGF-β/Smad signaling pathway and decreased self-renewal capacity and cell invasiveness. Our study suggests that CD44(+) gastric cancer cells show cancer stem cell properties with epithelial-mesenchymal transition (EMT). Increased miR-106b family expression regulated cancer stem-like cell properties, particularly EMT characteristics, through the TGF-β/Smad signaling pathway in CD44(+) stem-like cells. Taken together, these results indicate that targeting miR-106b may be an effective form of cancer therapy in gastric cancer through the modulation of cancer stem cell characteristics.</P>
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