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( Daisuke Hachinohe ),( Myung Ho Jeong ),( Shigeru Saito ),( Min Chol Kim ),( Kyung Hoon Cho ),( Khurshid Ahmed ),( Seung Hwan Hwang ),( Min Goo Lee ),( Doo Sun Sim ),( Keun-Ho Park ),( Ju Han Kim ),( 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.4
Background/Aims: To determine which drug-eluting stents are more effective in acute myocardial infarction (MI) patients with chronic kidney disease (CKD). Methods: This study included a total of 3,566 acute MI survivors with CKD from the Korea Acute Myocardial Infarction Registry who were treated with stenting and followed up for 12 months: 1,845 patients who received sirolimus-eluting stents (SES), 1,356 who received paclitaxel-eluting stents (PES), and 365 who received zotarolimus-eluting stents (ZES). CKD was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2 calculated by the modification of diet in renal disease method. Results: At the 12-month follow-up, patients receiving ZES demonstrated a higher incidence (14.8%) of major adverse cardiac events (MACEs) compared to those receiving SES (10.1%) and PES (12%, p = 0.019). The ZES patients also had a higher incidence (3.9%) of target lesion revascularization (TLR) compared to those receiving SES (1.5%) and PES (2.4%, p = 0.011). After adjusting for confounding factors, ZES was associated with a higher incidence of MACE and TLR than SES (adjusted hazard ratio [HR], 0.623; 95% confidence interval [CI], 0.442 to 0.879; p = 0.007; adjusted HR, 0.350; 95% CI, 0.165 to 0.743; p = 0.006, respectively), and with a higher rate of TLR than PES (adjusted HR, 0.471; 95% CI, 0.223 to 0.997; p = 0.049). Conclusions: Our findings suggest that ZES is less effective than SES and PES in terms of 12-month TLR, and has a higher incidence of MACE due to a higher TLR rate compared with SES, in acute MI patients with CKD.
Hoheum Cho,Daisuke Jige,Hiromasa Miyata,NORIHIRO INOUE 대한설비공학회 2018 International Journal Of Air-Conditioning and Refr Vol.26 No.1
This study experimentally investigated the flow pattern, void fraction, and evaporation heat transfer characteristic of R134a upward flow in a vertical narrow rectangular channel having a hydraulic diameter of 0.99 mm, resembling a plate heat exchanger. Experiments were performed with mass velocities and vapor quality ranging between 30–200 kgm −2 −2s −1 −1 and 0.05–0.9, respectively, at a saturation temperature of 15 ∘C. Flow patterns were classified into bubble, slug, churn, and annular flows. The void fraction increased with increasing quality, and decreased with decreasing mass velocity in the low-quality region. Further, the influence of flow inlet/outlet positions remarkably appeared when the superficial gas velocity was low. The observed flow patterns and the measured void fraction were compared to that in previous studies. The effects of mass velocity and heat flux on the evaporation heat transfer coefficient were small, and the heat transfer through the thin liquid film was dominant.
Drug-Eluting Stent as an Option for Intractable In-Stent Coronary Restenosis
Hachinohe, Daisuke,Jeong, Myung Ho,Kim, Min Chol,Cho, Kyung Hoon,Ahmed, Khurshid,Hwang, Seung Hwan,Lee, Min Goo,Sim, Doo Sun,Park, Keun-Ho,Kim, Ju Han,Hong, Young Joon,Ahn, Youngkeun,Kang, Jung Chaee The Korean Society of Cardiology 2011 Korean Circulation Journal Vol.41 No.11
<P>A 51-year-old man was admitted due to an acute anterior ST-segment elevation myocardial infarction. After thrombolytic therapy using recombinant tissue plasminogen activator, stent implantation was performed from the proximal left anterior descending artery (LAD) to the mid LAD using a bare-metal stent (BMS). Since then, the patient suffered five repeated episodes of in-stent restenosis (ISR). At the first ISR, he was treated with plain old balloon angioplasty (POBA). At the second ISR, he was treated with brachytherapy, and at the third ISR, he was treated with POBA and one more BMS distal to the previously implanted stent. At the forth, only POBA was performed, and finally, at the fifth ISR, a sirolimus-eluting stent was implanted. Following that, the patient remained asymptomatic and follow-up coronary angiography showed no ISR.</P>
충격 하중 시 암석의 파괴거동해석을 위한 GPGPU 기반 3차원 동적해석기법의 개발과 검증 연구
민경조 ( Gyeong-jo Min ),( Daisuke Fukuda ),오세욱 ( Se-wook Oh ),조상호 ( Sang-Ho Cho ) 대한화약발파공학회 2021 화약발파 Vol.39 No.2
최근에는 GPGPU(General-Purpose computing on Graphics Processing Units)와 같은 고성능 연산장치의 보급과 함께 국방, 우주항공분야에서 암질재료에 대한 충격실험을 대신할 수 있는 3차원 동적해석기법의 개발이 활발하게 진행되고 있다. 그러나 높은 충격하중을 수반하는 암 발파 또는 소형미사일 등의 지중 관통과 같은 과정을 실험적으로 관찰하거나 계측하는 것은 암질재료의 비 균질성 및 불투명성 때문에 어려움이 있었다. 본 연구에서는 고속충돌에 의한 암석의 파괴 거동을 모사하기 위하여 3차원 동적 파괴 과정 해석 기법 (3D-DFPA)를 개발하였으며, 연산속도를 향상시키기 위하여 순차해석(explicity analysis) 및 접촉요소검색(Searching algolitm of contact elements)에 GPGPU연산이 가능한 알고리듬을 적용하였다. 제안된 동적파괴과정해석 기법에 대한 검증을 위해 Straight Notched Disk Bending (SNDB) 석회암시료에 대한 동적파괴인성시험을 모사하였고, 충격응력파의 전파과정, 암석-충격봉 경계면에서 반사 및 전달과정, 암석 시료의 파괴과정을 비교분석하여, 개발된 해석기법에 대한 검증을 수행하였다. Recently, with the development of high-performance processing devices such as GPGPU, a three-dimensional dynamic analysis technique that can replace expensive rock material impact tests has been actively developed in the defense and aerospace fields. Experimentally observing or measuring fracture processes occurring in rocks subjected to high impact loads, such as blasting and earth penetration of small-diameter missiles, are difficult due to the inhomogeneity and opacity of rock materials. In this study, a three-dimensional dynamic fracture process analysis technique (3D-DFPA) was developed to simulate the fracture behavior of rocks due to impact. In order to improve the operation speed, an algorithm capable of GPGPU operation was developed for explicit analysis and contact element search. To verify the proposed dynamic fracture process analysis technique, the dynamic fracture toughness tests of the Straight Notched Disk Bending (SNDB) limestone samples were simulated and the propagation of the reflection and transmission of the stress waves at the rock-impact bar interfaces and the fracture process of the rock samples were compared. The dynamic load tests for the SNDB sample applied a Pulse Shape controlled Split Hopkinson presure bar (PS-SHPB) that can control the waveform of the incident stress wave, the stress state, and the fracture process of the rock models were analyzed with experimental results.
Kim, Hakman,Fukuda, Daisuke,Kaneko, Katsuhiko,Lee, Juhyung,Cho, Sang-ho Trans Tech Publications 2017 Key Engineering Materials Vol.744 No.-
<P> Mechanical breakage systems are generally employed to demolish a portion of a concrete building, however it is time consuming and costly. And the mechanical demolition work involves various risks such as those associated with occupational safety and presents a noise hazard to the general public living in the vicinity. Therefore, alternative methods for such work have been sought. For this purpose, a dynamic breakage system utilizing diamond-shaped charge holders was proposed to rapidly remove the desired portion of the concrete foundation. The charge holders which initiate crack growth were placed inside a concrete mass along the desired fracture plane. In this study, full-scale blast experiments utilizing the charge holders were introduced and the roughness of fracture planes was observed using a 3-dimensional photography system. In order to verify the effect of the charge holders on fracture controlling in full-scale blast experiments, the fracture processes of the concrete blocks were analyzed using the dynamic fracture process analysis (DFPA) code. The mechanism required to achieve controlled breakage was discussed after taking into account the influence of various loading conditions and crack tip velocity. It was found that the DFPA tool is a useful instrument in the analysis of full scale blast experiments. </P>
( Doo Sun Sim ),( Myung Ho Jeong ),( Daisuke Hachinohe ),( Youngkeun Ahn ),( Myeong Chan Cho ),( Chong Jin Kim ),( Young Jo Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Background:The role of thrombus aspiration (TA) as an adjunct to primary percutaneous coronary intervention (PPCI) remains a matter of controversy. Methods and Results: A total of 2,105 patients enrolled in the nationwide prospective Korea Acute Myocardial Infarction Registry, a cohort of 745 (35.4 %) patients who underwent TA during PPCI was compared with 1,360 (64.6 %) patients who underwent conventional PCI without TA. Clinical outcomes at 12-month of overall enrolled patients and subgroups according to key variables were assessed using Cox regression models adjusted by propensity score. Although there was no significant difference among overall patients, in subgroup analyses, administration of glycoprotein (GP) IIb/IIIa inhibitor during PPCI [adjusted hazard ratio (HR) 0.329, 95 % confidence interval (CI) 0.126 to 0.860, p=0.023] and left anterior descending (LAD) as a culprit lesion (adjusted HR 0.516, 95 % CI 0.275 to 0.971, p=0.040) were the settings, in which TA was associated with a lower major adverse cardiac events (MACE) rate compared with non-TA. Conclusions: Although TA does not improve clinical outcomes in overall patients who underwent PPCI, TA for LAD occlusion improves 12-month MACE. Furthermore, use of GP IIb/IIIa inhibitor with TA has synergetic effect on clinical outcomes.