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Binh Hai Nguyen,Binh Thanh Nguyen,Hanh Van Vu,Chuc Van Nguyen,Dzung Tuan Nguyen,Loc Thai Nguyen,Thu Thi Vu,Lam Dai Tran 한국물리학회 2016 Current Applied Physics Vol.16 No.2
In this work, a lactose biosensor was developed by co-immobilizing b-galactosidase (b-Gal) and glucose oxidase (GOx) on microelectrodes pre-modified with Pt/graphene/P(1,5-DAN) for estimation of lactose in dairy products to prevent lactose intolerance. The Pt microelectrode was modified with graphene and 1,5-polydiaminonaphthalene film. Graphene was synthesized by chemical vapor deposition on copper tape and manually transferred to the electrode surface. Polymeric P(1,5-DAN) was grafted on top of the graphene film by electropolymerization. Modified surface of the electrode was characterized by Raman spectra analysis, FE-SEM, AFM and cyclic voltammetry. The results indicated that deposition graphene film on electrode surface induced considerable enhancement in current signal, over 20 times as high as the uncoated electrode surface. The developed sensor was successfully used to determine lactose in model samples with sensitivity, correlation coefficient (R2) and limit of detection (LOD) estimated to be 1.33 mA/(mgml1), 0.995 and 1.3 mg/ml, respectively. The combined graphene and conductive P(1,5-DAN) could serve as a novel sensing platform on electrochemical sensors with superior sensitivity.
Ngoc Thuy Nguyen,Nhat Thong Tran,Tan Phat Phan,Anh Thu Nguyen,My Xuyen T. Nguyen,Nguyen Ngan Nguyen,Young Ho Ko,Dai Hai Nguyen,Tran T.T. Van,DongQuy Hoang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
While the efficient usage of biomass waste can significantly help in addressing environmental issues,there are only a few reports that discuss about processing such waste effectively at a low-cost. Such challengearises from the strong association between the components biomass. In this study, an abundantagricultural byproduct, rice husk (RH), was used as the starting resource. A simple biorefining processof alkaline peroxide treatment followed by acid precipitation and ethanol extraction was performed onRH to obtain cellulose, hemicellulose, lignin, and silica. The chemical structures, morphologies, andphysic-chemical properties of the separated components were identified through a wide range of characterizationapproaches. The final products obtained from of this process were (i) bundles of fiber-likecellulose with a fiber width of 6 mm and (ii) small particles of hemicellulose and lignin with nonuniformshapes. The lignocelluloses products had over 90 wt% carbon with 52.28% crystalline ratio. Meanwhile, the other products comprising hemicelluloses, lignin, and silica were amorphous. The outcomeof this study contributes to expanding and developing the simple and efficient conversion processof biomass waste into sustainable value-added materials. It is crucial to reduce the environmental impactby using renewable materials as the new building block resources for synthetic chemicals.
Hoang Anh Nguyen,Thi Nam Pham,Le Thanh Nguyen Huynh,Tran Ha Trang Nguyen,Viet Hai Le,Nguyen Thai Hoang,Thi Thom Nguyen,Thi Thu Trang Nguyen,Dai Lam Tran,Thi Mai Thanh Dinh The Korean Electrochemical Society 2024 Journal of electrochemical science and technology Vol.15 No.2
Due to its high theoretical capacity, Silicon (Si) has shown great potential as an anode material for lithium-ion batteries (LIBs). However, the large volume change of Si during cycling leads to poor cycling stability and low Coulombic efficiency. In this study, we synthesized Si/Carbon C45:Graphene composites using a ball-milling method with a fixed Si content (20%) and investigated the influence of the C45/Gr ratio on the electrochemical performance of the composites. The results showed that carbon C45 networks can provide good conductivity, but tend to break at Si locations, resulting in poor conductivity. However, the addition of graphene helps to reconnect the broken C45 networks, improving the conductivity of the composite. Moreover, the C45 can also act as a protective coating around Si particles, reducing the volume expansion of Si during charging/discharging cycles. The Si/C45:Gr (70:10 wt%) composite exhibits improved electrochemical performance with high capacity (~1660 mAh g<sup>-1</sup> at 0.1 C) and cycling stability (~1370 mAh g<sup>-1</sup> after 100 cycles). This work highlights the effective role of carbon C45 and graphene in Si/C composites for enhancing the performance of Si-based anode materials for LIBs.
Targeted doxorubicin nanotherapy strongly suppressing growth of multidrug resistant tumor in mice
Nguyen, Dai Hai,Lee, Jung Seok,Bae, Jin Woo,Choi, Jong Hoon,Lee, Yunki,Son, Joo Young,Park, Ki Dong Elsevier 2015 International journal of pharmaceutics Vol.495 No.1
<P><B>Abstract</B></P> <P>The rational design of nanomedicine to treat multidrug resistant (MDR) tumors <I>in vivo</I> is described in the study. We prepared multifunctionalized Pluronic micelles that are already well-established to be responsive to low pH and redox in order to systemically deliver doxorubicin (DOX) to MDR tumors. Folic acids (FAs) were introduced on the micelle surface as tumor-targeting molecules. In vitro, the DOX-loaded micelles exerted high cytotoxicity in the DOX-resistant cells by bypassing MDR efflux. Cellular uptake studies clearly demonstrated that FA-conjugated DOX micelles (FA/DOX micelles) were efficiently internalized and accumulated in the MDR cells. In vivo studies indicated significant efficacy of FA/DOX micelles for MDR tumors in mice, and that the volume of tumors was 3 times smaller in this group than that of tumors in the free DOX group, and 8 times smaller than the tumors in the saline group. To the best of our knowledge, this methodology has been recognized to have significantly high efficacy, compared to previously reported DOX nanoparticle formulations. This superior anti-tumor efficacy of FA/DOX micelles in MDR tumor-bearing mice can be attributed to FA-targeted and -mediated endocytosis, inhibition of MDR effect, and subsequent DOX release triggered by dual stimuli (low pH and redox) inside the tumor. Given the promise of the multifunctional micelle mediated delivery on inhibition of MDR tumor growth, FA/DOX micelle platform is a much sought after goal for cancer chemotherapy, especially for cancers resistant to anticancer drugs.</P> <P><B>Graphical abstract</B></P> <P>Folic acid (FA) and doxorubicin (DOX)-conjugated micelles (FA/DOX micelles) that are responsive to pH and redox show superior anti-tumor efficacy in multidrug resistant (MDR) tumor-bearing mice because of FA-targeted and -mediated endocytosis, inhibition of MDR efflux, and subsequent DOX release triggered by dual stimuli (low pH and redox) inside the tumor. The volume of tumors was 8 times smaller in the micelle group than the tumors in the saline group.</P> <P>[DISPLAY OMISSION]</P>
Nguyen, Dai Hai Institute of Korean Electrical and Electronics Eng 2017 전기전자학회논문지 Vol.21 No.3
Porous nanosilica (PNS) has been identified as a potential candidate for controlled drug delivery. However, unmodified PNS-based carriers exhibited an initial release of loaded bioactive agents, which may limit their potential clinical applications. In this study, the surface of PNS was functionalized with adamantylamine (ADA) via disulfide bonds (-S-S-), PNS-S-S-ADA, which was then modified with cyclodextrin (CD)-heparin (Hep) (CD-Hep), PNS-S-S-CDH, for redox triggered rhodamine B (RhB) delivery. The obtained samples were then characterized by proton nuclear magnetic resonance ($^{1}H\;NMR$), Fourier transform infrared (FTIR), and transmission electron microscope (TEM). These results showed that PNS-S-S-CDH was successfully formed with spherical shape and average diameter of $45.64{\pm}2.33nm$. In addition, RhB was relatively encapsulated in the PNS-S-S-CDH (RhB@PNS-S-S-CDH) and slowly released up to 3 days. The release of RhB, in particular, was triggered due to the cleavage of -S-S- in the presence of dithiothreitol (DTT). It might be anticipated that the modified PNS can be used as redox-responsive drug delivery system in cancer therapy.
Dai Hai Nguyen 한국전기전자학회 2017 전기전자학회논문지 Vol.21 No.3
Porous nanosilica (PNS) has been identified as a potential candidate for controlled drug delivery. However, unmodified PNS-based carriers exhibited an initial release of loaded bioactive agents, which may limit their potential clinical applications. In this study, the surface of PNS was functionalized with adamantylamine (ADA) via disulfide bonds (-S-S-), PNS-S-S-ADA, which was then modified with cyclodextrin (CD)-heparin (Hep) (CDHep), PNS-S-S-CDH, for redox triggered rhodamine B (RhB) delivery. The obtained samples were then characterized by proton nuclear magnetic resonance (<SUP>1</SUP>H NMR), Fourier transform infrared (FTIR), and transmission electron microscope (TEM). These results showed that PNS-S-S-CDH was successfully formed with spherical shape and average diameter of 45.64 ± 2.33 nm. In addition, RhB was relatively encapsulated in the PNS-S-S-CDH (RhB@PNS-S-S-CDH) and slowly released up to 3 days. The release of RhB, in particular, was triggered due to the cleavage of -S-S- in the presence of dithiothreitol (DTT). It might be anticipated that the modified PNS can be used as redox-responsive drug delivery system in cancer therapy.
Enzyme-mediated fabrication of an oxidized chitosan hydrogel as a tissue sealant
Phuong, Nguyen Thi,Anh Ho, Viet,Hai Nguyen, Dai,Khoa, Nguyen Cuu,Quyen, Tran Ngoc,Lee, Yunki,Park, Ki Dong Technomic Pub. Co 2015 Journal of bioactive and compatible polymers Vol.30 No.4
<P>Oxidized polysaccharide-based hydrogels have recently attracted much attention for tissue regeneration because of their biocompatibility and tissue-adhesive property. In this study, we introduce a new type of chitosan-based hydrogel as a tissue sealant, which was prepared by enzymatic mediation from periodate-oxidized chitosan–polyethylene glycol–tyramine. The oxidized chitosan backbone was expected to enhance the interconnection between the hydrogel layer and collagen in the tissues via the Schiff-base reaction. Proton nuclear magnetic resonance spectra indicated that tyramine-functionalized polyethylene glycol-nitrophenyl carbonate ester was conjugated to the oxidized chitosan. The degree of oxidation of the chitosan backbone was around 14% of the glucosamine units by proton nuclear magnetic resonance. The hydrogel was rapidly formed in situ (within a few seconds) in the presence of horseradish peroxidase and hydrogen peroxide. In vitro experiments with live/dead cell assays showed that the oxidized chitosan-based hydrogel was cytobiocompatible. The hydrogel exhibited high tissue adhesion strength on porcine skin models as well as good tissue-adhesive ability and wound healing properties on rabbit skin. These positive results could be promising for the application of oxidized chitosan-based hydrogels as a wound sealant.</P>