Interaction between an Eco-Spiral Bolt and Crushed Rock in a Borehole Evaluated by Pull-Out Testing

Kang, Seong-Seung,Hirata, Atsuo,Jang, Bo-An,Seo, Yong-Seok,Kim, Daehyeon Hindawi Limited 2017 Advances In Materials Science And Engineering Vol.2017 No.1

<P>The interactions between an eco-spiral bolt and crushed rocks in a borehole were evaluated by pull-out testing in a laboratory and numerical analysis. The porosity of the crushed rock surrounding the bolt depended on the size of the eco-spiral bolt and affected the eco-spiral bolt’s axial resistance force. The axial resistance force and the porosity of the crushed rocks in the borehole showed an inverse relationship. The porosity was also related to the size of the eco-spiral bolt. The maximum principal stress between the bolt and the rock was related to the porosity of the crushed rock and the size difference between the eco-spiral bolt and the borehole. At low porosity the experimental and numerical analyses show similar relationships between the axial resistance force and the displacement. However, at high porosity, the numerical results deviated greatly from the experimental observation. The initial agreement is attributed to the state of residual resistance after the maximum axial resistance force, and the latter divergence was due to the decreasing axial resistance force owing to slippage.</P>

그라우트 재료로서 광물찌꺼기 혼화재의 활용 가능성 평가

김대현(Daehyeon Kim),노정두(Jeongdu Noh),강성승(Seong-Seung Kang) 한국암반공학회 2016 터널과지하공간 Vol.26 No.1

전남 해남에 위치한 ○○광산의 광물찌꺼기를 이용하여 그라우트 재료로서의 활용 가능성을 평가하였다. 광물찌꺼기의 광물학적 특성을 살펴보기 위하여 XRD 분석을 실시하였다. 또한 광물찌꺼기와 시멘트를 3가지 비율로 혼합한 그라우트 재료의 물리적 및 역학적 특성을 살펴보기 위하여 양생기간에 따른 흐름도, 탄성파속도, 일축압축강도 시험을 각각 실시하였다. XRD 분석 결과에 의하면 본 광산의 광물찌꺼기는 대부분 석영, 방연석, 황철석 등의 광물들로 구성된 것으로 나타났다. 흐름시험 결과는 광물찌꺼기의 혼합비율이 높아질수록 흐름도가 감소하는 경향을 보였다. 탄성파속도는 흐름도와 마찬가지로 양생기간에 관계없이 광물찌꺼기의 혼합비율이 높아질수록 낮아지는 경향을 보였다. 일축압축강도 및 탄성계수 또한 양생기간에 관계없이 광물찌꺼기 혼합비율이 증가할수록 작아지는 경향을 보였다. 광물찌꺼기를 혼합한 그라우트 주입재의 물리적 및 역학적 특성만을 고려할 때 이들 결괏값은 그라우트 재료로서 충분히 활용 가능성을 가지고 있다고 판단된다. 하지만 광물찌꺼기 내에 방연석과 황철석 등 금속광물이 포함되어 있어 지반 내 주입 시 환경오염을 일으킬 수 있으므로 향후 이에 대한 대책방안이 고려되어야 할 것으로 사료된다. The purpose of this study is to evaluate the applicability of tailing in the OO mine as a grout material. For the purpose, XRD analysis was performed for mineralogical properties of tailing. In addition, flow, velocity, and uniaxial compressive strength tests were carried out for physical and mechanical properties of a grout material with the mixing ratio of cement and tailing and curing periods. By the result of XRD analysis, tailing of the mine was found to mostly consist of quartz, galena, and pyrite. The flow observed by the flow test showed decreasing tendency with increasing the mixing ratio of tailing. The velocity was also lowered with increasing the mixing ratio of tailing regardless of curing periods. The uniaxial compressive strength as well as Young’s modulus also show a tendency to decrease with increasing the mixing ratio of tailing independently on the curing periods. Considering only the physical and mechanical properties of a grout material with tailing, the results are considered to be sufficiently used as a grout material. However, since metallic minerals such as galena and pyrite in tailing contents and these are causing environmental contamination, countermeasures should be considered for this problem in future.

Eco-SB 지중변위계를 이용한 옹벽구조물 거동 평가

강성승 ( Seong-seung Kang ),노정두 ( Jeongdu Noh ),이건주 ( Geon-ju Lee ),김대현 ( Daehyeon Kim ),정희철 ( Heechul Jung ),고진석 ( Chin-surk Ko ) 조선대학교 공학기술연구원 2017 공학기술논문지 Vol.10 No.1

This study is to evaluate the ground behavior of the retaining wall using the Eco-SB displacement meter in the ground. For the purpose, bending and compression test in laboratory were firstly performed to examine the characteristics of the Eco-SB displacement meter. Secondly, the numerical analysis was carried out to determine the location of the Eco-SB displacement meter in the ground. Thirdly, after installing the Eco-SB displacement meter periodic monitoring of the retaining wall was performed. By the result, the ground by retaining wall was relatively stable except for the rainfall or rainy season. However the ground was unstable when the water penetrated the ground. Considering the measurement results, bending, tensile and compressive phenomena in the ground as well as the ground condition can be presented by the Eco-SB displacement meter. The ground behavior might be affected by seasonal changes, climate change, temperature and precipitation, and so on. Therefore, it suggests that short and long term monitoring for more accurate analysis is necessary.

Influence of microbial activity on the physical properties and strength of ilmenite and magnetite ores

Taejin Choi,Daehyeon Kim,Bo-An Jang,Seong-Seung Kang 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.6

The influence of microorganisms on the physical properties and strength of ilmenite and magnetite ores was determined in culture studies and laboratory tests of rock parameters such as absorption, porosity, elastic wave velocity, and uniaxial compressive strength. Initial pH condition was determined in the culture experiments, and then abiotic and biotic oxidation tests were performed to determine variations in pH, physical properties, and the strengths of the two ferruginous ore rocks. For ilmenite and magnetite ores, average initial values were, respectively, 0.185% and 0.496% for porosity, 0.046% and 0.123% for absorption, 1919 m/s and 1467 m/s for elastic wave velocity, and 432 MPa and 168 MPa for uniaxial compressive strength. The pH of ilmenite ore at the end of the abiotic and biotic oxidation tests was in the range of 3.82–4.26 and 2.20–2.57, respectively, while that of magnetite ore was 4.02–5.16 and 1.50–1.90, respectively. In magnetite ore, the changes in porosity and absorption due to the biotic oxidation test were larger than those observed in the abiotic oxidation test, while the variations in ilmenite ore due to both tests (abiotic and biotic oxidation) were small. The differences in porosity and absorption between the abiotic and biotic oxidation tests were larger in magnetite ore than in ilmenite ore, while the elastic wave velocity was smaller in magnetite ore than in ilmenite ore. In addition, the variations in uniaxial compressive strength due to the abiotic oxidation test were not significantly different than initial values in both ilmenite and magnetite ores, while variations caused by the biotic oxidation test were relatively large in both ferruginous ore rocks. Our results suggest that variations in the physical properties and strength of ilmenite and magnetite ores are largely dependent on microbial activity.

Multifaceted C-terminus of HSP70-interacting protein regulates tumorigenesis via protein quality control

서진호,Su Yeon Han,Daehyeon Seong,Hyun-Ji Han,Jaewhan Song 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.1

C-terminus of heat shock protein 70 (HSP70)-interacting protein (CHIP) is an E3 ligase involved in a variety of protein homeostasis events implicated in diverse signaling pathways. Its involvement in varied and even opposite signaling circuits might be due to its hallmark signature of associating with molecular chaperones, including HSP90 and HSP70. Together, these proteins may be pivotal in implementing protein quality control. A curious and puzzling aspect of the function of CHIP is its capability to induce protein degradation via the proteasome- or lysosome-dependent pathways. In addition, these pathways are combined with ubiquitin-dependent or -independent pathways. This review focuses on the role of CHIP in the development or suppression of tumorigenesis. CHIP can act as a tumor suppressor by downregulating various oncogenes. CHIP also displays an oncogenic feature involving the inhibition of diverse tumor suppressors, including proteins related to intrinsic and extrinsic apoptotic pathways. The ability of CHIP to exhibit dual roles in determining the fate of cells has not been studied analytically. However, its association with various proteins involved in protein quality control might play a major role. In this review, the mechanistic roles of CHIP in tumor formation based on the regulation of diverse proteins are discussed.

그라우트 재료로서 광물찌꺼기 혼화재의 활용 가능성 평가

김대현,노정두,강성승,Kim, Daehyeon,Noh, Jeongdu,Kang, Seong-Seung 한국암반공학회 2016 터널과지하공간 Vol.26 No.2

전남 해남에 위치한 ${\bigcirc}{\bigcirc}$광산의 광물찌꺼기를 이용하여 그라우트 재료로서의 활용 가능성을 평가하였다. 광물찌꺼기의 광물학적 특성을 살펴보기 위하여 XRD 분석을 실시하였다. 또한 광물찌꺼기와 시멘트를 3가지 비율로 혼합한 그라우트 재료의 물리적 및 역학적 특성을 살펴보기 위하여 양생기간에 따른 흐름도, 탄성파속도, 일축압축강도 시험을 각각 실시하였다. XRD 분석 결과에 의하면 본 광산의 광물찌꺼기는 대부분 석영, 방연석, 황철석 등의 광물들로 구성된 것으로 나타났다. 흐름시험 결과는 광물찌꺼기의 혼합비율이 높아질수록 흐름도가 감소하는 경향을 보였다. 탄성파속도는 흐름도와 마찬가지로 양생기간에 관계없이 광물찌꺼기의 혼합비율이 높아질수록 낮아지는 경향을 보였다. 일축압축강도 및 탄성계수 또한 양생기간에 관계없이 광물찌꺼기 혼합비율이 증가할수록 작아지는 경향을 보였다. 광물찌꺼기를 혼합한 그라우트 주입재의 물리적 및 역학적 특성만을 고려할 때 이들 결괏값은 그라우트 재료로서 충분히 활용 가능성을 가지고 있다고 판단된다. 하지만 광물찌꺼기내에 방연석과 황철석 등 금속광물이 포함되어 있어 지반 내 주입 시 환경오염을 일으킬 수 있으므로 향후 이에 대한 대책방안이 고려되어야 할 것으로 사료된다. The purpose of this study is to evaluate the applicability of tailing in the ${\bigcirc}{\bigcirc}$ mine as a grout material. For the purpose, XRD analysis was performed for mineralogical properties of tailing. In addition, flow, velocity, and uniaxial compressive strength tests were carried out for physical and mechanical properties of a grout material with the mixing ratio of cement and tailing and curing periods. By the result of XRD analysis, tailing of the mine was found to mostly consist of quartz, galena, and pyrite. The flow observed by the flow test showed decreasing tendency with increasing the mixing ratio of tailing. The velocity was also lowered with increasing the mixing ratio of tailing regardless of curing periods. The uniaxial compressive strength as well as Young's modulus also show a tendency to decrease with increasing the mixing ratio of tailing independently on the curing periods. Considering only the physical and mechanical properties of a grout material with tailing, the results are considered to be sufficiently used as a grout material. However, since metallic minerals such as galena and pyrite in tailing contents and these are causing environmental contamination, countermeasures should be considered for this problem in future.

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

Seo, Jinho,Lee, Eun-Woo,Sung, Hyerim,Seong, Daehyeon,Dondelinger, Yves,Shin, Jihye,Jeong, Manhyung,Lee, Hae-Kyung,Kim, Jung-Hoon,Han, Su Yeon,Lee, Cheolju,Seong, Je Kyung,Vandenabeele, Peter,Song, Jae Nature Publishing Group 2016 NATURE CELL BIOLOGY Vol. No.

<P>Receptor-interacting protein kinase 3 (RIPK3) functions as a key regulator of necroptosis. Here, we report that the RIPK3 expression level is negatively regulated by CHIP (carboxyl terminus of Hsp70-interacting protein; also known as STUB1) E3 ligase-mediated ubiquitylation. Chip(-/-) mouse embryonic fibroblasts and CHIP-depleted L929 and HT-29 cells exhibited higher levels of RIPK3 expression, resulting in increased sensitivity to necroptosis induced by TNF (also known as TNF alpha). These phenomena are due to the CHIP-mediated ubiquitylation of RIPK3, which leads to its lysosomal degradation. Interestingly, RIPK1 expression is also negatively regulated by CHIP-mediated ubiquitylation, validating the major role of CHIP in necrosome formation and sensitivity to TNF-mediated necroptosis. Chip(-/-) mice (C57BL/6) exhibit inflammation in the thymus and massive cell death and disintegration in the small intestinal tract, and die within a few weeks after birth. These phenotypes are rescued by crossing with Ripk3(-/-) mice. These results imply that CHIP is a bona fide negative regulator of the RIPK1-RIPK3 necrosome formation leading to desensitization of TNF-mediated necroptosis.</P>

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death

Seo, Jinho,Lee, Eun-Woo,Shin, Jihye,Seong, Daehyeon,Nam, Young Woo,Jeong, Manhyung,Lee, Seon-Hyeong,Lee, Cheolju,Song, Jaewhan Nature Publishing Group 2018 Oncogene Vol. No.