발푸로酸의 小兒癲癎에 對한 治療效果

Coulter, David L.,Wu, Helen,Allen, Richard J. 藥業新聞社 1981 (月刊) 醫藥情報 Vol.1981 No.8

호주 미술치료의 현황과 미술치료사 양성 모형

Annette Coulter 한국미술치료학회 1999 한국미술치료학회 학술발표대회 Vol.6 No.-

주제발표 2

FXR Regulates Intestinal Cancer Stem Cell Proliferation

Fu, Ting,Coulter, Sally,Yoshihara, Eiji,Oh, Tae Gyu,Fang, Sungsoon,Cayabyab, Fritz,Zhu, Qiyun,Zhang, Tong,Leblanc, Mathias,Liu, Sihao,He, Mingxiao,Waizenegger, Wanda,Gasser, Emanuel,Schnabl, Bernd,Atk Elsevier 2019 Cell Vol.176 No.5

<P><B>Summary</B></P> <P>Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant transformations in Lgr5-expressing (Lgr5<SUP>+</SUP>) cancer stem cells and promote an adenoma-to-adenocarcinoma progression. Mechanistically, we show that BAs that antagonize intestinal farnesoid X receptor (FXR) function, including tauro-β-muricholic acid (T-βMCA) and deoxycholic acid (DCA), induce proliferation and DNA damage in Lgr5<SUP>+</SUP> cells. Conversely, selective activation of intestinal FXR can restrict abnormal Lgr5<SUP>+</SUP> cell growth and curtail CRC progression. This unexpected role for FXR in coordinating intestinal self-renewal with BA levels implicates FXR as a potential therapeutic target for CRC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Genetic and dietary risk factors for colorectal cancer converge on the BA-FXR axis </LI> <LI> FXR controls proliferating Lgr5<SUP>+</SUP> intestinal stem cells </LI> <LI> FXR agonists curtail colorectal cancer progression </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>

Dating Violence Among Adolescents: A Review of Empirical Studies

Jang, Si-Won,Coulter, Martha The Korean Society for School Community Health Edu 2008 한국학교지역보건교육학회지 Vol.9 No.2

연구배경: 데이트 폭력은 청소년을 포함한 젊은 인구집단의 신체적, 정신적 건강을 위협하는 중요한 공중보건 문제이다. 친밀한 남녀관계에서 시작되는 데이트 폭력의 위협에 노출되는 시기가 바로 청소년들이 생애주기 상 가장 급격히 발달하면서 많은 변화를 겪는 시기라는 것이 더 민감한 관심을 끈다. 그러나 이 문제 또는 이 문제를 해결하기 위한 노력들의 정도와 심각성을 이해하기 위한 구조적인 노력은 그다지 많이 이루어지지 않았다. 연구목적: 본 연구의 목적은 미국 청소년과 성인 초기 연령집단의 데이트 폭력 예방, 측정 도구, 위험 요인, 이환정도에 대해 지금까지의 관련 연구자료 고찰하여 일반적인 경향을 소개하는데 있다. 연구방법: 1990년부터 2007년까지 발표된 청소년과 성인 초기 인구의 데이트 폭력에 관한 60개의 논문을 검색하여 고찰하였다. 사회과학과 보건과학 관련 연구논문의 검색모듈을 활용하였는데 PsycInfo, Pubmed, 그리고 CINAHL였다. 연구결과: 데이트 폭력의 위험요인은 크게 개인적 요인, 심인적 요인, 가족 요인, 학교 및 친구 집단 요인으로 나뉘어진다. 개인적 요인으로는 자아존중감, 성, 인종, 약물사용, 성상대자 수, 과거 폭력경험이 유의미한 것으로 나타났다. 이 밖의 다른 개인적 요인, 즉 심인적 요인으로는 자기효능감, 식습관, 반사회적 행동 등이 있었다. 가족 요인으로는 가족 구조, 부모 성향이 유의미한 특성들이었으며 이 밖에 학교, 친구, 지역사회의 환경적 요인이 관련 있는 것으로 보고되었다.

Adjuvant-그 분류 및 작용방법에 대한 개관

Cox John C.,Coulter Alan R. 대한수의사회 1997 대한수의사회지 Vol.33 No.11

금세기초부터 갖가지 물질이 vaccine에 가해졌으며, 일정한 처방이 vaccine을 더욱 유효하게 만들기 위해서 고안되고 있다. 많은 선택권에도 불구하고 다만 aluminium 염(鹽)만이 사람용 vaccine adjuvant(면역응답강화물질)로 받아들여지고 있으며, 수의(동물)용 vaccine도 크게 aluminium 염의 사용에 의존하고 있다. 현재 많은 새로운 vaccine들이 개발되고 있으나 vaccine당 구성분의 수를 증가시키고 또한 vaccine 과정에서 요구되는 dose 수를 줄이는 vaccine 접종 schedule을 단순화시키고져 하는 욕구가 대두되고 있다. 이제 더욱 유효한 adjuvant들이 이 욕구를 성취시키기 위해서 요구되는 것이다.

Spot Welding of Aluminum and Cast Iron by Friction Bit Joining

Michael Miles,홍성태,Coulter Woodward,정용하 한국정밀공학회 2013 International Journal of Precision Engineering and Vol.14 No.6

Dissimilar combinations of aluminum alloy A356 and grey cast iron were spot welded by friction bit joining. In order to facilitate bonding, an intermediate layer of interstitial free steel was placed between the aluminum and the cast iron. Welding development resulted in cycle times of approximately 5 seconds, and lap shear fracture loads of up to 6.8 kN.

Sodium Propionate or Sodium Butyrate Promotes Fatty Acid Oxidation in HepG2 Cells Under Oxidative Stress

Kristina J. Cook,Ann Coulter,Michael Keenan,Frank Greenway,Jack N. Losso 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.1

The beneficial effects of sodium butyrate (NaB) and sodium propionate (NaP) on fatty acid oxidation (FAO) genes and production of proinflammatory cytokines related to nonalcoholic fatty liver disease (NAFLD) were evaluated using HepG2 human liver hepatocellular carcinoma cells exposed to palmitate/oleate or lipopolysaccharides (LPSs) as a model. The results showed that NaP or NaB was able to promote FAO, regulate lipolysis, and reduce reactive oxygen species production by significantly increasing the mRNA expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), peroxisome proliferator-activated receptor alpha (PPARα), adipose triglyceride lipase (ATGL), carnitine palmitoyltransferase 1 alpha (CPT1α), fibroblast growth factor 21 (FGF21), and uncoupling protein 2 (UCP2) in HepG2 cells. Together, NaP and NaB may produce greater effects by increasing CPT1α, PPARα, and UCP2 mRNA expression in LPS-treated HepG2 cells and by increasing CPT1α and ATGL mRNA expression in palmitate-/oleate-treated HepG2 cells. Only NaP treatment significantly increased FGF21 mRNA expression in palmitate-/oleate-treated HepG2 cells. The enzyme-linked immunosorbent assay results revealed that only pretreatment with LPSs and not palmitate/oleate significantly increased tumor necrosis factor alpha (TNF-α) expression in HepG2 cells. NaP alone or in combination with NaB significantly decreased TNF-α expression in LPS-induced HepG2 cells. The expression of interleukin-8 in both models showed no significant differences in all treatments. NaP and NaB show potential for in vivo studies on NAFLD.

Dating Violence Among Adolescents : A Review of Empirical Studies

Siwon Jang,Martha Coulter 한국학교・지역보건교육학회 2008 한국학교지역보건교육학회지 Vol.9 No.2

Pushing Coated Conductor Critical Currents Beyond 1 kA per cm Width: Stacks of YBCO Layers

Yehyun Jung,Sheehan, C J,Coulter, J Y,Matias, V,Dojun Youm IEEE 2011 IEEE transactions on applied superconductivity Vol.21 No.3

<P>For a number of superconducting power applications, a high value of the engineering critical current density (<I>Je</I>) for the wire is crucial. The superconducting layer in the coated conductor is typically a small portion of the overall cross-section, so increasing the superconductor fraction will directly result in an increase of <I>Je</I> . However, as the thickness of the superconductor is increased, <I>Jc</I> eventually drops. We describe a way to increase <I>Je</I> by making a stack of superconducting layers using sequential Ion-Beam Assisted Deposition (IBAD)/Superconductor deposition. Reactive Co-Evaporation by Cyclic Deposition and Reaction (RCE-CDR) is used for superconductor. An IBAD-textured layer resets the crystalline structure after each superconducting layer and we use IBAD-MgO for this purpose. However, IBAD-MgO texturing requires an extremely smooth starting surface (about 1 nm root mean square roughness), whereas the YBCO layer is typically 10-100 times rougher. We employ the Solution Deposition Planarization (SDP) process to planarize the rough surface of YBCO. The SDP layer is insulating and it provides for an easy way to separate the superconducting layers electrically. We discuss unique features of the stacking structure that allow for high <I>I</I><SUB>c</SUB>, low ac-losses in applied fields, as well as high <I>Je</I> .</P>

Naringenin Increases Insulin Sensitivity and Metabolic Rate: A Case Study

Navya Murugesan,Kaylee Woodard,Rahul Ramaraju,Frank L. Greenway,Ann A. Coulter,Candida J. Rebello 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.3

Our studies in primary human adipocytes show that naringenin, a citrus flavonoid, increases oxygen consumption rate and gene expression of uncoupling protein 1 (UCP1), glucose transporter type 4, and carnitine palmitoyltransferase 1β (CPT1β). We investigated the safety of naringenin, its effects on metabolic rate, and blood glucose and insulin responses in a single female subject with diabetes. The subject ingested 150 mg naringenin from an extract of whole oranges standardized to 28% naringenin three times/day for 8 weeks, and maintained her usual food intake. Body weight, resting metabolic rate, respiratory quotient, and blood chemistry panel including glucose, insulin, and safety markers were measured at baseline and after 8 weeks. Adverse events were evaluated every 2 weeks. We also examined the involvement of peroxisome proliferator-activated receptor α (PPARα), peroxisome proliferator-activated receptor γ (PPARγ), protein kinase A (PKA), and protein kinase G (PKG) in the response of human adipocytes to naringenin treatment. Compared to baseline, the body weight decreased by 2.3 kg. The metabolic rate peaked at 3.5% above baseline at 1 h, but there was no change in the respiratory quotient. Compared to baseline, insulin decreased by 18%, but the change in glucose was not clinically significant. Other blood safety markers were within their reference ranges, and there were no adverse events. UCP1 and CPT1β mRNA expression was reduced by inhibitors of PPARα and PPARγ, but there was no effect of PKA or PKG inhibition. We conclude that naringenin supplementation is safe in humans, reduces body weight and insulin resistance, and increases metabolic rate by PPARα and PPARγ activation. The effects of naringenin on energy expenditure and insulin sensitivity warrant investigation in a randomized controlled clinical trial.