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RISS 인기검색어
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- 저자 : Chunming Li (검색결과 11 건)
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Association between STAT4 polymorphisms and risk of primary biliary cholangitis: a meta-analysis
Li Zhang,Chunming Gao,Chuanmiao Liu,Jiasheng Chen,Kuihua Xu 한국유전학회 2018 Genes & Genomics Vol.40 No.10
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease. Several studies reported that SATA4 (signal transducer and activator of transcription 4) polymorphisms were significantly associated with PBC susceptibility. In order to derive a more comprehensive estimation of the association between STAT4 and PBC risk, this meta-analysis was conducted. Thirteen eligible studies from 8 articles with a total number of 11,310 cases and 27,844 controls were included in this meta-analysis. Pooled odds ratios (OR) and 95% confidence intervals (CI) were estimated with fixed effects model or random effects model. The results showed statistically significant association between polymorphisms of rs7574865, rs3024921, rs6752770, rs7601754 and rs10168266 in STAT4 and PBC risk under the allelic effect model (rs7574865, T vs. G, OR = 1.24, 95% CI 1.14–1.35; rs3024921, T vs. A, OR = 1.65, 95% CI 1.44–1.91; rs6752770, G vs. A, OR = 1.24, 95% CI 1.11–1.39; rs7601754, A vs. G, OR = 1.35, 95% CI 1.17–1.55; and rs10168266, T vs. C, OR = 1.31, 95% CI 1.22–1.41). Furthermore, the rs7574865 polymorphism was significantly associated with PBC risk under all genotype genetic models (dominant effect model: TT + TG vs. GG, OR = 1.43, 95% CI 1.19–1.71; recessive effect: TT vs. TG + GG, OR = 1.40, 95% CI 1.24–1.58; and co-dominant effect: TT vs. GG, OR = 1.67, 95% CI 1.37–2.02). The sensitivity analysis by omitting one study at a time showed that the results were stable. No publication bias was indicated from both Begg’s test and Egger’s weighted regression. This meta-analysis suggested that polymorphisms of rs7574865, rs3024921, rs6752770, rs7601754 and rs10168266 in STAT4 were significantly associated with the risk of PBC.
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Influence of cleaning modes on the microstructure and performance of 5083 alloy substrate
Yunkai Li,Chunming Wang,Gaoyang Mi 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.9
In this study, the paint layer was removed on the surface of 5083 aluminum alloy using laser cleaning and mechanical grinding. The microstructure and performance of experimental samples were carefully investigated using scanning electron microscope, energy disperse spectroscopy and other methodologies. The results showed that compared with mechanical grinding, laser cleaning can improve the surface paint coating of aluminum alloy more effectively. The surface of the matrix formed uniformly distributed volcanic craters and small holes emerged at the spot junction after laser cleaning. The carbon and oxygen content on the substrate surface after laser cleaning was much lower than that after mechanical grinding. In addition, the corrosion resistance and coating adhesion of the substrate were obviously improved using laser cleaning. It was closely associated with refinement of the grains and reduction in surface roughness. We concluded that laser cleaning can be widely used to replace mechanical grinding in manufacturing on the premise of meeting industrial needs.
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A Novel Multiobjective Optimization Method Based on Improved Artificial Bee Colony Algorithm
Wu Chunming,Li Tingting,Wang Yanjiao 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.3
In order to improve the convergence and diversity of multiobjective optimization algorithms, the harmonic average distance is employed to improve the aggregating function combined L-rank value. Selection model and searching scheme of artificial bee colony algorithm and diversity maintaining scheme are improved in this paper. This novel many objectives optimization method based on improved artificial bee colony algorithm (ABC) in this paper is compared with other three many objectives optimization methods on 3 to 8 objectives DTLZ. Simulation results show that the proposed algorithm is superior to other algorithms in the diversity and convergence of solutions.
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Grafting Effects on Root Activity and Amino Acid Contents in Bleeding Sap of Muskmelon
Tianlai Li,Yifei Liu,Hongyan Qi,Chunming Bai 한국원예학회 2009 Horticulture, Environment, and Biotechnology Vol.50 No.3
The grafting effects on the yield and quality of muskmelon fruits were studied based on the measurements of root activity, acidity, electric conductivity and amino acids of bleeding sap. The results revealed that grafting enhanced significantly the activities of root systems and increased the volume and electric conductivity of bleeding sap in muskmelon during growth period. The fruit yield of grafted plants increased by 9.12%. The amino acids in bleeding sap of self-rooted and grafted muskmelon mainly consisted of threonine and glutamic acid. Grafting decreased significantly the contents of threonine, glutamic acid, cysteine, lysine and NH₃ in bleeding sap in the early and late growth stages, but increased the contents of aspartic acid, threonine, serine, glutamic acid, alanine, valine, isoleucine, leucine, tyrosine, phenylalanine, lysine, histidine and arginine in the middle growth stage. In the late growth stage, the contents of threonine, glutamic acid, cysteine, lysine and arginine in bleeding sap of grafted plants were reduced by 44.88%, 52.45%, 41.67%, 58.62% and 62.61%, respectively. The total amino acid content of self-rooted and grafted muskmelon plants showed the same trend of high-low-high in the whole growth period. In the early and late growth stages, the total amino acid content of self-rooted plants was significantly higher than that of the grafted plants. The increment of total amino acid in self-rooted muskmelon from middle to late growth stage was also greater than that in grafted muskmelon. It is suggested that the nutritional quality of grafted muskmelon fruits might be due to the changes of amino acid supply in bleeding sap.
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Jieqin Li,Yihua Wang,Juntao Chai,Lihua Wang,Chunming Wang,Wuhua Long,Di Wang,Yunlong Wang,Ming Zheng,Cheng Peng,Mei Niu,Jianmin Wan 한국식물학회 2013 Journal of Plant Biology Vol.56 No.5
The nuclear genes involved in chloroplast developmentand chlorophyll biosynthesis must be investigated tounderstand their functions in plant growth and development. In this study, we isolated and identified a unique leaf-colormutant of rice with a green-yellow phenotype before thefour-leaf stage and named the mutation green-revertiblechlorina 1 (grc1). The mutants had significantly lower plantheight, number of tillers, and panicle length and headedsignificantly earlier than the wild type. The levels ofchlorophylls, carotenoids, and chlorophyll precursors werealso lower. The mutation in grc1 affected chloroplastultrastructure, particularly thylakoid development. Geneticanalysis indicated that the green-yellow phenotype wascontrolled by a single recessive gene. We mapped the grc1gene to a 32.4-kb region on the long arm of chromosome 6. Through map-based cloning, we identified a 45-bp insertionin the genomic region of LOC_Os06g40080, which encodeda heme oxygenase. Expression of LOC_Os06g40080 wassignificantly down-regulated in the grc1 mutant. Subcellularlocalization showed that this heme oxygenase was localizedin the chloroplast. In summary, we isolated and identified thegene for grc1, which plays an important role in chlorophyllbiosynthesis and chloroplast development in rice.
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Cong Weixuan,Li Ning,Wang Jinbin,Kang Ying,Miao Yiling,Xu Chunming,Wang Ziqi,Liu Tongtong,Gong Lei,Liu Bao,Ou Xiufang 한국유전학회 2022 Genes & Genomics Vol.44 No.3
Background: Albeit a relatively stable epigenetic modification, DNA methylation in plants can be repatterned and play important roles in response to biotic and abiotic stresses. However, whether DNA methylation dynamics may contribute to cope with mercury (Hg) stress in plants remains to be fully investigated. Objective: To probe the potential roles of DNA methylation dynamics in coping with Hg stress in rice. Methods: Whole-genome bisulfite sequencing was used to profile the DNA methylation patterns of a rice Hg-resistant line (RHg) selected from a heterozygous mutant of the DNA methyltransferase 1 gene (OsMET1+/-), together with its Hg-sensitive wild-type plants of cv. Nipponbare (Nip) under both normal and Hg stress conditions. Results: Genome-wide locus-specific differential methylation regions (DMRs) were detected between RHg and Nip under normal condition, the predominant DMR patterns were CG hypo-DMRs, CHG hypo-DMRs and CHH hyper-DMRs. In both lines, more hyper- than hypo-DMRs were detected at all three sequence contexts (CG, CHG and CHH) under Hg stress relative to normal condition. Comparison of DNA methylation changes in the two lines under Hg stress indicates that RHg had a more dynamic methylome than the control (Nip). Original DMRs in RHg trended to transform to opposite status (from hyper- to hypo- or vice versa) under Hg stress condition. Gene ontology analysis revealed that Hg-resistance-related DMGs were enriched in diverse biological processes. Conclusions: Our results suggest genome-wide locus-specific DNA methylation repatterning can facilitate rapid acquisition of Hg resistance in rice.
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Xiaogang Lu,Zhenghua Lin,Peng Pan,Yunbo Chen,Lingli Zuo,Chunming Li 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.6
WC-10Co-4Cr have been well known material with attractive corrosion resistance and excellent hardness in the WC-basedcoatings. To widen the application of the WC-10Co-4Cr coatings deposited on high-hardness metal cutting tools, theinvestigation of its preparation parameters and properties are required. In this study, dense micro-structured WC-10Co-4Crcoatings deposited on high-hardness M42 steel were performed with high velocity oxy-fuel (HVOF) spray process. Theprepared coatings exhibit excellent properties by improving the size of spray gun and injecting high flow nitrogen into theflame stream. A maximum micro-hardness of 1353.3 HV0.3 was achieved. In addition, the frictional properties of uncoated M42steel and the WC-10Co-4Cr coating were comparably studied under dry sliding wear tests. A low friction coefficient of 0.34-0.37 was achieved for WC-10Co-4Cr coating, showing a 57% decrease than that of uncoated M42 steel. X-ray diffractometrywas used to identify the phase composition, and scanning electron microscopy was adopted to characterize the microstructureof deposited coatings and worn-out surfaces.
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