Current Status of Molecular Diagnosis of Hereditary Hemolytic Anemia in Korea

Chueh Hee Won,Shim Ye Jee,Jung Hye Lim,Kim Namhee,Hwang Sang Mee,Kim Myungshin,Choi Hyoung Soo 대한의학회 2024 Journal of Korean medical science Vol.39 No.18

Hereditary hemolytic anemia (HHA) is considered a group of rare hematological diseases in Korea, primarily because of its unique ethnic characteristics and diagnostic challenges. Recently, the prevalence of HHA has increased in Korea, reflecting the increasing number of international marriages and increased awareness of the disease. In particular, the diagnosis of red blood cell (RBC) enzymopathy experienced a resurgence, given the advances in diagnostic techniques. In 2007, the RBC Disorder Working Party of the Korean Society of Hematology developed the Korean Standard Operating Procedure for the Diagnosis of Hereditary Hemolytic Anemia, which has been continuously updated since then. The latest Korean clinical practice guidelines for diagnosing HHA recommends performing nextgeneration sequencing as a preliminary step before analyzing RBC membrane proteins and enzymes. Recent breakthroughs in molecular genetic testing methods, particularly nextgeneration sequencing, are proving critical in identifying and providing insight into cases of HHA with previously unknown diagnoses. These innovative molecular genetic testing methods have now become important tools for the management and care planning of patients with HHA. This review aims to provide a comprehensive overview of recent advances in molecular genetic testing for the diagnosis of HHA, with particular emphasis on the Korean context.

Role of Balloon Guide Catheter in Modern Endovascular Thrombectomy

Chueh, Ju-Yu,Kang, Dong-Hun,Kim, Byung Moon,Gounis, Matthew J. The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.1

Proximal flow control achieved with a balloon guide catheter (BGC) during endovascular treatment of acute ischemic stroke is reviewed in this article. In clinical practice, BGCs offer a multi-faceted approach for clot retrieval by creating proximal flow arrest, reducing embolic burden, and shortening procedure time. Evaluation of frontline thrombectomy procedures with BGCs revealed advantages of combined use over the conventional guide catheter (CGC), notably in the significant reduction of distal emboli to both the affected and previously unaffected territories. Recently, new measures of early and complete reperfusion at first thrombectomy pass have been identified as independent predictors of improved outcomes, which were consistently demonstrated with use of BGC as a safe and effective option to minimize number of passes during intervention. Prior randomized controlled trials reported the positive correlation between BGC-treated patients and a lower risk of mortality as well as shortened procedure time. While BGC use is more common in stent retriever-mediated mechanical thrombectomy, preliminary data has shown the potential benefit of device application during contact aspiration thrombectomy to achieve successful recanalization. However, the question of which major endovascular strategy reigns superior as a frontline remains to be answered. Along with clinical case assessments, BGC performance during in-vitro simulation was analyzed to further understand mechanisms for optimization of thrombectomy technique.

여성주의 비평가들의 엘리엇(T. S. Eliot) 연구

최영승(Chueh Young-Sung) 새한영어영문학회 2000 새한영어영문학 Vol. No.

One of the most striking aspects of modem literature can be said to be a rising feminism, and feminists have contributed a great deal to our understanding of twentieth century woman writers, but they limit their understanding of both men and women writers by insisting on interminable sexual warfare as an explanation of literary modernism. Especially Sandra M. Gilbert and Susan Gubar among them seem dedicated to perpetuating wars between men and women by criticizing a massive critic T. S. Eliot. In this respect, this thesis aims to show the right way to approach his criticism by studying their methodology to maintain the polarity in his critical writings. Gilbert and Gubar contend that literary history is an exercise designed to retrieve male heroes and that tradition involves an attempt to define and protect the territory of male writers. They also, by using binary logic, devaluate Eliot's critical views on tradition and unified sensibility. But their strategy makes it impossible for them to see the complexity and subtlety of his thoughts. While undermining binary logic, he recovers harmony. He argues in his early philosophical writings that all oppositions and binary sets are unstable, and that fruitfulness is only possible through a combination of masculine and feminine values. Meanwhile Gilbert and Gubar, by polarizing men and women, eliminate all of the complexities in Eliot's literary criticism and completely miss the point of his concept on complementarity, but even though in fact he clearly suggests that unity can be imagined by insisting on difference.

엘리엇(T.S. Eliot)의 시와 극에 나타난 추리 소설적 요소

최영승(Chueh Young-Sung) 새한영어영문학회 2001 새한영어영문학 Vol. No.

This study aims to analyze T. S. Eliot's poetry and plays with a view to bringing out the modem mystery elements which function in them both as a dramatic device and as a theme with religious connotations. While many critics including Frank Wilson and David Jones have written on the plays of T. S. Eliot, only some have discussed these elements, but their analyses are not enough. Therefore, this study attempts to show how far Eliot uses the mystery elements to entertain the audience and at the same time to present his religious themes with an eye on the secular and rationalistic trend of the age. By employing the mystery elements Eliot had taken a significant step towards reviving religious mind in secular theater. In conclusion, Eliot uses the mystery elements to his own purposes. He introduces mystery aspects into some poems of his, where these thriller elements play a basic role in developing his interest in detective stories. In Murder in the Cathedral and the subsequent plays the mystery elements impart greater dramatic interest to the religious themes. The insertion of the crime mystery into his works plays a key role in showing his interest in the popular culture. Murder in the Cathedral is a unique play not only because it is an example of a modem mystery play but also because it illustrates the combination of the religious and the secular, the high and the low, and more specifically the use of mystery elements for the exposition of a serious theme. The Family Reunion nearly completes the pattern of a story of crime and punishment ironically reminding of Dickens and Dostoevsky again which is finally transformed into the drama of sin and expiation. The mysterious guest and his companions in The Cocktail Party who remind of several mystery detectives are finally recognized as symbolic figures who help to unite the estranged couple and dispatch the protagonists on different paths of salvation. In The Confidential Clerk there is some real fun in the thriller type of pursuit and analysis of evidence to explore the identities of an unknown father, whose money was swindled away, and a "true" father who had some connections with the church. In The Elder Statesman Eliot shows consistency in the employment of mystery elements such as hidden "crimes", horror and fear of detection, the evidence, and confession of guilt.

Low-Temperature Growth of Two-Dimensional Layered Materials Toward Phase-Engineered hybrid Films

Yu-Lun Chueh 한국진공학회 2017 한국진공학회 학술발표회초록집 Vol.2017 No.8

Improving Performance and Stability of Polymer and Organic-Inorganic Hybrid Perovskite Solar Cells by Rational Interface Engineering

Chu-Chen Chueh 한국고분자학회 2018 한국고분자학회 학술대회 연구논문 초록집 Vol.43 No.2

Anti-GQ1b 항체 양성을 보인 Mycoplasma pneumoniae 감염에 의한 Miller-Fisher 증후군 1례

최희원(Heewon Chueh),권은영(Eun Young Kwon),신해영(Hye Young Shin),황규근(Kyu Geun Hwang) 대한소아신경학회 2007 대한소아신경학회지 Vol.15 No.2

저자들은 전형적인 외안근 마비와 운동실조, 심부건반사 소실 증상을 보이고 항 GQ1b 항체가 양성으로 측정되면서 선행 감염원으로 Mycoplasma pneumoniae 항체가가 양성으로 증명된 8세 남아의 Miller-Fisher 증후군 1례를 경험하였기에 보고하는 바이다. Miller Fisher syndrome, first reported by Miller Fisher in 1956, is characterized by a triad of external ophthalmoplegia, areflexia, and ataxia. Many features shared with Guillain-Barré syndrome; CSF usually shows elevated proteins and the syndrome is often is preceded by an infectious disorder. It is believed that the level of anti-GQ1b IgG antibody is elevated during an acute phase, increases and decreases rapidly during clinical recovery, that the level of anti-GQ1b IgG can be used as a diagnostic tool for Miller Fisher syndrome during an acute phase. We report an 8 year-old boy who showed typical clinical manifestations of Miller Fisher syndrome, with respiratory tract illness, associated with the seroconversion of Mycoplasma pneumoniae titers during the development of neurological symptom, with positive anti-GQ1b IgG.

엘리엣 시극에 비친 미스테리

최영승(Young-sung Chueh) 한국T.S.엘리엇학회 2000 T.S. 엘리엇 연구 Vol.9 No.-

엘리엇과 재즈 -초기 시와 『투사 스위니』를 중심으로-

최영승 ( Young Sung Chueh ) 21세기영어영문학회 2008 영어영문학21 Vol.21 No.2

엘리엇(T.S. Eliot)의 시와 극에 나타난 추리 소설적 요소

최영승 새한영어영문학회 2001 새한영어영문학 Vol.43 No.1

This study aims to analyze T. S. Eliot's poetry and plays with a view to bringing out the modern mystery elements which function in them both as a dramatic device and as a theme with religious connotations. While many critics including Frank Wilson and David Jones have written on the plays of T. S. Eliot, only some have discussed these elements, but their analyses are not enough. Therefore, this study attempts to show how far Eliot uses the mystery elements to entertain the audience and at the same time to present his religious themes with an eye on the secular and rationalistic trend of the age. By employing the mystery elements Eliot had taken a significant step towards reviving religious mind in secular theater. In conclusion, Eliot uses the mystery elements to his own purposes. He introduces mystery aspects into some poems of his, where these thriller elements play a basic role in developing his interest in detective stories. In Murder in the Cathedral and the subsequent plays the mystery elements impart greater dramatic interest to the religious themes. The insertion of the crime mystery into his works plays a key role in showing his interest in the popular culture. Murder in the Cathedral is a unique play not only because it is an example of a modern mystery play but also because it illustrates the combination of the religious and the secular, the high and the low, and more specifically the use of mystery elements for the exposition of a serious theme. The Family Reunion nearly completes the pattern of a story of crime and punishment ironically reminding of Dickens and Dostoevsky again which is finally transformed into the drama of sin and expiation. The mysterious guest and his companions in The Cocktail Party who remind of several mystery detectives are finally recognized as symbolic figures who help to unite the estranged couple and dispatch the protagonists on different paths of salvation. In The Confidential Clerk there is some real fun in the thriller type of pursuit and analysis of evidence to explore the identities of an unknown father, whose money was swindled away, and a "true" father who had some connections with the church. In The Elder Statesman Eliot shows consistency in the employment of mystery elements such as hidden "crimes", horror and fear of detection, the evidence, and confession of guilt.