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- 저자 : Cheriyan, Mary (검색결과 5 건)
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Effect of certain trimethoxy flavones on paclitaxel - induced peripheral neuropathy in mice
Jagan Nadipelly,Vijaykumar Sayeli,Parimala Kadhirvelu,Jaikumar Shanmugasundaram,Binoy Varghese Cheriyan,Viswanathan Subramanian 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.2
Background: The anti - nociceptive effect of 7, 2′, 3′ – trimethoxy flavone, 7, 2′, 4′ – trimethoxy flavone, 7, 3′, 4′ – trimethoxy flavone and 7, 5, 4′ – trimethoxy flavone against inflammatory, neurogenic and thermal pain in mice was reported earlier. The present study was designed to investigate the effect of the above trimethoxy flavones in amelioration of peripheral neuropathy induced by paclitaxel. Methods: Peripheral neuropathy was induced in mice by administration of a single i.p. dose (10 mg/kg) of paclitaxel. The manifestations of peripheral neuropathy such as tactile allodynia, cold allodynia and thermal hyperalgesia were assessed 24 h later by employing hair aesthesiometer test, acetone bubble test and hot water tail immersion test respectively. Further, the role of inflammatory cytokines like TNF – α, IL - 1β and free radicals in the action of trimethoxy flavones was investigated using in vitro assays. Results: The test compounds dose dependently attenuated paclitaxel - induced tactile allodynia, cold allodynia and thermal hyperalgesia in mice. The test compounds inhibited TNF – α, IL - 1β and free radicals in a concentration dependent manner. Conclusion: The investigated trimethoxy flavones attenuated paclitaxel – induced peripheral neuropathy in mice. The inhibition of cytokines and free radicals in addition to many neuronal mechanisms reported earlier may contribute to this beneficial effect.
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Thulaseedharan, Jissa V.,Malila, Nea,Hakama, Matti,Esmy, Pulikottil O.,Cheriyan, Mary,Swaminathan, Rajaraman,Muwonge, Richard,Sankaranarayanan, Rengaswami Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Background: India shows some of the highest rates of cervical cancer worldwide, and more than 70% of the population is living in rural villages. Prospective cohort studies to determine the risk factors for cervical cancer are very rare from low and medium resource countries. The aim of this study was to quantify the effect of risk factors related to cervical cancer in a rural setting in South India. Material and methods: Sociodemographic and reproductive potential risk factors for cervical cancer were studied using the data from a cohort of 30,958 women who constituted the unscreened control group in a randomised screening trial in Dindigul district, Tamilnadu, India. The analysis was accomplished with the Cox proportional hazard regression model. Results: Women of increasing age (HR=2.4; 95% CI: 1.6, 3.8 in 50-59 vs 30-39), having many pregnancies (HR=7.1; 1.0, 52 in 4+ vs 0) and no education (HR=0.6; 0.2, 0.7 in high vs none) were found to be at significantly increased risk of cervical cancer. Conclusion: This cohort study gives very strong evidence to say that education is the fundamental factor among the sociodemographic and reproductive determinants of cervical cancer in low resource settings. Public awareness through education and improvements in living standards can play an important role in reducing the high incidence of cervical cancer in India. These findings further stress the importance of formulating public health policies aimed at increasing awareness and implementation of cervical cancer screening programmes.
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Monisha Baby,Vijayalakshmi K. Periya,Bhuvaneshwari Soundiraraju,Nisha Balachandran,Suchithra Cheriyan,Santhosh K. Sankaranarayanan,Satheesh Chandran Maniyeri 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.100 No.-
Thermoplastic materials like High Density Polyethylene (HDPE) and Polytetrafluoroethylene (PTFE) arepromising candidates for specialty industry/aerospace sectors considering their exceptional propertiesand lower densities. However, the low surface energy leading to poor wetting and reduced adhesioncurtails the scope of their wide-spread usage. In this work, we report adhesion promoter primers basedon epoxy–catechol with and withoutfluorinated polymer and investigated their adhesion promotionefficiency on low/high surface energy substrates. The rational design of catechol-fluorine-epoxy hybridnetwork, mimicking mussel chemistry enabled a non-destructive surface activating approach resultingin profound adhesion promotion. Thefluorine containing primer could effectively enhance adhesionbetween homo and hetero interfaces of Aluminium/HDPE/PTFE owing to the good interface interactionand could outperform common etching methods. A series of molecular level characterizations togetherwith computational and AFM studies provided evidences for the high degree of interaction of the primerbetween the substrates and epoxy-based adhesives. Bond integrity endurance test using a weight of 10and 20 kg resulted in ‘no fail’ categorization for the primed substrates during the entire 40 days testduration. The catechol-functionalized primers reported here can be a good overreaching approach tokeep non-polar substrates afloat in advanced sectors.
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Sasidharan Nishanth Kumar,Bala Nambisan,B. S. Dileep Kumar,Nisha Girija Vasudevan,Chellapan Mohandas,Vino T. Cheriyan,Ruby John Anto 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
3,5-Dihydroxy-4-isopropylstilbene is a naturalphytoalexin and was first identified as bacterial secondarymetabolites. The aim of this study is to investigate in vitroantioxidant and anticancer activity of 3,5-dihydroxy-4-isopropystilbene purified from the cell free culture filtrateof Bacillus sp. N strain associated with rhabditid entomopathogenicnematode. Antioxidant activity was evaluatedby five separate methods: free radical scavenging, reducingpower assay, chelating effects on ferrous ions, NBTsuperoxide radical scavenging assay and hydroxyl radicalscavenging activity. The stilbene recorded powerful antioxidantactivity at various antioxidant systems in vitro. Thesuperoxide radical scavenging (92.1 %) and hydroxylradical scavenging (83.4 %) activities of the stilbenes at100 lg/ml were higher than the butylated hydroxyanisole,the known antioxidant agent. Anticancer activity of stilbenewas tested against breast cancer (MDAM B-231),cervical cancer (HeLa), lung cancer (A 549), colon cancer (HTL 116) cell lines using MTT method. The induction ofapoptosis was studied by morphological analysis, apoptoticcell staining, caspase 3 activation assay and cell cycleanalysis using flow cytometry. Stilbene induced significantmorphological changes and DNA fragmentation associatedwith apoptosis in HeLa cells. Acridine orange/ethidiumbromide stained cells indicated apoptosis induction bystilbene. Up-regulation of caspase 3 activity was also foundin cells treated with stilbene. Flow cytometry analysisshowed an increase in the percentage of apoptotic cells insub G0 phase (2.4 % in control plates to 11.4 %in 25 lg/mlof stilbene) confirming the stilbene induced apoptosis. Theresults of the present study showed that stilbene demonstrateda strong antioxidant and anticancer effects. Thesesuggest that stilbene may be used as possible naturalantioxidant and anticancer agents to control various humandiseases.
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