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- 저자 : Chengxin Gong (검색결과 2 건)
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Functional mechanisms for diabetic nephropathy-associated genetic variants
Hong Xu,Chengxin Gong,Yonghu Xu,Yongfang Fan,Xingzi Liu,Chaopeng Xiong,Luling He,Changle Liu,Shenqiang Rao,Wen Xiao,Lu Ding,Lan Tang,Fangfang Hu,Mengqi Xiong,Mei Yang,Shangdong Liang 한국유전학회 2016 Genes & Genomics Vol.38 No.7
Diabetic nephropathy (DN) is one of the major complications of diabetes. A tremendous amount of genetic variations have been identified to be associated with DN. However, most of them only generate from statistical associations at the DNA level, generally without direct functional evidence regarding their association mechanisms underlying DN. Based on the publicly available datasets and resources, this study performed integrative analyses (expression quantitative trait loci analysis, differential gene expression analysis and functional prediction analysis) to detect the molecular functional mechanisms underlying the associations for DN. Among 150 selected (P\E-4) genetic associations that were archived in the public databases, two single nucleotide polymorphisms (SNPs) (rs3135377 and rs9469220) have been found to act as cis-effect regulators of the ‘‘identified’’ gene (HLADRA and HLA-DRB1). These eQTL genes have differential expression signals in the DN-associated cell groups. These SNPs were predicted as regulatory sites by utilizing online prediction tools. Our data suggest potential mechanistic links underlying the association between DN and two identified SNPs. These results could help us to have a deeper understanding of the functional relevance of genetic variants with susceptibility to DN, which is useful for pursuit of in-depth validation studies to dissect their involvements and molecular functional mechanisms in DN.
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Monitoring Sluice Health in Vibration by Monocular Digital Photography and a Measurement Robot
Guojian Zhang,Chengxin Yu,Guangli Guo,Long Li,Yongqian Zhao,Huaizhan Li,Yaqiang Gong 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.6
This study uses monocular digital photography and a measurement robot (MDP&MR) to monitor the sluice vibration deformation in the gate lift test and in the sluicing test. The photographing scale transformation and time baseline parallax (PST-TBP) method is proposed in the field of monocular digital photography. Results show that the PST-TBP method improves measurement accuracy slightly. Measurement accuracies on the reference plane were 0.62 pixels (0.40 mm), 0.76 pixels (0.49 mm), and 1.10 pixels (0.71 mm) in the X, Z, and comprehensive-directions, respectively. The PST-TBP method overcomes the limitation that the photographing direction must be perpendicular to the sluice plane when monocular digital photography is used to monitor the sluice. MDP&MR proves an effective method in monitoring the sluice vibration deformation as MDP can be used to monitor the trend of the sluice vibration deformation and the MR allows high-accuracy monitoring of the short periodic deformation of the sluice. They have complementary advantages to achieve better results. Thus, MDP&MR can provide a new way to assess sluice health in vibration.
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