Fixed-time Consensus Tracking for Second-order Leader-follower Multiagent Systems with Nonlinear Dynamics Under Directed Topology

Cong Wang,Cheng-Lin Liu,Yang-Yang Chen,Ya Zhang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.8

In this paper, we address the fixed-time consensus tracking problem of second-order leader-follower multi-agent systems with nonlinear dynamics under directed topology. The consensus tracking algorithm consists of distributed observer and observer-based decentralized controller. The fixed-time distributed observer guarantees that each follower estimates the leader’s state under directed topology within a fixed time, where the upper bound of convergence time is independent on the initial conditions. The fixed-time decentralized controller makes each follower converge to the leader’s state in fixed time via tracking the distributed observer’s state and overcome the nonlinear dynamics without adding linear control terms. Finally, the numerical example is provided to illustrate the effectiveness of the results.

Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population

Yang Sun,Lin Wen,Yi-Yang Luo,Wen-Juan Hu,Hui-Wen Ren,Ye Lv,Cong Zhang,Ping Gao,Li-Na Xuan,Guan-Yu Wang,Cheng-Jie Li,Zhi-Xin Xiang,Zhi-Lin Luan 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.12

Objective Schizophrenia is a complex and devastating psychiatric disorder with a strong genetic background. However, much uncertainty still exists about the role of genetic susceptibility in the pathophysiology of schizophrenia. TEA domain transcription factor 1 (TEAD1) is a transcription factor associated with neurodevelopment and has modulating effects on various nervous system diseases. In the current study, we performed a case–control association study in a Northeast Chinese Han population to explore the characteristics of pathogenic <i>TEAD1</i> polymorphisms and potential association with schizophrenia.Methods We recruited a total of 721 schizophrenia patients and 1,195 healthy controls in this study. The 9 single nucleotide polymorphisms (SNPs) in the gene region of <i>TEAD1</i> were selected and genotyped.Results The genetic association analyses showed that five SNPs (rs12289262, rs6485989, rs4415740, rs7113256, and rs1866709) were significantly different between schizophrenia patients and healthy controls in allele or/and genotype frequencies. After Bonferroni correction, the association of three SNPs (rs4415740, rs7113256, and rs1866709) with schizophrenia were still evident. Haplotype analysis revealed that two strong linkage disequilibrium blocks (rs6485989-rs4415740-rs7113256 and rs16911710-rs12364619-rs1866709) were globally associated with schizophrenia. Four haplotypes (C-C-C and T-T-T, rs6485989-rs4415740-rs7113256; G-T-A and G-T-G, rs16911710-rs12364619-rs1866709) were significantly different between schizophrenia patients and healthy controls.Conclusion The current findings indicated that the human <i>TEAD1</i> gene has a genetic association with schizophrenia in the Chinese Han population and may act as a susceptibility gene for schizophrenia.

R&D activities dispersion and innovation: implications for firms in China

Ying Ying,Yang Liu,Cong Cheng 기술경영경제학회 2016 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.24 No.3

Despite the increasing attention paid to the dispersion of research and development (R&D)activities, scholars have presented opposing arguments with respect to its effects oninnovation output to date. To address this controversy, we conceptualize and empirically testa model that links different dimensions of R&D activities dispersion and innovation output. Moreover, few studies have explicitly addressed R&D activities dispersion among firms inemerging markets. Using a sample of 244 Chinese high-tech firms collected from 2000 to2009, this study aims to determine how firms in developing countries domestically andglobally distribute their activities. The results show that a firm in an emerging market with adecentralized R&D organizational structure with geographically centralized R&D activitieshas better innovation outputs. Moreover, institutional development positively moderates therelationship between the dispersion of R&D activities and innovation performance.

DBOP specifies palea development by suppressing the expansion of the margin of palea in rice

Chun-Hai Shi,Dong-Dong Zeng,Ran Qin,Md. Alamin,Rong Liang,Cheng-Cong Yang,Xiao-Li Jin 한국유전학회 2016 Genes & Genomics Vol.38 No.11

Palea and lemma are grass specific floral organs, and their identities to the typical floral organs in eudicots remains unclear. In the present study, we identified and characterized a defective body of palea (dbop) from ethyl methyl sulfonate mutagenesis lines of Oryza sativa ssp. japonica cv. Nipponbare. The dbop mutant exhibited abnormal palea without the body of palea. By map-based cloning, the DBOP was narrowed down to a 68.9 kb interval on the long arm of chromosome 9. Sequencing result showed that there was G to A substitution and C to A substitution at the 245th and 383rd nucleotide of LOC_Os09g24480 coding sequence region, respectively. DBOP was found allelic to the RETARDED PALEA1 (REP1) gene which encoded a TCP family transcription factor. DBOP/REP1 might specify palea development by suppressing the expansion of the margin of palea.

Expression Characteristics of Proteins of the Insulin-like Growth Factor Axis in Non-small Cell Lung Cancer Patients with Preexisting Type 2 Diabetes Mellitus

Ding, Jing,Tang, Jie,Chen, Xin,Men, Hai-Tao,Luo, Wu-Xia,Du, Yang,Ge, Jun,Li, Cong,Chen, Ye,Cheng, Ke,Qiu, Meng,Liu, Ji-Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression characteristics of proteins in IGF/IR axis in non-small cell lung cancer (NSCLC) cases with preexisting T2DM. Methods: Fifty-five NSCLC patients with preexisting T2DM were retrospectively included and matched by 55 NSCLC without diabetes at a 1:1 ratio. The expression of proteins in IGF/IR axis was detected by immunohistochemical staining. Clinicopathological data were collected to analyze their relationship with the protein expression. Results: Both IGF 1 receptor (IGF-1R) and insulin receptor substrate 2 (IRS-2) showed higher expression in the NSCLC with T2DM group, compared with those without T2DM. The high expression of IGF-1R and IRS-2 were found to be negatively associated with lymph node metastases and T staging in the T2DM group, respectively, and IRS-2 expression was also found more in the subgroup whose T2DM duration was more than 4 years. No difference was detected in the expression of IRS-1, IGF-1, IGF-2, IGFBP3, IR and mTOR between groups with or without T2DM. Conclusion: Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes.

Serum Carbohydrate Antigen 19-9 as an Indicator of Liver Metastasis in Colorectal Carcinoma Cases

Dong, Hang,Tang, Jie,Li, Long-Hao,Ge, Jun,Chen, Xin,Ding, Jing,Men, Hai-Tao,Luo, Wu-Xia,Du, Yang,Li, Cong,Zhao, Feng,Chen, Ye,Cheng, Ke,Liu, Ji-Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Purpose: The liver is the organ to which colorectal carcinomas (CRCs) most commonly metastasize, and surgical resection has been established as the most effective and potentially curative treatment for CRC with liver metastasis (LM). Therefore, surveillance of LM is vital for improvement of prognosis of CRC patients. In this study, we aimed to explore the potential value of carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), and marker enzymes in indicating LM with CRC. Methods: Three groups of eligible patients with metastatic cancers were retrospectively included: CRC patients with LM (CRC-LM) or without LM (CRC-NLM), and non-CRC patients with LM (NCRC-LM). All metastatic lesions were identified by CT or MRI. Data on characteristics of the patients, the primary site, the locations of metastasis, CA 19-9, CEA, and biochemical parameters were collected for analysis. Results: A total of 493 patients were retrospectively included. More alcohol consumption was found in CRC-LM than CRC-NLM. Some biochemical enzymes were found to be significantly higher in groups with LM than without (CRC-LM or NCRC-LM v.s CRC-NLM). Both CEA and CA 19-9 were much higher in CRC-LM than CRC-NLM or NCRC-LM. For CRC patients, CA 19-9, ${\gamma}$-glutamyl transpeptidase, CEA and alcohol consumption were identified as independent factors associated with LM. Conclusion: Our analysis suggested the CA 19-9 might be a potential valuable indicator for LM of CRC in the clinic.