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Effects of incubation pH on the membrane deformation of a single living human red blood cell
Cheng-Can Yao,Zhen-gang Zha 한국물리학회 2007 Current Applied Physics Vol.7 No.s1
(RBC) were studied. A novel multi-dimensional microscope was employed to perform real time, non-invasivein situmeasurementson the cell shape and size, as well as the membrane bending and shearing elastic moduli of the cell. A phase-analysis micro-electropho-resis laser scattering technique was used to measure the surface charge density. It was shown that the incubation pH markedly inuencesthe surface charge density and the membrane elastic properties of the RBCs and thus leads to a change in their morphology anddeformability.
Wang, Cheng-Can(왕성찬),Jang, Youngeun(장영은),Kim, Seok-Jung(김석중),Han, Jin-Tae(한진태) 대한토목학회 2019 대한토목학회논문집 Vol.39 No.2
기존건물의 수직증축시, 추가되는 증축하중을 지지하기 위해서 기초를 보강하는 것은 필수적이다. 일반적으로 기초의 지지력을 증대시키고 침하를 감소시키기 위하여 마이크로파일공법이 널리 활용되고 있다. 본 연구에서는 기존의 마이크로파일에 전단키가 추가된 새로운 형식의 파형마이크로파일을 활용하여 연구를 수행하였다. 유한요소해석법(FEM)을 통해 기초보강시 파형마이크로파일의 하중침하거동과 하중분담율을 평가하였으며, 3가지 길이 다른 일반적인 마이크로파일들의 지지거동과 비교를 통해 보강효과를 확인하였다. 해석 결과, 파형마이크로파일의 지지력과 축강성이 일반 마이크로파일보다 크게 나타났으며, 이는 파형 마이크로파일의 전단키에 의한 효과인 것으로 판단된다. 또한, 수직증축 리모델링 시, 기존하중 대비 20 %의 증축하중이 재하될 때, 파형마이크로파일의 하중분담율이 동일한 길이의 일반 마이크로파일에 비해 약 40 % 증가하였으며, 보강효과는 길이 1~1.5배의 일반적인 마이크로파일보다 우수한 것으로 나타냈다. Micropiles are widely used for foundation underpinning to enhance bearing capacity and reduce settlement of existing foundation. In this study, the main objective is to evaluate underpinning performance of a newly developed micropile called waveform micropile for foundation underpinning during vertical extension. Finite element method (FEM) was used to evaluate the underpinning performance of waveform micropile in terms of load-settlement response of underpinned foundation and load sharing behavior. For comparison, underpinning effects of three conventional micropiles with different lengths were also discussed in this study. Numerical results of load-settlement response for single pile demonstrated that bearing capacity and axial stiffness of waveform micropiles were higher than those of conventional micropiles because of the effect of shear keys of waveform micropiles. When additional loads 20 %, which is according to design loads of the vertical extension, were applied to the underpinned foundation, load sharing capacity of waveform micropile was 40 % higher than conventional micropile at the same size. The waveform micropile also showed better underpinning performance than the conventional micropile of length 1~1.5 times of waveform micropile.
단삼(Salvia miltiorrhiza) 추출물의 암세포 증식 억제 효과에 관한 연구
정국찬(Guo Can Cheng),이지영(Ji-Young Lee),김동청(Dong Chung Kim),서성옥(Sung-Ock Suh),황우익(Woo-Ik Hwang) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.4
본 연구에서는 단삼(Salvia miltiorrhiza)의 추출물이 인체 결장암세포인 HT-29, 간암세포인 HepG2 및 직장암세포인 HRT-18의 증식에 미치는 영향을 in vitro에서 확인하였다. 암세포의 배양액에서 단삼의 수용성 추출물과 에탄올 추출물의 암세포 증식억제효과는 농도에 비례하며 에탄올 추출물에서 더 효과적이었다. 이를 토대로 단삼의 에탄올 추출물의 급성독성, 수명연장 및 고형암형성억제를 살펴보기 위해 in vivo 실험을 하였다. 급성독성실험결과 대조군의 15일째의 평균체중은 32.3 g이었고 실험군은 31.6 g으로 정상적인 상태를 유지하였으며, 흰쥐의 육종암세포인 sarcoma-180를 접종한 mouse의 수명연장실험결과 대조군에 비해 61%의 수명연장 효과가 있음을 관찰하였다. 고형암억제 실험 결과에서도 대조군에 비해 에탄올 추출물 처리군이 35%의 고형암 형성 억제능을 나타내었다.<br/> 따라서 단삼의 에탄올 추출물 중에는 in vitro와 in vivo 실험을 통해 항암활성을 갖는 성분이 존재하며, 이 성분은 유효한 항암제로 개발될 수 있으리라 사료된다. This study was performed to evaluate the antitumor activities of water and ethanol (EtOH) extract of Salvia miltiorrhiza in vitro and in vivo. The proliferation of the human hepatoma (HepG2), rectum cancer (HRT-18) and colon cancer (HT-29) cells was inhibited by administration of extracts in a dose- dependent manner. Particularly, EtOH extract inhibited proliferation of the cells more effectively than water extract did. The morphology of cells induced by EtOH extract was characterized by reduction of cell size and deformation. Oral administration of the EtOH extract (3 mg/head) to tumor-bearing mice inhibited the tumor (sarcoma-180) growth by 35% and prolonged their survival rate by 61%. The EtOH extract was shown to be nontoxic at 37.5 mg/head/day on the acute toxicity test. These studies suggest that the EtOH extract of Salvia miltiorrhiza may have antitumor activity in vitro and in vivo.
Na Li,Can Cui,Yue Cheng,Yanhong Wu,Jianzhong Yin,Wen Shen 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.4
Objective: The study aimed to evaluate the contributions of levator ani muscle (LAM) injury, vesical neck movement, urethral length and mobility, and urethral sphincter dysfunction observed on magnetic resonance imaging (MRI) towards stress urinary incontinence (SUI) after vaginal delivery. Materials and Methods: Fifty primiparous women after 6 months of delivery (15 with SUI and 35 without) and 35 nulliparous as continent controls underwent MRI at rest and Valsalva maneuver. A published levator ani scoring system was used to characterize morphological changes of LAM. The severity of the injury was divided into three categories as none, minor, and major. A series of common parameters including levator plate angle, iliococcygeal angle, and levator hiatus were used to describe the functional conditions of LAM. Urethral mobility was defined based on the rotation of the urethra between Valsalva and rest status. Vesical neck movement was evaluated by its distance to the pubococcygeal line. Urethral sphincter dysfunction was defined as the widening of the proximal urethra and/or funneling at the urethrovesical junction during Valsalva. Results: Primiparous incontinent (PI) women had additional major levator ani defects (33.3% vs. 17.1%) while less minor defects (0.7% vs. 31.4%) than primiparous continent (PC) women. Vesical neck downward movement in PI women was more obvious than PC women (28.5 mm vs. 24.2 mm, p = 0.006). Urethral mobility was more active in primiparous women than in nulliparous continent controls (57.4 vs. 52.4), whereas no difference was observed on urethral mobility in the primiparous group (p = 0.25). Urethral sphincter dysfunction and funneling were present in 80% of PI women versus 22.9% in PC women (p < 0.001). Conclusion: The MRI findings revealed that de novo SUI was associated with major LAM injury, vesical neck downward movement as well as urethral sphincter dysfunction. Vesical neck funneling on sagittal images can be treated as a valuable predictor for SUI. The intervention for the PI should focus on the elevation of vesical neck, rehabilitation of LAM as well as recovery of the urethral sphincter muscle.
Jun Hu,Can Tao,Aining Yuan,Junjie Bao,Qin Cheng,Gewen Xu,Yiping Huang 한국고분자학회 2019 폴리머 Vol.43 No.2
Series of waterborne polyurethanes (WPUs) containing poly(tetra methylene glycol) (PTMG), 4,4-dicyclohexylmethane diisocyanate (HMDI), 2,2-dimethylolpropionic acid (DMPA), 2,2,4-trimethyl-1,3-pentanediol (TMPD), isosorbide (ISO) and ethylenediamine (EDA) were synthesized. The effects of ISO on the structure and properties of WPUs were studied by gel permeation chromatography (GPC), Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), dynamic mechanical analyzer (DMTA), X-ray diffraction (XRD), thermogravimetry (TG), mechanical test, chemical resistance and hardness test. The deconvolution analysis of FTIR of WPUs revealed that the hydrogen bond interaction in the WPUs increased with the increase of ISO content. Furthermore, the degree of microphase separation was increased with the increase of hydrogen bond interaction, which was confirmed by DSC, XRD and DMTA test. The results demonstrated that the addition of ISO can increase the hydrogen bond interaction between the hard and hard segments in WPUs, which improved the mechanical properties of the WPU films. The highest tensile strength was obtained of 59.67 MPa when the content of isosorbide was 10.35 wt%. Moreover, the ISO was helpful to improve the chemical resistance and hardness of the coatings by the comprehensive performance analysis.