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Flat-bottomed design philosophy of Y-typed bifurcations in hydropower stations
Chang-zheng Shi,Yang Wang,He-gao Wu,Qi-ling Zhang,Kai Su 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.57 No.6
The drainage problem in bifurcations causes pecuniary losses when hydropower stations are undergoing periodic overhaul. A new design philosophy for Y-typed bifurcations that are flat-bottomed is proposed. The bottoms of all pipe sections are located at the same level, making drainage due to gravity possible and shortening the draining time. All fundamental curves were determined, and contrastive analysis with a crescent-rib reinforced bifurcation in an actual project was conducted. Feasibility demonstrations were researched including structural characteristics based on finite element modeling and hydraulic characteristics based on computational fluid dynamics. The new bifurcation provided a well-balanced shape and reasonable stress state. It did not worsen the flow characteristics, and the head loss was considered acceptable. The proposed Y-typed bifurcation was shown to be suitable for pumped storage power stations
Shi, Xueliang,Lee, Sangsu,Son, Minjung,Zheng, Bin,Chang, Jingjing,Jing, Linzhi,Huang, Kuo-Wei,Kim, Dongho,Chi, Chunyan The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.67
<P>A pro-aromatic bisphenaleno-thieno[3,2-b]thiophene (BPT-TIPS) was synthesized and compared with an anti-aromatic bisindeno-thieno[3,2-b]thiophene (S2-TIPS). BPT-TIPS showed larger diradical character, stronger absorption, longer excited state lifetime and better redox amphotericity than S2-TIPS.</P>
Liang Shi-Bing,Hou Wen-Bin,Zheng Ruo-Xiang,Liang Chang-Hao,Yan Li-Jiao,Wang Hao-Nan,Cao Hui-Juan,Han Mei,Robinson Nicola,Liu Jian-Ping 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.1
Background: Compound glycyrrhizin injection (CGI) is a preparation with glycyrrhizin as the main active ingredient extracted from licorice. As clinical trials suggest that CGI is effective in improving liver function for acute icteric hepatitis in children (AIHC), this systematic review aimed to evaluate and verify its therapeutic effects and safety. Methods: Six electronic databases were searched from their inception to 15 May 2021. Randomized controlled trials (RCTs) assessing therapeutic effects and safety of CGI for AIHC were included. The risk of bias for each trial was assessed using the Cochrane Risk of Bias Tool 2.0. Primary outcomes were indexes related to liver function, including total bilirubin (TBiL), alanine aminotransferase (ALT) and aspartate transaminase (AST). RevMan 5.4 software was used for data analyses. The certainty of the evidence was assessed using the online GRADEpro tool. Results: Six RCTs involving 608 children were included. The overall bias was assessed as having “high risk of bias” in all trials. All trials compared the combination of CGI and conventional western medicine (CWM) with CWM alone. Regarding the effects of CGI for AIHC, results showed that CGI plus CWM was superior to CWM alone in reducing the levels of TBiL (mean difference (MD) = -8.19 mmol/L, 95% CI -9.86 to -6.53), ALT (MD = -24.09 U/L, 95% CI -30.83 to -17.34) and AST (MD = -18.67 U/L, 95% CI -21.88 to -15.45). No trial reported adverse events. The certainty of the evidence for outcomes were all evaluated as low or very low. Conclusion: CGI may have adjuvant therapeutic effects on improving the liver function of children with AIHC. There is no evidence to determine the safety of CGI for AIHC. As current evidence is weak, further well-designed RCTs are required for verification of the therapeutic effects of CGI. Background: Compound glycyrrhizin injection (CGI) is a preparation with glycyrrhizin as the main active ingredient extracted from licorice. As clinical trials suggest that CGI is effective in improving liver function for acute icteric hepatitis in children (AIHC), this systematic review aimed to evaluate and verify its therapeutic effects and safety. Methods: Six electronic databases were searched from their inception to 15 May 2021. Randomized controlled trials (RCTs) assessing therapeutic effects and safety of CGI for AIHC were included. The risk of bias for each trial was assessed using the Cochrane Risk of Bias Tool 2.0. Primary outcomes were indexes related to liver function, including total bilirubin (TBiL), alanine aminotransferase (ALT) and aspartate transaminase (AST). RevMan 5.4 software was used for data analyses. The certainty of the evidence was assessed using the online GRADEpro tool. Results: Six RCTs involving 608 children were included. The overall bias was assessed as having “high risk of bias” in all trials. All trials compared the combination of CGI and conventional western medicine (CWM) with CWM alone. Regarding the effects of CGI for AIHC, results showed that CGI plus CWM was superior to CWM alone in reducing the levels of TBiL (mean difference (MD) = -8.19 mmol/L, 95% CI -9.86 to -6.53), ALT (MD = -24.09 U/L, 95% CI -30.83 to -17.34) and AST (MD = -18.67 U/L, 95% CI -21.88 to -15.45). No trial reported adverse events. The certainty of the evidence for outcomes were all evaluated as low or very low. Conclusion: CGI may have adjuvant therapeutic effects on improving the liver function of children with AIHC. There is no evidence to determine the safety of CGI for AIHC. As current evidence is weak, further well-designed RCTs are required for verification of the therapeutic effects of CGI.
Ji-Chang Zhou,Yu-Mei Zhu,Zheng Chen,Shan He,Shi-jie Zheng,Jun-luan Mo,Xiao-Li Liu,Chun-mei Gong,Bin Hou,Hui Yang 한국유전학회 2015 Genes & Genomics Vol.37 No.5
Two single nucleotide polymorphisms (SNPs), rs2280788 (-28C[G) and rs2107538 (-403G[A), in the promoter region of chemokine (C–C motif) ligand 5 (CCL5) was reported to be involved in the immunoglobulin E (IgE) expression and IgE-mediated allergic reactions. This study was to investigate the characteristics of total serum IgE level, specific allergen sensitivities and the two SNPs in the allergic skin disease (ASD) patients. ASD patients visiting the dermatological outpatient department of a local hospital were included with certain criteria, and the fasting venous blood was sampled for analysis. Total serum IgE was assayed with an ELISA kit, and 14 kinds of allergen-specific IgE were tested with an allergen screening system. The polymerase chain reaction–restriction fragment length polymorphism method was used to analyze the two SNPs. Among the finally included 437 patients aged from 16 to 85 years, 68.2 % was positive for the total serum IgE, 49.2 % was positive for at least one of the assayed allergen-specific IgE, and 35.0 % was sensitive to house dust mite. In the SNPs analysis, the GG/(GA?AA) ratio and G/A ratio for the -403G[A locus in the male and/or female C45 years subgroup were significantly lower in the total serum IgE positive patients than in the negative patients (P\0.05). Weak linkage disequilibrium was found between -403A and -28C alleles in male subgroups adjusted by age. Conclusively, house dust mite was the most common allergen in ASD patients, and -403A allele of CCL5 promoter was a risk factor for IgE-mediated sensitization.
Jin-Hong Yu,Chang-Zheng Shi,He-Gao Wu,Zhu Ma 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.12
Large-diameter buried steel pipes (BSPs) play critical roles in water transport for major water diversion and hydropower projects. Due to poor pipe-soil composite system properties and installation conditions, they are prone to excessive deformation, resulting in safety hazards. This paper takes a BSP project subjected to excessive deformation as an example. A simplified numerical model is first established to analyze the structural performance, including the stress and plasticity, and the relationship between the stress and deformation of the pipe. Furthermore, a jacking method to rehabilitate the pipe-soil composite system is conducted to explore its influences on pipe deformation, stress, and plasticity. The results show that considerable bending stresses occur in the pipe and that sections of the midspan and stiffening ring are in the pure bending state and eccentric bending state, respectively. Areas of high stress and plasticity center at the crown, springline, and invert of the pipe, and steel pipes with ring deformation of 8.9% can be continued to be used, as the full yielding of the pipe walls occurs at the ring deformation of 15.8%. The jacking method is an effective solution for the rehabilitation of BSPs subjected to large deformation and can reduce pipe deformation significantly while increasing the stress at the pipe crown and the pipe plasticity only slightly.
Regional Difference of Inflammatory Acne Lesions According to β-Defensin-2 Expression
Choi, Dae Kyoung,Li, Zheng Jun,Chang, In Kyu,Sohn, Kyung Cheol,Lee, Young,Seo, Young Joon,Lee, Young Ho,Shi, Ge,Kim, Chang Deok,Lee, Jeung Hoon,Im, Myung The Society for Investigative Dermatology, Inc 2014 The Journal of investigative dermatology Vol.134 No.7
Pipe-Soil Interaction and Sensitivity Study of Large-Diameter Buried Steel Pipes
He-Gao Wu,Jin-Hong Yu,Chang-Zheng Shi,Zhu Ma 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.3
Large-diameter buried steel pipes (BSPs) have been widely utilized in water diversion and hydropower fields. This paper presents a comprehensive numerical investigation on the interaction between the large-diameter pipe and soil under three typical working conditions, to capture the structural mechanical behaviors of pipe deformation, soil displacement, and soil pressure. Furthermore, a parametric analysis of pipe diameter is conducted, along with the sensitivity study of soil parameters based on the orthogonal test method. The results show that the water weight increases the pipe deformation significantly by 14%, while the high internal water pressure decreases the deformation greatly with the maximum effect of 39%. The pattern of soil pressure at the top of the pipe changes from parabola to double-hump as the pipe diameter varies from 0.5 m to 5.0 m. The pipe deformation and soil pressure keep increasing with the pipe diameter, but the safety margin for prism load decreases gradually. Pipe deformation and soil pressure are very sensitive to the elastic modulus and Poisson's ratio of backfill. Friction coefficients of soil-soil (trench sidewall) and pipe-soil have great influences on the soil pressure, while the bedding material and backfill cohesion have small effects on it.
Fan, Fang-Tian,Shen, Cun-Si,Tao, Li,Tian, Chao,Liu, Zhao-Guo,Zhu, Zhi-Jie,Liu, Yu-Ping,Pei, Chang-Song,Wu, Hong-Yan,Zhang, Lei,Wang, Ai-Yun,Zheng, Shi-Zhong,Huang, Shi-Le,Lu, Yin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Pyruvate kinase isozyme type M2 (PKM2) was first found in hepatocellular carcinoma (HCC), and its expression has been thought to correlate with prognosis. A large number of studies have demonstrated that epithelial-mesenchymal transition (EMT) is a crucial event in hepatocellular carcinoma (HCC) and associated metastasis, resulting in enhanced malignancy of HCC. However, the roles of PKM2 in HCC EMT and metastasis remain largely unknown. The present study aimed to determine the effects of PKM2 in EGF-induced HCC EMT and elucidate the molecular mechanisms in vitro. Our results showed that EGF promoted EMT in HCC cell lines as evidenced by altered morphology, expression of EMT-associated markers, and enhanced invasion capacity. Furthermore, the present study also revealed that nuclear translocation of PKM2, which is regulated by the ERK pathway, regulated ${\beta}$-catenin-TCF/LEF-1 transcriptional activity and associated EMT in HCC cell lines. These discoveries provide evidence of novel roles of PKM2 in the progression of HCC and potential therapeutic target for advanced cases.