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Cellular behavior controlled by bio-inspired and geometry-tunable nanohairs
Heo, Chaejeong,Jeong, Chanho,Im, Hyeon Seong,Kim, Jong Uk,Woo, Juhyun,Lee, Ji Yeon,Park, Byeonghak,Suh, Minah,Kim, Tae-il Royal Society of Chemistry 2017 Nanoscale Vol.9 No.45
<P>A cicada wing has a biocidal feature of rupturing the membrane of cells, while the cactus spine can transmit a water drop to the stem of the plant. Both of these properties have evolved from their respective unique structures. Here, we endeavor to develop geometry-controllable nanohairs that mimic the cicada‘s wing-like vertical hairs and the cactus spine-like stooped hairs, and to quantitatively characterize the cell migration behavior of the hairy structures. It was found that the neuroblastoma cells are highly sensitive to the variation of surfaces: flat, vertical, and stooped nanohairs (100 nm diameter and 900 nm height). The cells on the vertical hairs showed significantly decreased proliferation. It was found that the behavior of cells cultured on stooped nanohairs is strongly influenced by the direction of the stooped pattern of hairs when we quantitatively measured the migration of cells on flat, vertical, and stooped structures. However, the cells on the flat structures showed random movement and the cells on the vertical nanohairs restricted the nanohair movement. Cells on the stooped structure showed higher forward migration preference compared to that of the other structures. Furthermore, we found that these cellular behaviors on the different patterns of nanohairs were affected by intracellular actin flament change. Consistent with these results, the vertical and stooped structures can facilitate the control of cell viability and guide directional migration for biomedical applications such as organogenesis.</P>
Heo, Chaejeong,Lee, Si Young,Jo, Areum,Jung, Susie,Suh, Minah,Lee, Young Hee American Chemical Society 2013 ACS NANO Vol.7 No.6
<P>Enhancing cerebral blood volume (CBV) of a targeted area without causing side effects is a primary strategy for treating cerebral hypoperfusion. Here, we report a new nonpharmaceutical and nonvascular surgical method to increase CBV. A flexible, transparent, and skin-like biocompatible graphene electrical field stimulator was placed directly onto the cortical brain, and a noncontact electric field was applied at a specific local blood vessel. Effective CBV increases in the blood vessels of mouse brains were directly observed from <I>in vivo</I> optical recordings of intrinsic signal imaging. The CBV was significantly increased in arteries of the stimulated area, but neither tissue damage nor unnecessary neuronal activation was observed. No transient hypoxia was observed. This technique provides a new method to treat cerebral blood circulation deficiencies at local vessels and can be applied to brain regeneration and rehabilitation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-6/nn305884w/production/images/medium/nn-2012-05884w_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn305884w'>ACS Electronic Supporting Info</A></P>
( Intae Kim ),( Chaejeong Park ),( Taehyon Choi ) 한국행정학회 2022 한국행정학회 학술발표논문집 Vol.2022 No.2
For explaining the mechanism of policy actors' behavioral change, the narrative policy framework (NPF) has shed light on the persuasive role of narratives on individuals’ attitudes, Although narrative transportation is a key to understanding the power of narratives, little is known about the psychological mechanisms of policy actors and how to craft a compelling narrative that is able to induce them to act. The purpose of this study is to contribute a micro-level NPF analysis by introducing the concept of psychological threshold that can capture the process by which a policy actor's intention, exposed to narratives, becomes actual policy-related action in the NPF. Relying on psychological models of human intention and behavior, we make the assumption that the psychological threshold in mind that exists between them may cause discontinuous actions. By applying the concept to the existing rooms of the NPF-constructing persuasive narratives and narrative deployment strategies-we propose theoretical implications for future research projects.
( Intae Kim ),( Chaejeong Park ),( Taehyon Choi ) 한국정책학회 2023 한국정책학회 학술대회 Vol.2023 No.-
The narrative policy framework (NPF) has shed light on the persuasive role of narratives on individuals’ policy communication. Specifically, narrative transportation is key to understanding the power of narratives, and scholars have been interested in what affects effective narrative transportation. For one thing, the NPF literature tends to assume a smooth transition from decision to action, and there has been little discussion about the psychological mechanisms that produce dramatic changes in perception and action. Considering that in narratology a dramatic psychological and behavioral change plays a central role to enhance the audience’s immersive experience, we may benefit from adopting a concept of threshold in mind when policy actors turn their intention and action in a discontinuous rather than continuous manner. The purpose of this study is to contribute to the sophistication of the micro-level NPF analysis by introducing the concept of psychological threshold that can capture the discontinuous process of human perception and behavior. Relying on the psychological models of human intention and behavior, as well as the framework from the narratology with regard to character and plot, we propose that the concept of psychological threshold well fits the NPF and can expand it by applying the concept into the construction of persuasive policy narratives.
Human mini-blood–brain barrier models for biomedical neuroscience research: a review
Minh Tran,Heo Chaejeong,Lee Luke P.,조한상 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
The human blood–brain barrier (BBB) is a unique multicellular structure that is in critical demand for fundamental neuroscience studies and therapeutic evaluation. Despite substantial achievements in creating in vitro human BBB platforms, challenges in generating specifics of physiopathological relevance are viewed as impediments to the establishment of in vitro models. In this review, we provide insight into the development and deployment of in vitro BBB models that allow investigation of the physiology and pathology of neurological therapeutic avenues. First, we highlight the critical components, including cell sources, biomaterial glue collections, and engineering techniques to reconstruct a miniaturized human BBB. Second, we describe recent breakthroughs in human mini-BBBs for investigating biological mechanisms in neurology. Finally, we discuss the application of human mini-BBBs to medical approaches. This review provides strategies for understanding neurological diseases, a validation model for drug discovery, and a potential approach for generating personalized medicine.