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        Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm

        Ding Sheng-Long,Zhang Tai-Wei,Zhang Qi-Chen,Ding Wang,Li Ze-Fang,Han Guan-Jie,Bai Jin-Song,Li Xi-Lei,Dong Jian,Wang Hui-Ren,Jiang Li-Bo 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

        Night shift workers with disordered rhythmic mechanical loading are more prone to intervertebral disc degeneration (IDD). Our results showed that circadian rhythm (CR) was dampened in degenerated and aged NP cells. Long-term environmental CR disruption promoted IDD in rats. Excessive mechanical strain disrupted the CR and inhibited the expression of core clock proteins. The inhibitory effect of mechanical loading on the expression of extracellular matrix genes could be reversed by BMAL1 overexpression in NP cells. The Rho/ROCK pathway was demonstrated to mediate the effect of mechanical stimulation on CR. Prolonged mechanical loading for 12 months affected intrinsic CR genes and induced IDD in a model of upright posture in a normal environment. Unexpectedly, mechanical loading further accelerated the IDD in an Light-Dark (LD) cycle-disrupted environment. These results indicated that intrinsic CR disruption might be a mechanism involved in overloading-induced IDD and a potential drug target for night shift workers.

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        서비스디자인 개선을 위한 사례분석

        딩즈보(Zhi-Bo Ding),송승근(Seung-Keun Song) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.11

        본 연구는 해외 관광객들의 문화욕구를 분석하고 감천문화마을에서 제공할 수 있는 문화 서비스 요소를 조사하여 문화 서비스를 개선하는 구체적인 방책을 제시하고 궁극적으로 감천문화마을을 우수한 국제 관광 문화 브랜드를 육성하는 것을 목적으로 한다. 외국관광객들의 문화욕구가 무엇인지 알아보기 위해 도시 재생이 진행된 곳 가운데 감천문화마을을 대상으로 사례 연구를 수행하였다. 연구수행 기간은 4개월이었으며 6개국 외국관광객을 대상으로 문헌조사, 인터뷰, 참여관찰을 통해 기초자료를 수집하였다. 자료 분석은 도시재생, 문화욕구, 서비스 디자인 이론을 토대로 내용분석을 실시하였다. 본 연구는 감천문화마을의 5가지 문화 서비스 목표를 제시하였다. 첫째, 현지 특색문화의 전시 및 홍보, 둘째, 문화상품의 개발과 판매, 셋째, 좋은 관광이미지 부각, 넷째, 특이한 먹거리 제공, 다섯째, 문화체험 최적화이다. 본 연구를 통해 감천문화마을에 대한 문화서비스 향상에 도움을 줄 것으로 기대된다. The purpose of this study is to analyze the cultural needs of foreign tourists, to investigate the cultural service elements that can be provided in ‘Gamcheon Culture Village’, to suggest concrete policy to improve cultural services, and ultimately to cultivate excellent international tourism culture brands in ‘Gamcheon Culture Village’. In order to find out the cultural needs of foreign tourists, we conducted a case study on ‘Gamcheon Culture Village’ among the places where the urban regeneration proceeded. The study period was four months, and basic data were collected from foreign tourists from six countries through literature reviews, interviews and participation observation. Analysis of data was based on urban regeneration, cultural desire and service design theory, and we conducted content analysis. This study presented five cultural service goals of ‘Gamcheon Culture Village’. First, it displays and promotes local characteristic culture. Second, it develops and sells cultural products. Third, it brings up a good tourist image. Fourth, it provides an unusual food. Fifth, cultural experience optimization. Through this study, it is expected to help improve the cultural service of ‘Gamcheon Culture Village’.

      • Mobile sand barriers for windblown sand mitigation: Effects of plane layout and included angle

        Li Gao,Jian-jun Cheng,Bo-song Ding,Jia Lei,Yuan-feng An,Ben-teng Ma 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.34 No.3

        Mobile sand barriers are a new type sand-retaining structure that can be moved and arranged according to the engineering demands of sand control. When only used for sand trapping, mobile sand barriers could be arranged in single row. For the dual purposes of sand trapping and sand stabilization, four rows of mobile sand barriers can be arranged in a staggered form. To reveal the effect of plane layout, the included angle between sand barrier direction and wind direction on the characteristics of flow fields and the sand control laws of mobile sand barriers, numerical computations and wind tunnel tests were conducted. The results showed that inflows deflected after passing through staggered arrangement sand barriers due to changes in included angle, and the sand barrier combination exerted successive wind resistance and group blocking effects. An analysis of wind resistance efficiency revealed that the effective protection length of staggered arrangement sand barriers approximately ranged from the sand barrier to 10H on the leeward side (H is sand barrier height), and that the effective protection length of single row sand barriers roughly ranged from 1H on the windward side to 20H on the leeward side. The distribution of sand deposit indicated that the sand interception increased with increasing included angle in staggered arrangement. The wind-breaking and sand-trapping effects were optimal when included angle between sand barrier direction and wind direction is 60°-90°.

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