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Synthesis of Ibuprofen Conjugated Molecular Transporter Capable of Enhanced Brain Penetration
Biswas, Goutam,Kim, Wanil,Kim, Kyong-Tai,Cho, Junhwi,Jeong, Dongjun,Song, Keon-Hyoung,Im, Jungkyun Hindawi Limited 2017 Journal of chemistry Vol.2017 No.-
<P>Based on the strong evidences between inflammation and neurodegeneration, nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are considered as effective agents to reduce the risk of Alzheimer’s and Parkinson’s disease. However, the clinical use of NSAIDs in these diseases is limited by low brain distribution. In this study, we had synthesized ibuprofen conjugate which has good brain penetration.<I> S</I>-(+)-Ibuprofen was covalently attached to a molecular transporter having FITC and eight terminal guanidine groups. This conjugate showed good cellular uptake property in live cells. It was also injected into a mouse and the distribution of the compound was examined in each organ. The conjugate was well delivered to mouse brain indicating the conjugate is able to cross the blood-brain barrier. Our novel synthetic ibuprofen conjugate will hopefully deliver other NSAIDs into brain and is therefore applicable to the neurodegenerative diseases treatment or prevention.</P>
Effect of Vitamin E on Production Performance and Egg Quality Traits in Indian Native Kadaknath Hen
Biswas, Avishek,Mohan, J.,Sastry, K.V.H. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.3
This experiment investigated the effects of increasing dietary vitamin E (VE) on production performance and egg quality traits of Indian reared Kadaknath (KN) hens. One hundred and eighty (180), day old female KN chicks were randomly distributed to three dietary treatment groups for a period of 30 weeks. Each treatment comprised three replicates, each containing 20 chicks. The basal diet ($T_1$) contained 15 IU VE/kg and the two experimental diets were supplemented with 150 and 300 IU VE/kg (diets $T_2$ and $T_3$, respectively). DL-${\alpha}$-tocopherol acetate was used as the source of VE. All chicks were provided feed and water ad libitum. Production performance in terms of body weight, egg weight and hatchability did not differ significantly (p>0.05), whereas sexual maturity, egg production and fertility differed significantly (p<0.05) in $T_2$ compared to the other two groups. Egg quality traits in terms of albumin weight, yolk weight, shell thickness, albumin index and yolk index did not differ significantly (p>0.05), whereas the Haugh unit score was significantly higher (p<0.05) in $T_2$ than the control ($T_1$) and high dose treatment group ($T_3$). From this study, it can be concluded that lower levels of dietary VE may be beneficial for production performance and Haugh unit score but have no effect on egg quality traits in Indian reared KN hens.
CHICKEN MYCOPLASMOSIS IN BANGLADESH
Biswas, H.R.,Khatun, H.,Mustafa, A.H.M.,Miah, A.H.,Hoque, M.M.,Rahman, M.L. Asian Australasian Association of Animal Productio 1993 Animal Bioscience Vol.6 No.2
A total of 4,800 chicken sera from Broiler, Layer, and Local chicken were tested to detect the presence of Mycoplasma gallisepticum (Mg) antibody by Rapid Serum Plate and Tube Agglutination Test. Positive cases recorded in this study were 945 (27%) in Broiler, and 436 (36.7%) in layer chicken sera and no. M. gallisepticum antibody could be seen in the local chicken sera. It is evident from the present findings that Mycoplasma gallisepticum infection has been prevailing in this country in improve breeds of chickens.
Dark-photon searches via Higgs-boson production at the LHC
Biswas, Sanjoy,Gabrielli, Emidio,Heikinheimo, Matti,Mele, Barbara American Physical Society 2016 Physical review. D Vol.93 No.9
<P>Dark photons (gamma) over bar mediating long-range forces in a dark sector are predicted by various new physics scenarios, and are being intensively searched for in experiments. We extend a previous study of a new discovery process for dark photons proceeding via Higgs-boson production at the LHC. Thanks to the nondecoupling properties of the Higgs boson, BR(H ->gamma(gamma) over bar) values up to a few percent are possible for a massless dark photon, even for heavy dark-sector scenarios. The corresponding signature consists (for a Higgs boson at rest) of a striking monochromatic photon with energy E-gamma = m(H)/2, and a similar amount of missing energy. We perform a model-independent analysis at the LHC of both the gluon-fusion and vector-boson fusion (VBF) Higgs production mechanisms at 14 TeV, including parton-shower effects, and updating our previous parton-level analysis at 8 TeV in the gluon-fusion channel by a more realistic background modeling. We find that a 5 sigma sensitivity can be reached in the gluon-fusion channel for BR(H ->gamma(gamma) over bar) similar or equal to 0.1% with an integrated luminosity of L similar or equal to 300 fb(-1). The corresponding VBF reach is instead restricted to 1%. Such decay rates can be naturally obtained in dark-photon scenarios arising from unbroken U(1)(F) models explaining the origin and hierarchy of the Yukawa couplings, strongly motivating the search for this exotic Higgs decay at the LHC.</P>
Biswas, Tanmay The Kangwon-Kyungki Mathematical Society 2018 한국수학논문집 Vol.26 No.1
The main aim of this paper is to prove some results related to the growth rates of composite entire and meromorphic functions on the basis of their relative (p, q)-th order, relative (p, q)-th lower order, relative (p, q)-th type and relative (p, q)-th weak type where p and q are any two positive integers.
Biswas, M.,An, H.,Choi, S.M.,Son, J.W.,Lee, J.H.,Kim, B.K.,Lee, H.W.,Yoon, K.J. Ceramurgica ; Elsevier Science Ltd 2016 CERAMICS INTERNATIONAL Vol.42 No.8
The major barrier to the practical application of Ba(Zr,Y)O<SUB>3</SUB> (BZY) as an electrolyte material for proton-conducting fuel cells (PCFCs) lies in its extremely inferior sintering characteristics. In this research, flux composed of 28mol% BaO and 72mol% CuO was employed as a novel sintering aid for BZY. Incorporation of nano-crystalline BaO-CuO flux, with a eutectic point of 890<SUP>o</SUP>C, remarkably enhanced the sintering behavior of BZY due to the formation of a transient liquid phase, and a relative density of up to 97% of the theoretical density was obtained at 1300<SUP>o</SUP>C with a short soaking time of 2h.
Biswas, Tanmay The Honam Mathematical Society 2019 호남수학학술지 Vol.41 No.3
In the paper we establish some new results depending on the comparative growth properties of composite entire and meromorphic functions using relative (p, q, t)L-th order and relative (p, q, t)L-th type of entire and meromorphic function with respect to another entire function.
Biswas Arunangshu,Pradhan Oishika,Thati Anand,Mukherjee Debdyuti,Sau Tapan K.,Roy Chowdhury Shubhajit 한국물리학회 2022 Current Applied Physics Vol.44 No.-
The article presents a combined theoretical and experimental study attempting to show how Pd nanoparticles (NPs) loading onto SnO2 substrate improves the acetone gas sensing performance. Pristine nanostructured SnO2 and Pd nanoparticles (Pd NPs) loaded SnO2 substrates have been prepared, characterized, and their acetone sensing performances have been measured. Experimental measurements have shown that Pd NP loading onto SnO2 suppresses the interfering effects of ethanol, water vapors, etc., and enhances the acetone sensor response, reversibility, response/recovery speeds, and signal-to-noise ratio. Various parameters like the adsorption energy, HOMO–LUMO energy gap, charge distribution, polarizability change, electrophilicity index, global hardness, etc., of several model systems, have been computed by using DFT. The computed parameters have been correlated with the conductivity, local reactivity, sensor response and selectivity, response/recovery times, etc., of the systems to understand the molecular-level effects of the Pd NP loading onto the SnO2 on the gas sensing process.
Thermal Evolution of BaO-CuO Flux as Sintering Aid for Proton Conducting Ceramic Fuel Cells
Biswas, Mridula,Hong, Jongsup,Kim, Hyoungchul,Son, Ji-Won,Lee, Jong-Ho,Kim, Byung-Kook,Lee, Hae-Weon,Yoon, Kyung Joong The Korean Ceramic Society 2016 한국세라믹학회지 Vol.53 No.5
The eutectic melt of BaO-CuO flux is known to be a potential sintering aid for $Ba(Zr,Y)O_3$ (BZY) electrolyte for proton-conducting ceramic fuel cells (PCFCs). A density of BZY higher than 97% of theoretical density can be achieved via sintering at $1300^{\circ}C$ for 2 h using a flux composed of 28 mol% BaO and 72 mol% CuO. In the present study, chemical and structural evolution of BaO-CuO flux throughout the sintering process was investigated. An intermediate holding step at $1100^{\circ}C$ leads to formation of various impurity compounds such as $BaCuO_{1.977}$, $Ba_{0.92}Cu_{1.06}O_{2.28}$ and $Cu_{16}O_{14.15}$, which exhibit significantly larger unit cell volumes than the matrix. The presence of such secondary compounds with large lattice mismatch can potentially lead to mechanical failure. On the other hand, direct heating to the final sintering temperature produced CuO and $Cu_2O$ as secondary phases, whose unit cell volumes are close to that of the matrix. Therefore, the final composition of the flux is strongly affected by the thermal history, and a proper sintering schedule should be used to obtain the desired properties of the final product.