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Treatment of Osteoporosis: Unmet Needs and Emerging Solutions
Bente Lomholt Langdahl,Jane Dahl Andersen 대한골대사학회 2018 대한골대사학회지 Vol.25 No.3
Efficient therapies are available for the treatment of osteoporosis, however, there are still unmet needs. Anti-resorptive therapies only increase bone mineral density to a certain extent and reduce the risk of non-vertebral fractures by 20%, only one anabolic option is available in most parts of the world –the effect of which levels off over time, and the evidence for combination therapy targeting both resorption and formation is limited. In addition, identification and treatment of patients with high and imminent fracture risk following a recent fracture and long-term adherence to treatment are 2 other very prominent challenges to the management of osteoporosis. The current review will focus on emerging osteoporosis treatments and optimized use of the existing treatments that may help overcome the currently unmet needs in the management of osteoporosis.
Modeling of coupled THMC processes in porous media
Kowalsky, Ursula,Bente, Sonja,Dinkler, Dieter Techno-Press 2014 Coupled systems mechanics Vol.3 No.1
For landfill monitoring and aftercare, long-term prognoses of emission and deformation behaviour are required. Landfills may be considered as heterogeneous porous soil-like structures, in which flow and transport processes of gases and liquids interact with local material degradation and mechanical deformation of the solid skeleton. Therefore, in the framework of continuous porous media mechanics a model is developed that permits the investigation of coupled mechanical, hydraulical and biochemical processes in municipal solid waste landfills.
Skeletal Fragility in Type 2 Diabetes Mellitus
Jakob Starup-Linde,Katrine Hygum,Bente Lomholt Langdahl 대한내분비학회 2018 Endocrinology and metabolism Vol.33 No.3
Type 2 diabetes (T2D) is associated with an increased risk of fracture, which has been reported in several epidemiological studies. However, bone mineral density in T2D is increased and underestimates the fracture risk. Common risk factors for fracture do notfully explain the increased fracture risk observed in patients with T2D. We propose that the pathogenesis of increased fracture risk inT2D is due to low bone turnover caused by osteocyte dysfunction resulting in bone microcracks and fractures. Increased levels ofsclerostin may mediate the low bone turnover and may be a novel marker of increased fracture risk, although further research isneeded. An impaired incretin response in T2D may also affect bone turnover. Accumulation of advanced glycosylation endproductsmay also impair bone strength. Concerning antidiabetic medication, the glitazones are detrimental to bone health and associated withincreased fracture risk, and the sulphonylureas may increase fracture risk by causing hypoglycemia. So far, the results on the effectof other antidiabetics are ambiguous. No specific guideline for the management of bone disease in T2D is available and current evidenceon the effects of antiosteoporotic medication in T2D is sparse. The aim of this review is to collate current evidence of thepathogenesis, detection and treatment of diabetic bone disease.
Herrero, Maria-Luz,Brurberg, May Bente,Ojeda, Dario I.,Roleda, Michael Y. The Korean Society of Phycology 2020 ALGAE Vol.35 No.1
Pythium species are ubiquitous organisms known to be pathogens to terrestrial plants and marine algae. While several Pythium species (hereafter, Pythium) are described as pathogens to marine red algae, little is known about the pathogenicity of Pythium on marine green algae. A strain of a Pythium was isolated from a taxonomically unresolved filamentous Ulva collected in an intertidal area of Oslo fjord. Its pathogenicity to a euryhaline Ulva intestinalis collected in the same area was subsequently tested under salinities of 0, 15, and 30 parts per thousand (ppt). The Pythium isolate readily infected U. intestinalis and decimated the filaments at 0 ppt. Mycelium survived on U. intestinalis filaments for at least 2 weeks at 15 and 30 ppt, but the infection did not progress. Sporulation was not observed in the infected algal filaments at any salinity. Conversely, Pythium sporulated on infected grass pieces at 0, 15, and 30 ppt. High salinity retarded sporulation, but did not prevent it. Our Pythium isolate produced filamentous non-inflated sporangia. The sexual stage was never observed and phylogenetic analysis using internal transcribed spacer suggest this isolate belongs to the clade B2. We conclude that the Pythium found in the Oslo fjord was a pathogen of U. intestinalis under low salinity.
Zimin, S P,Gorlachev, E S,Mokrov, D A,Amirov, I I,Naumov, V V,Gremenok, V F,Juskenas, R,Skapas, M,Kim, W Y,Bente, K,Chung, Y-D IOP 2017 Semiconductor science and technology Vol.32 No.7
<P>In this work we report a phenomenon of the self-formation of nanostructure arrays during low-energy inductively coupled argon plasma treatment of the surface of copper indium gallium diselenide films grown by different methods on glass substrates. Selenization, pulsed laser deposition and multistage co-evaporation technological methods were used for the growth of polycrystalline CuIn<SUB>1−<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB>Se<SUB>2</SUB> (0.04?≤?<I>x</I>?≤?0.45) films. The plasma treatment of the surface of the films grown by all three methods resulted in the plasma-assisted self-formation of arrays of uniform cylindrical or conical nanostructures with the surface density of (0.8–1.8)?×?10<SUP>11</SUP> cm<SUP>−2</SUP>. Using scanning electron microscopy, transmission electron microscopy and atomic force microscopy, we describe the morphological parameters and chemical composition of the fabricated nanostructures and discuss possible physical mechanisms of the observed plasma-assisted nanostructuring.</P>