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Bei, Chun-Hua,Bai, Hua,Yu, Hong-Ping,Yang, Yan,Liang, Qing-Qing,Deng, Ying-Ying,Tan, Sheng-Kui,Qiu, Xiao-Qiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Cytokine gene single nucleotide polymorphisms (SNPs) are involved in the genesis and progression of hepatocellular carcinoma (HCC). We hypothesized that combined effects of cytokine gene SNPs and SNP-SNP interactions are associated with HCC risk. Six SNPs in cytokine genes (IL-2, IFN-${\gamma}$, IL-$1{\beta}$, IL-6, and IL-10) were genotyped in a study of 720 Chinese HCC cases and 784 cancer-free controls. Although none of these SNPs individually had a significant effect on the risk of HCC, we found that the combined effects of these six SNPs may contribute to HCC risk (OR=1.821, 95% CI=1.078-3.075). This risk was pronounced among smokers, drinkers, and hepatitis B virus carriers. A SNP-SNP interaction between IL-2-330 and IFN-${\gamma}$-1615 was associated with an increased HCC risk (OR=1.078, 95% CI=1.022-1.136). In conclusion, combined effects of SNPs and SNP-SNP interactions in cytokine genes may contribute to HCC risk.
Yu-Hang Wang,Qi Tang,Mei-Ni Su,Ji-Ke Tan,Wei-Yong Wang,Yong-Sen Lan,Xiao-Wei Deng,Yong-Tao Bai,Wei Luo,Xiao-Hua Li,Jiu-Lin Bai 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.38 No.1
Post-earthquake fire is a common disaster which causes serious safety issues to infrastructures. This study aims to investigate the residual loading capacities of circular concrete-filled steel tube (CFST) columns under post-earthquake fire experimentally and numerically. The experimental programme contains two loading steps - pre-damage cyclic loading at room temperature and transient state tests with constant compression loads. Three finite element models are developed and validated against the test results. Upon validation, a total of 48 numerical results were generated in the parametric study to investigate the effects of thickness and strengths of steel tube, axial compression ratio and damage degree on the fire resistance of circular CFST columns. Based on the analysis on experimental and numerical results, the loading mechanism of circular CFST columns is discussed. A design method is proposed for the prediction of fire resistance time under different seismic pre-damage and compression loads. The predictions by the new method is compared with the newly generated experimental and numerical results and is found to be accurate and consistent with the mean value close to the unity and a coefficient of variation around 1%.
Preparation of bioactive nano-hydroxyapatite coating for artificial cornea
Run-Rong Lin,Xuan Mao,Qi-Cong Yu,Bai-Hua Tan 한국물리학회 2007 Current Applied Physics Vol.7 No.s1
Bioactive coatings containing hydroxyapatite(HA) nano crystals were prepared on PHEMA membrane by a sol dipping method.A cellcoating and the aggregation degree of HA particles inuence the adhesion of the cornea broblasts to the membrane, which dependsdramatically on the weight ratio between the nano-HA and the dispersant. The optimal condition of the coating preparation is with adispersant/HA = 1.25 weight ratio. The PHEMA membrane covered with nano-HA coating is promising for articial cornea use.