http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, S R,Kong, S-Y,Nam, B-H,Choi, I J,Kim, C G,Lee, J Y,Cho, S J,Kim, Y W,Ryu, K W,Lee, J H,Rhee, J,Park, Y-I,Kim, N K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7
<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>
Aggravation of post-ischemic liver injury by overexpression of A20, an NF-κB suppressor
Yu, J.,Lee, H.S.,Lee, S.M.,Yu, H.C.,Moon, W.S.,Chung, M.J.,Park, J.W.,Park, B.H. Elsevier Science Publishers 2011 Journal of hepatology Vol.55 No.2
Backgroud & Aims: A20 is an intracellular ubiquitin-editing enzyme that plays an important role in the negative feedback regulation of NF-κB activation in response to a diverse range of stimuli. Liver ischemia/reperfusion injury is associated with rapid activation of NF-κB signaling, but the role of NF-κB in hepatic ischemia/reperfusion injury remains controversial. The NF-κB signaling pathway mediates both protective and deleterious effects in the liver. Here, we examined whether A20 inhibited or aggravated hepatic ischemia/reperfusion injury. Methods: We used IκBα super-repressor as a positive control and overexpressed A20 and IκBα super-repressor in the liver of C57BL/6 mice. Mice underwent 45min of partial hepatic ischemia and were then reperfused. Results: Protein level of A20 was increased after reperfusion. Mice subjected to ischemia/reperfusion injury showed increased NF-κB activation, as evidenced by phosphorylation of IκBα and nuclear translocation of NF-κB. Prior transfection with Ad-A20 or Ad-IκBα super-repressor attenuated NF-κB activation and aggravated liver injury. Serum aminotransferases and proinflammatory cytokines, hepatocellular necrosis, and hepatic neutrophil infiltration were markedly increased compared to those of uninfected or control virus infected mice. In addition, A20 abolished the beneficial effect of ischemic preconditioning. Conclusions: Our results suggest that inhibition of NF-κB activation by A20 aggravated partial hepatic ischemia/reperfusion injury. Understanding how the NF-κB pathway plays a role in directing a clinical outcome may lead to better prospects of more rational approaches to reduce post-ischemic liver injury.
유병우(B.W. Ryu),한정만(J.M. Han),이동욱(D.W. Lee),이종달(J.D. Lee),이병희(B.H. Lee),최성욱(S.W. Choi),문건우(G.W. Moon) 전력전자학회 2009 전력전자학술대회 논문집 Vol.2009 No.1
최근 LCD 모니터, Note PC, 가정용 게임기, Mobile Phone, MP3 등의 소형 전자 제품의 사용이 증가함에 따라 이들 전자제품의 전원 공급에 필요한 다양한 AC/DC 어댑터가 요구된다. AC/DC 어댑터는 밀폐형의 구조를 가지므로, 열적인 문제 때문에 용량과 사이즈가 제한되어 왔다. 하지만 최근에는 소형전자제품의 용량이 점차 증가하고, 더불어 소비자의 휴대성 및 심미적 요구에 부응하기 위하여 소형 및 경량의 고밀도 AC/DC Adapter를 개발하여야 한다. 이를 위해서 높은 수준의 회로 설계 및 방열 기술이 필요하다. 본 논문에서는 Laptop PC에 적용되는 85W급 AC/DC Adapter용 고밀도전원을 개발하고 실험으로 검증하였다.
Fe-Cu-M-(Si, B) (M = V, Nb, Mo, Ta, W) 합금의 연자기특성 (軟磁氣特性)
강일구,김희중,노태환,이명복,피우갑 대한금속재료학회(대한금속학회) 1990 대한금속·재료학회지 Vol.28 No.4
Dependence of the effective permeability on annealing and the annealing-induced structural change for amorphous Fe_(73.5)Cu₁M₃Si_(13.5)B_9(M=V, Nb, Mo, Ta or W)and Fe_(73.5)Cu₁Nb₃(Si_xB_(1-x))_(22.5)(x=0∼0.8) alloys were investigated. Crystalline Fe_(73.5)Cu₁M₃Si_(13.5)B_9(M=V, Nb, Mo, W)alloys with α-Fe phase which was obtained by annealing at above T_x showed higher effective permeability than with amorphous phase, and the increase in permeability upon crystallization was large in the order of V$lt;W$lt;Mo$lt;Nb. For amorphous Fe_(73.5)Cu₁Nb₃(Si_xB_(1-x))_(22.5) alloys in the composition range from x=0.5 to 0.8, soft magnetic property was improved by crystallization. Moreover, in that composition range, the effective permeability increased with the Si content(x). Superior soft magnetic property of the high-Si alloys was attributed to both the small magnetocrystalline anisotropy and the low magnetostriction. The effective permeabilities measured at 1㎑ and 5 m0e for crystalline Fe-Cu-Mo-Si-B and Fe-Cu-Nb-Si-B(0.5≤x≤0.8) alloys were about 1∼2 × 10⁴, and it was comparable to that of the zero-magnetostriction Co-based amorphous alloys.
Droop Method를 용한 50[W]급 태양전지 가상구현 시스템의 병렬연결 출력특성에 대한 연구
이병인(B.I. Lee),이상용(S.Y. Lee),오방원(B.W. Oh),정병환(B.H. Jung),최규하(G.H.Choe) 전력전자학회 2003 전력전자학술대회 논문집 Vol.2003 No.7(2)
General1y, photovoltaic system is composed with several solar cell modules. For increasing power of photovoltaic systems, serial and parallel connection needed. A Desirable characteristic of a parallel supply system is that individual converters share the load current equally and stably. The current sharing(CS) can be Implemented using two approaches. The first one, known as a droop method, relies on the high output impedance of each converter. and The second approach, known as active current-sharing techniques. In this paper, using droop method at parallel connection with it's convenience and simplicity.<br/>
Fe-Co-W 소결체와 탄소강의 레이저 용융부 결함형성에 미치는 공정변수의 영향
김성욱(S. W. Kim),윤병현(B. H. Yoon),정우광(W. G. Jung),이창희(C. H. Lee) 한국레이저가공학회 2004 한국레이저가공학회지 Vol.7 No.3
This study was performed to clarification of the formation of weld discontinuities in the dissimilar laser fusion zone. Welding parameters were beam power of 1300, 1430, 1560, and 1700 W and travel speed of 1, 1.3, and 1.7 m/min. Most cavities in the fusion zone were observed near the tip. Cavities in the fusion zone observed to be formed and grown from pores in the tip. More cavities were formed as the beam position moves to the tip side. Small cavities were decreased but large cavities were increased when the energy input increased. W content in the fusion zone was increased with heat input and as the beam position close to the tip. In the fusion zone, W content in the dendrite boundary was increased with heat input. Considering the propagation path and fracture morphology, cracks were solidification cracking, and were initiated and propagated along the dendrite boundaries. The formation of cracks might be related with the W rich μ phase which was formed in the grain boundaries and dendrite boundaries.