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- 저자 : B. S. Dileep Kumar (검색결과 3 건)
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Sasidharan Nishanth Kumar,Bala Nambisan,B. S. Dileep Kumar,Nisha Girija Vasudevan,Chellapan Mohandas,Vino T. Cheriyan,Ruby John Anto 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
3,5-Dihydroxy-4-isopropylstilbene is a naturalphytoalexin and was first identified as bacterial secondarymetabolites. The aim of this study is to investigate in vitroantioxidant and anticancer activity of 3,5-dihydroxy-4-isopropystilbene purified from the cell free culture filtrateof Bacillus sp. N strain associated with rhabditid entomopathogenicnematode. Antioxidant activity was evaluatedby five separate methods: free radical scavenging, reducingpower assay, chelating effects on ferrous ions, NBTsuperoxide radical scavenging assay and hydroxyl radicalscavenging activity. The stilbene recorded powerful antioxidantactivity at various antioxidant systems in vitro. Thesuperoxide radical scavenging (92.1 %) and hydroxylradical scavenging (83.4 %) activities of the stilbenes at100 lg/ml were higher than the butylated hydroxyanisole,the known antioxidant agent. Anticancer activity of stilbenewas tested against breast cancer (MDAM B-231),cervical cancer (HeLa), lung cancer (A 549), colon cancer (HTL 116) cell lines using MTT method. The induction ofapoptosis was studied by morphological analysis, apoptoticcell staining, caspase 3 activation assay and cell cycleanalysis using flow cytometry. Stilbene induced significantmorphological changes and DNA fragmentation associatedwith apoptosis in HeLa cells. Acridine orange/ethidiumbromide stained cells indicated apoptosis induction bystilbene. Up-regulation of caspase 3 activity was also foundin cells treated with stilbene. Flow cytometry analysisshowed an increase in the percentage of apoptotic cells insub G0 phase (2.4 % in control plates to 11.4 %in 25 lg/mlof stilbene) confirming the stilbene induced apoptosis. Theresults of the present study showed that stilbene demonstrateda strong antioxidant and anticancer effects. Thesesuggest that stilbene may be used as possible naturalantioxidant and anticancer agents to control various humandiseases.
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Dileep K G,Pradeep Goutam,Laxmaiah P,Nithin Kumar S,Hari Prasad S V,Nithin B 대한전자공학회 2017 대한전자공학회 학술대회 Vol.2017 No.1
This paper demonstrates the implementation of a QPSK/Time Division Multiple Access (TDMA) satellite receiver using short preamble-based synchronization in the presence of timing, frequency and phase offsets, and with Additive White Gaussian Noise (AWGN). The detection and estimation of synchronization parameters of the received signal, i.e., frequency, phase and symbol timing, are highly dependent on the preamble of the burst. Moreover, computational complexity and acquisition time of the receiver are directly proportional to the preamble length. The implemented receiver uses a 64-bit short preamble for synchronization and gives better bit error rate (BER) performance at low signal to noise ratio (SNR), close to -3dB. The functional verification of the synchronization algorithm is done using Matlab simulations and the algorithm implementation uses fixed-point C. The receiver design has been prototyped for 4 TDMA channels in Texas Instruments (TI) multi-core C66x DSP. The design and implementation of this receiver have been done for C-DOT indigenous satellite project.
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Swarnalee Dutta,Pranjal Morang,Nishanth Kumar S,B.S. Dileep Kumar 한국미생물학회 2014 The journal of microbiology Vol.52 No.9
A Pseudomonas aeruginosa strain, RRLJ 04, and a Bacilluscereus strain, BS 03, were tested both individually and in combinationwith a Rhizobium strain, RH 2, for their ability toenhance plant growth and nodulation in pigeon pea (Cajanuscajan L.) under gnotobiotic, greenhouse and field conditions. Both of the rhizobacterial strains exhibited a positive effecton growth in terms of shoot height, root length, fresh and dryweight, nodulation and yield over the non-treated control. Co-inoculation of seeds with these strains and RhizobiumRH 2 also reduced the number of wilted plants, when grownin soil infested with Fusarium udum. Gnotobiotic studies confirmedthat the suppression of wilt disease was due to thepresence of the respective PGPR strains. Seed bacterizationwith drug-marked mutants of RRLJ 04 and BS 03 confirmedtheir ability to colonize and multiply along the roots. Theresults suggest that co-inoculation of these strains with Rhizobiumstrain RH 2 can be further exploited for enhancedgrowth, nodulation and yield in addition to control of fusarialwilt in pigeon pea.
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