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The pharmacological and biological roles of eriodictyol
Anowarul Islam,Md Sadikul Islam,Md Khalesur Rahman,Md Nazim Uddin,Md Rashedunnabi Akanda 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.6
Eriodictyol is a fl avonoid in the fl avanones subclass. It is abundantly present in a wide range of medicinalplants, citrus fruits, and vegetables that are considered tohave potential health importance. Having the considerablemedicinal properties, eriodictyol has been predicted toclarify the mode of action in various cellular and molecularpathways. Evidence for the existing therapeutic roles of eriodictyolincludes antioxidant, anti-infl ammatory, anti-cancer,neuroprotective, cardioprotective, anti-diabetic, anti-obesity,hepatoprotective, and miscellaneous. Therefore, this reviewaims to present the recent evidence regarding the mechanismsof action of eriodictyol in diff erent signaling pathwaysin a specifi c disease condition. In view of the immense therapeutic eff ects, eriodictyol may serve as a potential drugsource to enhance community health standards.
The potential health benefits of the isoflavone glycoside genistin
Anowarul Islam,Md Sadikul Islam,Md Nazim Uddin,Mir Md Iqbal Hasan,Md Rashedunnabi Akanda 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.4
Genistin is a type of isoflavone glycoside andhas a broad range of health benefits. It is found in a varietyof dietary plants, such as soybean, kudzu (Japanese arrowroot),and other plant-based products. Genistin has beendescribed to have several beneficial health impacts, suchas decreasing the risk of osteoporosis and post-menopausalsymptoms, as well as anti-cancer, anti-oxidative, cardioprotective,anti-apoptotic, neuroprotective, hepatoprotective,and anti-microbial activities. It may also assist individualswith metabolic syndrome. This review summarizes some ofthe molecular impacts and prospective roles of genistin inmaintaining and treatment of health disorders. The reviewcould help to develop novel genistin medicine with significanthealth benefits for application in the nutraceutical andpharmaceutical fields.
The Anti-Stress Effect of <i>Mentha arvensis</i> in Immobilized Rats
Tian, Weishun,Akanda, Md Rashedunnabi,Islam, Anowarul,Yang, Hae-Dong,Lee, Sang-Cheon,Lee, Jeong-Ho,Kim, Sang-Ki,Choi, Yu-Jin,Im, So-Yeon,Park, Byung-Yong MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.2
<P>Stress can lead to inflammation, accelerated aging, and some chronic diseases condition. <I>Mentha arvensis</I> (MA) is a traditional medicine having antioxidant and anti-inflammatory activities. The present study investigated the anti-stress role of MA and fermented MA (FMA) extract in immobilized rats. We studied the lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells and rats were immobilized for 2 h per day for 14 days using a restraining cage. MA (100 mg/kg) and FMA (100 mg/kg) were orally administered to rats 1 h prior to immobilization. Using high-performance liquid chromatography (HPLC) analysis, we determined the rosmarinic acid content of MA and FMA. The generation of malondialdehyde (MDA) and nitric oxide (NO) in RAW 246.7 cells were suppressed by both MA and FMA. In rats, MA and FMA notably improved the body weight, daily food intake, and duodenum histology. MDA and NO level were gradually decreased by MA and FMA treatment. MA and FMA significantly controlled the stress-related hormones by decreasing corticosterone and β-endorphin and increasing serotonin level. Moreover, protein expression levels of mitogen activated protein kinases (MAPK) and cyclooxygenase-2 (COX-2) were markedly downregulated by MA and FMA. Taken together, MA and FMA could ameliorate immobilized-stress by reducing oxidative stress, regulating stress-related hormones, and MAPK/COX-2 signaling pathways in rats. Particularly, FMA has shown greater anti-stress activities than MA. </P>
Akanda, Md Rashedunnabi,Nam, Hyeon-Hwa,Tian, Weishun,Islam, Anowarul,Choo, Byung-Kil,Park, Byung-Yong Elsevier 2018 BIOMEDICINE AND PHARMACOTHERAPY Vol.100 No.-
<P><B>Abstract</B></P> <P>Ulcerative colitis (UC) is a major inflammatory bowel disease (IBD) has become a worldwide emergent disease. <I>Veronica polita</I> (VP) is a medicinal herb that has strong antioxidant and anti-inflammatory properties. In the present study, we studied the protective effect of VP on dextran sulfate sodium (DSS)-induced experimental colitis in mice. Phytochemical screening of VP extract demonstrated the presence of high total phenolic and flavonoid contents. Compared with the DSS group, VP significantly reduced clinical symptoms with less weight loss, bloody stool, shortening of the colon, and the severity of colitis was considerably inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in the colon and spleen. Also, treatment with VP considerably decreased the nitric oxide (NO) and malondialdehyde (MDA) level. VP remarkably downregulated the expression of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) in the colon tissue. Likewise, activation of the signal transducer and activator of transcription 3 (STAT3) and nuclear factor-kappa B (NF-κB) was effectively blocked by VP. Taken together, these results demonstrate that VP has an ameliorative effect on colonic inflammation mediated by modulation of oxidative stress and inflammatory mediators by suppressing the JAK2/STAT3 and NF-κB signaling pathways.</P>
Akanda, Md Rashedunnabi,Tae, Hyun-Jin,Kim, In-Shik,Ahn, Dongchoon,Tian, Weishun,Islam, Anowarul,Nam, Hyeon-Hwa,Choo, Byung-Kil,Park, Byung-Yong MDPI 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.7
<P>Sodium arsenite (NaAsO<SUB>2</SUB>) has been recognized as a worldwide health concern. <I>Hydrangea macrophylla</I> (HM) is used as traditional Chinese medicine possessing antioxidant activities. The study was performed to investigate the therapeutic role and underlying molecular mechanism of HM on NaAsO<SUB>2</SUB>-induced toxicity in human liver cancer (HepG2) cells and liver in mice. The hepatoprotective role of HM in HepG2 cells was assessed by using 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), and lactate dehydrogenase (LDH) assays. Histopathology, lipid peroxidation, serum biochemistry, quantitative real-time polymerase chain reaction (qPCR) and Western blot analyses were performed to determine the protective role of HM against NaAsO<SUB>2</SUB> intoxication in liver tissue. In this study, we found that co-treatment with HM significantly attenuated the NaAsO<SUB>2</SUB>-induced cell viability loss, intracellular ROS, and LDH release in HepG2 cells in a dose-dependent manner. Hepatic histopathology, lipid peroxidation, and the serum biochemical parameters alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were notably improved by HM. HM effectively downregulated the both gene and protein expression level of the mitogen-activated protein kinase (MAPK) cascade. Moreover, HM well-regulated the Bcl-2-associated X protein (Bax)/B-cell lymphoma-2 (Bcl-2) ratio, remarkably suppressed the release of cytochrome <I>c</I>, and blocked the expression of the post-apoptotic transcription factor caspase-3. Therefore, our study provides new insights into the hepatoprotective role of HM through its reduction in apoptosis, which likely involves in the modulation of MAPK/caspase-3 signaling pathways.</P>