Post-mortem assessment of vimentin expression as a biomarker for renal tubular regeneration following acute kidney injury

Juan Carlos Alvarez Moreno,Hisham F. Bahmad,Christopher A. Febres-Aldana,Andrés Pirela,Andres Azuero,Ali Salami,Robert Poppiti 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.6

Background: Acute kidney injury (AKI) is a common cause of morbidity and mortality. It mainly targets the renal tubular epithelium with pathological changes, referred to as acute tubular injury. The latter is followed by a regenerative response that is difficult to visualize on routine hematoxylin and eosin (H&E) stains. In this study, we examined the regenerative capacity of renal tubules by correlating vimentin (VIM) immunohistochemical (IHC) expression and pathological findings of AKI and renal tubular regeneration (RTR) on H&E.Methods: We reviewed 23 autopsies performed in the clinical setting of AKI and RTR. VIM expression was scored in the renal cortical tubular epithelium using a statistical cutoff ≥ 3% for high expression and < 3% for low expression.Results: Of the 23 kidney tissues examined, seven (30.4%) had low VIM expression, and 16 (69.6%) had high VIM expression. Kidney tissues with evidence of AKI and RTR had significantly higher VIM expression. Renal peritubular microenvironment features showing regenerative changes on H&E were associated with high VIM expression. In the univariate model, kidney tissues with RTR were 18-fold more likely to have high VIM expression.Conclusions: In conclusion, our findings suggest that VIM could serve as an IHC marker for RTR following AKI. However, correlation with H&E findings remains critical to excluding chronic tubular damage. Collectively, our preliminary results pave the way for future studies including a larger sample size to validate the use of VIM as a reliable biomarker for RTR.

Development of a Machine Vision System for Automotive Part-Car Seat Frame Inspection

Nelson S. Andres(Nelson S. Andres),장봉춘(Jang Bong-Choon) 한국자동차공학회 2005 한국자동차공학회 지부 학술대회 논문집 Vol.- No.-

Meeting the growing demand deadlines, reducing the production cost and upgrading the quality control measurements are the reasons why the automotive part manufacturers are venturing into automation. Attaining these objectives is impossible with human inspection for many reasons. Accordingly, the introduction of machine vision system purposely for car seat frame inspection is presented in this study as an alternative for human inspection. This proposal is designed to meet the demands, features and specifications of car seat frame manufacturing companies in striving for increased throughput of better quality. More specifically, this computer-based inspection proposal is designed to perform quality measures to detect holes, nuts and welding spots on every car seat fiame in real time and ensuring these portions to be intact, precise and in proper place. In this study, the NI Vision Builder software for Automatic Inspection is used as a solution in configuring the aimed quality measurements. These quality measurement techniques for visual inspection are optimized through qualitative analysis and simulation of human tolerance on inspecting car seat frames. Furthermore, this study exemplifies the incorporation of the optimized vision inspection environment to the pre-inspection and post-inspection phases using LabVIEW software.

'적대감'을 넘어서서

Andres Aguilera (사)북한연구소 2010 北韓 Vol.- No.460

Combined Conduction Radiation in Absorbing and Emitting Media Using a Two-Flux Model

Andres Tremante,Freddy Malpica 대한기계학회 1993 International Symposium on Transport Phenomena in Vol.1 No.1

The Practice of Sport and Physical Activity in College Students Venezolanos

( Andres De Jesus Diaz Llus ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1

Purpose: The purpose of this study was to examine the level of physical activity, along with sex, age, body mass index, mention of study, the sport of your choice and working hours in a group of college students. Participants were 284 students in the first semester of Education Program UNELLEZ - Barinas, 62.3% were female and 37.7% male, mean age of 20 years. Method: The instrument used to evaluate the variables was the International Physical Activity Questionnaire (IPAQ) short form. This field study, part of the quantitative paradigm, crosscutting descriptive correlational, using its own to collect socio-demographic questionnaire. The SPSS version 19 was used for data analysis (α = 5%). Result: The results show an average body mass index of 25.19. In relation to sex, 35.5% of men and 36.7% of women are overweight or obese. Even the youngest age group (17-20 years) exhibits a 21.3% overweight and 6.6% obese. In fact, contrary to what you might expect, students mention PE have a percentage in the low level of physical activity (72%) than that of the students of the other sections (52%). Moreover, the latter shown in vigorous level much higher (29%) than students in PE (8%) percentage. Meanwhile, 81.7% of students do not work and over half of those who do work less than 10 hours per week. Conclusion: This study conclude that although physical inactivity is the shortest path toward obesity, which facilitates the emergence of certain diseases generally do not perceive youth and sports physical inactivity as a risk to their health. However, and as a final conclusion, it is hoped that the knowledge gained in this research demonstrates support for developing various strategies to promote physical activity and acquiring new healthy lifestyles among university students in a stable and durable , to help improve their quality of life

Regulation and Control of the Privatization of Security in Conflict Zones

Andres Macias 한국국제정치학회 2011 한국국제정치학회 기타간행물 Vol.2011 No.6

The presence of private providers of military and security services in conflict zones has increased in the aftermath of the Cold War. Although the use of Private Security Companies (PSC) and Private Military Companies (PMC) has become very popular among States, international organizations, and multinational corporations, regulation over them is scarce, insufficient, and inadequate. This paper examines the main reasons behind the tendency to rely on private security providers and the impact they have on the promotion of peace and on the safeguard of human rights in conflict areas. PSCs and PMCs carry out military training programs and in some cases bear the same duties and responsibilities as armies do, becoming also potential perpetrators of violations of human rights. Stricter control and regulation is needed in order to make their actions and omissions accountable. The privatization of security entails difficult challenges to the promotion of human rights and awareness on the implications they represent needs to be raised to national and international levels.

Preparation of Ni-Fe layered double hydroxide - Carbon composite using solution plasma generated seeds

Andres Eduardo Romero Valenzue,Mongkol Tipplook,Katsuya Teshima 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.11-1

Manifestation of the Pacific Decadal Oscillation in the Kuroshio

Andres, Magdalena,Park, Jae-Hun,Wimbush, Mark,Zhu, Xiao-Hua,Nakamura, Hirohiko,Kim, Kuh,Chang, Kyung-Il American Geophysical Union 2009 Geophysical research letters Vol.36 No.16

Design optimization of reinforced concrete structures

Andres Guerra,Panos D. Kiousis 한국계산역학회 2006 Computers and Concrete, An International Journal Vol.3 No.5

A novel formulation aiming to achieve optimal design of reinforced concrete (RC) structures is presented here. Optimal sizing and reinforcing for beam and column members in multi-bay and multi-story RC structures incorporates optimal stiffness correlation among all structural members and results in cost savings over typical-practice design solutions. A Nonlinear Programming algorithm searches for a minimum cost solution that satisfies ACI 2005 code requirements for axial and flexural loads. Material and labor costs for forming and placing concrete and steel are incorporated as a function of member size using RS Means 2005 cost data. Successful implementation demonstrates the abilities and performance of MATLAB's (The Mathworks, Inc.) Sequential Quadratic Programming algorithm for the design optimization of RC structures. A number of examples are presented that demonstrate the ability of this formulation to achieve optimal designs.

Genotoxic evaluation of occupational exposure to antineoplastic drugs

Andres Felipe Aristizabal-Pachon,Willian Orlando Castillo 한국독성학회 2020 Toxicological Research Vol.36 No.1

During the last years, several reports have provided evidence about adverse health effects on personal involved in Antineoplastic Drugs (ANPD) handling. ANPD has the ability to bind DNA, thus produce genotoxic damage. In this way, XRCC1 and XRCC3 proteins are necessary for efficient DNA repair and polymorphisms in this genes can be associated with an individual response to ANPD exposure. Therefore, the aim of this study was to evaluate genetic damage of occupational exposure to antineoplastic drugs and the possible effect of XRCC1 and XRCC3 polymorphisms in oncology employees from Bogotá, Colombia. Peripheral blood samples were obtained from 80 individuals, among exposed workers and healthy controls. The comet assay and Cytokinesis-block micronucleus cytome assay was performed to determinate genetic damage. From every sample DNA was isolated and genotyping for XRCC1 (Arg194Trp, Arg280His and Arg399Gln) and XRCC3 (Thr241Met) SNPs by PCR–RFLP. The exposed group showed a significant increase of comet assay results and micronucleus frequency, compared with unexposed group. It was observed a gender, exposure time and workplace effect on comet assay results. Our results showed no significant associations of comet assay results and micronucleus frequency with either genotype, allele, nor haplotype of XRCC1 and XRCC3 SNPs. The results suggest that occupational exposure to ANPD may lead to genotoxic damage and even be a risk to human health. To our knowledge, this is the first study to assess the genotoxic damage of occupational exposure to APND in South America.