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RISS 인기검색어
- 검색키워드
- 저자 : Aminov, R.I. (검색결과 3 건)
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Molecular Analysis of Archaea, Bacteria and Eucarya Communities in the Rumen - Review-
White, B.A.,Cann, I.K.O.,Kocherginskaya, S.A.,Aminov, R.I.,Thill, L.A.,Mackie, R.I.,Onodera, R. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.1
If rumen bacteria can be manipulated to utilize nutrients (i.e., ammonia and plant cell wall carbohydrates) more completely and efficiently, the need for protein supplementation can be reduced or eliminated and the digestion of fiber in forage or agricultural residue-based diets could be enhanced. However, these approaches require a complete and accurate description of the rumen community, as well as methods for the rapid and accurate detection of microbial density, diversity, phylogeny, and gene expression. Molecular ecology techniques based on small subunit (SSU) rRNA sequences, nucleic acid probes and the polymerase chain reaction (PCR) can potentially provide a complete description of the microbial ecology of the rumen of ruminant animals. The development of these molecular tools will result in greater insights into community structure and activity of gut microbial ecosystems in relation to functional interactions between different bacteria, spatial and temporal relationships between different microorganisms and between microorganisms and reed panicles. Molecular approaches based on SSU rRNA serve to evaluate the presence of specific sequences in the community and provide a link between knowledge obtained from pure cultures and the microbial populations they represent in the rumen. The successful development and application of these methods promises to provide opportunities to link distribution and identity of gastrointestinal microbes in their natural environment with their genetic potential and in situ activities. The use of approaches for assessing pupulation dynamics as well as for assessing community functionality will result in an increased understanding and a complete description of the gastrointestinal communities of production animals fed under different dietary regimes, and lead to new strategies for improving animal growth.
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Nano-Drone for T2 Turbo Spin Echo (TSE) MRI In Gastric Cancer Mice Model
Gippeum Park,Muzaffar Annaev,Sejin Park,Soe Lwin Aye,Zafar Aminov,Ken Karl Zhang,Hwunjae Lee 한국자기학회 2024 Journal of Magnetics Vol.29 No.1
In the ever-evolving field of Magnetic Resonance Imaging (MRI), an array of innovative techniques are emerging that incorporate the use of contrast agents, with a particular focus on their application in the diagnosis of cancer. These cutting-edge strategies commonly involve the integration of MRI with a biocompatible targeting entity and Magnetic Nanoparticles (MNPs), a combination that has demonstrated significant efficacy in the detection of cancerous cells. Among these pioneering approaches, one strategy that shows remarkable promise involves the coupling of MRI with a Nano-drone (NH2-PEGylated Hyaluronic Acid-Manganese ferrite). This novel nano-drone is fabricated using a thermal decomposition method, a process known for its precision and reliability. The resultant Nano-drone exhibits sensitivity to T2 weighted or T2 Turbo Spin Echo (TSE) MRI, paving the way for new diagnostic possibilities in the realm of cancer detection. To validate the efficacy of this innovative approach, we designed an experiment that involved the injection of a specific Gastric Cancer cell line, known as MKN-45, into murine gastric tissue. This strategic application allowed us to closely monitor the interaction of the Nano-drone with the cancer cells. In the subsequent stages of the experiment, we utilized T2 TSE magnetic resonance sequences to evaluate the imaging impact of the Nano-drone. This assessment was crucial in determining the targeting proficiency of the Nano-drone, and how effectively it could pinpoint the cancer cells within the gastric tissue. Our findings from this comprehensive study suggest the potential of the Nano-drone as a groundbreaking probe for the visualization of Gastric Cancer. Furthermore, they underscore the significance of TSE validation in unveiling new diagnostic possibilities. The results of our study offer a beacon of hope in the fight against cancer, demonstrating the potential of the Nano-drone to open new avenues in cancer diagnosis and treatment.
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