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      • KCI등재

        Associations between Dietary Allium Vegetables and Risk of Breast Cancer: A Hospital-Based Matched Case-Control Study

        Ali Pourzand,Aynaz Tajaddini,Saeed Pirouzpanah,Mohammad Asghari-Jafarabadi,Nasser Samadi,Ali-Reza Ostadrahimi,Zohre Sanaat 한국유방암학회 2016 Journal of breast cancer Vol.19 No.3

        Purpose: The protective effect of Allium vegetables against carcinogenesis has been reported in experimental studies particularly focusing on the gut. Therefore, we conducted a hospital-based matched case-control study to explore the association between dietary Allium consumption and risk of breast cancer among Iranian women in northwest Iran. Methods: A validated, quantitative, food frequency questionnaire was completed in 285 women (aged 25–65 years old) newly diagnosed with histopathologically confirmed breast cancer (grade II, III or clinical stage II, III) in Tabriz, northwest Iran, and the completed questionnaires were included in an age- and regional-matched hospital based-control study. The odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression models. Results: Multivariate analysis showed that there was a negative association between the consumption of raw onion and risk of breast cancer after adjustment for covariates (OR, 0.63; 95% CI, 0.40–1.00); however, this association was insignificant. On the other hand, there was a positive association between consumption of cooked onion and risk of breast cancer, after adjustment for covariates (OR, 1.54; 95% CI, 1.02–2.32). However, reduced risk of breast cancer was associated with higher consumption of garlic and leek with adjusted ORs of 0.41 (95% CI, 0.20–0.83) and 0.28 (95% CI, 0.15–0.51), respectively. Conclusion: Our findings suggest that high consumption of certain Allium vegetables, in particular garlic and leek, may reduce the risk of breast cancer, while high consumption of cooked onion may be associated with an increased risk of breast cancer.

      • SCOPUSKCI등재

        Effect of Turmeric Supplementation on Blood Pressure and Serum Levels of Sirtuin 1 and Adiponectin in Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial

        Ali Kalhori,Maryam Rafraf,Roya Navekar,Aida Ghaffari,Mohammad Asghari Jafarabadi 한국식품영양과학회 2022 Preventive Nutrition and Food Science Vol.27 No.1

        Nonalcoholic fatty liver disease (NAFLD) is commonly associated with obesity. This randomized, double-blind, placebo-controlled trial aimed to evaluate the effects of turmeric on serum adiponectin and sirtuin 1 (SIRT1) levels, blood pressure, and body mass index (BMI) in patients with NAFLD. A total of 46 eligible patients with NAFLD (BMI, 25.0∼39.9 kg/m²) were randomly allocated to turmeric and placebo groups using block randomization. The turmeric group (n=23) was administered 3,000 mg/d turmeric powder in six 500-mg capsules for 12 weeks, whereas the placebo group (n=23) was administered six placebo capsules/d for 12 weeks. Body weight, BMI, serum SIRT1 and adiponectin levels, and systolic and diastolic blood pressures were measured at baseline and 12 weeks after intervention. Serum SIRT1 levels increased significantly in the turmeric group compared with the placebo group. Additionally, participants in the turmeric group exhibited lower weight, BMI, and systolic blood pressure after 12 weeks of intervention compared with the baseline. Turmeric effectively improved SIRT1 levels in patients with NAFLD compared with the placebo. The efficacy of turmeric might increase with long-term use at higher doses.

      • KCI등재

        Fabrication and characterization of AlPO₄-5 nanozeolites : effect of hydrothermal temperature and duration

        Ali Hassanvand,Morteza Asghari 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.1

        Molecular sieves and zeolites are materials whose crystalline frameworks form nanometre or subnanometre pores. A variety of different crystal structures are known having a range of pore sizes. Because the pore sizes are usually smaller than 2 nm, they are classified as microporous materials. Although microporous materials have ordered structures over the nanometre scale, they do not typically have ordered structures at larger dimensions. Crystals with a well-defined morphology and a small size distribution can be used as building blocks for generating complex structures by particle assembly techniques. Synthesis of microporous materials is usually conducted by a high temperature treatment (80-200 oC) of aqueous synthesis gels. The process of heating aqueous mixtures to elevated temperatures for crystallization is typically described as hydrothermal synthesis. The raw materials for synthesis of microporous materials include silicon and aluminum containing precursors, an organic structure directing agent (SDA), and a fluoride-containing mineralizing agent. AlPO4-5 nano-zeolite has been synthesized via a hydrothermal technique. The crystals have been structurally characterized using X-ray diffraction (XRD), a scanning electron microscope (SEM), and energy dispersive X-ray analysis (EDAX). The effect of crystallization temperature and duration on morphology of the powder have been studied

      • SCOPUSKCI등재SCIE

        The potential of common duckweed (Lemna minor) in phytoremediation of phenanthrene and pyrene

        Mohammad Ali Zazouli,Somayeh Asghari,Roshanak Tarrahi,Seyed Yahya Salehi Lisar,Esmaeil Babanezhad,Nafise Dashtban 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.1

        The distribution of polycyclic aromatic hydrocarbons (PAHs) as a group of toxic and persistent aromatic pollutants in the environment is rapidly enhancing. These compounds have adverse impacts on the health of living organisms. Hence, in the present study, we investigated the potential of duckweed (Lemna minor) as an aquatic plant species for uptake, accumulation, and biodegradation of phenanthrene and pyrene under controlled conditions. L. minor plants were treated with 10 and 20 mg L<SUP>-1</SUP> concentrations of phenanthrene and pyrene at the experimental duration of ten days. According to the results obtained, the toxicity of phenanthrene and pyrene contaminants on L. minor was influenced by the different initial PAHs concentrations. An increase in phenanthrene and pyrene concentration significantly decreased all studied growth parameters such as fresh weight, dry weight, and RFN and also photosynthetic pigment contents of the plant. Phenanthrene and pyrene concentrations were measured using high-performance liquid chromatography (HPLC) technique after 10 days of exposure to the PAHs. The results revealed that L. minor species could bioaccumulate effectively both typical PAHs. Furthermore, the gas chromatography-mass spectroscopy (GC/MS) technique explained the biological degradation of phenanthrene and pyrene by L. minor in the present research, and accordingly, several intermediate by-products were identified.

      • SCIESCOPUS

        Enhanced Electrocatalytic Activity of Low Ni Content Nano Structured NiPd Electrocatalysts Prepared by Electrodeposition Method for Borohydride Oxidation

        Zolfaghari, Mahdieh,Arab, Ali,Asghari, Alireza The Korean Electrochemical Society 2020 Journal of electrochemical science and technology Vol.11 No.3

        Some nano structured bimetallic NiPd electrocatalysts were electrodeposited on glassy carbon electrodes using a double potential step chronoamperometry. The morphology of the electrodeposited samples was investigated by field emission-scanning electron microscopy, while their compositions were evaluated using energy dispersive X-ray spectroscopy. It was observed that the electrodeposited samples contained a low Ni content, in the range of 0.80 - 7.10%. The electrodeposited samples were employed as the anode electro-catalysts for the oxidation of sodium borohydride in NaOH solution (1.0 M) using cyclic voltammetry, chronoamperometry, rotating disk electrode, and impedance spectroscopy. The number of exchanged electrons, charge transfer resistances, apparent rate constants, and double layer capacitances were calculated for the oxidation of borohydride on the prepared catalysts. According to the results obtained, the NiPd-2 sample with the lowest Ni content (0.80%), presented the highest catalytic activity for borohydride oxidation compared with the other NiPd samples as well as the pure Pd sample. The anodic peak current density was obtained to be about 1.3 times higher on the NiPd-2 sample compared with that for the Pd sample.

      • KCI등재

        False-Positive Mycobacterium tuberculosis Detection: Ways to Prevent Cross- Contamination

        ( Mohammad Asgharzadeh ),( Mahdi Asghari Ozma ),( Jalil Rashedi ),( Behroz Mahdavi Poor ),( Vahid Agharzadeh ),( Ali Vegari ),( Behrooz Shokouhi ),( Khudaverdi Ganbarov ),( Nima Najafi Ghalehlou ),( H 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.3

        The gold standard method for diagnosis of tuberculosis is the isolation of Mycobacterium tuberculosis through culture, but there is a probability of cross-contamination in simultaneous cultures of samples causing false-positives. This can result in delayed treatment of the underlying disease and drug side effects. In this paper, we reviewed studies on falsepositive cultures of M. tuberculosis . Rate of occurrence, effective factors, and extent of false-positives were analyzed. Ways to identify and reduce the false-positives and management of them are critical for all laboratories. In most cases, falsepositive is occurring in cases with only one positive culture but negative direct smear. The three most crucial factors in this regard are inappropriate technician function, contamination of reagents, and aerosol production. Thus, to reduce false-positives, good laboratory practice, as well as use of whole-genome sequencing or genotyping of all positive culture samples with a robust, extra pure method and rapid response, are essential for minimizing the rate of false-positives. Indeed, molecular approaches and epidemiological surveillance can provide a valuable tool besides culture to identify possible false positives.

      • KCI등재

        Statistical and Machine Learning-Based FHB Detection in Durum Wheat

        Nasrin Azimi,Omid Sofalian,Mahdi Davari,Ali Asghari,Naser Zare 한국육종학회 2020 Plant Breeding and Biotechnology Vol.8 No.3

        Pathogens are the major causes of wheat crop yield losses, including the fungus Fusarium graminearum, an agent of Fusarium Head Blight (FHB). A better understanding of the relationship between plant morphological and biochemical traits and resistance to FHB can be effective in implementing a successful breeding program. This study investigated the relationship between FHB resistance as well as the morphological and biochemical traits in 20 durum wheat lines. Both morphological and biochemical traits were investigated using statistical tools. Therefore, analyses of variance, mean, as well as the correlation between the traits were considered. In addition, for the morphological traits, cluster analyses were performed to identify similar genotypes in control and infected conditions. Furthermore, machine learning (ML) classification techniques, including Support Vector Machine (SVM), were proposed to detect the infected plants using morphological traits. The results show a great promise for the application of data-driven ML-based methods in plant breeding and disease detection.

      • siRNA-mediated Silencing of Survivin Inhibits Proliferation and Enhances Etoposide Chemosensitivity in Acute Myeloid Leukemia Cells

        Karami, Hadi,Baradaran, Behzad,Esfahani, Ali,Estiar, Mehrdad Asghari,Naghavi-Behzad, Mohammad,Sakhinia, Masoud,Sakhinia, Ebrahim Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

        Background: Overexpression of survivin, a known inhibitor of apoptosis, is associated with tumor progression and drug resistance in numerous malignancies, including leukemias. The aim of this study was to investigate the effect of a specific survivin small interference RNA (siRNA) on proliferation and the sensitivity of HL-60 acute myeloid leukemia (AML) cells to the chemotherapeutic drug etoposide. Materials and Methods: The cells were transfected with siRNAs using Lipofectamine $^{TM}2000$ transfection reagent. Relative survivin mRNA and protein levels were measured by quantitative real-time PCR and Western blotting, respectively. Trypan blue exclusion assays were performed to monitor tumor cell proliferation after siRNA transfection. The cytotoxic effects of etoposide and survivin siRNA, alone and in combination, on leukemic cells were determined using MTT assay. Apoptosis was assessed by ELISA cell death assay. Results: Survivin siRNA markedly reduced both mRNA and protein expression levels in a time-dependent manner, leading to distinct inhibition of cell proliferation and increased spontaneous apoptosis. Surprisingly, survivin siRNA synergistically increased the cell toxic effects of etoposide. Moreover, survivin down-regulation significantly enhanced its induction of apoptosis. Conclusions: Our study suggests that down-regulation of survivin by siRNA can trigger apoptosis and overcome drug resistance of leukemia cells. Therefore, survivin siRNA may be an effective adjuvant in AML chemotherapy.

      • Effect of Beta Glucan on White Blood Cell Counts and Serum Levels of IL-4 and IL-12 in Women with Breast Cancer Undergoing Chemotherapy: A Randomized Double-Blind Placebo-Controlled Clinical Trial

        Ostadrahimi, Alireza,Ziaei, Jamal Eivazi,Esfahani, Ali,Jafarabadi, Mohammad Asghari,Movassaghpourakbari, Aliakbar,Farrin, Nazila Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

        Background: Breast cancer is the most common female malignancy in the world. Beta glucan can be a hematopoietic and an immune modulator agent in cancer patients. The aim of this trial was to determine the effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy. Materials and Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 30 women with breast carcinoma aged 28-65 years. The eligible participants were randomly assigned to intervention (n=15) or placebo (n=15) groups using a block randomization procedure with matching based on age, course of chemotherapy and menopause status. Patients in the intervention group received two 10-mg capsules of soluble 1-3, 1-6, D-beta glucan daily and the control group receiving placebo during 21 days, the interval between two courses of chemotherapy. White blood cells, neuthrophil, lymphocyte and monocyte counts as well as serum levels of IL-4 and IL-12 were measured at baseline and at the end of the study as primary outcomes of the study. Results: In both groups white blood cell counts decreased after 21 days of the intervention, however in the beta glucan group, WBC was less decreased non significantly than the placebo group. At the end of the study, the change in the serum level of IL-4 in the beta glucan group in comparison with the placebo group was statistically significant (p=0.001). The serum level of IL-12 in the beta glucan group statistically increased (p=0.03) and comparison between two groups at the end of the study was significant after adjusting for baseline values and covariates (p=0.007). Conclusions: The findings suggest that beta glucan can be useful as a complementary or adjuvant therapy and immunomodulary agent in breast cancer patients in combination with cancer therapies, but further studies are needed for confirmation.

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