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TP53 variants in p53 signatures and the clonality of STICs in RRSO samples
Tomoko Akahane,Kenta Masuda,Akira Hirasawa,Yusuke Kobayashi,Arisa Ueki,Miho Kawaida,Kumiko Misu,Kohei Nakamura,Shimpei Nagai,Tatsuyuki Chiyoda,Wataru Yamagami,Shigenori Hayashi,Fumio Kataoka,Kouji Ban 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.4
Objective: Precursor lesions may be identified in fallopian tube tissue after risk-reducing salpingo-oophorectomy (RRSO) in patients with pathogenic variants of . Serous tubal intraepithelial carcinoma (STIC) is considered a precursor of high-grade serous carcinoma, whereas the significance of the p53 signature remains unclear. In this study, we investigated the relationship between the p53 signature and the risk of ovarian cancer. Methods: We analyzed the clinicopathological findings and conducted DNA sequencing for variants of p53 signatures and STIC lesions isolated using laser capture microdissectionin 13 patients with pathogenic variants of who underwent RRSO and 17 control patients with the benign gynecologic disease. Results: pathogenic variants were detected significantly higher in RRSO group than control (p<0.001). No difference in the frequency of p53 signatures were observed between groups (53.8% vs 29.4%; p=0.17). sequencing and next-generation sequencing analysis in a patient with STIC and occult cancer revealed 2 mutations causing different p53 staining for STICs and another mutation shared between STIC and occult cancer. Conclusion: The sequence analysis for revealed 2 types of p53 signatures, one with a risk of progression to STIC and ovarian cancer with pathological variants in and the other with a low risk of progression without pathological variants in as seen in control.
Manabu Akahane,Takamasa Shimizu,Yusuke Inagaki,Tsutomu Kira,Takuya Egawa,Akinori Okuda,Tadanobu Onishi,Tomoaki Imamura,Yasuhito Tanaka 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.1
The purpose of this study was to evaluate the osteogenesis ability of osteogenic matrix cell sheets (OMCS) derived from old donor cells. Bone marrow stromal cells (BMSC) were obtained from young (7-week-old) and old (1-yearold) Fischer344 rats donors and cultured with modified Eagle’s medium (MEM group) alone or containing dexamethasone (Dex; 10 nM) and ascorbic acid phosphate (AscP; 0.28 mM) (Dex/AscP group). We prepared four in vitro experimental groups: (1) young MEM, (2) young Dex/AscP, (3) old MEM and (4) old Dex/AscP. Cell proliferation and osteogenic marker mRNA expression levels were evaluated in vitro. To assess bone formation in vivo, the cells of each group were combined with beta tricalcium phosphate (TCP) disks followed by implantation in recipient rats. The in vitro study showed significant differences in the mRNA expression of osteocalcin, ALP, and BMP2 between MEM and Dex/AscP groups. Bone formation following implantation was observed upon histological analyses of all groups. TCP combined with OMCS (OMCS/TCP group) resulted in enhanced bone formation compared to that following combination with BMSC (BMSC/ TCP). The osteocalcin content of the OMCS/TCP group 4 weeks after implantation was significantly higher than that in the BMSC/TCP construct for both young and old donors. The present study clearly indicated that OMCS could be generated from BMSCs of old as well as young donors using a mechanical retrieval method. Thus, through its usage of OMCS, this method may represent a potentially effective therapeutic option for cell-based therapy in elderly patients.
Inoue, Y.,Kuramoto, Y.,Hattori, M.,Adachi, M.,Kimura, M.,Akahane, T. The Korean Infomation Display Society 2011 Journal of information display Vol.12 No.3
Alignment failure sometimes occurs during the rubbing process because the rubbing cloth comes in direct contacts with the surface of the alignment film. A number of researches observed and evaluated the surface of the alignment film after the rubbing process had been reported. The real-time rubbing process has not been observed directly yet, though. In this study, the movement of the piles of the rubbing cloth during the rubbing process was observed with a high-speed camera. Furthermore, the relationship between the rubbing scratch on the alignment films and the movement of the pile was investigated. It was found that the movement of the pile affected the rubbing scratches.
Alignment film abrasion caused by rubbing
Kamada, Hirokazu,Ihara, Ikuo,Kim, Hong-Dae,Nakayama, Tadachika,Kimura, Munehiro,Akahane, Tadashi The Korean Infomation Display Society 2011 Journal of information display Vol.12 No.4
The alignment film abrasion caused by the rubbing process was quantitatively evaluated via atomic-force microscopy (AFM). First, a patterned alignment film structure, which was molded through the imprint method, was artificially formed. Then, the surface topography of the alignment film was evaluated via AFM after rubbing, and the degree of abrasion of the alignment film was estimated by subtracting the value after rubbing from the value before rubbing. It was recognized that the degree of abrasion increased with an increase in the rubbing strength. The relationship between the number of rubbing cycles and the degree of abrasion of the alignment film was also estimated.
Y. Inoue,Y. Kuramoto,M. Kimura,M. Hattori,M. Adachi,T. Akahane 한국정보디스플레이학회 2011 Journal of information display Vol.12 No.3
Alignment failure sometimes occurs during the rubbing process because the rubbing cloth comes in direct contacts with the surface of the alignment film. A number of researches observed and evaluated the surface of the alignment film after the rubbing process had been reported. The real-time rubbing process has not been observed directly yet, though. In this study, the movement of the piles of the rubbing cloth during the rubbing process was observed with a high-speed camera. Furthermore,the relationship between the rubbing scratch on the alignment films and the movement of the pile was investigated. It was found that the movement of the pile affected the rubbing scratches.
Abstract : Soil washing for rice paddy soils contaminated with cadmium
( Tomoyuki Makinoa ),( Takashi Kamiya ),( Naoki Sekiya ),( Yuji Maejima ),( Ikuko Akahane ),( Hiroyuki Takano ) 한국환경농학회 2012 한국환경농학회 워크샵자료 Vol.2012 No.2
Codex Alimentarius Commission (Codex) has adopted the maximum permissible concentration of cadmium (Cd) in polished rice and other relevant crops, which requires an alleviation of the Cd contamination in rice grain. Various chemicals were tested for their Cd extraction efficiency by using three paddy soils, selecting ferric chloride (FeCl3) as a promising chemical for on-site soil washing. The comparison of FeCl3 extraction ability to that of various iron, manganese, and zinc salts revealed the primary extraction mechanism of FeCl3 to be proton release coupled with hydroxide generation (hydrolysis). This indicates that proton release from FeCl3 is controlled by the chemical equilibrium of hydroxide formation, and minimizes the negative effect on soil properties and environment, which are different from hydrochloric acid (HCl). Washing with FeCl3 led to the formation of Cd?chloride complexes, enhancing Cd extraction from the soils. We also developed in situ three-step washing method for Cd-contaminated paddy fields with FeCl3. The method was comprised of 1) chemically washing the field soil with a FeCl3 solution; 2) washing the treated soil with water to eliminate residual Cd and FeCl3; and 3) on-site treatment of wastewater using a portable wastewater treatment system. Concentrations of Cd in the treated water were below Japan`s environmental quality standard (0.01 mg L-1). The on-site soil washing confirmed the effectiveness of FeCl3 for decreasing Cd in soil and rice grains without negative effect on rice yield.
Liquid crystal alignment on patterned-alignment films
Lias, Jais Bin,Oo, Thet Naing,Yazawa, Tomohiro,Kimura, Munehiro,Akahane, Tadashi The Korean Infomation Display Society 2011 Journal of information display Vol.12 No.2
To come up with a bistable liquid crystal (LC) device using unpolarized UV light, single-step laser patterning on a photoalignment layer using a photomask was proposed to achieve an equilibrium configuration of LC molecules in contact with a periodically patterned substrate. The patterns were formed by stripes of alternating random planar and homeotropic anchoring on a submicrometer scale in the order of $0.5{\mu}m$. Two possible configurations of bistable LC cells that can be obtained by combining a micropatterned surface formed with alternating random-planar- and homeotropic-alignment with planar- or homeotropic-alignment surfaces were proposed. The alignment properties of the two proposed models were investigated, along with the microscopic switching behavior of micropatterned nematic LC cells.
Kei Moriya,Tadashi Namisaki,Shinya Sato,Masanori Furukawa,Akitoshi Douhara,Hideto Kawaratani,Kosuke Kaji,Naotaka Shimozato,Yasuhiko Sawada,Soichiro Saikawa,Hiroaki Takaya,Koh Kitagawa,Takemi Akahane,A 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.4
Background/Aims: We previously reported the comparable efficacy of bi-monthly hepatic arterial infusion chemotherapy (B-HAIC) to that of sorafenib chemotherapy for the treatment of advanced hepatocellular carcinoma (aHCC) in patients with compensated cirrhosis. In this study, we demonstrate the efficacy of B-HAIC in patients with decompensated cirrhosis. Methods: Forty-five patients with aHCC refractory to transcatheter arterial chemo-embolization (TACE) were treated with B-HAIC and were divided into two groups according to hepatic functional reserve (Child-Pugh grade). Overall survival period, treatment response, and adverse events in each group were analyzed. Results: Efficacy and disease control rates in the Child-Pugh B group (n=24; 21% and 71%, respectively) were not significantly impaired compared the Child-Pugh A group (n=21; 38% and 67%, respectively). Median survival time and survival rate at 12 months in the Child-Pugh B group were 422 days and 58.3%, respectively, whereas those in the Child- Pugh A group were 567 days and 70.8%, respectively. Importantly, the hepatic functional reserve of patients did not worsen in either group during the treatment period. Furthermore, the occurrence rate of adverse events leading to discontinuation of anti-tumor treatment was not significantly increased in the Child-Pugh B group. Conclusions: Given the preservation of hepatic functional reserve afforded by B-HAIC chemotherapy in patients with decompensated cirrhosis, B-HAIC might be an acceptable alternative strategy for aHCC patients who do not respond to TACE.