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Family Origin Names and Haplotypes of Y - DNA in Korean Population
Kim, Jong Soon,Kim, Yung Jin,Ahn, Gwang Sook,Lee, Ju Won,You, Sun Ah 한국유전학회 1996 Genes & Genomics Vol.18 No.4
The use of restriction fragment length polymorphisms (RFLPs) has been proposed for the construction of a human genetic linkage map and also become a powerful tool in human population genetics. Human Y-chromosome which is haploid and paternally inherited is valuable for investigating male-mediated gene flow and for complement maternally based studies of mtDNA. We have studied 166 samples from 4 kinds of family origin names such as Kyungju Kim, Kimhae Kim, Chunju Lee and Milyang Park based on the 49aTaq 1 polymorphisms, and a total of 25 haplotypes were observed. The B, F, and I bands is observed in all haplotypes and haplotype showing A3, B, D2, D3, F, and I bands is common haplotype except for Chunju Lee. The result obtained are summarized as follows.
Lee, Hyun-A,Lee, Hye Won,Ryuk, Jin Ah,Kil, Ki-Jung,Ko, Byoung Seob The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6
Effects of 70% ethanol extract of the stems and leaves of V. rotundifolia (VRE) on the activation of IgG2 and histology in collagen-induced arthritis (CIA) as a model of rheumatoid arthritis were examined. Histological changes in the knee joints were evaluated and determined the serum anti-type II collagen IgG2a and IgG2b levels in CIA. VRE treatment significantly decreased the arthritis index, the synovial cartilage erosion, and the serum IgG2a and IgG2b levels, suggesting that V. rotundifolia might be useful for treating rheumatoid arthritis.
Synthesis of Neplanocin A Analog with 2′-“up”-C-Methyl Substituent as Potential Anti-HCV Agent
Lee, Hyung-Rock,Kang, Jin-Ah,Park, Ah-Young,Kim, Won-Hee,Chun, Pu-Soon,Kim, Jung-Su,Kim, Jin-Ah,Lee, Bo-Eun,Jeong, Lak-Shin,Moon, Hyung-Ryong Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.9
2′-$\beta$-C-Methylneplanocin A (3) was synthesized via 2-$\beta$-C-methylribonolactone, prepared by a modified Whistler and BeMiller’s method developed by our laboratory, as potential anti-HCV agent. Reduction of 14 with Dibal-H afforded 26 in a good yield with a trace of 25, whereas a Luche reduction gave 26/25 = 4/1 mixture. Several attempts were made to chemoselectively remove TBS group in the presence of TBDPS group and treatment with both PPTS and TsOH showed the best result. Condensation of 26 with 6-chloropurine under Mitsunobu conditions produced an $S_N$2 product 27 along with an $S_N$2′ product 28.
Won Gi Kim,Seul Ah Lee,Sung Min Moon,Jin-Soo Kim,Su-Gwan Kim,Yong Kook Shin,Do Kyung Kim,Chun Sung Kim 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.4
Anthricin (Deoxypodophyllotoxin), a naturally occurring flavolignan, has well known anti-cancer properties in several cancer cells, such as prostate cancer, cervical carcinoma and pancreatic cancer. However, the effects of Anthricin are currently unknown in oral cancer. We examined the anticancer effect and mechanism of action of Anthricin in human FaDu hypopharyngeal squamous carcinoma cells. Our data showed that Anthricin inhibits cell viability in a dose- and time-dependent manner (IC50 50 nM) in the MTT assay and Live & Dead assay. In addition, Anthricin treated FaDu cells showed marked apoptosis by DAPI stain and FACS. Furthermore, Anthricin activates anti-apoptotic factors such as caspase-3, -9 and poly (ADP-ribose) polymerase (PARP), suggesting that caspase-mediated pathways are involved in Anthricin- induced apoptosis. Anthricin treatment also leads to accumulation of the pro-apoptotic factor Bax, followed by inhibition of cell growth. Taken together, these results indicate that Anthricn-induced cell death of human FaDu hypopharyngeal squamous carcinoma cells is mediated by mitochondrial-dependent apoptotic pathway. In summary, our findings provide a framework for further exploration on Anthricin as a novel chemotherapeutic drug for human oral cancer.
Lee, Hyun Ju,Ko, Jung Hwa,Ko, Ah Young,Kim, Mee Kum,Wee, Won Ryang,Oh, Joo Youn Informa Healthcare USA, Inc. 2014 Current eye research Vol.39 No.8
<P>Purpose: To investigate the effects of intravenous (IV) infusion of human mesenchymal stem/stromal cells (hMSCs) on activation and migration of CCR7(+) antigen presenting cells (APCs) in allogeneic corneal transplantation. Materials and Methods: We first analyzed the cellular and molecular profiles of draining lymph nodes (DLNs) in early and late phases after syngeneic or allogeneic corneal transplantation in mice, and then investigated the effects of hMSCs on APCs expressing CCR7, a key molecule implicated in APC migration to DLNs. Results: After early transplantation, the numbers of MHC class II(+)CD11b(+)CD11c(+), MHC class II(+)CD11b(-)CD11c(+), and MHC II(+)CD11b(+)CD11c(+) cells as well as the levels of APC-derived cytokines (IL-12a and IL-12b) driving the Th1 response were increased in both syngeneic and allogeneic transplants indicating activation of APCs. In late phase, the numbers of CD3(+)CD4(+)CD8(-) and CD3(+)CD4(-)CD8(+) cells and the levels of T cell-derived cytokines were increased in allogeneic transplants, but not in syngeneic transplants indicating immune rejection. The peri-transplant infusion of IV hMSCs significantly reduced the numbers of CCR7(+)CD11b(+) or CCR7(+)CD11c(+) cells in DLNs and the cornea in the early phase. Also, the expression of CCR7 and its ligands, CCL19, CCL21, and CXC3R as well as IL-12 were markedly decreased by hMSCs in the cornea and DLNs. Conclusions: IV hMSCs reduced the activation and migration of CCR7(+) APCs in the cornea and DLNs in allogeneic corneal transplantation.</P>
Lee, Sung Jong,Lee, Ah Won,Kim, Tae Jung,Kim, Jin Hwi,Bae, Jeong Hoon,Lee, Chung Won,Song, Min Jong,Yoon, Joo Hee,Hur, Soo Young,Park, Jong Sup Blackwell Publishing Asia 2011 JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH -TO Vol.37 No.9
<P><B>Abstract</B></P><P><B>Aim: </B> The aim of this study was to evaluate the behavior of low‐grade squamous intraepithelial lesion (LSIL) in Korean women infected with human papillomavirus (HPV) in relation to the immunocytochemical detection of the HPV L1 capsid protein.</P><P><B>Material and Methods: </B> From January 2006 to December 2007, a total of 353 immunocytochemistry tests were performed on specimens from HPV‐infected patients with LSIL. Due to exclusions, the study population was reduced to 318. Subjects were monitored at 4–6 month intervals. The regression, persistence, and progression of the cytologic abnormalities of the 318 cases were compared with the results of HPV L1 capsid protein immunocytochemical detection.</P><P><B>Results: </B> Of the 137 patients negative for the HPV L1 capsid protein, 38 (27.7%) showed progression to high‐grade lesions, 50 (36.5%) showed persistence, and 49 (35.8%) showed regression to normal cytological features. In contrast, of the remaining 181 patients positive for the HPV L1 capsid protein, 15 (8.3%) showed progression to high‐grade lesions, 74 (40.9%) showed persistence, and 92 (50.8%) showed regression. The results of immunocytochemical testing for the HPV L1 capsid protein show a linear association with the progression or regression behavior of low‐grade cervical cytology in patients infected with HPV (linear by linear association test, <I>P</I> < 0.05).</P><P><B>Conclusion: </B> Immunocytochemical detection of HPV L1 was significantly related with the biological patterns of LSIL in Korean women. Hence, immunocytochemistry for the detection of HPV L1 is beneficial in providing further information for LSIL.</P>
Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer.
Lee, Kyung-Hun,Chang, Hye Jung,Han, Sae-Won,Oh, Do-Youn,Im, Seock-Ah,Bang, Yung-Jue,Kim, Sun Young,Lee, Keun-Wook,Kim, Jee Hyun,Hong, Yong Sang,Kim, Tae Won,Park, Young Suk,Kang, Won Ki,Shin, Sang Joo Springer 2013 Cancer chemotherapy and pharmacology Vol.71 No.4
<P>Ethnic diversity of genetic polymorphism can result in individual differences in the efficacy and toxicity of cancer chemotherapy.</P>
Lee, Jun Ah,Lee, Jae Min,Park, Hyeon Jin,Park, Meerim,Park, Byung Kiu,Ju, Hee Young,Kim, Ji Yoon,Park, Sang Kyu,Lee, Young Ho,Shim, Ye Jee,Kim, Heung Sik,Park, Kyung Duk,Lim, Yeon-Jung,Chueh, Hee Won The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.4
Background: For children and adolescents with cancer, going back to school is a key milestone in returning to "normal life." Purpose: To identify the support vital for a successful transition, we evaluated the parents' needs and the challenges they face when their children return to school. Methods: This multi-institutional study was conducted by the Korean Society of Pediatric Hematology and Oncology. The written survey comprised 24 questions and was completed by 210 parents without an interviewer. Results: Most parents (165 of 206) reported that their children experienced difficulties with physical status (n=60), peer relationships (n=30), academic performance (n=27), emotional/behavioral issues (n=11), and relationships with teachers (n=4) on reentering school. Parents wanted to be kept informed about and remain involved in their children's school lives and reported good parent-teacher communication (88 of 209, 42.1%). Parents reported that 83.1% and 44.9% of teachers and peers, respectively, displayed an adequate understanding of their children's condition. Most parents (197 of 208) answered that a special program is necessary to facilitate return to school after cancer therapy that offers emotional support (n=85), facilitates social adaptation (n=61), and provides tutoring to accelerate catch up (n=56), and continued health care by hospital outreach and school personnel (n=50). Conclusion: In addition to scholastic aptitude-oriented programs, emotional and psychosocial support is necessary for a successful return to school. Pediatric oncologists should actively improve oncology practices to better integrate individualized school plans and educate peers and teachers to improve health literacy to aid them in understanding the needs of children with cancer.